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The knowledge base required of the modern-day head and neck surgeon, as a key member of a comprehensive and wide-ranging multidisciplinary team, is significant. The sixth edition of Stell & Maran's Head and Neck Surgery and Oncology continues to be the leading reference book in the specialty.This accessible and authoritative text is fully revised and updated to reflect international practice across the multidisciplinary team. A global community of expert authors have provided chapters entailing the expertise required by today's head and neck surgeon. The book encompasses fundamentals of head and neck oncologic practice including pathology, imaging, staging, prehabilitation, surgical approaches and reconstruction, radiation therapy, chemotherapy, biological therapies and many more. Key sections discuss the broad range of tumours by anatomical site and rare cancers. Future perspectives are reviewed with topics on how to become a clinical trialist, delivering surgical innovation and personalised approaches to head and neck cancer therapy with insights for the future.With contributions from the full spectrum of the multidisciplinary team, this book will be a major up-to-date resource for both trainees and established practitioners in otolaryngology, maxillofacial surgery, plastic surgery, endocrine surgery, clinical oncology, oncology nursing and those professions allied to medicine, such as speech and language therapy and dietetics.

Collaborative approaches are becoming a key driver in drug discovery and development. They come in many types and forms ranging from project-based collaborations and strategic alliances to large international consortia. The volume discusses various types of such collaboration including the specific uses, advantages, and challenges. Based on the nature of public-private partnerships, we present views and experiences from academia, industry, and public stakeholders.

This book now published in its fully updated second edition comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract and highlights the latest efforts in multimodality treatment options before and after surgery, important ongoing trials as well as future areas of investigation. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including Immunotherapy, personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.

The book offers a comprehensive update on bone tumors and tumor like conditions including clinical, pathological and radiological features. It provides a comprehensive coverage of the topic including molecular biology and provides the readers a solid foundation of knowledge for tumor recognition and evaluation. The book includes chapters on synovial and odontogenic tumors as well. Chapters are uniformly designed and provide systematic approach to various tumors and tumor-like lesions of bone. They are divided according to the predominant cell of origin or the predominant matrix produced, such as osteoid producing lesions, chondroid tumors or giant cell rich tumors, thus assisting the reader, as to how to approach such lesions. Chapters include ample radiology and microscopy images and tables for quick reference.The book is an ideal resource and offers assistance to practicing pathologists, radiologists, clinical oncologists, orthopedicians as well as residents and interns in pathology, radiology, oncology and orthopedics in understanding the approach to bone tumors in a systematic way. The book emphasizes on the need for a multidisciplinary approach for the diagnosis of bone tumors.

This open access book is written by world-renowned experts on radiomolecular precision oncology to celebrate the work, life, principles and ideology of Richard P Baum.It includes commentaries, reviews and some thought provoking novel ideas on radionuclide precision oncology, covering topics such as various aspects of theranostics and molecular radiotherapy like radiolabeled peptides, radiolabeled antibodies, dosimetry, and quality control as well as the diagnosis and treatment of specific tumor types. Featuring contributions by biologists, physicists, chemists, mathematicians, geneticists, and physicians from a range of specialties, this Festschrift is highly interdisciplinary and will be a valuable resource for future precision oncologists.

This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches. This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.

Es ist „normal“, nicht normalgewichtig zu sein. Die Adipositas ist mehr als eine Befindlichkeitsstörung, sie ist eine Krankheit, eine Volkskrankheit.Was sind die Grundlagen und Ursachen? Psychologisch und physiologischGenetische Faktoren und UmweltfaktorenDysregulation von Hunger und Sättigung sowie des EnergiestoffwechselsFolgekrankheiten Vom Diabetes bis zu KarzinomenVom Fersensporn bis zur WirbelsäulendegenerationVon der Stigmatisierung bis zur Essstörung Welche Therapie ist wann sinnvoll? Keine Crashdiäten – langfristige ErnährungsumstellungAdipositasgerechte BewegungstherapieVerhaltensmodifikation, ggf. VerhaltenstherapieBariatrische Chirurgie als ultima ratio NEU u.a. Digitale Ansätze zur GewichtssenkungNeue MedikamenteStabilisierung des GewichtserfolgsModerne laparoskopische Adipositaschirurgie Nach den Leitlinien DAG, Deutsche Adipositas-GesellschaftDGE, Deutsche Gesellschaft für ErnährungDGEM, Deutsche Gesellschaft für ErnährungsmedizinDDG, Deutsche Diabetes-Gesellschaft DAS Nachschlagewerk, das alle Bereiche der Adipositas umfassend, interdisziplinär darstellt. Für alle Fachleute, die in Krankenhäusern, Reha-Kliniken und niedergelassenen Praxen mit adipösen Patienten arbeiten: Ärzte (Internisten, Allgemeinmediziner, Pädiater, Gynäkologen, Endokrinologen …), Ernährungsfachkräfte, Klinische Psychologen, Psychotherapeuten, Bewegungstherapeuten, Gesundheitsberater …

This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner's guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists.

While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.

Dieses Buch enthält aktuelle Informationen über die allgemeinen Grundsätze der diagnostischen und therapeutischen Nuklearmedizin im Kontext der Endokrinologie.Der Inhalt ist in sechs Teile gegliedert. In Abschnitt I werden allgemeine Aspekte der Radiopharmaka, der Szintigraphie, der Single-Photon-Emissions-Computertomographie (SPECT), der Positronen-Emissions-Tomographie (PET), der Radionuklidtherapien und der strahlengesteuerten Chirurgie behandelt. Abschnitt II befasst sich mit diagnostischen Anwendungen bei gutartigen Schilddrüsenerkrankungen und der Beurteilung von Schilddrüsenknoten. Abschnitt III gibt einen Überblick über die Behandlung von Nebenschilddrüsenerkrankungen. In Abschnitt IV werden diagnostische Verfahren bei gut differenziertem Schilddrüsenkrebs vorgestellt. Abschnitt V befasst sich mit Verfahren und Therapie bei gut- und bösartigen Erkrankungen der Nebenniere (Phäochromozytome und Paragangliome). Schließlich werden in Abschnitt VI die Diagnose und Behandlung neuroendokriner Tumoren vorgestellt.Nuklearmedizin bei endokrinen Erkrankungen: Diagnose und Therapie richtet sich an nicht spezialisierte Nuklearmediziner, die auf dem Gebiet der Endokrinologie arbeiten, und ist auch für Forscher und Studenten eine wertvolle Ressource.

Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer. Covers both the conceptual bases and the clinical applications Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice Covers the whole range of cancers in practical detail

This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe. - Provides comprehensive coverage and is basically a'one-stop'resource across all disciplines contributing to precision medicine - Authoritative guide edited by distinguished authorities who are shaping the advancement of precision medicine - Thematically organized, allowing for easy exploration across interconnecting disciplines - Digitally innovative resource with multimedia features that complement the text and provide additional learning and teaching resources

The New Era of Precision Medicine: What it Means for Patients and the Future of Healthcare highlights aspects of precision medicine in different specialties and offers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions and disease prevention. The book explains how precision healthcare differs among countries, as well as how there is a collaboration among many labs to share resources and knowledge to advance the field across the globe. The book also discusses the cultural differences and cultural sensitivity that may be involved in the precision medicine approach. Finally, with regard to safety and quality outcomes, the book presents a range of current and possible future concerns related to those outcomes. Precision medicine is the new standard of quality healthcare delivery. It aims to optimize patient safety and clinical outcomes, enhance the efficacy of therapeutic interventions, and facilitate disease prevention, offering a way to customize patient care, decision-making, and clinical practice. - Highlights the characteristics of precision medicine in different areas - Offers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions, and disease prevention - Emphasizes how medicine has transformed from a'one-size-fits-all approach to personalized medicine influenced by individual characteristics - Introduces complex topics delivered in terms that target a broad range of audiences

The book delves into the intricate realm of pharmacokinetics and pharmacodynamics as they apply to modern advancements in drug delivery systems. It offers a comprehensive exploration of novel drug delivery methods, with a particular focus on nanoparticles and nanocarriers. The absorption, distribution, metabolism, and excretion processes of nanoparticles are extensively examined. It also covers various evaluation models, spanning from preclinical to clinical, aimed at assessing the effectiveness and safety of nanoparticles in drug delivery. It also covers the integration of Artificial Intelligence and Machine Learning in pharmacokinetics and pharmacodynamics, showcasing how these cutting-edge approaches can enhance our understanding of drug behavior and optimize therapeutic outcomes. It serves as a comprehensive guide, highlighting the fusion of traditional pharmacological concepts with contemporary drug delivery systems and innovative technologies, all in the pursuit of refining medical treatments and patient care and is a valuable resource for academicians, researchers, and pharmacologists.

Survival of patients with metastatic cancer has increased over the past two decades as a result of a progressive improvement of regional and systemic therapies. However, oncologists'estimates of patients'predicted overall survival in metastatic cancer are imprecise. The purpose of this book is to systematize the evidence regarding the prognostic factors of metastatic gastrointestinal tumors, separating the findings with the highest level of evidence among those available for each disease by selecting studies with the highest scientific evidence level.

This Handbook on cancer biology comprehensively reviews the current status of the oncobiology of major cancer types, cancer detection and treatment strategies, principles and processes of cancer drug development, and nanomedicine and other emerging cancer medicine applications to cancer diagnosis and treatment. The book also provides practical and implementable nutritional guidance in cancer prevention, treatment, and quality of life for cancer survivors. It discusses pharmacogenetics strategies for predicting cancer prognosis and treatment exposure, response, and toxicity. Further, it presents bioinformatics approaches for predicting anti-cancer drugs and drug combinations based on the multi-omic data, including transcriptomics, toxicogenomics, functional genomics, and biological networks. The Handbook also examines major factors and pathways that regulate cancer stem cells development and discusses potential targeted therapy for cancer stem cells. The book explores the application of the CRISPR/Cas9-based gene-editing technique in basic cancer research, diagnosis, and treatment of cancer. This Handbook is an invaluable source for oncologists, researchers, public health specialists, epidemiologists, and policy makers.​

This book provides an easy-going, high-quality and updated work focused on the most common diagnoses of Traumatology and Orthopaedics. It's structured with several sub-headings, including bullet-point tips for basic concepts.Each chapter is focused on a specific pathology and includes the following sub-headings: short introduction, applied anatomy and physiology, prevalence, classification, diagnosis (including anamnesis, physical examination and complementary imaging, from plain x-ray to cross-sectional imaging), treatment (conservative-surgical options), controversies, complications, future directions and author's preference for treatment apart from references. Orthopaedics and Trauma - Current Concepts will be an inspiration to the young orthopaedic resident, fellow or even general orthopaedic surgeon and senior medical student. It will definitely help with their careers and also be a useful tool to prepare for the board certified orthopaedic examination.

This book covers all diagnostic and therapeutic aspects of neuro-oncological diseases. In the last decade, the management of brain tumors has been revolutionized following the new WHO classification and thanks to the introduction of molecular markers into the clinical routine. From an imaging point of view, the continuous technological developments and the implementation of various radiopharmaceuticals have paved the way to new clinical indications and has helped optimize patient management. In this context, a major breakthrough could derive from the introduction of radiomics and artificial intelligence in the diagnostic and therapeutic pathway. Not forgetting the emerging role of heavy-ion therapy as a complement to the innovative drugs and treatments adopted in medical oncology and radiation therapy. In the present book, all above-mentioned aspects are covered, starting with the novel standards for the WHO classification of brain tumors, to the up-to-date surgical techniques and advanced therapeutic approaches, passing through the currently available imaging modalities and ongoing developments embracing both radiology and nuclear medicine discipline. Imaging represents indeed the “trait d'union” for all the arguments described in the book; therefore, in most chapters there are dedicated sessions focused on the role of imaging in each specific context. The publication aims to fill the gap between the clinicians and all professionals directly involved in the management of patients with brain tumors and the newest scientific outreach. Moreover, thanks to the comprehensive insight into the latest technological developments, scientists and researchers interested in the topic will find the book a useful tool for future studies and perspective discoveries.

Pediatrics is an evolving field of medicine and with many new advancements in knowledge, scientific research, and technology in recent years. This concise and comprehensive 2nd Edition of the textbook'Update in Pediatrics'provides an update and overview of the latest advances and current literature in Pediatrics, assisting health professionals to review cutting-edge information in the different subspecialties in Pediatrics. This book is structured into chapters based on the various subspecialties in Pediatrics, and includes chapters ranging from traditional disciplines such as Infectious Disease and Cardiology, to more current disciplines such as Adolescent Medicine and Child Maltreatment. The team of authors is made up of experienced and expert clinicians and researchers in their respective fields. The target audience for this book includes any practitioner who cares for children, including pediatricians, family doctors, nurses and nurse practitioners, allied health professionals, residents, medical students, and health researchers providing an indispensable resource for the busy clinician and learner who wishes to stay up-to-date with the latest advances and knowledge in the field.

O conhecimento abrangente da anatomia, fisiologia e doenças da tireoide e paratireoides é essencial na prática clínica dos diversos especialistas interessados nessas glândulas. Reunimos neste Volume do Guia Prático de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, endocrinologistas, radiologistas, oncologistas clínicos, radioncologistas, patologistas, médicos nucleares, fonoaudiólogas, otorrinolaringologistas e cirurgiões de cabeça e pescoço, com o objetivo de fornecer as melhores e mais atuais informações. Especialistas que participam diariamente do diagnóstico e tratamento de pacientes com enfermidades dessas glândulas. Os diversos capítulos foram pensados para trazer informações práticas e multidisciplinares com o objetivo de facilitar a aplicação nos cuidados aos pacientes. Os colaboradores são, em sua maioria, especialistas ligados à Faculdade de Medicina da Universidade de São Paulo e ao Hospital das Clínicas, mas não nos esquecemos de incluir alguns renomados especialistas vinculados a outras instituições nacionais e internacionais, que engradeceram o conteúdo da obra. Acreditamos que o resultado desse esforço conjunto será muito útil para desvendar os mistérios relacionados a essas glândulas tão fascinantes.

This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book's dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

The book provides an overview of different nanoparticles, their classification, and their applications in healthcare, food sciences, environmental sciences, and agricultural sciences. The introductory chapters discuss different types of nanoparticles, their types, and their structural properties. The subsequent chapter examines factors that influence the biocompatibility and toxicity of NPs for the safe and sustainable development of emerging nanoparticles. The chapter systematically reviews the nanoparticle-based contrast agents employed in most common biomedical imaging modalities. The book further examines the applications of advanced nanoparticle design that are utilized for both non-personalized and precision applications for improving precision therapies. The book provides a comprehensive update on nanoparticles'toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. This book is an ideal guide for researchers and students interested in understanding the applications of nanoparticles in biomedical sciences and the healthcare sector.

Schachner and Hansen's Pediatric Dermatology has been the gold-standard reference in pediatric dermatology for more than 33 years. The new edition is a comprehensive textbook covering all the skin conditions of children and adolescents in a two-volume masterwork that will meet the expectations of pediatric dermatologists, dermatologists, pediatricians and all who provide pediatric healthcare.

This is the third, completely updated edition of a comprehensive book in which many of the world's leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.

Renowned experts in the neuro-oncological field bring their expertise together for Neuro-Oncology Compendium for the Boards and Clinical Practice. This volume reviews the core topics of neuro-oncology including adult and pediatric neuro-oncology, management, central nervous system tumor complications, genetic considerations, and more. With a focus on updated treatments and terminology, this volume is designed to comprehensively review all major facets of neuro-oncology so that physicians-in-training may prepare for the board review and practicing specialists can stay up to date in their treatment of patients. This essential text includes hundreds of figures and tables, succinct review flashcards, end-of-chapter questions and answers, as well as end-of-volume exams so readers can review and test their own comprehension. Each chapter has been reviewed by the editors to ensure cohesive board-level verbiage, emphasizing practical clinical knowledge. Neuro-Oncology Compendium for the Boards and Clinical Practice is up-to-date and comprehensive, eliminating the need for multiple sources of study. Key features of this volume include: -End of chapter flashcards to summarize key content -End of chapter Questions and Answers for review -Practice exams to simulate board questions -Updated terminology and practices -Complimentary images and tables to support learning

Using a practical, question-and-answer approach, Evidence-Based Practice of Palliative Medicine, 2nd Edition, helps you provide optimal care for patients and families who are dealing with serious illness. This unique reference focuses on patient and family/caregiver-centered care, highlighting the benefits of palliative care and best practices for delivery. The highly practical, user-friendly format sets it apart from other texts in the field, with concise, readable chapters organized around clinical questions that you're most likely to encounter in everyday care. - Uniquely organized using a question-and-answer approach, making it easy to find answers to common questions asked by practitioners and patients. - Up-to-date, reader-friendly chapters explore interventions, assessment techniques, treatment modalities, recommendations and guidelines, communication techniques, and available resources for palliative care. - Expanded discussions on hospice in every chapter, and a new emphasis on pediatrics, with increased material on pediatric malignancies, developmental delays, cystic fibrosis, and perinatal palliative care. - New chapters on wellness of the palliative care practitioner, patients with opioid use disorders, telehealth in palliative care, health disparities, rural palliative care, caring for people with hematologic malignancies, integrative and alternative therapies, LGBTQ+ populations, mobile health technologies, and national palliative care implementation strategies. - High-quality evidence gathered and reviewed by leading experts in palliative medicine, including clinicians, educators, and researchers across a broad range of disciplines. - Numerous algorithms throughout help you make informed decisions, and'take-home'points in every chapter provide a quick summary of key content. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Malignome des Kopf-Halsbereichs sind eine heterogene Gruppe bösartiger Tumoren, deren Diagnostik und Therapie ein inter- und multidisziplinäres Konzept erfordern. Ein Team unter anderem bestehend aus Mund-, Kiefer-, Gesichtschirurgen, Hals-Nasen-Ohren-Ärzten, Dermatologen, Onkologen, Strahlentherapeuten, Radiologen, Nuklearmedizinern, Pathologen, Zahnärzten, onkologischen Pflegefachkräften, Physiotherapeuten, Ernährungsberatern und Psychologen sind für die krankheitsgerechte Betreuung der Patienten zuständig.

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs - Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution - Features chapter contributions from leading experts in the field

This updated edition of the book provides radiation oncologists with a structured, state-of-the-art guide to target volume delineation for all major cancer types. It provides an overview of recent advances in radiation treatment techniques and multimodal imaging for radiation treatment planning. It also offers clear and structured guidelines for the contouring of target volumes and organs at risk, taking into account the available imaging modalities including PET/CT and multiparametric MR imaging. Each chapter addresses the target volume concepts of a particular tumor type and has been written by experts in the field. Covering all major tumor entities, the book provides practicing radiation oncologists with a guide to defining target volumes based on multimodal imaging.

This volume discusses new developments in the etiology, diagnosis, and treatment of cholangiocarcinoma induced by the liver fluke Opisthorchis viverrini. Although cholangiocarcinoma is rare in the Western world, it has a very high incidence in continental Southeast Asian countries, where it is linked to infection with O. viverrini. In Southeast Asia this cancer causes thousands of deaths every year and places a severe socioeconomic burden on the affected families. Diagnosis is usually at a late disease stage, and in the past palliative surgery and care have been the major therapeutic options. Recently, however, techniques have become available for early-stage diagnosis that offer the possibility of curative surgery, and novel chemotherapeutic options are also under development. In Thailand alone, more than 2 million individuals have now been registered for screening for this cancer. The aim of this book is to highlight the latest research in the field and to explain how the newly available techniques can be applied to reduce the risk of developing cholangiocarcinoma and increase the likelihood of survival.

Medicines for Cancer: Mechanism of Action and Clinical Pharmacology of Chemo, Hormonal, Targeted, and Immunotherapies covers most known anti-cancer therapeutics. Cancer is the second leading cause of death worldwide, with its various forms resulting in nearly one out of every six mortalities each year. This book describes all US FDA-approved drugs (up to 2021), such as small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, cell therapy, and immunotherapies, along with information on their generic and brand names, medical uses, details dosage, mechanisms of actions, pharmacokinetics and side effects. Chemical structures of small molecules, small peptides, antibody-drug conjugates are also provided. This book is ideal for medicinal chemists, oncologists, and pharmacologists, but it will also be indispensable for professional researchers, whether they are working in the clinic or the pharmaceutical industry. - Covers precise information on each drug treatment - Catalogues and lists all FDA-approved drugs for cancer group by chemical classes - Provides easy access to specific drugs

Orthopaedic Knowledge Update® 14, edited by Leesa M. Galatz, MD, MBA, FAAOS, and Frederick M. Azar, MD, FAAOS, brings you a comprehensive synthesis of the latest clinical thinking and best practices across all orthopaedic specialty areas. OKU® 14 covers developments of the last three years with revisions and updates based on new evidence, outcomes, and innovations in the recent literature, including annotated references. Keep pace with the rapidly evolving body of orthopaedic knowledge and clinical practice with OKU's objective, balanced coverage. Backed by clinical research, informed by practical experience, and rigorously edited by thought leaders across the orthopaedic specialties, OKU®14 is your most up-to-date resource to guide your delivery of high-quality orthopaedic patient care today.

This is an open access book.With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up.All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

We are in the era of large-scale science. In oncology there is a huge number of data sets grouping information on cancer genomes, transcriptomes, clinical data, and more. The challenge of big data in cancer is to integrate all this diversity of data collected into a unique platform that can be analyzed, leading to the generation of readable files. The possibility of harnessing information from all the accumulated data leads to an improvement in cancer patient treatment and outcome. Solving the big data problem in oncology has multiple facets. Big data in Oncology: Impact, Challenges, and Risk Assessment brings together insights from emerging sophisticated information and communication technologies such as artificial intelligence, data science, and big data analytics for cancer management.This book focuses on targeted disease treatment using big data analytics. It provides information about targeted treatment in oncology, challenges and application of big data in cancer therapy. Recent developments in the fields of artificial intelligence, machine learning, medical imaging, personalized medicine, computing and data analytics for improved patient care. Description of the application of big data with AI to discover new targeting points for cancer treatment. Summary of several risk assessments in the field of oncology using big data. Focus on prediction of doses in oncology using big data The most targeted or relevant audience is academics, research scholars, health care professionals, hospital management, pharmaceutical chemists, the biomedical industry, software engineers and IT professionals.

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. - Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. - Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. - Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. - Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase. - NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. - NEW! Updated, peer-reviewed content provides the most current information possible. - NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+. - NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

There have been many advances in the diagnosis and treatment of cancer, but it is still a feared disease with a lot of work left to be done. The importance of gastrointestinal cancer as a frequently occurring disease goes without saying. It accounts for half of human cancer cases but differs from other forms of cancer. Complete prevention is possible through proper treatment of precancerous lesions. There is still no comprehensive book about prevention, early diagnosis, and proper treatment of precancerous lesions and new developed diagnostic modality, and treatment such as endoscopic treatment and minimal invasive surgery and chemotherapy and immunotherapy. Also, this book will contain conservative treatment methods for patients suffering from diverse complications. There will be plentiful clinical cases including endoscopic findings, radiologic images, pathology and treatment outcome in this book. For these reasons, this book will give very valuable information to many gastroenterologists, oncologists, surgeons and general physicians.

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via textbookscom.support@elsevier.com.

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and'WELLNESS'molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents.This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquidbiopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world's population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

Oncology is a field characterized as “medicine of high complexity” and cancer is generally regarded as a complex system. Therefore, it cannot be classified and treated according only to its biology. Even though research on the biology of cancer has increased and more studies have been published, the related sociological, political and economic dimensions, as well as mathematical models that predict whether this condition will take one course or another, have often been neglected. The Invisible Hand of Cancer—The Complex Force of Socioeconomic Factors in Oncology Today unfolds the variables behind the biological disease, exploring the social aspects and presenting cancer as a model inside of the Complexity Theory. Cancer is a generic word for more than 200 diseases. In a wider view of cancer treatment, the various factors of cancer interact in multiple ways and it is a difficult task to identify and understand all the possible combinations in this system. All these variablesand how they interact can be defined as the invisible hand of cancer. This book does not intend to be an exhaustive analysis of these aspects. It is a door being opened to the cancer research journey, along the years and beyond its biology. It will also discuss how social behavior can interfere in the evolution of cancer treatment, as a result of society's way of thinking and choices, thus the importance of truly addressing cancer as an intricate system and a public health issue. After the success of my children's books about cancer (Chubby's Tale: The true story of a teddy bear who beat cancer, Bald is Beautiful: A letter for a fabulous girl, Cancer Daily Life, and What is Cancer?: A book for kids), I have developed a passion for writing about science in a simple way for non-scientist readers. I have also worked to build a career as a writer, communicating with patients, advocates, and oncology and pediatric oncology professionals, mostly on Twitter. Everyone knows someone whohas or had cancer, so more and more popular science books on this topic are becoming bestsellers. This book is directed to a general audience and follows scientific standards, encompassing high-quality data, but in an easy-to-read format. Furthermore, it will raise awareness and show how simple actions such as not judging patients and not spreading false popular beliefs can contribute to achieve a new milestone in the cancer journey.

This book provides the reader with a focused review of multimodality imaging strategies (radiology and molecular imaging) in staging and re-staging the major types of cancer (i.e. thyroid, breast, colon-rectum, lung, prostate, pancreas, liver, head and neck, and hematological cancer), including rare neoplasms. In addition to presenting the possible diagnostic pathways for all oncologic diseases, the book identifies those interventions currently available in clinical practice (these being a branch of interventional radiology), while also examining and detailing molecular radiotherapy strategies. The work has an interdisciplinary appeal and, thanks to its highly informative and cutting-edge coverage, professionals as well as advanced students and residents in radiology, oncology and surgery will find it of particular interest.

Die Labormedizin gilt nach Expertenmeinung als ausschlaggebend für rund 70% aller klinischen Entscheide, wird jedoch hinsichtlich ihrer Kosten und des Kosten-Nutzen-Verhältnisses labordiagnostischer Verfahren kritisch betrachtet. Mit diesem Buch veröffentlicht das Institut für Innovation & Evaluation im Gesundheitswesen eine von der schweizerischen Foederatio Analyticorum Medicinalium Helveticorum (FAMH) veranlassten Studie, um den gegenwärtig generierten und zukünftig zu erwartenden Nutzen von Laboranalysen aus der Perspektive von Patienten und Gesellschaft zu untersuchen. Dies ist ein Open-Access-Buch.

Since the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available “quick reference” for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.

Neuauflage in 3 Bänden: Standardwerk der Urologie für Klinik und PraxisDas in 3 Bänden gegliederte Standardwerk gilt als das umfassendste Nachschlage-Kompendium zum Fachbereich der Urologie. In Zusammenarbeit mit der Deutschen Gesellschaft für Urologie (DGU) und der Akademie der Deutschen Urologen haben die Experten aus Deutschland, Österreich und der Schweiz ein einzigartiges Buch für alle Urologen geschaffen.Die ganze Urologie in 3 Bändenvon der bildgebenden Diagnostik bis zur medikamentösen und operativen Therapieumfangreiche Ausstattung mit hervorragenden Zeichnungen, Fotos, Grafiken und Tabellen an den neuesten Leitlinien orientiertspezielle Tipps für Praxis und Klinikhervorragend didaktisch strukturiert: ideal zum Lernen für die FacharztprüfungZusammenfassung der wichtigsten Fakten eines Kapitels erleichtert die schnelle Informationsaufnahme, wenn die Zeit knapp istNeu in der 2. Auflagekomplett aktualisiert und erweitertneue Abbildungen und Grafikenneue Sektionen: Individuelle Tumortherapie, Geschlechtsinkongruenz, Prothetik, Laparoskopie, Geschichte der Urologie, Prinzipien der Bildgebung'Die Urologie': Ein Buch, an dem man als Urolog•in nicht vorbeikommt.