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This book strives to fill in the following gaps. First, there is no comprehensive descriptive treatment of deposits emplaced by lahars, debris avalanches, and muddy floods at volcanoes. Second, until now there has not been a comprehensive effort to describe and differentiate the full range of fragmental deposits on volcanoes—the initially wet volcaniclastic mass-flow and fluid-flow deposits usually studied by geomorphologists and sedimentologists, the initially dry pyroclastic mass-flow, fluid-flow, and tephra-fall deposits studied by volcanologists, and the deposits transported and deformed by flowing glacier ice that are studied by glacial geologists. All these deposits are mainly composed of volcaniclastic particles, are deposited on the flanks of volcanoes, all these deposits are mainly composed of volcanic particles and can closely resemble one another. Third, all these processes have vastly different hazard implications, so a means for reliable identification of past processes from deposits is critical for hazard assessment.

Focusing on today's complex business setting, The Legal and Ethical Environment of Business, Fourth Edition, by Ferrera, Alexander, Kirschner, Wiggins, and Darrow offers a comprehensive survey of topics affecting the legal environment of business today. By providing students with a thorough understanding of the legal and ethical issues they will face in their careers, this text is designed to prepare students to work within modern industry norms, practices, and legal and regulatory frameworks. Ethics coverage is integrated and featured throughout, ensuring the reader is well-informed and knowledgeable about both the legal and ethical aspects of business. In addition, ethical theory is interwoven with practical applications using novel pedagogical tools, such as simulated manager's meetings, to promote thoughtful inquiry and highlight the interplay between ethics and law. Covering classical ethicists and philosophers as well as non-traditional voices, such as sub-Saharan African Ubuntu philosophy, this text extends and broadens students'thinking about ethical frameworks. Chapters include questions and sidebar features that address how diversity, equity, and inclusion issues relate to the topic at hand. The book's international focus ensures students are well-prepared for the global business environment. It covers critical topics in international business law such as key provisions of the Convention on Contracts for the International Sales of Goods, updates to Article 9 of the Uniform Commercial Code, and the new provision added to the UCC (Article 12).New to the Fourth Edition: Updated discussions on new technologies, including: Treatment of AI-related legal and ethical issues (e.g., the copyrightability of AI-created graphical art and patentability of AI-developed inventions; the use of AI to create “deepfakes” use of AI as part of alleged price-fixing schemes) Coverage of how AI is changing business practices and the extensive legal and ethical implications of these changes, such as changes to contract negotiations and drafting Incorporation of new US Supreme Court cases: 303 Creative LLC (2023) Loper Bright Enterprises v. Raimondo (2024) (overturning Chevron) Turkiye Halk Bankasi A.S. v. United States (2023) Students for Fair Admissions, Inc. v. President & Fellows of Harvard College (2023) Sackett v. EPA (2023) Professors and students will benefit from discussions of: The 2024 real estate fee splitting settlement of $418 million (Burnett et al v. Nat'l Ass'n of Realtors et al., Case No. 19-CV-00332-SRB (W.D. Mo. Aug. 8, 2024 (amended order)) The 2021 creation of a new agency in New York State for the regulation of cannabis COVIID19-era calls to make the FDA more independent from the Executive Branch US blockage of new appointments to the WTO's appellate body Enhanced antitrust enforcement against Amazon and other large technology companies Compliance and ethical aspects of off-shore manufacturing Updated caselaw example of questions involving apparent authority (Stein Eriksen Lodge Owners Ass'n Inc. v. MX Technologies Inc., 508 P.3d 138) and respondeat superior (Tammen v. Tronvold, 965 N.W.2d 161) The FTC rule regarding non-competes

Un octogénaire épris de son assistante de vie plus que parfaite, une mamie qui cumule les matchs amoureux, un gamin qui propose ses briquets à des passants indifférents, un accro de la webcam prêt à tout pour exister sur le net, une psy éternellement compétente et disponible… voici quelques-uns des personnages qui peuplent les quinze nouvelles de ce recueil.Dans un futur pas si lointain, la technologie est devenue omniprésente. Elle a remodelé en profondeur les esprits et les comportements. Si certains en souffrent et se rebellent, d'autres s'en accommodent ou s'en réjouissent… Entre tendresse, ironie et noirceur, ce recueil se joue de la réalité et pousse le curseur jusqu'à l'absurde pour explorer la frontière ténue entre progrès et dérive. Un miroir dystopique qui invite au questionnement : jusqu'où le progrès est-il bénéfique? Pouvons-nous échapper à ses effets pervers? Le meilleur est-il vraiment à venir?

This book assembles critical contributions on the work of TRS Allan, the Professor Emeritus of Jurisprudence and Public Law at the University of Cambridge, whose leading work in legal and constitutional theory spans almost 45 years. Allan has charted a distinctive path for legal, political, and moral theory and practice and has become a highly significant figure in the UK and in common law/parliamentary systems around the world. His ideas challenge established opinions about constitutional law within these systems as well as established views about the rule of law from more abstract or philosophical perspectives. Allan claims that law and morality find an inherent connection through the rule of law. He argues that there is a connection that flourishes in common law jurisdictions because although Parliament has sovereign legislative powers, its laws gain their full legal meaning only through an interpretive lens. This lens seeks to reconcile sovereign will with legality's basic moral ideals, especially the idea that law must be general and capable of guiding behaviour and thus respectful of the equality and dignity of its subjects. Allan's scholarship is powerful yet controversial, and it has inspired 20 leading scholars from the UK, Canada, Australia and New Zealand to engage with the central themes of his work. By doing so, the contributors help to make that work accessible to a new generation of scholars and students. They also provide a timely framework for engaging in the most important challenges facing our democracies today: how our legal systems do, or do not, honour and respect democracy and therefore legislative sovereignty while at the same time honouring and respecting the rule of law, or the'Promise of Legality'.

This book comprehensively explores the latest advancements in the understanding, diagnosis, and treatment of neurodegenerative diseases. The chapters provide an in-depth review of current approaches and treatment strategies for Alzheimer's disease, offering insights into the latest developments and breakthroughs. It also reviews the cutting-edge research on potential novel targets for Alzheimer's pharmacotherapy, with a focus on JNK3, GSK3β, and Fyn kinase inhibitors, providing an update on related approaches and their implications. It discusses the potential of ethnomedicines as a promising tool for mitigating Alzheimer's disease, offering insights into traditional remedies and their modern applications. Additional chapters explore the influence of microglia, the neuropharmacological mechanisms associated with SARS-CoV-2, and the molecular intricacies of Parkinson's disease. The book further covers the evolving role of artificial intelligence and machine learning in the management of neurodegenerative disorders. The chapters also examine the role of nanotechnology in addressing the challenges of diseases like multiple sclerosis. Towards the end, the book examines the role of oxidative damage in neurodegeneration and its management in related disorders. This book is an important source for neuroscientists, neurologists, and students of neuroscience.

This book seeks to represent the main concepts and theories related to psychoneuroimmunology with the aim of their application in clinical settings and formation of novel theories to further elucidate the mutual connection of the psyche and the physiology of humans'body. Psychoneuroimmunology, as an integration of popular research fields such as psychology, immunology, neurology, and neuroscience, is a perfect example of interdisciplinary and transdisciplinary studies that could potentially result in developing alternative diagnostic tools and treatment strategies besides facilitating the understanding of the pathophysiology of some conditions that might not properly be understood with a single point of view. Considering the stressful lifestyle and the high prevalence of neuropsychiatric, metabolic, and immune-related disorders, psychoneuroimmunology could be the path to the management of these conditions and reduction of the burden of the diseases.

Neurodegenerative diseases, like Alzheimer's, Parkinson's, and Huntington's, cast a long shadow over millions of lives, stealing memories, independence, and futures. The rising tide of these age-related disorders threatens to overwhelm healthcare systems worldwide, prompting an urgent search for effective treatments. While current options offer temporary relief, they fail to halt the relentless march of these devastating conditions. However, a beacon of hope shines at the intersection of cutting-edge neuroscience and the world of small molecules. These tiny chemical warriors, with their inherent advantages of cost-effectiveness, scalability, and diverse functionalities, are emerging as powerful weapons in the fight against neurodegeneration. This book stands as a testament to this increasing revolution. It investigates deep into the intricacies of small molecules, exploring their potential to unravel the mysteries of neurodegenerative diseases and pave the way for innovative therapeutic interventions.Key Features: Provides a comprehensive and accessible overview of the emerging field of small molecules in neurodegenerative diseases. Bridges the gap in current literature by addressing the specific impact of small molecules on these devastating conditions. Offers an in-depth exploration of the various mechanisms by which small molecules can combat neurodegeneration. Serves as a valuable resource for a wide audience, from students to professionals in the field. Lays the foundation for a deeper understanding of neurodegenerative diseases and unlocks new avenues for the development of effective therapies.

In Canada, the Attorney General holds a complex and unique role within the federal, provincial, and territorial governments. Despite this key position, there is relatively little knowledge and understanding of the role and professional responsibilities of the Attorney General among the public, the media, policymakers, and politicians – including at least some Attorney Generals themselves. Legal Ethics and the Attorney General adopts a doctrinal approach to examine and explain how legal ethics, and particularly the law of lawyering, applies to the Attorney General. The book illustrates that, while the role of the Attorney General is unique, the individual occupying this position practises law and should be held to the same standards as any other lawyer. It addresses common misconceptions: that the Attorney General is not truly a lawyer, that actions deemed wrongful for other lawyers may not be considered wrongful for the Attorney General, or that the accountability measures appropriate for lawyers do not apply to the Attorney General. Ultimately, Legal Ethics and the Attorney General reveals the importance of the accountability of the Attorney General, especially to the provincial and territorial law societies that serve as regulators of the legal profession. This accountability is essential not only for upholding the rule of law but also for enabling these societies to fulfil their statutory mandates to regulate the legal profession in the public interest.

This essential guide provides up-to-date knowledge on the epidemiology, clinical features, assessment, and treatment of common psychiatric disorders over a lifespan. It contains key points relevant to residents in training, fellows, and practitioners in private and academic settings by giving them solid information about the topics. This guide discusses the topics listed in DSM-5 TR and also contains subjects relevant to the practice of psychiatry in the 21st century, such as gender-affirming care and discussions about neuromodulation, recommendations on the use of TMS and Ketamine, and newly approved medications. The authors have also addressed topics of global interest, including the effects of climate change on mental health, global conflicts, and mental health, and a chapter on COVID-19 and its effects on the population. This book will give readers a solid understanding of the basics of the topics in psychiatry and will provide them with a good starting point to further expand their knowledge.

The definitive text on the diagnosis and treatment of sports-related neurological injuriesAlthough musculoskeletal injuries are by far the most common injuries seen in sports, neurological injuries are often the most serious and potentially devastating. The Brain, Spine and Nerves in Sports is a comprehensive textbook edited by neurosurgeons Nicholas Theodore and Russell R. Lonser, internationally renowned experts in sports-related brain and spine trauma. The book covers intricacies associated with the diagnosis and treatment of sports-related neurological injuries, with firsthand, collaborative insights from a who's who of multidisciplinary neurological experts in sports injury medicine.The book is organized into four sections and 40 thoughtfully curated chapters covering diagnosis, surgical and nonsurgical approaches, and management of traumatic brain injuries, concussions, spinal cord injuries, and peripheral nerve injuries. The final chapter focuses on leveraging concussion data to improve the safety of American football. Each chapter blends theoretical knowledge, evidence-based practices, case studies, and practical insights derived from the authors'extensive clinical experience.Key FeaturesContributions and pearls from leading authorities in the fields of neurosurgery, spine surgery, sports medicine, and rehabilitationThe latest advancements, techniques, and best practices for managing neurological conditions in athletes, presented in a succinct, easy-to-digest format, with short videosDetailed, critical overviews of sports-related neurological injuries in American football, soccer, cycling, baseball, skiing, combat sports, ice hockey, rugby, and moreA wealth of tables and assessment tools to enhance management of challenging, often time-sensitive situations, including complex return-to-play issuesThis definitive textbook will help neurosurgeons, orthopedic surgeons, neurologists, trainers, sports medicine physicians, and pain management physicians optimize patient outcomes, enhance performance, and promote the overall well-being of athletes at all levels of competition.

Canada's largest cities have faced exponential growth, with the trajectory rising further still. Due to their high density, cities are the primary sites for opportunities in economic prosperity, green innovation, and cultural activity, and also for critical challenges in homelessness and extreme poverty, air pollution, Indigenous-municipal relationship-building, racial injustice, and transportation gridlock. While city governments are at the forefront of mitigating the challenges of urban life, they are given insufficient power to effectively attend to public needs.Cities and the Constitution confronts the misalignment between the importance of municipalities and their constitutional status. While our constitution is often considered a living document, Canada has one of the most complicated amending formulas in the world, making change very difficult. Cities are thus constitutionally vulnerable to unilateral provincial action and reliant on other levels of government for funding. Could municipal power be reimagined without disrupting the existing constitutional structure, or could the Constitution be reformed to designate cities a distinct tier of government? Among other novel proposals, this groundbreaking volume explores the idea of recognizing municipalities in provincial constitutions.The first volume of a complementary pair, authored by renowned Canadian legal and urban studies scholars, Cities and the Constitution suggests contemporary solutions to one of our most pressing policy dilemmas.

This textbook deals comprehensively with livestock production diseases and their prevention in the major species: ruminants, swine, and poultry. It gives an interdisciplinary view on pathophysiology, prophylaxis, and health management.Livestock breeding and husbandry is often accompanied by a conflict of interest between the animal´s biological requirements and economic producer needs. This conflict is increasingly gaining attention not only by producers, animal scientists, and veterinarians, but also by the public. It creates significant future challenges, which are described and addressed in this book. The main topics covered are: •the use of antimicrobials with emphasis on security and safety for producers/consumers•the impact of locomotion disorders on performance and welfare of farm animals •the interactions of gut microbiome, genetics, climate change, metabolic status and mineral homeostasis with reproduction, performance, animal health and welfare•infectious and respiratory diseases•the raising of neonatesA special section is devoted to behavioural signs indicating an impaired animal welfare. These are the basis for precision livestock farming (PLF) technology and the development of new management concepts. The present work is a valuable resource for veterinarians, students, as well as expert readers from animal and agricultural sciences, food safety and technology. Supplementary videos can be accessed online as well as directly from the print book; simply download the Springer Nature More Media App for free and scan the links with the play button.

Is it normal aging, Alzheimer's, or another dementia? Two of three Americans will experience cognitive impairment by the age of 70. But is it natural age-related forgetfulness, or the early indication of Alzheimer's Disease or other types of dementia? How worried should older people—or their families and friends—be about their memory loss? And what happens next? Kenneth Frumkin, PhD, MD, recently retired from a 36-year medical career and facing his own age- and memory-related challenges, provides an empathetic and comprehensive guide to answering those questions. Aging or Alzheimer's? explains what is currently known about the challenges to memory and cognition that come with longevity. Dr. Frumkin describes the progression of Alzheimer's Disease and other dementias; discusses when to see a doctor and what to expect from the visit; weighs the pros and cons of available tests, treatments, and research; shares personal and passionate tips for coping with decline; and gives the best ways to preserve cognitive health. There are an average of 15 new Alzheimer's publications per day. While busy practicing doctors often wait for the consensus reviews of new Alzheimer's studies that are published about every 10 years, Dr. Frumkin provides evidence-based, up-to-date guidance from the most current memory research. The result is your complete, modern guide to understanding and managing your—or your loved ones'—memory loss or cognitive decline.

Governments around the world use machine learning in automated decision-making systems for a broad range of functions. However, algorithmic bias in machine learning can result in automated decisions that produce disparate impact and may compromise Charter guarantees of substantive equality. This book seeks to answer the question: what standards should be applied to machine learning to mitigate disparate impact in government use of automated decision-making?The regulatory landscape for automated decision-making, in Canada and across the world, is far from settled. Legislative and policy models are emerging, and the role of standards is evolving to support regulatory objectives. While acknowledging the contributions of leading standards development organizations, the authors argue that the rationale for standards must come from the law and that implementing such standards would help to reduce future complaints by, and would proactively enable human rights protections for, those subject to automated decision-making. The book presents a proposed standards framework for automated decision-making and provides recommendations for its implementation in the context of the government of Canada's Directive on Automated Decision-Making.As such, this book can assist public agencies around the world in developing and deploying automated decision-making systems equitably as well as being of interest to businesses that utilize automated decision-making processes.

Principles and Advances in Population Neuroscience is aimed at enhancing our understanding of forces that shape the human brain and, as such, contribute to inter-individual variations in cognitive abilities, behavior and mental health throughout the lifespan. This book builds on a monograph'Population Neuroscience'(published by Springer in 2013; ISBN: 978-3-642-36450-1), a recent book on “Digital Ethology: Human Behavior in Geospatial Context” (published by MIT Press in 2024; ISBN: 9780262548137), and the collaborative work carried in the CHARGE and ENIGMA Consortia. Using collective expertise and knowledge with combining epidemiology, genetics and neuroimaging, the authors provide an overview of the basic principles and current advances in this field.

This book offers a wide comparative overview of the legal measures enacted by countries throughout the world to react to the unprecedented public health emergency caused by the COVID-19 pandemic. The volume gathers the General Reports and selected National Reports presented at the 2022 General Congress of the International Academy of Comparative Law. While the National Reports focus on single countries, the General Report provides a comparative analysis of observed trends and main legal issues. In doing so, it draws some guidelines on how to improve responses to potential forthcoming emergencies characterized by a global reach, as COVID-19 was.

This book discusses the latest advances in chemistry research. Chapter 1 summarizes the current state of C-scorpionate coordination chemistry, exploring the synthesis of their metal complexes and the exciting array of applications that these compounds have unlocked. Chapter 2 discusses the charge-transfer (CT) reactivity in A(acid)B(base) systems and how it is approached in both the gas-phase and on catalytic surface. Chapter 3 covers information on fundamental knowledge on ligand-protein interaction and how it can be utilized to design a variety of new aggregation inhibitors and anti-amyloid therapeutics. Chapter 4 introduces the successful drug discovery process that includes not only optimization of drug-biological receptor interactions but also efficient delivery to the site of action by means of crossing biomembranes. Chapter 5 discusses how drugs on the pharmaceutical market use hydrophobic poorly soluble substances to successfully distribute into the body. Chapter 6 is aimed at determining the influence of coal charge grindability on the scheme of preparing coal for coking by optimizing the operation of the crushing department.

Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It's molecular imaging approach to experimental research and clinical practice will drive the field forward and improve research outcomes. - Introduces a new concept of molecular imaging-guided precise biopsy - Links in vivo and ex vivo information at various scales by using multi-modality imaging technologies - Integrates future technologies for the non-invasive cross-validation of underlying mechanisms

Since the first edition of this popular text was published in 1984, the Charter of Rights and Freedoms has transformed the role of the courts in Canadian politics. Addressing current controversies – including the invocation of the federal Emergencies Act, the fallout from the Supreme Court's Greenhouse Gas References, and the resignation of Supreme Court Justice Russell Brown – Law, Politics, and the Judicial Process in Canada, 5th Edition offers ten updated chapters, all-new chapter introductions, and over two dozen new readings addressing current issues Canadian law and politics. It engages with multiple perspectives on controversial issues, juxtaposing competing perspectives to foster debate. Taking a critical approach to the Charter of Rights and Freedoms and the growth of judicial power, editors F.L. Morton and Dave Snow provide an even-handed examination of the institutional implications of an increasingly-important Supreme Court of Canada. Law, Politics, and the Judicial Process in Canada, 5th Edition is the leading source for students, and all readers, interested in judicial power in Canada.

Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into'building blocks'that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry. - Uses practice-based evidence for developing and delivering quality assurance and management systems - Includes case studies associated with'failures'and'lessons learned'- Discusses clinical trials in academic, clinical and industry settings - Demonstrates how to build resilience into systems that could evolve to promote best practices, even with limited resources - Compares and contrasts different QA/QC practices

This book gives a complete overview of current developments in the nano drug delivery technology in the management of neurological disorders and brain diseases. The book is divided into three main sub-sections: A) Fundamental study on nanomaterials, nanocarriers, and nanoformulation-based drug delivery in neurological diseases management, B) Nano drug delivery therapy - a novel approach towards common neurological disorders and C) Novel nano delivery strategies in targeted neurological diseases management. This collective work presents diverse nano-based drug delivery technologies that are high-throughput, reliable, pioneering, and applicable to researchers of different countries despite their socio-economic conditions. It hopefully encourages researchers, innovators and policymaker to adapt nanomaterial-based drug delivery vehicles technologies using diverse nano-based formulation techniques as targeted therapy for treating and managing neurological disorders.

Coffee in Health and Disease Prevention, Second Edition, presents a comprehensive look at the compounds in coffee, their benefits (or adverse effects), and explores coffee as it relates to specific health conditions. Embracing a holistic approach, this book covers the coffee plant, coffee production and processing, the major varieties of coffee, and its nutritional and compositional properties. Coffee's impact on human health, disease risk, and prevention comprises the majority of the text. Diseases covered including Alzheimer's, anxiety and depression, asthma, diabetes, cancer, and more. This book also covers coffee's impact on organs and organ systems, including the cardiovascular system, the nervous system, and the gut microbiome.Coffee in Health and Disease Prevention, Second Edition, is the only book on the market that covers all varieties of coffee in one volume and their potential benefits and risks to human health. This is an essential reference for researchers in nutrition, dietetics, food science, biochemistry, and public health. - Presents a comprehensive, translational source on the role of coffee in disease prevention and health - Focuses on coffee's nutritional and protective aspects, as well as specific coffee components and their effects on tissue and organ systems - Offers a'one stop shop'for research in this area, compiling both foundational and cutting-edge topics into one resource - Includes a dictionary of key terms, other health effects of coffee or extracts, and a summary points section within each chapter for a quick reference

This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.

This edited volume examines current themes in the neurolinguistic study of multilingual and monolingual adults and highlights several new directions the field is moving toward.The organization of the book is as follows. Part I focuses on language processing in multilingual and monolingual adults, Part II explores language processing in multilingual and monolingual adults with dementia, and Part III centers on language processing in multilingual and monolingual adults with stroke-induced aphasia. Chapters feature empirical data and/or literature reviews, discussing the key issues in the field that are currently engaging scholars and practitioners with topics including language attrition, cognitive flexibility, aging and the brain, eye-tracking studies of aphasia, translanguaging, and multilingualism in dementia. The book includes cuttingedge research from researchers and practitioners who are all alumni and colleagues of Professor Loraine K. Obler, to whom this book is dedicated.Presenting crucial topics in the field, the book is highly relevant for students, researchers, and practitioners in the fields of neurolinguistics, psycholinguistics, sociolinguistics, applied linguistics, and language disorders.

A scathing critique of the colonial legal system's denial of children's rights One afternoon in 2016, law professor Robin Hansen receives a call. On the other end of the line is “Jacquie”—a pregnant Indigenous woman, nine weeks from her due date and terrified for the welfare of her unborn son. Jacquie has been sentenced to a custodial prison sentence and her son will be automatically separated from her immediately after his birth. As Hansen works to help Jacquie with her appeal, she uncovers the legal system's inherent discrimination against mothers in custody and the children born to them. Using Access to Information requests along with extensive research, Hansen examines the legal rights of these women—the majority of whom are Indigenous—and finds that Jacquie and her son are by no means alone: automatic mother-infant separation without due process remains the norm in most jurisdictions in Canada. Prison Born calls attention to the colonial and gendered assumptions that continue to underpin the legal system—assumptions that so frequently lead to the violation of the rights and denial of personhood for children and their mothers.

El VII Congreso Internacional de Innovación Pedagógica y Praxis Educativa, Innovagogía 2024, celebrado del 28 al 30 de mayo, ha vuelto a demostrar su papel como un referente en el ámbito educativo internacional. En esta ocasión, el formato online permitió una participación diversa y global, reuniendo a educadores, investigadores y expertos de distintas partes del mundo para reflexionar sobre los grandes desafíos y oportunidades en el campo de la educación. Organizado por INNOVAGOGÍA y AFOE Formación, el Congreso se enfocó en promover el diálogo y la colaboración en torno a las prácticas pedagógicas innovadoras, facilitando la interacción entre profesionales individuales y organizaciones internacionales. A lo largo de sus siete ediciones, Innovagogía ha consolidado su reputación como un espacio de intercambio y enriquecimiento mutuo, en el que confluyen las experiencias más vanguardistas en el ámbito educativo.Este libro de actas refleja las contribuciones más destacadas a la línea temática 2. Innovación pedagógica, calidad y TIC en contextos formativos, un testimonio del compromiso de la comunidad educativa con la innovación y la excelencia pedagógica. A través de estas páginas, se plasma el esfuerzo colectivo por avanzar hacia una educación más inclusiva, creativa y transformadora. En cuanto a los contenidos, el Congreso abarcó una amplia gama de temas que reflejan la complejidad y diversidad del mundo educativo actual. Un eje central fue la calidad e innovación pedagógica, en el que se presentaron experiencias docentes que integran tecnologías aplicadas a las aulas, redefiniendo las formas en que se imparte y recibe la enseñanza. Las nuevas metodologías pedagógicas también ocuparon un lugar destacado, enfatizando la importancia de adaptarse a los cambios continuos que experimenta el entorno educativo. Asimismo, se puso en valor el impacto de la educación emocional en el bienestar de los estudiantes, reconociendo que el aprendizaje efectivo no solo depende de los contenidos académicos, sino también del desarrollo integral de la persona. Las ponencias relacionadas con el desarrollo de competencias y habilidades ofrecieron enfoques prácticos para preparar a los estudiantes para un futuro incierto, dotándolos de herramientas útiles en un mundo cada vez más interconectado y tecnológico.La inclusión educativa y la diversidad fueron otros temas clave, abordados desde múltiples perspectivas, reconociendo la importancia de garantizar una educación equitativa para todos. En este contexto, la formación docente fue un área central, subrayando la necesidad de que los educadores se formen continuamente para responder a las demandas de una sociedad cambiante. Igualmente, el debate sobre la evaluación y el rendimiento académico ofreció nuevas perspectivas sobre cómo medir el éxito educativo de manera más integral. La educación en valores y el fomento de una ciudadanía activa también fueron temas recurrentes, insistiendo en la necesidad de formar ciudadanos responsables y comprometidos con su entorno social. Además, el Congreso ofreció un espacio para el diálogo interdisciplinario, abordando la educación colaborativa como una vía para mejorar la experiencia educativa en su conjunto.Los participantes también analizaron la creciente importancia de la educación para la sostenibilidad y su conexión con los Objetivos de Desarrollo Sostenible (ODS), así como la educación intercultural y multilingüismo, cruciales en un mundo cada vez más globalizado. La creatividad también tuvo su espacio, con ponencias sobre la educación artística, destacando su rol en el desarrollo integral del estudiante. Por último, se profundizó en áreas emergentes como la neuroeducación y su relación con los procesos cognitivos, explorando cómo los avances en el conocimiento del cerebro pueden transformar las prácticas educativas. En conjunto, Innovagogía 2024 se configuró como un espacio dinámico de aprendizaje y debate, donde cada participante pudo aportar su visión y enriq

En el momento actual, la educación superior se enfrenta a una de las épocas de mayor transformación de la historia reciente. Los avances tecnológicos y las cambiantes expectativas sociales han obligado a estas instituciones educativas a replantearse sus métodos, objetivos y responsabilidades. En este contexto, la presente obra, titulada Buenas prácticas universitarias para la mejora del compromiso educativo y social', emerge como una guía que nos permite comprender y afrontar los desafíos contemporáneos presentes en el ámbito de la educación superior. Con un enfoque integral, esta obra explora algunas de las dimensiones fundamentales para fomentar un compromiso educativo y social más profundo y efectivo.'

This volume in the book series Healthy Ageing and Longevity focuses on the interaction and co-dependence of the brain and mental health during ageing. A wide-range of topics discussed here include conceptual and historical understanding, descriptive analyses, and evidence-based interventions for the maintenance, enhancement and recovery of the brain and mental health, especially in old age. The emphasis is on the effective biological and psycho-social lifestyle factors, and complementary medicine and traditional cultural practices that could be health beneficial. Potential readership includes the early stage- and experienced researchers in biogerontology and cognitive sciences, and college/university teachers, medical practitioners, health care personnel, and public educationists.

In human rights adjudication, courts sometimes face issues that they lack the expertise or constitutional legitimacy to resolve. One way of dealing with such issues is to'defer', or accord a margin of appreciation, to the judgments of public authorities. This raises two important questions: what devices courts should use to exercise deference, and how deference can be made more workable for judges and predictable for litigants. Combining in-depth conceptual analysis with practice in a broad range of jurisdictions, Deference in Human Rights Adjudication answers these questions. It introduces six devices for deference (namely, the burden of proof, standard of proof, standard of review, giving of weight, choice of interpretation, and choice of remedy), analyzes how courts should choose amongst them, and proposes techniques for rendering deference practicable. The book has two distinctive features. First, it engages with the jurisprudence of six common law jurisdictions that apply a structured proportionality test in rights adjudication, namely, Canada, Hong Kong, Ireland, Israel, New Zealand, and the United Kingdom. Second, it offers guidelines for judges who wish to apply its theoretical arguments. As such, Deference in Human Rights Adjudication will enable human rights adjudication to be more principled and in line with the rule of law and separation of powers. Insightful and pioneering, this book will be an important reference for researchers, teachers, and students of constitutional theory, comparative constitutional law, and human rights law around the world. It will also assist practitioners, judges, and policymakers who have to grapple with issues of deference in adjudication.

Modern life is brain-unfriendly: We are flooded with information and excessive cognitive demands, when we are often already depleted from chronic stress, sleep deprivation, and health issues. Many of us experience frequent'glitches'or memory lapses, despite tests showing there is nothing wrong with our brains. This book provides concrete strategies, derived from neuropsychological science and clinical practice, to help people improve how they function in daily life.Menchola draws on her experience as a clinical neuropsychologist who has worked with a widely diverse group of patients, to translate the findings from highly controlled research into concrete strategies that people can implement in their messy worlds to make their days more brain-friendly. The book also provides advice on how to address those factors that drain our brain resources, and gives guidance on when and how to seek a neuropsychological evaluation.It is valuable reading for anyone experiencing frustrating cognitive problems that are not due to brain disease. It is also essential for neuropsychologists, psychologists and physicians in primary care, psychiatry, and neurology, who need a resource to offer to patients to help their healthy brains function better.

In The Life and Death of Freedom of Expression, Richard Moon argues that freedom of expression is valuable because human agency and identity emerge in discourse – in the joint activity of creating meaning. Moon recognizes that the social character of individual agency and identity is crucial to understanding not only the value of expression but also its potential for harm. The book considers a range of issues, including the regulation of advertising, hate speech, pornography, blasphemy, and public protest. The book also considers the shift to social media as the principal platform for public engagement, which has added to the ways in which speech can be harmful while undermining the effectiveness of traditional legal responses to harmful speech. The Life and Death of Freedom of Expression makes the case that the principal threat to public discourse may no longer be censorship, but it is rather the spread of disinformation, which undermines public trust in traditional sources of information and makes engagement between different positions and groups increasingly difficult.

Alzheimer's disease (AD) poses a significant global health challenge, with an estimated 50 million people affected worldwide and no known cure. Traditional methods of diagnosis and prediction often rely on subjective assessments. They are limited in detecting the disease early, leading to delayed intervention and poorer patient outcomes. Additionally, the complexity of AD, with its multifactorial etiology and diverse clinical manifestations, requires a multidisciplinary approach for effective management. AI-Driven Alzheimer's Disease Detection and Prediction offers a groundbreaking solution by leveraging advanced artificial intelligence (AI) techniques to enhance early diagnosis and prediction of AD. This edited book provides a comprehensive overview of state-of-the-art research, methodologies, and applications at the intersection of AI and AD detection. By bridging the gap between traditional diagnostic methods and cutting-edge technology, this book facilitates knowledge exchange, fosters interdisciplinary collaboration, and contributes to innovative solutions for AD management. It also benefits data scientists, engineers, policymakers, and professionals in the pharmaceutical and biotechnology industries. Graduate students interested in healthcare and technology will find accessible information on the latest developments in AI-driven approaches to AD detection and prediction.

The Oxford Handbook of Human Memory provides an authoritative overview of the science of human memory, its application to clinical disorders, and its broader implications for learning and memory in real-world contexts. Bringing together experts in the field, the Handbook integrates behavioral, neural, and computational evidence with current theories of how we learn and remember. Organized into two volumes and eleven sections, chapters cover foundational concepts, laws, and methods to study human memory; forms and attributes of memory; encoding and retrieval processes; interference, inhibition, and consolidation; memory distortion, inference, and prediction; individual differences and memory development; memory disorders and therapies; learning and memory in educational settings; and the role of memory in society. An authoritative and comprehensive treatment, The Oxford Handbook of Human Memory documents the current state of knowledge in the field and provides a roadmap for the next generation of memory scientists, established peers, and practitioners.

Canada's Surprising Constitution asks why the Constitution Act, 1982, keeps generating unexpected interpretations and outcomes.

Authoritative reference guide, using the documents in which arms and armour first appeared to explain and define them.Medieval arms and armour are intrinsically fascinating. From the smoke and noise of the armourer's forge to the bloody violence of the battlefield or the silken panoply of the tournament, weapons and armour - and those who made and bore them - are woven into the fabric of medieval society. This sourcebook will aid anyone who seeks to develop a deeper understanding by introducing and presenting the primary sources in which these artefacts are first mentioned. Over seventy original documents are transcribed and translated, including wills, inventories, letters and chronicle accounts, from a period which saw rapid advances in military technology. The book also includes an extensive glossary, and is lavishly illustrated with images of both extant armour and weapons from the period, and contemporary artistic depictions from illuminated manuscripts and other sources. This book will therefore be of interest to a wide audience, from the living history practitioner, crafter, and martial artist, to students of literature, military history, art, and material culture.

Band 4 umfaßt mit den Jahren 1926 bis 1929 einen Zeitraum, der mitten in den sogenannten Goldenen Zwanziger Jahren beginnt und mit der einsetzenden Weltwirtschaftskrise nach dem als Schwarzer Freitag erinnerten Börsencrash an der Wallstreet in den letzten Monaten der Großen Koalition − SPD, Zentrum, Bayerische Volkspartei (BVP), Deutsche Demokratische Partei (DDP), Deutsche Volkspartei (DVP) − unter dem sozialdemokratischen Reichskanzler Hermann Müller endet. Der Band enthält 211 Essays und sonstige publizistische Äußerungen Heinrich Manns (darunter vier bisher unveröffentlichte), außerdem achtzehn Interviews mit ihm und dreißig von ihm mitunterzeichnete Aufrufe und Erklärungen.

Biopsychologie präsentiert eine klare, ansprechende Einführung in die Disziplin durch eine einzigartige Kombination aus biopsychologischer Wissenschaft und persönlich ausgerichtetem Diskurs. Die Autoren John Pinel, Steven Barnes, Paul Pauli und Matthias Gamer sprechen die Studierenden direkt an und verweben die Grundlagen des Fachs mit klinischen Fallstudien, sozialen Themen, persönlichen Implikationen, nützlichen Metaphern und unvergesslichen Anekdoten. Die 11. Auflage integriert zwei neue Themen (»Gedanken zur Epigenetik« und »Bewusstsein«) und bietet eine aktuelle Berichterstattung über die neuesten Entwicklungen auf dem Gebiet.

The second edition of the'IAN Textbook of Neurology'has been prepared for clinicians who participate in the care of neurological patients, including those who are in training to become neurologists, internists, neurosurgeons, and neuroscientists. The basic structure of this second edition has changed. The book is divided into seven parts. Section 1 discusses the History-taking and the Neurological Examination, inclusive of the systemic examination that helps the neurological diagnoses. Section 2 covers the Applied Neuroanatomy and Neurophysiology aspects that are important to clinicians. Section 3 discusses the clinical Approach to various Common Neurological Symptoms. Section 4 describes Diseases of the Nervous System. Section 5 discusses Investigations, Section 6 the Principles of Management, and Section 7 is about the Counseling and Doctor–Patient Relationship.

Neurological illnesses pose one of the biggest hazards to the healthcare system today. This new book brings together the latest methods of gene therapy that can be used to treat both inherited and sporadic neurodegenerative diseases. It presents the most significant advances in gene transfer methods as well as the most recent understandings of the mechanisms behind specific neurodegenerative illnesses, placing these into the context of gene therapy approaches for the central nervous system. The book introduces the basics of neurodegenerative conditions and the physiological basis for their occurrence in humans. It also discusses the various proteins useful in neuro diseases and their viral applications. The book explores how stem cells can be used to learn about the future of gene therapy along with the significance of the sequences that silence genes. It discusses the functions of astrocytes in different brain regions, as well as in-vivo research in gene therapy for neurodegenerative disorders.

The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry. Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders. In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders. The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.

Administrative tribunals are a vital part of the public law frameworks of many countries. This is the 1st edited book collection to examine tribunals across the common law world. It brings together key international scholars to discuss current and future challenges.The book includes contributions from leading scholars from all major common law jurisdictions – the UK, the USA, Canada, Australia, New Zealand, Ireland, Israel, Hong Kong, Singapore, India and South Africa. This global analysis is both deep and expansive in its coverage of the operation of administrative tribunals across common law legal systems. The book has two key themes: one is the enduring question of the location and operation of tribunals within public law systems; the second is the continued mission of tribunals to provide administrative justice. The collection is an important addition to global public law scholarship, addressing common problems faced by the tribunals of common law countries, and providing solutions for how tribunals can evolve to match the changing nature of government.

The Law of Class Action: Fifty-State Survey 2024 is a valuable tool for both in-house and outside counsel who confront the prospect of litigating class actions in state forums with which they may have little or no experience and must make informed recommendations on removal. Succinct summaries are prepared by litigators from each of the respective states and address changes in rules and statutes as well as significant case law. These summaries are extremely useful in understanding state court rules essential to practitioners and parties alike.

This unique text encourages young adults to reflect on their prospective longevity for setting goals and making decisions, become aware of the aspirations and concerns of other generations, and consider personal direction in relation to peer group norms. The sources for learning about mental health and relationships include a blend of academic research, insights from literature, student interviews with older and younger relatives, and personal observations.Stages of adulthood including early adulthood, middle adulthood, retirement age, and old age, are described showing how people can pursue individual growth and nurture the mental health of relatives throughout life. The main themes of younger and middle-aged adults include stress, parenting, peer socialization, family conflict, career readiness, domestic abuse, intergenerational relationships, and mental health. In addition, the educational needs of older adults focus on mental health, family caregiving, grandparenting, physical and social health, problems of younger generations, retirement, loneliness and social isolation, elder abuse, death, grief, and recovery.All chapters conclude with a section about Generational Perspectives Activities, assignments with agenda for class and family discussions, problem-solving scenarios, key concepts, and criteria for self-evaluation. This will be of interest to undergraduate and graduate college students enrolled in lifespan courses offered by family studies, educational psychology, human development, counselling, social work, gerontology, nursing, and business.

This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders.Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Alzheimer's disease (AD) is the most common form of dementia in older adults, and although significant efforts have been made to find the mechanisms and biomarkers which would enable early detection and treatment, the disease remains a major scientific and clinical challenge. A number of therapeutic interventions have been developed to target the pathology believed to play a role in the course of the disease, with varying success, and this book, Therapeutic Trials in Alzheimer's Disease: Where Are We Now?, explores past and present clinical trials in AD based on pharmacological and non-pharmacological strategies. The book is divided into 6 parts. Part 1 focuses on pharmacological strategies aimed at the two proteins associated with AD, amyloid-β and tau; Part 2 discusses a broad range of therapeutic strategies, including metal-targeting agents and antioxidants. Part 3 deals with repurposed drugs, particularly antidiabetics and lipid-lowering therapies, and in Part 4, the challenges, advances, and therapeutic effects of stem cell and gene therapies for AD are detailed and discussed. Part 5 debates the therapeutic effects of non-pharmacological approaches, particularly ketogenic diets and supplements, as well as the benefits of physical exercise, yoga, and acupuncture. Finally, part 6 discusses the benefits of brain stimulation, and the usefulness of imaging techniques, and their ability to assess responses to treatment. Providing an overview of efforts to date in the attempt to address AD, the book will be of interest to all those involved in the research and treatment of Alzheimer's disease.

It is almost 120 years since Alzheimer's disease (AD) was first reported, and the concept of modifiable risk factors associated with the disease has been present from the outset. Thus, the idea of preventing AD is not new, with reference to strategies noted as early as the 1990s. This subfield of AD research has matured in recent years, with the number of modifiable risk factors – the AD preventome – rising from the 7 initially identified to the current 12, with an estimated contribution to dementia cases worldwide of about 40%. This book, the Handbook of Prevention and Alzheimer's Disease, introduces physicians, scientists, and other stakeholders to this subfield of AD research. It investigates the AD preventome, which will continue to expand as the understanding of new factors and related biomarkers is refined. Optimizing this preventome leads to an improvement in overall brain health, an outcome which reduces the risk of developing AD and improves quality of life. The book goes on to examine other domains of prevention, from vascular risk factors to social engagement and from sleep health to spirituality. If the journey to end AD can be likened to a long and arduous challenge, understanding every possible part of the overall toolkit of approaches for disease prevention and intervention is essential. Together with its companion volume on intervention, the book provides a comprehensive overview of strategies for tackling Alzheimer's disease, and will be of interest to all those working in the field. Cover illustration: White matter tracts showing sex differences in connectivity in men versus women as a function of increasing body mass index. Reprinted with permission from Rahmani F, Wang Q, McKay NS, Keefe S, Hantler N, Hornbeck R, Wang Y, Hassenstab J, Schindler S, Xiong C, Morris JC, Benzinger TLS, Raji CA. Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity. J Alzheimers Dis. 2022;86(4):1831-1848. doi: 10.3233/JAD-215329. PMID: 35180116; PMCID: PMC9108572.

It is almost 120 years since Alzheimer's disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer's Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer's disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.

Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications provides researchers with a comprehensive guide, detailing every aspect of Alzheimer's Disease research, including chapters on neuroinflammation, immunotherapy, biomarkers, and animal modeling. This book begins with historical perspectives of both pathological chronology and pathological biochemistry in relation to Alzheimer's disease. Other chapters review Amyloidogenic AB and Non-Amyloidogenic tau and Metabolism of AB major components to the research and understanding of Alzheimer's research. The book concludes with specific treatment chapters including how to develop safe, effective, and inexpensive medications and the application of genome editing to the treatment of Familial Alzheimer's Disease.Written by world renowned expert in Alzheimer's research, this book is a valuable resource for all researchers. - Reviews why familial Alzheimer's disease is vital to understanding sporadic Alzheimer's disease - Describes the latest'game changer'animal models of Alzheimer's disease and frontotemporal dementia in detail - Explains how various Alzheimer's disease medications have failed clinical trials - Discusses pros and cons of therapeutic antibodies, lecanemab and donanemab, that were recently found to be effective in recent clinical trials - Details the application of genome editing as a treatment for familial Alzheimer's disease - Proposes publishing'Journal of Negative Data'for the days of generative AI-assisted publication, AI being unable to distinguish between reproducible and unreproducible data, particularly important in Alzheimer's research