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This book constitutes the proceedings of the 20th International Conference on Conceptual Structures, ICCS 2013, held in Mumbai, India, in January 2013. The 22 full papers presented were carefully reviewed and selected from 43 submissions for inclusion in the book. The volume also contains 3 invited talks. ICCS focuses on the useful representation and analysis of conceptual knowledge with research and business applications. It advances the theory and practice in connecting the user's conceptual approach to problem solving with the formal structures that computer applications need to bring their productivity to bear. Conceptual structures (CS) represent a family of approaches that builds on the successes of artificial intelligence, business intelligence, computational linguistics, conceptual modeling, information and Web technologies, user modeling, and knowledge management.

This book arose from a meeting held at the University of Washington, Seattle, in July of 1986. The meeting was a satellite symposium of the XXXth International Congress of Physiological Sciences which occurred in Vancouver, canada, at that time. 2 Adjustments in the cytoplasmic Ca + concentration of cells occur in response to a variety of external signals. These fluctuations are a cen­ tral component of one mechanism by which cells adapt their activities to changes in the external environment and to the requirements of whole body 2 homeostatic mechanisms. It is now clear that redistribution of Ca + within 2 intracellular compartments, as well as changes in the rates of Ca + influx and extrusion at the whole cell level, occur during signal-dependent 2 changes in the cytoplasmic Ca + concentration. In summarizing current research in this area, this volume considers first the properties of indi­ vidual cation transporting activities located in various cell membranes. It then moves to the cellular level, where the consequence of individual transporting activities acting in concert is examined. l!D.phasis is also 2 p1 aced on pa tho1 ogica1 conditions which resu1 t in loss of cell Ca + regu1 a­ tion as a part of the disease process. We hope that this approach will help the reader to integrate developments in this large and rapdi1y changing fie1 d.

This volume contains selected papers presented at the 12th International C- ference on Conceptual Structures, ICCS 2004, held in Huntsville Alabama, July 19–23, 2004. The main theme of the conference, “Conceptual Structures at Work”, was chosen to express our intention of applying conceptual structures for hum- centered practical purposes. That invites us to develop not only clear conceptual theories,butalsomethodstosupporthumansintheapplicationofthesetheories in their societies. Some promising steps in this direction are being taken, but the gap between the researchers working on a highly sophisticated level on one side and the practitioners in many?elds of applications on the other side is usually di?culttobridge.Someofushaveexperiencesinsuchpracticalcooperation,but we need more members of our community to be engaged in “real life problems”. We all know that solutions of complex problems in practice require not only a well-developed formal theory, but also an understanding of the whole context of the given problems. To support our understanding we need general philo- phical methods as well as formal theories for the representation of fundamental structures in practice. We believe that our community has powerful tools and methodsforsuccessfulapplicationsinpractice,butthatwemustdevelopaforum to present our results to a broader audience. First we must understand the s- ni?cant developments in our own group, which has activities in many directions of research.