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Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Report on Medicinal Chemistry series - Updated release includes the latest information on The Design of Covalent-Based Inhibitors

Asphaltene Deposition Control by Chemical Inhibitors: Theoretical and Practical Prospects is the most advanced reference focused on chemical dispersants and inhibitors from both an experimental and modeling viewpoint. Adequate knowledge of the effective parameters in each treatment method, interactions, mechanisms and economic viewpoints involved in asphaltene treatment are crucial for future development, recovery forecast, and reserve prediction, hence this reference delivers on all these aspects. Sections cover the environmental impacts of asphaltene deposition, prevention methods, and experimental methods, both static and dynamic, to test the effectiveness of inhibitors on restricting asphaltene deposition. Rounding out with modeling methods used to simulate asphaltene-inhibitor interactions and a workflow to select suitable inhibitors by technical, economic and environmental considerations, this book will give today's engineers and researchers the right tool to mitigate formation damage in a sustainably responsible way. - Focuses on inhibitors, mitigators and the interplay between the asphaltene-inhibitors - Helps readers learn from experimental models and replicate treatments with screening workflows - Includes case studies that help readers make sustainable and economically-sound decisions on treatments

This book addresses several issues related to hydrate inhibition and monoethylene glycol (MEG) recovery units (MRUs) in offshore natural gas fields, from fundamentals to engineering aspects and from energy consumption assessment to advanced topics such as exergy analysis. The assessment of energy degradation in MRUs is critical in offshore rigs, and the topic of exergy theory has by no means been completely explored; it is still being developed. The book presents a comprehensive, yet concise, formulation for exergy flow and examines different approaches for the reference state of MEG and definition of the reference environment so as to obtain an effective exergy analysis with consistent results.It also provides new and useful information that has a great potential in the field of exergy analysis application by assessing energy degradation for three well-known MRU technologies on offshore rigs: the Traditional Atmospheric Distillation Process; the Full-Stream Process; and the Slip-Stream Process. The book then elucidates how the main design parameters impact the efficiency of MEG recovery units and offers insights into thermodynamic efficiency based on case studies of general distillation-based processes with sharp or not too sharp cut, providing ranges for expected values of efficiencies and enhancing a global comprehension of this subject. Since MEG recovery is an energy consuming process that invariably has to be conducted in a limited space and with limited power supply, the book is a valuable resource for those involved in design, engineering, economic evaluation and environmental evaluation of topside processing on offshore platforms for natural gas production.

Polyphenolic compounds are part of a division of secondary metabolites with high antioxidant capacity, found naturally in most edible and inedible plants. These compounds are responsible for pigmentation and plants defense of pathogens agents. Its molecular structure includes phenolic hydroxyl groups and aromatic rings. Polyphenols are increasingly studied because of the benefits to human health, introducing the ability to eliminate free radicals generated by oxidation, reducing risk of cancer, anti-aging, anti-diabetic, among others. This book provides new research on food sources of polyphenolic compounds, and their biochemistry and health benefits.

The growing concern for human wellbeing has generated an increase in the demand for polyphenols, secondary plant metabolites that exhibit different bioactive properties. This increasing demand is mainly due to the current applications in the food industry where polyphenols are considered essential for human health and nutrition. Advances in Technologies for Producing Food-relevant Polyphenols provides researchers, scientists, engineers, and professionals involved in the food industry with the latest methodologies and equipment useful to extract, isolate, purify, and analyze polyphenols from different available sources, such as herbs, flora, vegetables, fruits, and agro-industrial wastes. Technologies currently used to add polyphenols to diverse food matrices are also included. This book serves a reference to design and scale-up processes to obtain polyphenols from different plant sources and to produce polyphenol-rich foods with bioactive properties (e.g. antioxidant, antibacterial, antiviral, anticancer properties) of interest for human health and wellbeing.

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.

This reference describes almost 3800 trade name and generic chemicals used to prevent and remove corrosion and rust. Coverage includes chemicals that function as: Acid inhibitors • Antideposition aids • Corrosion inhibitors • Corrosion and rust intermediates • Dispersants • Film-formers • Rust inhibitors • Rust removers • Neutralizers • Metal deactivators Oxygen scavengers • pH adjusters • Phosphatizers • Protectants • Scale inhibitors • Water repellents In these Application Areas: Boiler water systems • Cement/Concrete • Consumer packaging • Cooling water systems • Dry cleaning processes • Ferrous/Nonferrous metals • Food processing • Fuel additives Industrial/Consumer equipment Lubricating systems • Metalworking fluids • Oil field applications • Paints/Coatings Pigments Pulp/Paper processing • Wastewater treatment

In the well-watered groves of academe, most of us are content to gather worshipful students and technicians in a shady nook to contemplate the eternal verities and to plan extravagant feasts to celebrate our contributions to “knowledge” and to the gradual improvement of the human condition. As one convocation follows another, and as our funding agencies pump billions of dollars into incremental research that?lls every possible pigeon-hole in which a gene makes a protein, a small number of intellectual athletes seize a pivotal concept and plunge into the real world. It is this small band of nimble and impossibly brave intellectual halfbackswho win gamesin the real world, and this book is the result of the drive and intellectual athleticism of its editor and several of her contributors. Bacteria affect humans more than any other life forms with which we share the blue planet, but our understandingof these invisible companionshas developed in a staggering pattern, crippled by our panic and consequent shifts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanitation and which we had to kill by immunization and chemical antibacterial compounds. By the time this overriding threat had been obviated, we began to examine na- ral and pathogenic ecosystems by direct methods, and we were surprised to?nd that planktonic bacteria are comparatively rare and that most prokaryotes grow in matrix-enclosedbio?lms.

'This practical industry-oriented guide has been compiled to meet the needs of personnel employed by operators, design engineers, contractors and chemical suppliers working in the oil and gas industry. The document draws on the experience of specialists employed in various organisations and incorporates appropriate industry and in-company guidelines. Both technical and management issues are addressed and key points are provided at the end of each chapter to aid in the assimilation of the many and varied aspects that contribute to successful corrosion inhibition.'