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Questa documentata ricerca offre una visione delle complesse vicende del Partito Socialista nei Circondari di Varese e di Gallarate, dalla nascita fino alla svolta autoritaria del fascismo e all'avvento della dittatura. Passando ripetutamente dai fatti locali a quelli nazionali, apporta informazioni assai utili per la conoscenza di un cinquantennio di vita sociale del territorio e dei movimenti che agitarono la società del tempo. Con uno sguardo complessivo fa riemergere dalla pieghe della storia una minuziosa rassegna di fatti e di nomi, molti dei quali dimenticati.

Understand forest responses to climate change with this timely introduction Forests are among the most critical parts of our global ecosystem, responsible for the air we breathe, home to most of the earth's species, and crucial sources of food and raw materials. Forest development is therefore one of the most important areas of ecological study, and damage to forests is potentially existential. Metabolomics, a toolkit which accrues data on interactions between genetic and environmental conditions, promises to advance our understanding of how these vital ecosystems respond to dramatic changes in climate and environment. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods offers a thorough, accessible discussion of metabolomic techniques and their applications in forest tree research. It promises to enrich the reader's understanding of how forests are being transformed by globe-spanning changes, and to arm researchers with tools for reacting to these potentially epochal developments. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods readers will also find: Analysis of specialized secondary metabolites such as phytohormones Detailed discussion of ecologically important tree genera such as Pinus, Populus, Quercus, and many more Supplementary materials related to study design, sample preparation, and instrumental analysis protocols Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods is ideal for researchers in analytical chemistry, mass spectrometry, metabolomics, forest research, the life sciences, and all other related fields.

Die Entdeckung der Dolomiten Von außen betrachtet wirkten die Dolomiten lange unnahbar. Kein Wunder, dass sie den Reisebuchverleger John Murray an die Zähne eines Alligators erinnerten. Die ersten Reisenden waren fasziniert! Ingrid Runggaldier vereint in diesem Buch Auszüge aus Werken der Weltliteratur genauso wie Reiseberichte, Briefe und Tagebücher, die diesen Entdeckergeist wiederaufleben lassen. Mit Texten des Geologen und Namensgebers Dolomieu, der Pioniere Josiah Gilbert und George C. Churchill, des Reisebuchautors Karl Baedeker, des Zionisten Theodor Herzl, des italienischen Dichters Giosuè Carducci, des Kriegsreporters Robert Musil, der Krimiautorin Agatha Christie, der Begründerin des modernen Frauenbergsteigens Jeanne Immink u.v.a.m. In jahrelanger Recherche hat Ingrid Runggaldier gesammelt, was Reisende über die Dolomiten schrieben – klug kommentiert und zu einem literarischen Reiseführer geformt.

On July 25, 1943, news of Mussolini's resignation and subsequent arrest stunned Italians leaving them dumbfounded. After two decades, fascism had fallen without any advance warning. As festive events marked the incredible outcome and reminders of the past were destroyed, an uncontainable joy seemed to pervade Italians. But what did people actually celebrate? How did they understand the bygone dictatorship, which was soon to be reincarnated in the Italian Social Republic (RSI)? Drawing on more than one hundred diaries written by ordinary citizens (and some prominent figures as well) and inspired by Raymond Williams's concept of structures of feeling, the book examines Italians'perspectives on fascism at a very critical moment in their history. With the country mired in a devastating war further complicated by the September 8, 1943 armistice with the Allies and subsequent German occupation--followed by the eruption of an Italian-against-Italian conflict, the switching of alliances, and the declaration of war against Germany on October 13, 1943--the fast pace of history seemed to deflect Italians'attention from their immediate past. Amidst the daily experience of bombings, hunger, displacement, and death, coming to terms with twenty years of dictatorship turned out to be an arduous enterprise. Whether those who had lived under the fascist regime wished'not to think of it and not to speak any more about it'as philosopher Benedetto Croce maintained, it is hard to ascertain. In truth, little is known of what Italians felt and thought about fascism after its precipitous demise. This book remedies the gap in historical scholarship by assessing how Italians confronted their present and negotiated their past during the two years from the fall of the regime to the definitive defeat of the RSI and the end of the world war in May 1945. By bringing to life the cultural imaginaries and practices of the past, the book raises ostensibly intractable questions on the epochal impact of what often appears as inconsequential: the typically unseen and seemingly banal power of everyday experiences.

Il rispetto delle persone e dell'ambiente deve essere al centro dell'impresa che guarda al futuro. Questo è in sintesi il paradigma dello sviluppo sostenibile, che chiama in causa non solo le aziende ma anche i consumatori e lo Stato. La sfida sarà vinta solo se il cambiamento culturale sarà preso in carico da tutti.

Milan is the European fashion capital with one of the world's most unique luxury fashion districts where the leaders of some of the most exclusive fashion houses are still living and working today. It's the Italian city whose skyline has changed more than any, and whose fashion industry has extended to encompass the worlds of design, restaurants, bars, exhibition spaces, hotels and more. Whether you're looking for designer labels within the city's luxury fashion district, prefer to browse the city's boutiques or pick up some quality vintage at the city's vintage shops and markets, this is the guide that will tell you where to go. Split into geographical sections along with relevant maps, cultural highlights and suggestions for where to eat and drink, it places Milan as the city of fashion within the context of Italian fashion history and a city, and brings the stories of its people to life. Why did Milan become Italy's fashion capital? And what does it offer the fashion lover as a city today?

Marco, figlio di una famiglia piccolo-borghese cresciuto ai margini di un quartiere operaio, non è mai stato in montagna. Per questo, quando grazie a una gita dell'oratorio vive la sua prima notte stellata in alta quota, è potentissima la scoperta del profumo del bosco, delle stelle così vicine, di un senso di libertà mai provato prima. Una scoperta che continua negli anni, intrecciandosi all'amicizia con Martino, figlio di operai e talento naturale dell'alpinismo anche grazie al rapporto forte con il padre, fervente comunista e ancor più fervente scalatore. Il legame tra i due ragazzi si approfondisce di anno in anno e di cima in cima, dalle falesie del lecchese alle Alpi Retiche, al Monte Bianco, al gruppo del Brenta. Ma tra gli entusiasmi dell'adolescenza e i dilemmi della maturità si apre la voragine. Un evento traumatico che della montagna rivela il volto più duro, quello della fatalità che non lascia scampo. Per i due amici di sempre la scelta è ineludibile: lasciarsi travolgere, o stringere i denti e cercare una nuova vetta? Anche nell'ora più fredda si può trovare la forza di rinascere, un nuovo senso della vita, persino l'amore. Il primo romanzo di Paolo Paci, attraverso decenni e luoghi fondamentali per la nostra storia collettiva, racconta con mano lieve ed emozionante il mestiere di crescere: tra gli amici, tra le montagne. Disegnando un'indimenticabile educazione sentimentale, politica e alpinistica.

Winner of the Banff Mountain Book Competition: Climbing Literature AwardThe first English-language biography of one of the most renowned Italian climbers, Emilio Comici, who bagged over 200 first ascents in the Eastern Alps prior to his death at 39 years of age in 1940.Between 1925 and his death in 1940, Emilio Comici was the pre-eminent climber in the Eastern Alps, the hotbed of global rock climbing at that time. He made first ascents on some of the highest and most notorious walls in the Alps, including the northwest face of the Civetta, as well as dozens of other climbs.Comici invented many modern big-wall techniques and the big-wall idiom itself that later took root in Yosemite Valley. Comici also made solo ascents of some of the hardest routes in the Alps, including his climb on the north face of the Cima Grande. He also designed the first artificial climbing wall that was ever actually built.This book explores how family tragedy and growing up in working class Trieste under Austrian occupation shaped Comici's complex personality and attitudes toward climbing. He was loyal to his friends, deeply concerned about the vulnerable, including his fellow climbers, and yet highly competitive, a born vagabond and yet also a dandy, irresistible to women, and yet unable to settle down, devoted to his mother and to the mountains, and finally, like many other Italian climbers of the period, a member of the Italian fascist party although he was profoundly anti-German and opposed to racial persecution.

L'epoca nella quale viviamo, caratterizzata da un'incessante evoluzione in termini culturali, estetici e morali del rapporto progresso-uomo-ambiente, suggerisce a ciascuno di noi una riflessione: quale è l'impatto delle tecnologie e delle scienze sull'arte, il design e la cultura contemporanea? Questo libro si pone come una complessa e articolata analisi che, in equilibrio tra la critica d'arte e il culture journalism, descrive in maniera esaustiva gli scenari e gli ambiti di ricerca della New Media Art contemporanea, guidando il lettore tra le pieghe di un contesto interdisciplinare che coinvolge il mondo delle autoproduzioni indipendenti, delle istituzioni, dei laboratori, delle industrie e che indaga il rapporto tra mercati ibridi a cavallo tra arte, design, architettura, suono, moda, performance, ricerca scientifica e innovazione tecnologica. Una trattazione che evidenzia attori e progetti del contemporaneo, arricchita da una serie di interviste a esperti del settore, per estrapolare esperienze, evidenziare strategie e rendere condiviso un possibile modello economico innovativo per l'arte e la cultura.

Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

An intimate biography of Richard Avedon, the legendary fashion and portrait photographer who “helped define America's image of style, beauty and culture” (The New York Times), by his longtime collaborator and business partner Norma Stevens and award-winning author Steven M. L. Aronson. Richard Avedon was arguably the world's most famous photographer—as artistically influential as he was commercially successful. Over six richly productive decades, he created landmark advertising campaigns, iconic fashion photographs (as the star photographer for Harper's Bazaar and then Vogue), groundbreaking books, and unforgettable portraits of everyone who was anyone. He also went on the road to find and photograph remarkable uncelebrated faces, with an eye toward constructing a grand composite picture of America. Avedon dazzled even his most dazzling subjects. He possessed a mystique so unique it was itself a kind of genius—everyone fell under his spell. But the Richard Avedon the world saw was perhaps his greatest creation: he relentlessly curated his reputation and controlled his image, managing to remain, for all his exposure, among the most private of celebrities. No one knew him better than did Norma Stevens, who for thirty years was his business partner and closest confidant. In Avedon: Something Personal—equal parts memoir, biography, and oral history, including an intimate portrait of the legendary Avedon studio—Stevens and co-author Steven M. L. Aronson masterfully trace Avedon's life from his birth to his death, in 2004, at the age of eighty-one, while at work in Texas for The New Yorker (whose first-ever staff photographer he had become in 1992). The book contains startlingly candid reminiscences by Mike Nichols, Calvin Klein, Claude Picasso, Renata Adler, Brooke Shields, David Remnick, Naomi Campbell, Twyla Tharp, Jerry Hall, Mikhail Baryshnikov, Bruce Weber, Cindy Crawford, Donatella Versace, Jann Wenner, and Isabella Rossellini, among dozens of others. Avedon: Something Personal is the confiding, compelling full story of a man who for half a century was an enormous influence on both high and popular culture, on both fashion and art—to this day he remains the only artist to have had not one but two retrospectives at the Metropolitan Museum of Art during his lifetime. Not unlike Richard Avedon's own defining portraits, the book delivers the person beneath the surface, with all his contradictions and complexities, and in all his touching humanity.

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman's lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways

Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes

Klettern und Extrembergsteigen liegen gegenwärtig im Phänomen der Moderne. Trend. Bergwandern ist seit langem ein Breitensport.Weltweit sind Millionen von Menschen in alpinen Vereinen unterschiedlichster Art organisiert. Doch was bewegt den Mensch zum Bergsteigen? Und worin unterscheidet sich der Bergsteiger vom Wanderer? Trotz einer fast unüberschaubaren Fülle an Publikationen fehlt bislang eine umfassende Dar-stellung, die als historischer Überblick systematisch Antworten auf diese Fragen bietet. Dem Historiker Peter Grupp ist es nun gelungen, die vielschichtigen Aspekte des Phänomens Alpinismus aufzudecken und zu einem eindrucksvollen Gesamtbild zusammenzufügen. Er verfolgt zunächst die Entstehung des Alpinismus und dessen wichtigsten Entwicklungsstu-fen weltweit von den Anfängen bis zur Gegenwart. Anschließend beleuchtet er alle Facet-ten des Alpinismus von den Spielarten des Bergsteigens und seine Techniken über die un-terschiedlichen Bergsteigertypen, ihre soziale Verortung und ihre Motive bis hin zur Organisation des Bergsteigens mit Vereinswesen, Ausrüstung, Hütten- und Wegebau. Eben-falls in den Blick genommen werden die Rolle von Wissenschaft und Sport, aber auch von Kommerz und Medien sowie die Verflechtungen des Bergsteigens mit Gesellschaft, Wirt-schaft und Politik. Mit einem Überblick über die Spiegelungen des Bergsteigens in Literatur, Kunst und Film und einem Ausblick auf seine mögliche Zukunft endet der informative Band.

Que devient le bâti des anciennes usines? Les contributeurs de notre dossier se concentrent sur une question centrale : la part que joue l'histoire sociale dans la réinterprétation et la représentation des lieux sauvegardés à l'intention du grand public. Le but est de mieux comprendre les critères qui motivent le choix des sites et des objets à'patrimonialiser'et de montrer quelle vision de l'histoire ce patrimoine est censé transmettre.

101 luoghi per combattere la fatica e la noia della vita quotidiana Una città a prova di stress Rigenerare corpo e spirito, fuggire dalla noia di ogni giorno, trovare rifugio dal caos in angolini tranquilli e vivere una dimensione più intima e umana. Da soli, in gruppo o in coppia, sono decine i posti dove ci si può rilassare lasciandosi alle spalle la metropoli inquinata e stressante: basta sapere dove andare. Dai locali raffinati arredati con gusto e pochi fronzoli, dove è bello scambiare quattro chiacchiere con gli amici in tranquillità, ai luoghi semplici e tradizionali dove si ha l'impressione di tornare indietro nel tempo, alla genuinità del passato, dalle inebrianti esperienze sensoriali dei centri benessere alla pace di un parco o di un chiostro immerso nel verde: Milano può rivelare suggestioni inaspettate, angoli di paradiso tutti da scoprire, a un solo passo dal tran tran quotidiano. Alcuni dei luoghi antistress a Milano • Una vista dall'alto immersi nel silenzio e nella pace • Un angolo di America tra pancake, bagel e hamburger • Una cascina del Settecento, tra città e campagna • Un massaggio al cioccolato per sentirsi belle come Venere • Alla scoperta di piante e arbusti nel giardino pubblico più bello della città • Una pausa caffè in una cucina americana anni Cinquanta • Sushi e spa giapponese con vista panoramicaFrancesca Cassaniè nata a Milano. È giornalista professionista e ha scritto per diversi quotidiani. Dal 2007 si occupa di comunicazione e ufficio stampa. Ha lavorato per il Comune di Milano e oggi lavora per Regione Lombardia.

Provides the latest'-omics'tools to advance the study of food and nutrition The rapidly emerging field of foodomics examines food and nutrition by applying advanced'-omics'technologies in order to improve people's health, well-being, and knowledge. Using tools from genomics, transcriptomics, epigenomics, proteomics, and metabolomics, foodomics offers researchers new analytical approaches to solve a myriad of current challenges in food and nutrition science. This book presents the fundamentals of foodomics, exploring the use of advanced mass spectrometry techniques in food science and nutrition in the post-genomic era. The first chapter of the book offers an overview of foodomics principles and applications. Next, the book covers: Modern instruments and methods of proteomics, including the study and characterization of food quality, antioxidant food supplements, and food allergens Advanced mass spectrometry-based methods to study transgenic foods and the microbial metabolome Mass spectrometry-based metabolomics in nutrition and health research Foodomics'impact on our current understanding of micronutrients (phenolic compounds and folates), optimal nutrition, and personalized nutrition and diet related diseases Principles and practices of lipidomics and green foodomics Use of chemometrics in mass spectrometry and foodomics The final chapter of Foodomics explores the potential of systems biology approaches in food and nutrition research. All the chapters conclude with references to the primary literature, enabling readers to explore individual topics in greater depth. With contributions from a team of leading pioneers in foodomics, this book enables students and professionals in food science and nutrition to take advantage of the latest tools to advance their research and open up new areas of food and nutrition investigation.

Today Mussolini is remembered as a hated dictator who, along with Hitler and Stalin, ushered in an era of totalitarian repression unsurpassed in human history. But how was he viewed by ordinary Italians during his lifetime? In Fascist Voices, Christopher Duggan draws on thousands of letters sent to Mussolini, as well as private diaries and other primary documents, to show how Italian citizens lived and experienced the fascist regime under Mussolini from 1922-1943. Throughout the 1930s, Mussolini received about 1,500 letters a day from Italian men and women of all social classes writing words of congratulation, commiseration, thanks, encouragement, or entreaty on a wide variety of occasions: his birthday and saint's day, after he had delivered an important speech, on a major fascist anniversary, when a husband or son had been killed in action. While Duggan looks at some famous diaries-by such figures as the anti-fascist constitutional lawyer Piero Calamandrei; the philosopher Benedetto Croce; and the fascist minister Giuseppe Bottai-the majority of the voices here come from unpublished journals, diaries, and transcripts. Utilizing a rich collection of untapped archival material, Duggan explores'the cult of Il Duce,” the religious dimensions of totalitarianism, and the extraordinarily intimate character of the relationship between Mussolini and millions of Italians. Duggan shows that the figure of Mussolini was crucial to emotional and political engagement with the regime; although there was widespread discontent throughout Italy, little of the criticism was directed at Il Duce himself. Duggan argues that much of the regime's appeal lay in its capacity to appropriate the language, values, and iconography of Roman Catholicism, and that this emphasis on blind faith and emotion over reason is what made Mussolini's Italy simultaneously so powerful and so insidious. Offering a unique perspective on the period, Fascist Voices captures the responses of private citizens living under fascism and unravels the remarkable mixture of illusions, hopes, and fears that led so many to support the regime for so long.

Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.

Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors'thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.

Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of illicit drug consumption in a given population can be developed from an analysis of the residues of illicit drugs in wastewater. An important resource for analytical chemists, environmental researchers, forensic scientists, biologists, and toxicologists.

A Rugged Nation uncovers how Italian identity and mountains have constituted one another. State regimes since unification in 1861 have made mountains into national symbols and resources. The nationalisation of Italian mountains has been a story of military conquest and resistance, ecological and social transformation, expropriating resources and imposing meanings. World War I permanently transformed mountain landscapes and people, nationalising both. When the Fascists came to power, the process of politicisation of mountains reached its acme; the regime constructed and exploited mountains both rhetorically and materially, on one hand celebrating ruralism and rural people and, on the other, giving mountain natural resources to large hydro-electric corporations. The book ends with two exemplar tales about mountains and their place in the Italian recent history: the Resistance against the Nazi-Fascists, which found its sanctuary up in the mountains, and the 1963 Vajont disaster, which, with 2,000 people killed, represents the tragic epilogue of the hydroelectric modernisation of the Alps.

Basics Product Design: Material Thoughts is an inspirational introduction to the many different materials and processes used in product design, exploring their properties and how they have been used by some of the most innovative designers around the world. Throughout the book, David Bramston covers everything from dresses and bridges made from paper, to felt washbasins and acrylic cribs. Key contributors include: Alessi, Chris Kabel, Demakersvan, droog, Drummond Masterton, Ettore Sottsass, Front, Gene Kiegel, Industreal, Inflate, Ingo Maurer, Jaime Hayon, Jurgen Bey, Kartell, Maarten Baas, Mathias Bengtsson, Matthias Pliessnig, Memphis, molo, Philippe Starck, Shigeru Ban, Simon Heijdens, Stuart Haygarth, Stuart Walker, Studio Libertiny, Tejo Remy and Rene Veenhuizen.

Annually published since 1930, the International bibliography of Historical Sciences (IBOHS) is an international bibliography of the most important historical monographs and periodical articles published throughout the world, which deal with history from the earliest to the most recent times. The works are arranged systematically according to period, region or historical discipline, and within this classification alphabetically. The bibliography contains a geographical index and indexes of persons and authors.

Das LRL (8 Bände mit Halbbänden, 1988‑2005) beschreibt zum ersten Mal in einem einzigen, einheitlich konzipierten Werk ausführlich alle romanischen Sprachen, ihre Dialekte und die von ihnen abgeleiteten Kreolsprachen in der Gesamtheit ihrer Aspekte: Darstellung des Sprachsystems in Gegenwart und Geschichte, Funktionieren des Systems in den Texten und in der Gesellschaft. Hinzu kommen die historisch-vergleichenden, die kontrastiven und die sprachtypologischen, also einzelsprachenübergreifenden Beschreibungen, die für das Verständnis des Faches Romanistik, aber auch für die Allgemeine Sprachwissenschaft und die Anthropologie und die Ethnologie von besonderer Bedeutung sind. Ähnlich fachübergreifende Bedeutung haben die Bände I,1 und I,2 mit der Darstellung vergangener und heutiger sprachwissenschaftlicher Methoden und der Vorstellung der verschiedenen Bereiche einer Sprache im allgemeinen. Das LRL bietet für jeden einzelnen Bereich eine erste inhaltliche terminologische und bibliographische Orientierung und weist zugleich auf mögliche Themen für weitere Forschungen (insbesondere im jeweiligen Schlußkapitel'Desiderata') hin.

Das LRL (8 Bände mit Halbbänden, 1988‑2005) beschreibt zum ersten Mal in einem einzigen, einheitlich konzipierten Werk ausführlich alle romanischen Sprachen, ihre Dialekte und die von ihnen abgeleiteten Kreolsprachen in der Gesamtheit ihrer Aspekte: Darstellung des Sprachsystems in Gegenwart und Geschichte, Funktionieren des Systems in den Texten und in der Gesellschaft. Hinzu kommen die historisch-vergleichenden, die kontrastiven und die sprachtypologischen, also einzelsprachenübergreifenden Beschreibungen, die für das Verständnis des Faches Romanistik, aber auch für die Allgemeine Sprachwissenschaft und die Anthropologie und die Ethnologie von besonderer Bedeutung sind. Ähnlich fachübergreifende Bedeutung haben die Bände I,1 und I,2 mit der Darstellung vergangener und heutiger sprachwissenschaftlicher Methoden und der Vorstellung der verschiedenen Bereiche einer Sprache im allgemeinen. Das LRL bietet für jeden einzelnen Bereich eine erste inhaltliche terminologische und bibliographische Orientierung und weist zugleich auf mögliche Themen für weitere Forschungen (insbesondere im jeweiligen Schlußkapitel'Desiderata') hin.