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This book covers nutrients, active principles from phytotherapy/herbal products, and drug classes while identifying potential interactions. Didactic approaches to drug and non-drug interactions and cutting-edge reports are included in each chapter that promotes safer drug prescription and use. The physiopathological overview in this book provides background for chemistry, pharmacology, and mechanistic bases of drug and non-drug interaction as well as clinical cases and predictive screenings. This book is intended for undergraduate students studying medicine, nursing, nutrition, biomedicine, and pharmacy.

In an era of increasingly interconnected information, graph-structured data has become pervasive across numerous domains, from social media platforms and telecommunication networks to biological systems and knowledge graphs. However, traditional database management systems often struggle when confronted with the unique challenges posed by graph-structured data, in large part due to the explosion of intermediate results, the complexity of join-heavy queries, and the use of regular path queries. This monograph provides a comprehensive overview of modern query processing techniques designed to address these challenges. Four key components that have emerged as pivotal in optimizing queries on graph-structured databases are focused on, namely: (1) Predefined joins, which leverage precomputed data structures to accelerate joins; (2) Worst-case optimal join algorithms, that avoid redundant computations for queries with cycles; (3) Factorized representations, which compress intermediate and final query results; and (4) Advanced techniques for processing recursive queries, essential for traversing graph structures. For each component, theoretical underpinnings are covered and design considerations are explored, and implementation challenges associated with integrating these techniques into existing database management systems are discussed. This monograph aims to serve as a comprehensive resource for both researchers pushing the boundaries of query processing and practitioners seeking to implement state-of-the-art techniques, in addition to offering insights into future research directions in this rapidly evolving field.

The two open access volumes LNCS 14574 and 14575 constitute the proceedings of the 27th International Conference on Foundations of Software Science and Computation Structures, FOSSACS 2024, which took place in Luxembourg in April 2024.The 24 full papers included in this book were carefully reviewed and selected from 79 submissions. They were organized in topical sections as follows: Part I: Infinite games; categorical semantics; automata and synthesis; Part II: Types and programming languages; logic and proofs; infinite-state systems.

Authoritative and comprehensive resource on the disease process and clinical management of dental caries. Dental Caries: The Disease and Its Clinical Management, 4th Edition maintains the same focus on high-level coverage of the disease etiology and process, clinical assessment and prognosis and wider public health issues connected with dental caries management, including an enhanced focus on caries control. Fully updated throughout, the chapters that discuss theory emphasize how the knowledge can be applied in both the clinic and in the public health domain to improve oral health. The new edition also includes up-to-date and validated diagnostic and management options for caries whilst ensuring that the tools provided allow practitioners to serve the needs of different socio-economic populations. All sections are complimented by high-quality color photographs, clear line drawings and references for further study. With contributions from international experts in research and clinical practice, Dental Caries includes information on: Acquisition and establishment of the oral microbiome, metabolism of the microbiome in caries, and the essential role of saliva for dental caries and erosionInitiation and progression of dental caries in dental hard tissues and the relationship between sugar, diets, and dental cariesThe caries control concept and consequences for minimally invasive management of cariesCaries control in children, adults, and the elderly, including root surface caries and oral health care in the elderlyImplication of caries control for the dental profession, including best practices for assessment of lesion activity, prognosis and risk for developing dental caries Dental Caries, Fourth Edition is an unrivaled guide to tooth decay, and a must-have resource for undergraduate and postgraduate students in dental public health, paediatric and restorative dentistry as well as all practitioners looking to develop their clinical skills.

A full-color text, lab manual, & atlas—all in one! Here are all the tools medical laboratory science students need to master the principles of hematology and the fundamentals of hemostasis. Author Denise M. Harmening has curated contributions from a team of expert educators and clinicians. With support from her Associate Editor LeAnne Hutson, she brings you comprehensive, yet focused coverage that prepares you for the real world in which you will practice. Begin with an introduction to clinical hematology and the anemias, and then progress through white blood cell disorders and hemostasis to thrombosis and laboratory methods. Find step-by-step laboratory procedures and critical-thinking cases online at FADavis.com for easy access anytime, anywhere.

This two-volume set constitutes the refereed proceedings of the 16th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2024, held in Ras Al Khaimah, UAE, during April 15–18, 2024. The 57 full papers presented in these proceedings were carefully reviewed and selected from 251 submissions. The papers of the 2 volume-set are organized in the following topical sections: Part I: advanced data analysis methods; AI-driven cybersecurity and medical solutions; application of generative models; computational intelligence. Part II: data modelling and smart information systems; image and video processing; machine learning algorithms in theory and practice; prediction and recommendation systems; text, speech and natural language processing.

Die »Enzyklopädie Philosophie- und Wissenschaftstheorie«, das größte allgemeine Nachschlagewerk zur Philosophie im deutschsprachigen Raum, wurde 1980 begonnen und 1996 mit dem vierten Band abgeschlossen. Sie erschien 2005 bis 2018 in einer komplett aktualisierten und erweiterten 8-bändigen Neuauflage, die hiermit nun in einer kartonierten Sonderausgabe vorliegt. Die »Enzyklopädie« umfasst in Sach- und Personenartikeln nicht nur den klassischen Bestand des philosophischen Wissens, sondern auch die neuere Entwicklung der Philosophie, insbesondere in den Bereichen Logik, Erkenntnis- und Wissenschaftstheorie sowie Sprachphilosophie. Zugleich finden Grundlagenreflexionen in den Wissenschaften und deren Geschichte ausführliche Berücksichtigung. Die umfassenden Bibliographien und Werkverzeichnisse wurden für die 2. Auflage in allen Artikeln auf den neuesten Stand gebracht.

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery, and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations, micro- and nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, nanoliposomes, micelles, nanosuspensions, lipid implants and inserts, and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties, and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy, health sciences, biotechnology, and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems.

A sentence of first-order logic is satisfiable if it is true in some structure, and finitely satisfiable if it is true in some finite structure. The question arises as to whether there exists an algorithm for determining whether a given formula of first-order logic is satisfiable, or indeed finitely satisfiable. This question was answered negatively in 1936 by Church and Turing (for satisfiability) and in 1950 by Trakhtenbrot (for finite satisfiability).In contrast, the satisfiability and finite satisfiability problems are algorithmically solvable for restricted subsets---or, as we say, fragments---of first-order logic, a fact which is today of considerable interest in Computer Science. This book provides an up-to-date survey of the principal axes of research, charting the limits of decision in first-order logic and exploring the trade-off between expressive power and complexity of reasoning. Divided into three parts, the book considers for which fragments of first-order logic there is an effective method for determining satisfiability or finite satisfiability. Furthermore, if these problems are decidable for some fragment, what is their computational complexity? Part I focusses on fragments defined by restricting the set of available formulas. Topics covered include the Aristotelian syllogistic and its relatives, the two-variable fragment, the guarded fragment, the quantifier-prefix fragments and the fluted fragment. Part II investigates logics with counting quantifiers. Starting with De Morgan's numerical generalization of the Aristotelian syllogistic, we proceed to the two-variable fragment with counting quantifiers and its guarded subfragment, explaining the applications of the latter to the problem of query answering in structured data. Part III concerns logics characterized by semantic constraints, limiting the available interpretations of certain predicates. Taking propositional modal logic and graded modal logic as our cue, we return to the satisfiability problem for two-variable first-order logic and its relatives, but this time with certain distinguished binary predicates constrained to be interpreted as equivalence relations or transitive relations. The work finishes, slightly breaching the bounds of first-order logic proper, with a chapter on logics interpreted over trees.

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. - Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. - Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. - Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. - Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase. - NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. - NEW! Updated, peer-reviewed content provides the most current information possible. - NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+. - NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

This book compiles state-of-the art and science of health professions education into an international resource showcasing expertise in many and varied topics. It aligns profession-specific contributions with inter-professional offerings, and prompts readers to think deeply about their educational practices. The book explores the contemporary context of health professions education, its philosophical and theoretical underpinnings, whole of curriculum considerations, and its support of learning in clinical settings. In specific topics, it offers approaches to assessment, evidence-based educational methods, governance, quality improvement, scholarship and leadership in health professions education, and some forecasting of trends and practices. This book is an invaluable resource for students, educators, academics and anyone interested in health professions education.

Interdisciplinary Cleft Care: Global Perspectives draws from the rich national and international relationships between the Global Smile Foundation and world experts in cleft care to provide comprehensive, clear, and user-friendly content for all cleft care professionals. This text is designed to be an inclusive resource that addresses the educational needs of all cleft care providers, from novice learners looking to develop their area's first multidisciplinary cleft team to seasoned specialists looking to improve their outcomes.v

Principles of Forensic Pathology: From Investigation to Certification offers a conceptual framework and foundational approach to a forensic practice grounded by evidence-based and mechanistic thinking. This book uses a systematic approach to address, explain, and guide the reader through diverse topics relevant to forensic pathologists and medicolegal death investigators. Nineteen chapters provide a comprehensive overview of the field of forensic pathology and discusses central topics such as scene investigation, the pathophysiology of death, death certification, the forensic autopsy, forensic imaging, pediatric forensic pathology, the importance of context, and approaches to frequently encountered medicolegal death circumstances, with mental checklists and suggestions for a consistent and considered approach. Written by forensic professionals, this book is a practical, yet comprehensive compendium for practicing forensic pathologists, coroners, medicolegal death investigators, forensic pathology fellows, pathology residents, medical students interested in forensic pathology, lawyers, and law enforcement professionals. - Presents a primary text that is ideal for daily forensic practice - Discusses how to properly investigate and certify death in a consistent and defensible way - Emphasizes best practices in the field, providing an approach that is in line with today's forensic pathologist

••Selected for Doody's Core Titles® 2024 in Microbiology••Understanding Microbial Biofilms: Fundamentals to Applications focuses on the microbial biofilms of different environments. The book provides a comprehensive overview of the fundamental aspects of microbial biofilms, their existence in nature, their significance, and the different clinical and environmental problems associated with them. The book covers both the fundamentals and applications of microbial biofilms, with chapters on the introduction to the microbial community and its architecture, physiology, mechanisms and imaging of biofilms in nature and fungal, algal, and bacillus biofilm control. In addition, the book highlights the molecular and biochemical aspects of bacterial biofilms, providing a compilation of chapters on the bacterial community and communication from different environments. Finally, the book covers recent advancements in various aspects of microbial biofilms including the chapters on their biotechnological applications. All the chapters are written by experts who have been working on different aspects of microbial biofilms. - Illustrates fundamental aspects surrounding microbial biofilms, along with recent advancements - Provides an overview on the principal aspects of biofilms, i.e., formation, regulation, distribution, control, and application - Updates on the progress on biofilm regulation through'omics'- Serves as a classical manual for all researchers, academicians, and students who would want complete insights on biofilms in a single resource - Covers all recent advancements and amendments on microbial biofilms

Kinderen doen vanaf hun geboorte mee in de wereld; ze gaan mee boodschappen doen, zijn deelnemer in het verkeer, spelen buiten of zitten op een sport- of muziekschool. Door mee te doen leren kinderen over de wereld. Ontwikkelingsgericht Onderwijs sluit aan bij dit principe en leerkrachten die hier mee werken laten kinderen door deelname aan betekenisvolle activiteiten leren in en over de wereld en zichzelf. Leerkrachten in de bovenbouw hebben handvatten nodig om uitdagende en inspirerende praktijken de klas in te halen, te verkennen en op te bouwen met kinderen. Sociaal-culturele praktijken waarbinnen kinderen zich kunnen ontwikkelen, de culturele waarden en instrumenten leren kennen en gebruiken. Zoals in groep 6 waar de kinderen hun eigen moestuin runnen. De leerlingen leren het verschil tussen onkruid en kruid, snoeien, schoffelen en hoe je met slakken om kan gaan in je tuin. Ook doen zich actuele kwesties voor in de moestuin: Welke mestsoort gaan we gebruiken? Kunnen we gif gebruiken om de mieren te bestrijden? Wat doet dat met het grondwater? En hoe gezond zijn onze groenten nu ze toch ook last hebben van microplastics? In Leren in en over de wereld lees je hoe je als leerkracht doelen en inhouden uit het bovenbouwcurriculum zinvol kunt verbinden aan betekenisvolle praktijken en kwesties die er toe doen. De leerkracht speelt een belangrijke rol. Leertrajecten worden samen met de groep opgebouwd. De ideeën en vragen van leerlingen worden serieus genomen, waardoor de kansen op brede en diepe leerresultaten toenemen. In dit boek vind je theoretische onderbouwingen en praktische handvatten voor deze aanpak. Dit boek is een inspiratiebron en handboek voor (aankomende) leerkrachten, interne en externe begeleiders, docenten, nascholers en directies die verbetering van het onderwijs aan oudere leerlingen belangrijk vinden. Over de auteurs Lorien de Koning is auteur van'Vakken en vorming in onderzoek'. Haar expertise ligt bij het ondersteunen van leerkrachten in de bovenbouw met het ontwerpen en uitvoeren van Ontwikkelingsgericht Onderwijs. Ze werkt als nascholer en onderwijsontwikkelaar bij De Activiteit: het Landelijk Centrum voor Ontwikkelingsgericht Onderwijs te Alkmaar. Bea Pompert is als auteur van onder andere'Naar lezen, schrijven en rekenen','Met jou kan ik lezen en schrijven'en ‘Lezen en schrijven doe je samen'een bekende naam in de wereld van de onderwijspedagogiek en taal in het basisonderwijs. Ze werkt als nascholer en onderwijsontwikkelaar bij De Activiteit: het Landelijk Centrum voor Ontwikkelingsgericht Onderwijs te Alkmaar. Tonny Bruin is auteur van de brochure'Leiding geven in een OGO-school'. In het onderwijsveld ondersteunt ze scholen op het samen verbeteren van OGO-kwaliteit. Ze werkt als nascholer en onderwijsontwikkelaar bij De Activiteit: het Landelijk Centrum voor Ontwikkelingsgericht Onderwijs te Alkmaar.

The use of technology in health sciences has a direct impact on health outcomes, as well as on the quality and the safety of healthcare processes. In addition, the use of new technological developments in medical education has proven to be greatly effective and creates realistic learning environments to experience procedures and devices that will become common in medical practice. However, bringing new technologies into the health sector is a complex task, which is why a comprehensive vision of the health sciences ecosystem (encompassing many different areas of research) is vital. Technological Adoption and Trends in Health Sciences Teaching, Learning, and Practice obtains an overview of the technological trends within the health sciences ecosystem, identifies the strengths and weaknesses of the research presented to date, and depicts possible future research directions within health science education and practice. Covering topics such as artificial intelligence and online laboratories, it is ideal for health sciences educators and practitioners, technological solution providers, health organizations, health and care workers, regulators, governing bodies, researchers, academicians, and students.

Recent years have seen a resurgence of interest in Datalog from both the industry and research community. Datalog is a declarative query language that extends relational algebra with recursion. It is used to express a wide spectrum of modern data management tasks such as data integration, declarative networking, graph analysis, business analytics, and program analysis. The result of this long line of research is a plethora of Datalog engines that support different variants of Datalog, and have different technical specifications and capabilities. In this monograph, the authors provide an overview of the architecture and technical characteristics of the various Datalog engines. They identify common architectural decisions and evaluation methods as well as data structures and layouts used to speed up the query execution. They also discuss the ways in which Datalog engines differ when they specialize to workloads with different characteristics. A particular focus of this monograph is how modern Datalog engines scale to massively parallel environments, which is necessary to support the processing of very large datasets. The authors conclude with opportunities for future research directions and new possible applications for Datalog engines.

This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy.Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.

The book provides up-to-date information on all aspects of colonic diverticular disease, particularly common in Western countries. Most people suffering from it remain asymptomatic, while about 20% develop symptoms without complications, experiencing the so-called'Symptomatic Non-Complicated Diverticular Disease'(SUDD). 10-25% of this last group eventually develop diverticulitis, with or without complications. The incidence of diverticulitis and diverticular colon disease is increasing worldwide, and is becoming a significant burden for national health systems in terms of direct and indirect costs, also because its prevalence increases with age. Unfortunately, the disease pathogenesis is relatively unknown and several aetiological factors may play a role in its onset. The first parts of the book will deal with the disease epidemiology and etiopathogenesis, focusing on the roles of inflammation and dysbiosis as part of the pathophysiology of diverticular disease. The clinical spectrum, the diagnostic approach and differential diagnosis, medical and surgical treatments are described in the following sections. Written by experts in the field, the volume will be a unique and valuable resource for all clinicians, residents, and physicians involved in the management of this disease.

This is the second book based on the 5S (Societies, Scenarios, Spaces, Structures, Streams) approach to digital libraries (DLs). Leveraging the first volume, on Theoretical Foundations, we focus on the key issues of evaluation and integration. These cross-cutting issues serve as a bridge for those interested in DLs, connecting the introduction and formal discussion in the first book, with the coverage of key technologies in the third book, and of illustrative applications in the fourth book. These two topics have central importance in the DL field, allowing it to be treated scientifically as well as practically. In the scholarly world, we only really understand something if we know how to measure and evaluate it. In the Internet era of distributed information systems, we only can be practical at scale if we integrate across both systems and their associated content. Evaluation of DLs must take place atmultiple levels,so we can address the different entities and their associated measures. Thus, for digital objects, we assess accessibility, pertinence, preservability, relevance, significance, similarity, and timeliness. Other measures are specific to higher-level constructs like metadata, collections, catalogs, repositories, and services.We tie these together through a case study of the 5SQual tool, which we designed and implemented to perform an automatic quantitative evaluation of DLs. Thus, across the Information Life Cycle, we describe metrics and software useful to assess the quality of DLs, and demonstrate utility with regard to representative application areas: archaeology and education. Though integration has been a challenge since the earliest work on DLs, we provide the first comprehensive 5S-based formal description of the DL integration problem, cast in the context of related work. Since archaeology is a fundamentally distributed enterprise, we describe ETANADL, for integrating Near Eastern Archeology sites and information. Thus, we show how 5S-based modeling can lead to integrated services and content. While the first book adopts a minimalist and formal approach to DLs, and provides a systematic and functional method to design and implement DL exploring services, here we broaden to practical DLs with richer metamodels, demonstrating the power of 5S for integration and evaluation.

This volume explores the compositional semantics of clausal complementation, and proposes a theory in which clause-embedding predicates are uniformly “question-oriented”, i.e., they take a set of propositions as their semantic argument. This theory opens up new horizons for the study of embedded questions and clausal complementation, and presents a successful case study on how lexical semantics interacts with syntax and compositional semantics. It offers new perspectives on issues in epistemology and the philosophy of language, such as the relationship between know-wh and know-that and the nature of attitudinal objects in general. Cross-linguistically, attitude predicates such as know, tell and surprise, can embed both declarative and interrogative clauses. Since these clauses are taken to represent different semantic objects, like propositions and questions, the embedding behavior of these predicates poses puzzles for the compositional semantics of clausal complementation. In addition, the fact that some verbs “select for” a certain complement type poses further challenges for compositional semantics. This volume addresses these issues based on a uniformly question-oriented analysis of attitude predicates, and proposes to derive their variable behaviors from their lexical semantics. The book is essential reading for linguists working on the syntax and semantics of clausal complementation, as well as those interested in the role of lexical semantics in compositional semantics. It will also be valuable for philosophers who are interested in applying linguistic tools to address philosophical problems.

Data exchange is the problem of finding an instance of a target schema, given an instance of a source schema and a specification of the relationship between the source and the target. Such a target instance should correctly represent information from the source instance under the constraints imposed by the target schema, and it should allow one to evaluate queries on the target instance in a way that is semantically consistent with the source data. Data exchange is an old problem that re-emerged as an active research topic recently, due to the increased need for exchange of data in various formats, often in e-business applications. In this lecture, we give an overview of the basic concepts of data exchange in both relational and XML contexts. We give examples of data exchange problems, and we introduce the main tasks that need to addressed. We then discuss relational data exchange, concentrating on issues such as relational schema mappings, materializing target instances (including canonical solutions and cores), query answering, and query rewriting. After that, we discuss metadata management, i.e., handling schema mappings themselves. We pay particular attention to operations on schema mappings, such as composition and inverse. Finally, we describe both data exchange and metadata management in the context of XML. We use mappings based on transforming tree patterns, and we show that they lead to a host of new problems that did not arise in the relational case, but they need to be addressed for XML. These include consistency issues for mappings and schemas, as well as imposing tighter restrictions on mappings and queries to achieve tractable query answering in data exchange. Table of Contents: Overview / Relational Mappings and Data Exchange / Metadata Management / XML Mappings and Data Exchange

The topic of using views to answer queries has been popular for a few decades now, as it cuts across domains such as query optimization, information integration, data warehousing, website design, and, recently, database-as-a-service and data placement in cloud systems. This book assembles foundational work on answering queries using views in a self-contained manner, with an effort to choose material that constitutes the backbone of the research. It presents efficient algorithms and covers the following problems: query containment; rewriting queries using views in various logical languages; equivalent rewritings and maximally contained rewritings; and computing certain answers in the data-integration and data-exchange settings. Query languages that are considered are fragments of SQL, in particular, select-project-join queries, also called conjunctive queries (with or without arithmetic comparisons or negation), and aggregate SQL queries.

This book examines new technologies (device and pharmacologic) that have evolved over the past few years in treating peripheral arterial disease. Chapters offer optimal strategies to treat PAD, supported by peer-reviewed data. The pillars of this strategy will focus on (a) changing vessel compliance to allow better lumen expansion, (b) less recoil and dissections, and (c) less bailout stenting. Chapters also review embolic protection devices and apply the adjunctive use of anti-proliferative therapy to maintain good long term outcomes. In addition, the book reviews drug coated balloons and drug eluting stent technologies and other means of drug delivery into the vessel wall. The goal of this book is to discuss all these emerging technologies under the strategy of treating patients with the focus on both acute and long term outcomes. Featuring world renown experts, this book offers a critical and comprehensive overview of the current data and future directions that would pave the wayfor optimal PAD management.Peripheral Arterial Interventions is an essential resource for physicians, residents, fellows, and medical students in cardiology, radiology, vascular surgery, primary care, and health promotion and disease prevention as well as internal and vascular medicine specialists.

Automata theory is a subject of study at the crossroads of mathematics, theoretical computer science, and applications. In its core it deals with abstract models of systems whose behaviour is based on transitions between states, and it develops methods for the description, classification, analysis, and design of such systems. The Handbook of Automata Theory gives a comprehensive overview of current research in automata theory, and is aimed at a broad readership of researchers and graduate students in mathematics and computer science. Volume I is divided into three parts. The first part presents various types of automata: automata on words, on infinite words, on finite and infinite trees, weighted and maxplus automata, transducers, and two-dimensional models. Complexity aspects are discussed in the second part. Algebraic and topological aspects of automata theory are covered in the third part. Volume II consists of two parts. The first part is dedicated to applications of automata in mathematics: group theory, number theory, symbolic dynamics, logic, and real functions. The second part presents a series of further applications of automata theory such as message-passing systems, symbolic methods, synthesis, timed automata, verification of higher-order programs, analysis of probabilistic processes, natural language processing, formal verification of programs and quantum computing. The two volumes comprise a total of thirty-nine chapters, with extensive references and individual tables of contents for each one, as well as a detailed subject index.

Need to develop strong cardiac nursing skills or advance your practice to a higher level? The newly updated Cardiac Nursing, 7thEdition is the gold standard reference and on-the-unit resource, offering crucial guidance and direction for nurses looking to provide up-to-date, evidence-based cardiac care.

This book contains the invited and contributed papers selected for presentation at SOFSEM 2021, the 47th International Conference on Current Trends in Theory and Practice of Computer Science, which was held online during January 25–28, 2021, hosted by the Free University of Bozen-Bolzano, Italy.The 33 full and 7 short papers included in the volume were carefully reviewed and selected from 100 submissions. They were organized in topical sections on: foundations of computer science; foundations of software engineering; foundations of data science and engineering; and foundations of algorithmic computational biology. The book also contains 5 invited papers.

This collection of new essays presents cutting-edge research on the semantic conception of logic, the invariance criteria of logicality, grammaticality, and logical truth. Contributors explore the history of the semantic tradition, starting with Tarski, and its historical applications, while central criticisms of the tradition, and especially the use of invariance criteria to explain logicality, are revisited by the original participants in that debate. Other essays discuss more recent criticism of the approach, and researchers from mathematics and linguistics weigh in on the role of the semantic tradition in their disciplines. This book will be invaluable to philosophers and logicians alike.

This book constitutes the proceedings of the 8th and 9th International Provenance and Annotation Workshop, IPAW 2020 and IPAW 2021 which were held as part of ProvenanceWeek in 2020 and 2021. Due to the COVID-19 pandemic, PropvenanceWeek 2020 was held as a 1-day virtual event with brief teaser talks on June 22, 2020. In 2021, the conference was held virtually during July 19-22, 2021. The 11 full papers and 12 posters and system demonstrations included in these proceedings were carefully reviewed and selected from a total of 31 submissions. They were organized in the following topical sections: provenance capture and representation; security; provenance types, inference, queries and summarization; reliability and trustworthiness; joint IPAW/TaPP poster and demonstration session.

This student-friendly book provides an accessible overview of the primary debates about the effects of video games. It expands on the original The Video Game Debate to address the new technologies that have emerged within the field of game studies over the last few years.Debates about the negative effects of video game play have been evident since their introduction in the 1970s, but the advent of online and mobile gaming has revived these concerns, reinvigorating old debates and generating brand new ones. The Video Game Debate 2 draws from the latest research findings from the top scholars of digital games research to address these concerns. The book explores key developments such as virtual and augmented reality, the use of micro-transactions, the integration of loot boxes, and the growth of mobile gaming and games for change (serious games). Furthermore, several new chapters explore contemporary debates around e-sports, gamification, sex and gender discrimination in games, and the use of games in therapy.This book offers students and scholars of games studies and digital media, as well as policymakers, the essential information they need to participate in the debate.

Emotions are at the core of the educational enterprise but their role is mostly left unexamined. This book explores the role of emotions across students, teachers and school leaders. It showcases current theoretical and empirical research on emotions in educational settings conducted in the Asian context. The book consists of three parts, namely, emotions in learning, emotions in teaching and emotions in leadership. These chapters cover different levels from students (e.g., school, university), to teachers (e.g., pre-service, in-service) and to school leaders (e.g., middle-level teachers, principals). Samples are recruited from a wide range of Asian contexts (e.g., Hong Kong SAR, Macau SAR, Mainland China, Singapore and the Philippines). Collectively, the authors use a variety of methods ranging from quantitative to qualitative approaches and demonstrate innovative theoretical work that pushes the boundaries of emotions research forward.

Im Zentrum des Bandes steht die Frage, welche Lehrmethoden im breiten Fächerspektrum der Hochschulen besonders geeignet sind. Zwar wird in der Hochschuldidaktik eine Vielzahl an Methoden für die Lehre vermittelt, doch stellt sich hier die Frage nach ihrer konkreten Umsetzung in der Praxis. Die Autorinnen und Autoren des Bandes identifizieren fachspezifische Herausforderungen und präsentieren Lehrmethoden, die sich als Antwort darauf im Lehralltag bewährt haben.Der InhaltEinleitung: Zur aktuellen Methodenentwicklung in der HochschullehreStudienbegleitende ProgrammeNaturwissenschaften, Mathematik und MedizinGeistes- und SozialwissenschaftenDigitale LehrmethodenDie HerausgebendenDr. Jörg Noller ist wissenschaftlicher Assistent an der Ludwig-Maximilians-Universität München im Fach Philosophie. Er ist Tutorenausbilder und leitet verschiedenedigitale Lehrprojekte.Dr. Christina Beitz-Radzio ist wissenschaftliche Mitarbeiterin im Studiendekanat der Tierärztlichen Fakultät der LMU. Sie ist unter anderem Tutorenausbilderin und Trainerin (sprachraum eG).Dr. Daniela Kugelmann ist wissenschaftliche Mitarbeiterin am Institut für Vegetative Anatomie der LMU München. Sie ist als Tutorenausbilderin für die fachlich- und methodisch-didaktische Ausbildung zuständig.Dr. Sabrina Sontheimer ist Lehrbeauftragte am Institut für Englische Philologie der LMU München und als freiberufliche Trainerin für Hochschuldidaktik, Kommunikation und wissenschaftliches Schreiben tätig. Dr. Sören Westerholz ist wissenschaftlicher Mitarbeiter am Lehrstuhl für Physiologische Chemie der LMU München.

The book begins with an extensive survey of the history of logic diagrams, including looking at possible diagrams from Aristotle, the development of both linear and closed figure diagrams by Leibniz, Lambert, Euler, Venn's new system, Peirce's Existential Graphs, and Frege's two-dimensional notation as a kind of logic diagram system. During most of the 20th century, there was little regard for efforts to construct logic diagrams. However, since the 1980s there has been an increasing interest in such diagrams. Ever larger numbers of philosophers, logicians, mathematicians, computational scientists, and cognitive scientists have turned their attention to building, analyzing, using, or exploring in other ways systems of logic diagrams. The system offered here makes use of line segments and points and it enjoys a number of important advantages: it is simple, natural, and both expressively and inferentially powerful. It can be used to analyze syllogisms (including those involving relational terms) and arguments involving unanalyzed statements. Understanding such a system can shed valuable light on how ordinary people naturally reason.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first eight chapters examine a variety of tools, techniques, methodologies and technologies which can be utilised to visualise and understand biological and medical data. This includes web-based 3D visualisation, ultrasound, virtual and augmented reality as well as functional connectivity magnetic resonance imaging, storyboarding and a variety of stereoscopic and 2D-3D transitions in learning. The final two chapters examine the pedagogy behind digital techniques and tools from social media to online distance learning techniques.

This edited book focuses on non-classical logics and their applications, highlighting the rapid advances and the new perspectives that are emerging in this area. Non-classical logics are logical formalisms that violate or go beyond classical logic laws, and their specific features make them particularly suited to describing and reason about aspects of social interaction. The richness and diversity of non-classical logics mean that this area is a natural catalyst for ideas and insights from many different fields, from information theory to game theory and business science. This volume is the post-proceedings of the 8th International Conference on Logic and Cognition, held at Sun Yat-Sen University Institute of Logic and Cognition (ILC) in Guangzhou, China in December 2016. The conference series started in 2001, and is organized by the ILC, often in collaboration with various international research groups. This eighth installment was jointly organized by ILC and Alessandra Palmigiano's Applied Logic research group. The conference series aims to foster the development of effective logical tools to study social behavior from a philosophical, cognitive and formal perspective in order to challenge the field of logic in ways that open up new and exciting research directions.Chapter'The Category of Node-and-Choice Forms, with Subcategories for Choice-Sequence Forms and Choice-Set Forms'of this book is available open access under a CC BY 4.0 license at link.springer.com

Semantic Web technologies enable people to create data stores on the Web, build vocabularies, and write rules for handling data. They have been in use for several years now, and knowledge extraction and knowledge discovery are two key aspects investigated in a number of research fields which can potentially benefit from the application of semantic web technologies, and specifically from the development and reuse of ontologies. This book, Applications and Practices in Ontology Design, Extraction, and Reasoning, has as its main goal the provision of an overview of application fields for semantic web technologies. In particular, it investigates how state-of-the-art formal languages, models, methods, and applications of semantic web technologies reframe research questions and approaches in a number of research fields. The book also aims to showcase practical tools and background knowledge for the building and querying of ontologies. The first part of the book presents the state-of-the-art of ontology design, applications and practices in a number of communities, and in doing so it provides an overview of the latest approaches and techniques for building and reusing ontologies according to domain-dependent and independent requirements. Once the data is represented according to ontologies, it is important to be able to query and reason about them, also in the presence of uncertainty, vagueness and probabilities. The second part of the book covers some of the latest advances in the fields of ontology, semantics and reasoning, without losing sight of the book's practical goals.

This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

This book provides a comprehensive overview of benign hematologic disorders in children. Divided into nine sections, the text reviews common hematologic disorders or conditions that affect children, while providing state-of-the-art information on pathophysiology, diagnosis, treatment, and management strategies.The text begins with a section on hematopoiesis, and the next section covers red blood cell disorders. The following sections provide overviews of platelet disorders, white blood cell disorders, and coagulation disorders. The sixth and seventh sections discuss neonatal hematology and bone marrow failure syndrome. The eighth section reviews supportive care, while the final section covers miscellaneous subjects including pediatric vascular anomalies and complement dysregulation syndromes.Written by experts in the field, Benign Hematologic Disorders in Children: A Clinical Guide is a valuable resourcefor clinicians and practitioners who treat children afflicted with these disorders.

This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.

Explore the exciting research where semantics meets morphology, syntax and pragmatics. In this book, leading researchers use in-depth articles to explain a wide range of topics at these interfaces, including the semantics of intonation, inflection, compounding, argument structure, type shifting, compositionality, implicature, context dependence, deixis and presupposition. Now in paperback for the first time since its original publication, the highly cited material in this book is an ideal starting point for anyone interested in semantics where it crosses over with other dimensions of grammar.

Transformative Learning in Healthcare and Helping Professions Education: Building Resilient Professional Identities is a co-edited book (Carter, Boden, and Peno) with invited chapters from educators who share our passion for learning in healthcare and the helping professions. The purpose of the book is to introduce professional learners (students, residents, and others in professional training) to transformative learning for building resilient professional identities amid practice environments that include widespread burnout and compassion fatigue. With a diverse set of authors engaged in clinical and educational practice in academic medicine, nursing, dentistry, physical therapy, mental health counseling, science education, psychology, social work, and inter-professional collaborative practice, we offer strategies for building resilience throughout the years of professional training and into professional practice. We do so through the experiences of authors involved in healthcare and the helping professions to illustrate how some are coping with the challenges of burnout and compassion fatigue through learning that can be transformative. This book explores the nature of professional identity formation by examining ways that professionals in training can thrive amid the challenges of today's stressful practice environments. First-hand stories of resilience illustrate how learners, as well as educators in these professions, are addressing adversity, career decision-making, service to the underserved, and the self-care needed to provide excellent care for others. The prominence of transformative learning within adult learning theory is illustrated for its potential to revise the meaning that learners make of their experiences and open up new possibilities for renewed vitality in professional education and practice environments. The book has two primary audiences: professional learners in healthcare and helping professions education, and their educators who are often professional practitioners themselves. These educators have a significant role in influencing the next generation of professionals by serving as mentors, role models, and teachers. The importance of fostering learning that is transformative has never been more important than it is today for those who will work in these demanding professions. We invite readers to discover experiences and strategies for achieving individual wellbeing, as well as opportunities for building a culture within professional education and practice settings that will foster resilience.

The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline, as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerate the time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. This book aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies, which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. This book serves as a reference to drug developers, IVD providers, clinical labs, healthcare givers, academicians, and researchers for best practices to help increase the probability of success in drug development and improve patient management. - Provides the unique insight of an expert with extensive experience in diagnostics and clinical laboratory on one side and drug discovery and development on the other side - Addresses the challenges of drug development and precision medicine and suggests how to eliminate or mitigate these challenges through better utilization of biomarkers and diagnostics in drug development and patient management - Features case studies and real-life examples from different classes of biomarkers on different platforms for different therapeutic areas and includes more than 200 illustrations

Dit boek behandelt de belangrijkste aspecten van het menselijke metabolisme op een inzichtelijke manier. Het bespreekt de basisbegrippen, de complexe relatie tussen metabolisme en voeding en tussen metabolisme en ziektemechanismen. Het boek is bestemd voor studenten geneeskunde, mondzorg, farmacie en biomedische wetenschappen, hbo voeding en diëtetiek. De inhoud van het boek is verweven met een van de pijlers van de bachelorfase van de hiervoor vermelde opleidingen: de chemische basis van gezondheid en ziekte. Metabolisme gaat over chemische reacties die brandstoffen omzetten in nuttige energie en bouwstenen vanuit de voeding opbouwen tot bestanddelen van het lichaam. Het is belangrijk om te weten hoe het metabolisme normaal werkt en inspeelt op dagelijkse veranderingen in de voedingstoestand en fysische activiteit. Maar ook wat er speelt bij specifieke stofwisselingsziekten en de complexe bijdragen van een veranderd metabolisme aan frequente ziekten zoals diabetes en kanker.De derde herziene druk van Leerboek metabolisme en voeding bestaat uit twaalf hoofdstukken. De kernleerstof wordt ondersteund door 270 afbeeldingen, concrete leerdoelen en studeeraanwijzingen. In elk hoofdstuk staan ook verdiepende kaders over de grenzen van wetenschappelijk verantwoorde vakkennis, de rol van pioniers in vroeger onderzoek, het belang hiervan voor huidige medische toepassingen en beschouwingen uit de evolutieleer. Daarbij wordt steeds verwezen naar recente literatuur.Op de bijbehorende website zijn 300 toetsvragen, casussen en hot topics te vinden.

This book provides a guide for the management of patients with cardiovascular emergencies in the ER. It covers a broad range of the most important and frequent acute cardiovascular events including coronary syndromes, aortic syndromes, pulmonary embolism, and left heart failure. Pragmatic in nature, chapters discuss frequent clinical presentations in a thorough fashion while emphasizing a practical and concise approach to diagnosis and treatment. In addition, the book explores how new knowledge and technological advances are improving the quality of patient care in the emergency room, highlighting technological advances in the use of pharmacotherapy, biomarkers, and imaging techniques such as X-ray, echocardiography, CT, MRI, and nuclear. Cardiology in the ER: A Practical Guide is an essential resource for physicians and related professionals, residents, and fellows in cardiology, emergency medicine, intensive and critical care, and internal medicine.

This book constitutes the refereed proceedings of the 13th IFIP WG 8.9 Working Conference on Research and Practical Issues of Enterprise Information Systems, CONFENIS 2019, held in Prague, Czech Republic, in December 2019. The 11 full and 2 short papers included in this volume were carefully reviewed and selected from 43 submissions. They were organized in topical sections named: EIS and industry; technical architecture and applications for EIS; collaborative networks and project management; and security and privacy issues.

Discover vital research on the lexical and cognitive meanings of words. In this exciting book from a team of world-class researchers, in-depth articles explain a wide range of topics, including thematic roles, sense relation, ambiguity and comparison. The authors focus on the cognitive and conceptual structure of words and their meaning extensions such as coercion, metaphors and metonymies. The book features highly cited material – available in paperback for the first time since its publication – and is an essential starting point for anyone interested in lexical semantics, especially where it meets other cognitive and conceptual research.

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors. - Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing - Includes new case studies that highlight clinical relevance and errors to avoid - Highlights the best titles published within a variety of medical specialties - Reviewed by medical librarians and content specialists, with key selections compiled in their annual list