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Designed to enhance the learning experience for both practicing otolaryngologists and otolaryngology residents, Bailey's Head & Neck Surgery—Otolaryngology, 6th Edition, delivers concise, practical information in all areas of this complex field. Dr. Clark A. Rosen (Laryngology) and his hand-picked editorial team representing all of the sub-disciplines of Head & Neck Surgery-Otolaryngology of Drs. Stacey Gray (rhinology), Patrick Ha (Head and Neck Surgery), Charles Limb (Otology), Stephen Park (Facial Plastics and Reconstructive Surgery), and Gresham Richter (Pediatric Otolaryngology) ensure that all content in this two-volume text is current, useful, and evidence based. Each chapter has been written to increase the reader's understanding, retention, and ability to successfully apply information in everyday practice.

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. - Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field - Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner - Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

This work is the first compilation of comprehensive deliberations on botany, cytogenetics and sex determination, genetic resources and diversity, classical breeding, molecular markers and genome sequence resources, and application of omics technology including transcriptomics, proteomics, and metabolomics resources in the multipurpose medicinal plant seabuckthorn. The book also presents a detailed narrative on antioxidative, radioprotective nutraceutical, and medicinal applications of seabuckthorn products. A detailed treatment has been included on analytical techniques and processing technologies. Altogether, the book contains about 300 pages over 17 chapters contributed by globally reputed experts on the relevant field in this important plant species. This book will be useful to the research students, teachers, and scientists in the academia and private sector engaged in horticulture, genetics, breeding, molecular biology, biotechnology, and breeding. The book will also be a useful source for workers involved in the development of plant-based medicines, nutraceuticals, therapeutics, and cosmeceuticals and extension workers involved in the development of rural farmers and small-scale industries.

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.

This book provides up-to-date guidance that will assist radiation oncologists during the day-to-day management of nasopharyngeal cancer. After discussion of diagnosis and staging, target delineation techniques and treatment planning are described for both intensity-modulated and particle radiation therapy. Detailed information is then presented on the application of radiation therapy in different disease settings, from early stage disease to metastatic disease. Due attention is paid to the role of multimodality treatment and new and advanced technologies in particular circumstances, such as local recurrence. In addition, follow-up and the management of late toxicities are explained and management strategies are documented for special situations and groups, including pediatric patients. The book is published within the Springer series Practical Guides in Radiation Oncology. Like other volumes in the series, it is designed for hands-on use by both radiation oncology residents and practicing radiation oncologists. It will also be of value for head and neck physicians.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.

This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.

The definitive survey of diagnostic dermatopathology—and the single-best resource for addressing differential diagnosis at the microscopic level For virtually every kind of skin lesion, this skill-sharpening resource has everything clinicians need to successfully perform differential diagnosis at the microscopic level. Dermatopathology features a systematic, algorithmic approach that cuts through the complexity of the discipline's traditional disease-oriented focus, providing a ready-to-use diagnostic tool that puts the entire world of dermatopathology into perspective. This classic has won acclaim as the only dermatology pathology resource that is valuable for both teaching and for clinical practice and differential diagnosis. While other references may be more exhaustive, denser, or larger, none are more clinically useful as Dermatopathology. With 25% of the dermatology board and recertification examination consisting of dermatopathology topics, this is also an outstanding board review tool. Filled with hundreds of color photomicrographs, the book features a clear five-part organization and nearly forty detailed chapters—each reflecting the scientifically rigorous, up-to-date insights of authors who are acknowledged experts in the field. The book's vast scope encompasses all skin disease processes—inflammatory, non-inflammatory, infections, and proliferations (harmatomas, hyperplasias, and neoplasms, plus disorders of nails and oral mucosa). •Includes Online Image Bank containing all the images in the book•Increased number of full-color images•Numerous tables assist clinicians differentiate similar conditions from one another•NEW CHAPTERS on laboratory methods and stains, and updated immunohistochemistry content

Thieme congratulates Dr. Eric M. Genden on being chosen by New York magazine for its prestigious'Best Doctors 2018'list!Head and Neck Cancer: Management and Reconstruction, 2nd Edition by Eric M. Genden masterfully blends two lauded Thieme books, Reconstruction of the Head and Neck, focusing on defect repair, and Head and Neck Cancer, a multidisciplinary, evidence-based approach to treatment. A significant increase in the incidence of oropharyngeal cancer in the U.S. and other countries, especially among men, is attributed to high-risk subtypes of the human papillomavirus (HPV). HPV associated tonsillar cancer and base of tongue cancer account for 90% of all oropharyngeal squamous cell carcinoma. Internationally renowned authors share the latest knowledge on HPV and other causes of head and neck cancers, from diagnosis to cutting-edge treatments.Thirty richly illustrated chapters feature open and endoscopic ablative techniques for treating a full spectrum of carcinomas and associated defects of the buccal, mandible and composite, laryngeal, hypopharyngeal, and parotid. The book encompasses the nuances of each pathology, step-by-step procedural guidance, clinical pearls, and the latest reconstructive techniques such as 3-D. For each disease, the authors discuss management concepts followed by principles of reconstruction and functional rehabilitation. Special topics include patient surveillance, monoclonal antibodies and immunotherapy, microvascular reconstruction, and minimizing wound complications.Key FeaturesState-of-the-art management of carcinomas impacting the oral and nasal cavities, salivary glands, oropharynx, hypopharynx, larynx, thyroid, anterior skull base, skin, and moreA chapter devoted to transoral robotic management of the oropharynx includes epidemiology, etiology, anatomy, staging, clinical presentation, diagnosis, work-up, and case studiesMore than 300 high-quality illustrations and photos elucidate complex anatomy and surgical approachesConcise videos posted online in the Thieme MediaCenter provide insightful hands-on surgical guidanceThis is the definitive, one-stop resource on the use of ablative and reconstructive approaches for head and neck cancers. Residents, fellows, and veteran practitioners in otolaryngology—head and neck surgery, radiation oncology, and medical oncology will benefit from this comprehensive reference.

This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.

Outstanding endoscopic skull base surgical resource presents cutting-edge approaches from multidisciplinary global expertsTransnasal endoscopic skull base and brain surgery have undergone major technical advances in recent years. The accumulation of experience and exciting technological innovations – including high-definition cameras, more ergonomic and precise surgical instruments, as well as new hemostatic agents – have enabled safer and more efficacious treatment of lesions affecting highly complex and delicate regions. This fully revised and updated second edition of Transnasal Endoscopic Skull Base and Brain Surgery: Surgical Anatomy and its Applications builds on the acclaimed first edition, focusing on the correlation between endoscopic skull base anatomy and state-of-the-art clinical applications. Among these are the transplanum/transtuberculum, transcribrifom, transclival, and craniocervical junction surgical approaches.Renowned skull base surgeon Aldo Stamm and leading worldwide experts have compiled a comprehensive multidisciplinary textbook with 72 chapters in 14 sections, didactically organized by regions and diseases. Detailed descriptions of sinonasal, orbital, cranial base, and intracranial anatomy, imaging modalities, and in-depth surgical navigation techniques form the foundation of this remarkable book. The content reflects significant knowledge and diverse perspectives from masters in neurosurgery, otorhinolaryngology, head and neck surgery, neuroendocrinology, intensive care, neuro-anesthesiology, and other disciplines.Key HighlightsChapter summaries and highlights facilitate understanding and retention of complex conceptsMore than 700 beautiful anatomical, operative, and dissection illustrations and photographs enhance understanding of impacted areas20 accompanying videos provide guidance on endoscopic transnasal approaches in patients with diverse skull base diseasesPearls, pitfalls, and nuances throughout this book provide invaluable insights on achieving optimal outcomesNeurosurgeons, otolaryngologists–head and neck surgeons, and others will greatly benefit from the step-by-step endoscopic procedural guidance and tips in this quintessential skull base surgical reference.

Nasopharyngeal Carcinoma: From Etiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong Kong. It encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of scientist-clinician collaboration, focusing on bench-to-bedside approach. Basic science is covered, discussing genetics and genomics in NPC and its epidemiology and the role of Epstein-Barr Virus (EBV). Translational research is also covered, presenting topics such as animal models, plasma EBV DNA, molecular imaging and immunotherapy, amongst other topics. This book is a valuable source for cancer researchers, oncologists, medical oncologists and several members of the biomedical field who are interested in learning more about NPC management from both clinical and research perspectives. - Written by members of the Centre for Nasopharyngeal Carcinoma Research - Extensively covers various aspects of NPC, including basic science and the clinical advances of both scientists and clinicians - Discusses the molecular information gained through laboratory studies to stimulate research on new treatment strategies

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. - Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. - Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management - Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis - Features contributions by leading experts in the field - Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Excerpt from Das Leben und die Lehre Epikurs, Diogenes Laertius, Buch X: Ubersetzt und mit Kritischen Bemerkungen Versehen (Classic Reprint)Leser nicht nur im Kreise der Philologen, sondern vor allem auch in dem der Philosophen fördern, und auch Epikur, dem Viel geschmähten und Vielbewunderten, zu seinem historischen Rechte verhelfen als einem nicht unwichtigen Markstein im Geistesleben der Menschheit.

“Overall, this is an excellent book on an important topic in cancer that medical oncologists, pharmacologists, and nurses, as well as related healthcare professionals, may find very helpful.”Score: 100, 5 Stars, Doody's Medical ReviewsHead and Neck Cancers: Evidence-Based Treatment presents a practical, state-of-the-art resource for any clinical oncologist treating or managing patients with head and neck cancers, including oropharyngeal cancer, cancer of the oral cavity, laryngeal cancer, nasopharyngeal cancer, hypopharyngeal cancer, cancer of the sinuses and the skull base, salivary gland cancer, and neck lymphadenopathy.Section 1 of the book covers the most pertinent details on the epidemiology, biology, diagnosis and staging of the disease including topics such as the genomic landscape of squamous cell carcinoma of the head and neck and novel imaging modalities. Section 2 discusses the evidence-based treatment modalities for conventional and novel chemotherapy regimens, the evidence behind emerging radiation therapy techniques and the minimally invasive surgical advances changing the landscape of care. The chapters in Section 3 are dedicated to site-specific management, including management guidelines, tables with FDA-approved therapies and relevant ongoing clinical trials as well as instructive clinical cases with important discussion on outcomes and follow up care. Finally, Section 4 focuses on recurrent and metastatic disease and Section 5 provides the essentials on supportive care, including managing the elderly, managing patients suffering from dysphagia and oral complications, and must-know details of quality of life assessment and patient-reported outcomes.Emphasizing the practice-changing techniques and the latest evidence-based treatment advances including targeted therapies, immunotherapy, transoral robotic surgery, and radiation therapy precision, this comprehensive yet accessible textbook is indispensable for any clinical oncologist of each discipline wanting a balanced and evidence-based reference on managing patients with head and neck malignancies.Key Features:Includes didactic clinical cases for each type of head and neck cancerNumerous tables highlight FDA approved therapies and ongoing clinical trialsProvides evidence-based recommendations for treating head and neck cancers at each stage of the disease with conventional and novel treatment strategiesCovers strategies for managing acute and late complications to treatment

This book presents the most up-to-date and innovative information on the targeting and treatment of a wide range of childhood cancers by means of radiation therapy. Written by global experts in pediatric radiation oncology, it documents in detail the treatment regimens appropriate to each disease, highlighting the recent advances that promise to improve rates of survival and cure. The use of image-guided and intensity-modulated radiation therapy is clearly described, and careful attention is also devoted to the roles of proton therapy, stereotactic radiosurgery, stereotactic fractionated radiosurgery, and modulated arc radiotherapy. Separate chapters address localization and verification procedures and anesthesia; pediatric radiation oncology in the palliative care setting; and aspects that are especially relevant in low- and medium-income countries. Beyond clinical radiation oncology, relevant information is provided on radiation physics. The book concludes by examining future directions in the field.

Das Nachschlagewerk für die Weiterbildung und die praktische Arbeit in der Klinik erscheint mit neuem Herausgeberteam komplett überarbeitet und präsentiert kompakt zusammengefasst die Highlights der aktuellen pädiatrischen Hämatologie und Onkologie. Verständlich und ohne Ballast präsentiert, ist das Buch für Spezialisten auf dem Gebiet ebensogut geeignet wie als anwendungsbezogener Einstieg in die Thematik. Das Werk ist in drei übersichtliche Abschnitte eingeteilt: die pädiatrische Hämatologie und Hämostaseologie, die allgemeine pädiatrische Onkologie und die spezielle pädiatrische Onkologie. Hier werden Leukozyten und Lymphome sowie solide Tumoren besprochen, darunter Tumoren im Zentralnervensystem, im Bauch und die Sarkome. Eine klare und einheitliche Einteilung jedes Krankheitsbildes macht das Buch übersichtlich und gut zugänglich von der Epidemiologie über die Pathogenese, Klassifikation, klinische Präsentation bis zu Diagnostik, Differenzialdiagnostik und prognostischen Faktoren. Die Therapie umfasst die Einordnung in internationale Konzepte und wird jeweils mit einem übersichtlichen Therapiealgorithmus einschließlich der Heilungsraten präsentiert. Zukünftige Therapieoptionen unter Einschluss möglicher Rezidive runden die Kapitel ab. Die Expertise führender pädiatrischer Onkologen und Hämatologen aus dem gesamten deutschsprachigen Raum sorgt dafür, dass dieses Buch das zeitgemäße Nachfolgewerk des ehemals von Gadner/Gaedicke/Niemeyer/Ritter herausgegebenen Standardwerks zur pädiatrischen Hämatologie und Onkologie wird. Das Buch richtet sich an Ärzte in Weiterbildung der Kinder- und Jugendmedizin und an alle pädiatrischen Onkologen bzw. Hämatologen.

This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapyin nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer.

Offering a comprehensive, multidisciplinary approach to head and neck oncology, Cancer of the Head and Neck, Fifth Edition, delivers authoritative guidance to the entire head and neck cancer care team. Retaining an expert surgical focus that has made it a classic in the field, this edition incorporates new disease- and site-specific chapters as well as a greater emphasis on reconstruction and rehabilitation. Written and edited by globally renowned head and neck surgeons, it's an indispensable resource for practitioners, trainees, and other health care professionals who care for patients with head and neck cancer.

This book describes the earliest reconstructable stages of the prehistory of English, focusing specifically on linguistic structure. It outlines the grammar of Proto-Indo-European, considers the changes by which one dialect of that prehistoric language developed into Proto-Germanic, and provides a detailed account of the grammar of Proto-Germanic. In the course of his exposition Don Ringe draws on a long tradition of work on many languages, including Hittite, Sanskrit, Greek, Latin, Slavic, Gothic, and Old Norse. This second edition has been significantly revised to provide a more in-depth account of Proto-Indo-European, with further exploration of disputed points; it has also been updated to include new developments in the field, particularly in the reconstruction of the Proto-Indo-European verb and nominal inflection. The author also reconsiders some of his original approaches to specific linguistic changes and their relative chronology based on his recent research. This new edition of the first volume in A Linguistic History of English will be of central interest to all scholars and students of comparative Indo-European and Germanic linguistics, the history of English, and historical linguistics more generally. The second volume, The Development of Old English by Don Ringe and Ann Taylor, was published by OUP in 2014 (paperback 2016)

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

A resource that combines oncologic principles with treatment plans for the surgical management of neoplasms Textbook of General Surgical Oncology is a practical and comprehensive reference that offers authoritative coverage of a wide variety of oncologic concepts and disorders. The book opens with detailed discussion of the general principles of molecular biology, cancer epidemiology, surgical oncology, radiation oncology, medical oncology, immunotherapy, nuclear imaging, and molecular diagnostics. The text then focuses on site-specific neoplasms, such as those of the skin, soft tissue, bone, head/neck, brain, lung, mediastinum, breast, pleura, peritoneum, as well as tumors that affect various systems, including the endocrine, gastrointestinal, hepatobiliary, genitourinary, gynecologic, and hematopoietic. · Each chapters is written by an internationally recognized expert on the topic · Learning aids include chapter-ending Q&A and Practical Pearls · Outstanding review for the new General Surgical Oncology certification examination

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression

The aim of this book is to focus on the otorhinolaryngology. Otorhinolaryngology is the medical discipline involving the assessment, diagnosis, treatment, and management of diseases, abnormalities, and other health problems affecting the ears, nose and throat, as well as the head and neck, mouth, sinuses, and voice box (larynx). Also referred to as ENT, otorhinolaryngology is considered as one of the oldest medical practices in the United States. Aside from medical management, they are also trained to perform surgeries that involve the above-mentioned body parts, including plastic or reconstructive surgeries. Otorhinolaryngologists training can take up to 15 years. This book comprises of 6 sections following as head & neck, cranial base and oncology, laryngology, rhinology, endoscopic sinus surgery, facial plastic and otology which consists of 166 chapters. It includes transsphenoidal pituitary surgery, fibrous dysplasia of the skull base, epidemiology of head and neck cancer, training of a head and neck surgeon, molecular markers in head and neck cancers, chemotherapy in head and neck cancers, thyroid cancer, oral cavity cancer, cancer of the temporal bone, tumors of the parathyroid gland, congenital anomalies of larynx and trachea, anatomy of the lateral nasal wall, diagnostic audiology and facial nerve testing, squamous cell carcinoma etc. Advances in the management of head and neck cancers take place on a continuous basis and this compendium provides an exhaustive overview of current practices in the field of head and neck cancer.

Endoscopic Approaches to the Paranasal Sinuses and Skull BaseWith the continuing evolution of endoscopic techniques for surgery of lesions of the paranasal sinuses and skull base, and the reduced morbidity associated with this minimally invasive modality, the method has gained widespread use in recent years. This work offers a thorough review of all endoscopic approaches for access to the nose and paranasal sinuses and, through them, to the skull base. Central to this guide is the emphasis on profound knowledge of the complex anatomy in this area, as well as the many vital structures that can be endangered there. To this end, more than 900 full-color images, most photographs from cadaver dissections, are put to brilliant use.Key Features:Internationally renowned specialists and pioneers from Europe and the United States as editors and contributorsFull-color photos from fresh cadaver dissections illustrate all steps for each approachSpecific anatomic landmarks as revealed during each step are detailed, providing confidence in spatial orientationCorrelative CT sections provide crucial additional informationRisks and potential complications are included, as well as methods to reduce themEndoscopic Approaches to the Paranasal Sinuses and Skull Base is intended as an indispensable guide for residents, fellows, and specialist surgeons in otolaryngology, neurosurgery, and skull base surgery.

The first edition of William Lincoln Ballenger's Diseases of the Nose, Throat and Ear: Medical and Surgical was published in 1908 and has since sold over 150,000 copies worldwide in 11 languages. The 18th edition has expanded to 114 chapters, continuing the tradition of excellence and applying Ballenger's original concept of combining an atlas with text to produce a comprehensive reference for practitioners of the 21st century. Color plates, illustrations, endoscopic photographs, and other color photographs illuminate surgical concepts, the foundations of underlying disease, and procedures. Section editors and senior authors were selected for their valuable contributions and international leadership in their disciplines. This edition blends state-of-the-art clinical techniques, methods, and outcomes with scientific foundations in an accessible, reader-friendly manner for both developing specialists and seasoned practitioners.

​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites – for quick access to information. Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors. Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance). Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases. Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.Disease Site chapters feature updated information on disease management and outcomes.Thirty all-new anatomy drawings increase your visual understanding.Medicine eBook is accessible on a variety of devices.

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model Lists of Essential Medicines.. The goal of the meeting was to review and update the 18th WHO Model List of Essential Medicines (EML) and the 4th WHO Model List of Essential Medicines for Children (EMLc). In accordance with approved procedures the Expert Committee evaluated the scientific evidence on the basis of the comparative effectiveness safety and cost effectiveness of the medicines. Both lists went through major revisions this year as the Committee considered 77 applications including 29 treatment regimens for cancer and innovative hepatitis C and tuberculosis (TB) medicines. The Expert Committee recommended the addition of 36 new medicines to the EML (15 to the core list and 21 to the complementary list); and recommended the addition of 16 new medicines to the EMLc (five to the core list and 11 to the complementary list). Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (19th edition) and the WHO Model List of Essential Medicines for Children (5th edition). In addition there is a list of all the items on the Model List sorted according to their Anatomical Therapeutic Chemical (ATC) classification codes.

'�the thoroughness of the text has to be admired. It is an excellent starting point for students of palliative care which makes an important contribution to any library.'-British Journal of Hospital Medicine'� covers a plethora of topics ranging from the development of palliative medicine in different countries to clinical topics and bioethics � an

This book presents original results on the leading edge of cancer research. Topics discussed include malignancy-related ascites; targeting cathepsin b for cancer therapies; cancer stem cells; metallomics of brain tumors; hepatitis b virus and Hepatitis C virus infections and risk of pancreatic ductal adenocarcinoma; the risk and prognostic factors associated with undifferentiated nasopharyngeal carcinoma; widespread expressions of TCRs in cancer cells and the implications in cancer immunology; hormone therapy in young cancer survivors; and inhibitory effects of ribosome inactivating proteins and compounds on choriocarcinoma cells.

This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content.microRNA: Cancer is an ideal companion to both microRNA: Basic Science andmicroRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

Principles and Practice of Stereotactic Radiosurgery, Second Edition serves as the definitive reference textbook for SRS practitioners. It provides a theoretical basis for the use of therapeutic radiation including imaging techniques and radiobiology. The bulk of the textbook contains chapters that are comprehensive in scope on all diseases that are treated by SRS. Lastly, it addresses administrative and technical aspects of running an SRS unit. Each chapter provides an expansive treatment of the subject, with emphasis placed on the technical aspects of SRS so that practitioners in this field can use it as a daily reference.Written by noted experts in the field, Principles and Practice of Stereotactic Radiosurgery, Second Edition is the only reference needed for neurosurgeons, radiation oncologists and medical physicists at all levels of training and practice who are interested in SRS.

This issue of Surgical Oncology Clinics of North America, edited by Dr. John Ridge, is devoted to Head and Neck Cancer.Articles in this issue include: Epidemiology of Head and Neck Cancer; Molecular Biology and Immunology; Examination of the patient with Head and Neck Cancer; Imaging of Head and Neck Cancer; Principles of Radiation Treatment; Principles of Chemotherapy; Principles and Practice of Reconstructive Surgery; Oral Cavity; Oropharynx; Unknown primary; Larynx and Hypopharynx; Nasopharynx; Nose and Sinus; Head and Neck Skin Cancer; and Tumors of the major Salivary Glands.

This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field.Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.

Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.

This issue of Hematology/Oncology Clinics of North America is devoted to Head and Neck Cancer. Guest Editor Alexander Colevas, MD has assembled a group of expert authors to review the following topics: Epidemiology of SCCHN; Genetics of Head and Neck Cancers; Molecular Biology of Head and Neck Cancers; Quality of Life in Head and Neck Cancer Treatment; Nasopharyngeal Carcinoma; Evolving Surgical Techniques in SCCHN; Radiation Oncology New Approaches in SCCHN; Thyroid Gland Malignancies; Sequential and Concurrent Chemoradiation; Systemic Chemotherapy for SCCHN Focus on New targets and Agents; EGFR Inhibition in SCCHN; Diagnostic and Therapeutic Assessment Imaging in Head and Neck Cancer; Salivary Gland Cancers; Immunotherapy in SCCHN; Human Papillomavirus in SCCHN; and Supportive Care Issues in SCCHN Treatment and Survivorship: Dental, Nutrition, Speech and Swallowing, Depression.

Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.

Das Manual des Tumorzentrums München zu den Kopf-Hals-Malignomen ist in einen allgemeinen und einen speziellen Teil aufgeteilt. Im allgemeinen Teil wird die Epidemiologie, die Diagnostik und die Therapie umfassend dargestellt; zusätzlich finden sich hier Aspekte zur Rehabilitation, Schmerzlinderung, Ernährung, Psychoonkologie, zur Arbeitsmedizin und zum Umgang mit Nebenwirkungen. Im speziellen Teil werden die einzelnen Malignome den verschiedenen Regionen des Kopf-Hals-Bereiches beschrieben und auch deren Therapie. Diese Kapitel wurden von verschiedenen Autoren geschrieben, die sich jeweils auf dieses Gebiet spezialisiert haben.Das Manual gibt einen praxisnahen Überblick über die wesentlichen Aspekte in der Diagnostik und Behandlung von Kopf-Hals-Malignomen, wobei die Plattenepithelkarzinome als häufigste Malignomform den meisten Raum einnehmen.

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Completely revised, this fifth edition of Bailey's Head and Neck Surgery – Otolaryngology offers the most current and useful evidence-based information available for the practicing otolaryngologist and otolaryngology resident. Written to increase the reader's understanding, retention, and ability to successfully apply the information learned, this easy-to-read text contains concise, practical content on all areas of head and neck surgery in Otolaryngology. With 207concise chapters, over 3,000 four-color illustrations, and helpful summary tables everything about this two-volume reference is designed to enhance the learning experience.

Management strategies and treatment guidelines from the world's leading expertsCovering tumors of the nose, sinuses, and nasopharynx for the first time in a single volume, this book is essential for all specialists. It incorporates the newest techniques for evaluation and treatment, including endoscopic approaches to the skull base, and offers a wealth of evidence-based data and analysis. For all members of the multidisciplinary health care teams who manage these complex cases, this book makes a major contribution to the field.Special Features:Written by three international authorities who have published and lectured widely and conducted landmark studies in this area Covers the full range of benign and malignant nose and sinus tumors, as well as the specific nasopharyngeal tumors that are more common to certain geographic regions (Far East) and ethnic groups (Chinese origin) Content is based on one of the largest single institutional studies ever undertaken, plus an extensive review of the international literature Encompasses every aspect of the field, from etiology, clinical features, histology, imaging studies, and diagnosis to natural history, treatment options, outcomes, and management of residual or recurrent disease Includes up-to-date contributions from experts on chemoradiation and head and neck imaging With the goal of centralizing data and long-term follow-up, this comprehensive guide is invaluable for all otolaryngologists, head and neck surgeons, oncologists, neurosurgeons, and maxillofacial and plastic surgeons who treat patients with challenging sinonasal, skull base, and nasopharyngeal neoplasms.

The third edition of Intensity Modulated Radiation Therapy was written to enhance the reader's understanding of the cutting-edge technology of Intensity Modulated Radiation Therapy. It is designed to both update old readers and inform new readers about the complexities and details of clinical management. This completely updated edition provides a step-by-step, practical approach to the use of IMRT in the evaluation and treatment of cancer patients. Because of IMRT's ability to employ individually controlled beamlets, it is an extremely promising technique, especially when paired with CT, PET, and/or MRI. With these improved procedures, doctors and clinicians will be able to take high resolution images of tumors while minimizing dosages to surrounding tissue. In order to focus on the most up to date IMRT techniques, the introductory chapters have been condensed to provide a brief overview of IMRT physics, mechanics and quality assurance, and also CT and MR imaging. To help assist in clinical decision-making it provides the reader with more than 700 full-color illustrations, IMRT tables and clear, straightforward descriptions that address a range of tumor types and sites including head and neck, urinary, and gynecologic cancers.