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More than 100 years ago, Dr Casimir Funk suggested the existence of a family of organic substances that are essential for life and thus introduced the concept of “vital amines” as essential nutrients with a specific action, requiring only minute amount with the power to cure a specific disease. Vitamins essential for human health are grouped according to whether they are soluble in water (hydrophilic) or in non-polar solvents (lipophilic). The hydrophilic vitamins are vitamin C and a series known as the vitamin B complex. Vitamin C is a reducing agent, whereas the vitamin B series are components of coenzymes. For example, riboflavin (vitamin B2) is a precursor of flavin adenine dinucleotide (FAD) and pantothenate (vitamin B5) is a component of coenzyme A. Indeed, several coenzymes contain a vitamin as part of their structure; this relation is undoubtedly responsible for creating an “essential” role for the vitamin. Since vitamins are involved in a wide range of biological processes and cell function, these are considered as essential nutrients. The essential nature of vitamins as well as their unique biochemistry, molecular mechanisms and cellular function in health and disease are emphasized in this book which will serve as a highly useful resource for health professionals, nutritional scientists, medical students, fellows, residents, and graduate students.

Written by physicians who are experts in both traditional and complementary medicine, Integrative Medicine, 5th Edition, uses a clinical, disease-oriented approach to safely and effectively incorporate alternative therapies into primary care practice. Drawing on available scientific evidence and the authors'first-hand experiences, it covers therapies such as botanicals, supplements, mind-body, lifestyle choices, nutrition, exercise, spirituality, and other integrative medicine modalities. This highly regarded reference offers practical guidance for reducing costs and improving patient care while focusing on prevention and wellness for a better quality of life. - Explains how to make the best use of integrative medicine and the mechanisms by which these therapeutic modalities work, keeping you at the forefront of the trend toward integrative health care. - Templated chapters make it quick and easy to find key information such as dosing, pearls, the Prevention Prescription, and Therapeutic Reviews that incorporates the Evidence vs Harm Icon. - Uses the reliable SORT method (Strength of Recommendation Taxonomy) to provide evidence-based ratings, grading both the evidence and the relative potential harm. - Thoroughly updated, ensuring that you remain well informed regarding the latest evidence. - Contains 10 new chapters covering clinician resilience, supporting immunity, NASH/fatty liver, hair loss, rethinking the movement prescription, compassion practices, prescribing low-dose naltrexone, psychedelics, tapering off PPIs and opioids, as well as an expanded osteopathy chapter. - Covers timely topics aimed at reducing the epidemics of polypharmacy and opioid overuse, as well as supporting immunity in the face of infectious diseases. - Provides online access to multiple-choice questions for every chapter—perfect for board exam review. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Now in a revised and expanded third edition, the aims of The Active Female are threefold: first, to increase the awareness of wellness and fitness issues for active females and their family members; second, to provide an avenue for medical practitioners, allied health professionals, health educators/providers, and certified individuals in sports medicine/athletics to gain critical, updated knowledge of a field specific to active females; and third, to introduce the concept of obesity as a growing health concern even for normal weight individuals. Part I of the book offers a foundation for understanding the interrelationships between female physiology, body image and other psychological issues, the female reproductive cycle, and the musculoskeletal anatomy and physiology of females that makes their health risks and concerns unique. In Part II, the concepts of eating disorders from a global perspective and the health disparities and inequities in women's health are discussed in detail. Part III describes the prevention and management of common musculoskeletal injuries in active females across the lifespan, including the management of osteoporosis. Appropriate exercise and nutritional guidelines and recommendations for active females are discussed in detail in Parts IV and V. Part VI is a new addition to the book and highlights the obesity epidemic and co-morbid diseases associated with obesity even for normal weight obese individuals. Each chapter is bookended by clear learning objectives and review questions for additional pedagogical appeal. An invaluable addition to the literature, The Active Female: Health Issues throughout the Lifespan, 3e will be of great interest to all clinicians and allied health care professionals concerned with women's health and related issues, from sports medicine and family practitioners to endocrinologists, gynecologists and orthopedic surgeons.

The Transgender Athlete: A Guide for Sports Medicine Providers presents sports medicine practitioners insights into the unique issues and concerns of transgender athletes in order to help them understand rules regarding transgender athlete participation and learn how to better provide competent care to transgender athletes. There are over 1.4 million transgender adults in the United States. Transgender individuals undergo gender-affirming treatments including sex hormone therapy and gender-affirming surgery. An increasing number of transgender people are participating in sports and presenting to sports medicine clinics with injuries, yet there is little research about this athlete population. It is important that sports medicine providers understand the types of hormone treatments and surgeries and how these changes affect the musculoskeletal health of transgender people. Additionally, transgender people may require specific considerations when interacting with medical providers. Furthermore, sports medicine providers are often consulted to formulate transgender athlete inclusion policy. These policies are continuously changing, as new evidence becomes available, which may be difficult to understand without knowledge of the gender transition process. - Covers the types of treatments, surgeries and affects of musculoskeletal health of transgender athletes - Intended for sports medicine providers, including physicians, physical therapists, athletic trainers and researchers who work with athletes - Written by experts in the sports medicine field

Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases presents strategies for the prevention of non-communicable diseases and undernutrition through the use of functional foods and nutraceuticals. Research has shown that the use of certain functional foods and nutraceuticals, including spices, herbs, and millets, animal foods and plant foods can play a role in the treatment and prevention of various diseases and in health promotion. Finally, the book explores epigenetic modulation as a new method for the development of functional foods and functional farming. Intended for nutritionists, food scientists and those working in related health science professions, this book contributes to the discussions focused on nutritional transition, globalization, how to administer foods in the treatment of metabolic syndrome, hypertension, diabetes, heart attacks, neuropsychiatric disorders, bone and joint diseases, and carcinogenesis. - Places emphasis on food diversity to provide perfect combinations of nutritional ingredients - Presents the utility and necessity of functional food production for health promotion - Offers suggestions to increase functional food production while simultaneously decreasing production costs

This book provides a review of the most recent data on osteoporosis and bone health, presenting a vision of diagnosis and management for the year 2021 and beyond. It covers all pertinent aspects of bone health including diagnosis, fracture prevention, optimized practice, impaired orthostasis, and falls. The book examines recent developments in therapeutics, including goal-directed therapy, individualizing therapy, sequential and combined therapies, pharmaceuticals, and anabolic vs. antiresorptive therapy. In addition, it provides an in-depth overview of osteoporosis and bone health in complex patients, covering Duchene dystrophy, renal failure, periodontal diseases, and steroid-induced osteoporosis as well as considerations for pediatric populations and men. New Horizons in Osteoporosis Management is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses in rheumatology, endocrinology, radiology, pediatrics, primary care, and internal medicine.

Nutritional Management of Renal Disease, Fourth Edition, offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease and serves as an in-depth reference source concerning nutrition and kidney disease. This classic translational reference provides correct diagnosis - and therefore correct treatment - of renal, metabolic, and nutritional disorders. Nephrologists, diebetologists, endocrinologists, dieticians, and nutritionists depend on a strong understanding of the molecular basis for the disease. This fourth edition includes thorough new case reports, offering expert advice on how to use the latest research and clinical findings in counseling patients about dietary and lifestyle options. Readers gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient. - Includes the latest comprehensive KDOQI clinical practice guidelines for the nutritional management of kidney disease from the National Kidney Foundation and the Academy of Nutrition and Dietetics, covering recommendations for each essential nutrient, as well as for some nonessential nutrients - Presents a comprehensive, translational look at all aspects of metabolic and nutritional disorders in one reference - Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to assimilate information and discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease - Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles

Musculoskeletal (MSK) disorders have a high prevalence and are one of the main reasons for patients to consult with a provider. For a range of issues from injury to back pain to rheumatic disease, musculoskeletal pathology is the second most common reason for a patient to see a primary care provider. However, despite their prevalence and significant socioeconomic impact, musculoskeletal disorders are relatively undertaught in medical schools in the United States. While all medical, nursing and physician assistant students receive exposure to some MSK content, in many medical schools this material does not receive curricular exposure commensurate with its prevalence. This practical textbook fills in that gap. All aspects of musculoskeletal disease and its management are presented concisely for quick reference and review, with each chapter opening with clear goals and objectives. The text begins with a discussion of the anatomy and physiology of bone, cartilage and muscle, including imaging techniques and interpretation. Musculoskeletal infections, tumors and vascular conditions are then covered, along with common rheumatic conditions such as rheumatoid and osteoarthritis, metabolic bone disease, and age-specific and traumatic conditions. Finally, the upper and lower extremity and spine are thoroughly discussed in terms of anatomy/pathoanatomy, common clinical conditions, physical exam, and common radiographic and clinical correlations. The main audience for Clinical Foundations of Musculoskeletal Medicine is medical students seeking to improve their understanding of common musculoskeletal conditions. Given the relevance of musculoskeletal conditions to a range of providers, this book can also be used for the musculoskeletal education of allied professionals such as physician assistants (PA) and nurse practitioner students. It could likewise serve as a resource for practicing medical professionals to develop and enhance their knowledge in this content area.

The Dietitian's Guide to Vegetarian Diets: Issues and Applications, Fourth Edition provides the most up-to-date information on vegetarian diets. Evidence-based and thoroughly referenced, this text includes case-studies, sample menus, and counseling points to help readers apply material to the real world. Written for dietitians, nutritionists, and other health care professionals, the Fourth Edition can be used as an aid for counseling vegetarian clients and those interested in becoming vegetarians, or serve as a textbook for students who have completed introductory coursework in nutrition.

Das Standardwerk zur vegetarischen Ernährung jetzt erweitert durch vegane Ernährungsformen und in neuem, größerem Format! Nahezu alle Kapitel der 4. Auflage des beliebten Standardwerks wurden von den Autoren vollständig überarbeitet. Sämtliche wissenschaftliche Studienergebnisse und alle Angaben zur Nährstoffzufuhr wurden aktualisiert, neue Studienergebnisse wurden aufgenommen. Der Teil der veganen Ernährung wurde deutlich erweitert: Alle wichtigen Aspekte zur veganen Ernährung wurden Kapitel übergreifend noch umfassender berücksichtigt, die bewährte Kapitelaufteilung wurde beibehalten. Hier finden Studierende der Ernährungswissenschaften, Ökotrophologie und Medizin in gleichem Maße wie Angehörige vieler Gesundheitsfachberufe und in der Ernährungsberatung Tätige fundiertes, aktuelles Wissen zu den Themen Vegetarismus und Veganismus.

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. - Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents - Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis - Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e.osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons.This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting ouraging population.The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

The 9th International Symposium is the only regular meeting in the bone field to be exclusively devoted to nutrition, bone and muscle, and it allows the authors of this book to review the new scientific data, discuss new concepts, and update the knowledge on several nutrients. The Symposium provides a unique opportunity to connect health professionals, researchers and industry across many disciplines, including nutrition and dietetics, exercise science, gerontology, nursing, general practice, academia and the food and fitness industry. Most causes for osteoporosis, like genetics, age, menopause, and associated diseases with their treatments, are not modifiable. The investigation of the influence of nutrition on bone health is important as a key modifiable factor of the development of bone and the prevention of osteoporosis. It is the privilege of this symposium to gather every three years with scientists from all overthe world working in this field.

Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA's aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.​Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide. There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.

Each issue of Orthopedic Clinics offers clinical review articles on the most cutting edge technologies, techniques, and more in the field. Major topic areas include: adult reconstruction, upper extremity, pediatrics, trauma, oncology, hand, foot & ankle, and sports medicine.

This newly revised edition contains updated versions of all of the topics that were in the first edition and has been substantially expanded with an additional 5 chapters. Each chapter includes information from the most up-to-date research on how nutritional factors can affect bone health, written with an evidence-based focus and complete with comprehensive references for each subject. Nutrition and Bone Health, second edition covers all aspects of nutrition and the skeleton, from the history and fundamentals, to the effects of macronutrients, minerals, vitamins, and supplements, and even covers the effects of lifestyle, the different life stages, and nutrition-related disorders and secondary osteoporosis. New chapters include HIV & AIDs and the skeleton, celiac disease and bone health, and nutrition and bone health in space. Nutrition and Bone Health, second edition is a necessary resource for health care professionals, medical students, graduate students, dietitians, and nutritionists who are interested in how nutrition affects bone health during all stages of life.

Management of Musculoskeletal Injuries in the Trauma Patient summarizes the most current concepts and clinical practices for the management of the patient with musculoskeletal traumatic injuries. The text covers optimal time frames for stabilization of orthopedic injuries and strategies to mitigate systemic injury while minimizing damage due to pelvic, spine and long bone trauma. The volume covers the gamut of traumatic axial and extremity injuries, including cervico-lumbar-thoracic spine injuries, spinal cord injuries, long bone fractures with special emphasis on the femoral shaft, pelvic and acetabular injuries, open fractures, mangled extremities, upper extremity injuries, combination and severe soft tissues injuries and periarticular fractures. These are discussed in the context of isolated injury and combined with orthopedic injuries of the brain, abdomen, chest and other musculoskeletal injuries. Written by internationally recognized experts, Management of Musculoskeletal Injuries in the Trauma Patient is a valuable resource for orthopedic surgeons.

Edited by Drs. Juergen Braun and Joachim Sieper, this issue of Rheumatic Disease Clinics comprehensively reviews the state of the art of spondyloarthritis (SpA) diagnosis, prognosis, pathogenesis and genetic insights, and treatment. The worldwide burden of SpA now exceeds that of rheumatoid arthritis. General topics covered include inflammatory back pain, pathophysiology, imaging techniques, and therapeutic strategies.

A debilitating disease of pain, inflammation, and loss of mobility and quality of life, arthritis takes victims of all ages, from young children to seniors. Usually chronic, the broad term arthritis refers to nearly 100 distinct manifestations, each with their own etiology, pathophysiology, and treatment. With medical research getting so much atten

This is a concise yet thorough review of the diagnosis and treatment of many forms of psoriasis and covers current concepts in the ever-expanding field of psoriasis pathophysiology. Emerging concerns, such as systemic disease associations, quality of life, and psoriatic arthritis, are discussed, plus recent advances in basic science and clinical trial data. The book is of interest to all physicians with an interest in inflammatory skin diseases with systemic associations, including dermatologists in training and practice, candidates for post-registration qualifications, primary care physicians, emergency physicians, and senior medical students.

One of the most prestigious, comprehensive texts on arthritis and related diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, lupus and more than one hundred others.

Psoriasis is an inherited skin disease that has been diagnosed in 4.5 million adults in the United States. About 10 percent to 30 percent of people with psoriasis also develop psoriatic arthritis, which causes pain, stiffness and swelling in and around the joints. The book reviews the clinical manifestations of these two entities. The main focus is on the evolving paradigm of therapy. Topical and ultraviolet therapy are discussed first, followed by traditional systemic therapy. A major focus is on biologic therapies. New agents in development are also reviewed. The book concludes with an evaluation of the quality of life impact of this disease. This volume provides an in-depth overview of the current state of psoriasis and its management. It is of interest to clinicians, researchers, and even patients who wish to learn more. It is also of interest to those in the pharmaceutical industry, and those in finance who cover the pharmaceutical field.