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Comprehensive Materials Processing, Second Edition, 13-vol set, consolidates and enhances the most up-to-date literature of the materials processing and manufacturing universe. It provides authoritative analysis of all processes, technologies, and techniques for converting industrial materials from a raw state into finished parts or products. Coverage encompasses solidification, powder, deposition, and deformation processing. Additional discussion includes plant and tool design, analysis and characterization of processing techniques, high-temperatures studies, and the influence of process scale on component characteristics and behavior. Building and expanding on the previous edition, it includes recent developments and advances in the field, such as updated processing technologies, costs and characterizations. This new edition will also explore sustainability and environmental impact of materials processing in greater detail. Comprehensive Materials Processing, Second Edition will serve as a valuable, one-stop resource to students, academics, and researchers in the fields of engineering and materials science, as well as those in adjacent fields. Industry professionals will also benefit from this comprehensive resource.Updated to include recent developments in the field, such as updated processing technologies and costsExplores sustainability and the environmental impact of materialsIncludes practical tools such as integrated case studies, user-defined process schemata, and multimedia modeling and functionalityMaximizes research efficiency by collating the most important and established information into one concise resource with consistently formatted chapters

This book presents select proceedings of the Indian Conference on Applied Mechanics (INCAM 2022). It includes the latest research on solid mechanics, impact mechanics, fluid mechanics, biomechanics, materials science and design engineering. Additional topics covered in this book are additive and advanced manufacturing, mechanics of energetic materials, mechanics in agriculture, flight and drone mechanics, mathematical methods in mechanics and precision metrology. The book is useful for researchers and academics from a broad range of engineering disciplines, such as civil engineering, mechanical engineering, aerospace engineering, automotive engineering, biomedical engineering and material science.

This book provides new insight and a better understanding of nanotechnology in mitigating crop biotic stresses.It covers crop diseases and different nano-based management strategies used to manage pathogens and plant-parasitic nematodes damaging crops. Nanoparticles have the potential to revolutionize crop yield and can control plant biotic stress. Nanotechnology in plant pathology is a new frontier among various nanotechnological applications. Nanotechnology applications include the development of nano-based pesticides and nanoformulations of chemicals for crop improvement by reducing biotic stress. Different nanomaterials like ZnONPs, SiO2NPs, CuONPs, AgNPs, and TiO2NPs have been examined for their impacts on plant growth and biotic stress management. This book deals with the advanced use of nanotechnology in managing the biotic stress of crops and improving crop production. It covers these issues and many more. Each chapter focus on one particular topic. Incorporate chapters provide detailed information on nanotechnology and may help in future research. This book will be useful for researchers, professors, and postgraduate and undergraduate students, especially concerning agriculture and plant pathology.

The book is a collection of peer-reviewed best selected research papers presented at the International Conference on Data Intelligence and Cognitive Informatics (ICDICI 2023), organized by SCAD College of Engineering and Technology, Tirunelveli, India, during June 27–28, 2023. This book discusses new cognitive informatics tools, algorithms and methods that mimic the mechanisms of the human brain which lead to an impending revolution in understating a large amount of data generated by various smart applications. The book includes novel work in data intelligence domain which combines with the increasing efforts of artificial intelligence, machine learning, deep learning and cognitive science to study and develop a deeper understanding of the information processing systems.

This book comprises select proceedings from the 4th International Conference on Data, Engineering, and Applications (IDEA 2022). The contents discuss novel contributions and latest developments in the domains of data structures and data management algorithms, information retrieval and information integration, social data analytics, IoT and data intelligence, Industry 4.0 and digital manufacturing, data fusion, natural language processing, geolocation handling, image, video and signal processing, ICT applications and e-governance, among others. This book is of interest to researchers in academia and industry working in big data, data mining, machine learning, data science, and their associated learning systems and applications.

This book covers experimental theory and practice of yoga that have enhanced its neuroscientific understanding. This is an excellent handbook for the researchers in the field of evidence-based integrative health. It encompasses traditional and modern tools used in neuroscience. It also provides information for the modern biologists, physicians and policymakers, of how mind-body complexities in neuroscience, mental health and preventive healthcare can be useful for health and disease. It serves as a guide for integrative health practitioners, patients, educationists, philosophers, graduate students and faculty pursuing research in the field of biology, complimentary medicine, and other alternative therapies. The chapters in this book also serve as a comprehensive resource for clinical trials in Yoga. In addition, flow charts and illustrations have been provided to understand how healthy brain ageing can be achieved.

The concept of “vital amines” as essential nutrients was introduced over a century ago by Dr Casimir Funk. It was suggested that there is a family of organic substances that are required in minute amounts and essential for life. The increase in incorporation of vitamins and supplementation in routine dietary practices is expected to increase. In fact, it has been estimated that 60% of worldwide consumers are taking vitamin supplements on a daily basis, a trend that will most likely rise across the world.This book brings together international experts in the field of vitamins for human health and disease, to update and integrate current understanding on the effects of different lipophilic vitamins on cellular, metabolic and molecular biochemical reactions with respect to different pathophysiological conditions including cardiovascular disease, cancer, metabolic defects, inflammatory and immune diseases. This book is uniquely positioned as it focuses on the biochemistry and molecular biology of lipophilic vitamins in diverse cell systems in relation to human health and disease.The book will certainly stimulate and motivate biomedical researchers and scientists to further explore the relationship between lipophilic vitamins and biological processes, as well as serve as a highly useful resource for nutritional investigators, health professionals, medical students, fellows, residents and graduate students. We hope that the reader will gain knowledge and further understanding of the importance of lipophilic vitamins. The novel insights provided by the contributing authors will assist in advancing preventive medicine worldwide as well as bring forward knowledge that may help in the use of lipophilic vitamins as adjuvant to therapeutic strategies for human disease.

The book presents selected papers from International Conference on Multi-Strategy Learning Environment (ICMSLE 2024), held at Graphic Era Hill University, Dehradun, India, during 12–13 January 2024. This book presents current research in machine learning techniques, deep learning theories and practices, interpretability and explainability of AI algorithms, game theory and learning, multi-strategy learning (MSL) in distributed and streaming environments, and adaptive data analysis and selective inference.

The book covers antimicrobial resistance in ocular diseases, including the microbiology of the ocular surface, the history and origin of antimicrobials, methods to detect antimicrobial resistance and antimicrobial resistance genes, and the impact of antimicrobial resistance on a variety of ocular diseases. The inclusion of chapters covers bacterial keratitis, fungal keratitis, viral keratitis, acanthamoeba keratitis, endophthalmitis, dry eye disease, post fever retinitis, and uveitis including management and prevention of antimicrobial resistance.Key Features: Focusses on various ocular diseases and their association with antimicrobial resistance; Includes data relevant to drug industry to develop drugs for specific ophthalmic use; Illustrates ocular surface microbiome under various diseased condition;s Highlights the microbes associated with the conjunctiva and cornea of the human eye; Enumerates the changes in the abundance and diversity of the antimicrobial resistant (AMR) microorganisms in the diseased eye. This book is aimed at professionals and researchers in ophthalmology, microbiologists, infectious disease specialists, and public health.

This book is a comprehensive review of secondary metabolite production from plant tissue culture. The editors have compiled 12 meticulously organized chapters that provide the relevant theoretical and practical frameworks in this subject using empirical research findings. The goal of the book is to explain the rationale behind in vitro production of secondary metabolites from some important medicinal plants. Biotechnological strategies like metabolic engineering and the biosynthesis, transport and modulation of important secondary metabolites are explained along with research studies on specific plants. In addition to the benefits of secondary metabolites, the book also aims to highlight the commercial value of medicinal plants for pharmaceutical and healthcare ventures.Topics covered in this part include:1. In vitro propagation and tissue culture for several plants including Withania somnifera (L.) Dunal, Aloe vera, Oroxylum indicum (L) Kurz, Ocimum basilicum L, Rhubarb, Tea, and many others (including plants in Northern India).2. Genetic Improvement of Pelargonium3. Bioactive Components in Senna alata L. Roxb4. Plant tissue culture techniquesThe book caters to a wide readership. It primarily prepares graduate students, researchers, biotechnologists, giving them a grasp of the key methodologies in the secondary metabolite production. It is a secondary reference for support executives, industry professionals, and policymakers at corporate and government levels to understand the importance of plant tissue culture and maximizing its impact in the herbal industry.

This book is a comprehensive review of secondary metabolite production from plant tissue culture. The editors have compiled 12 meticulously organized chapters that provide the relevant theoretical and practical frameworks in this subject using empirical research findings. The goal of the book is to explain the rationale behind in vitro production of secondary metabolites from some important medicinal plants. Biotechnological strategies like metabolic engineering and the biosynthesis, transport and modulation of important secondary metabolites are explained along with research studies on specific plants. In addition to the benefits of secondary metabolites, the book also aims to highlight the commercial value of medicinal plants for pharmaceutical and healthcare ventures.Topics covered in this part include:1. Elicitation Strategies and Metabolic Engineering to boost metabolite production with case studies in metabolic engineering with examples of Scaevola Taccada and Catharanthus Roseus.2. Stress response investigation and the role of glandular trichomes as bio-cell factories3. Plant growth regulators and rapid regeneration techniques using swift plantlets regeneration and phytochemical characterization4. Nutraceuticals, antimicrobials, and genomic applications of in vitro cultures with an example of Hassawi rice and its genomics5. Sustainable approaches for saving endangered medicinal plantsThe book caters to a wide readership. It primarily prepares graduate students, researchers, biotechnologists, giving them a grasp of the key methodologies in the secondary metabolite production. It is a secondary reference for support executives, industry professionals, and policymakers at corporate and government levels to understand the importance of plant tissue culture and maximizing its impact in the herbal industry.

This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

From the latest vaccination evidence, recommendations, and protocols... to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as'an indispensable guide to the enhancement of the well-being of our world,'Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. Analyzes the cost-benefit and cost-effectiveness of different vaccine options. Helps you clearly visualize concepts and objective data through an abundance of tables and figures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book mainly focuses on the recent trends and sustainability challenges in the valorization of agro-wastes, emphasizing the role of microbial biotechnology. Processing of various kinds of agro-wastes such as lignocellulosic materials, food industry wastes, dairy wastes, etc., into several bioactive compounds, enzymes, biofuels, biogas, biofertilizers, nutraceuticals, nanoparticles, etc., will be discussed elaborately in more detail. This book investigates the theoretical and practical aspects of modern research regarding the valorization of agro-wastes through microbial technology. Moreover, the role of valorization research in circular bio-economy will also be addressed in this book.

This book covers cadmium contamination of soil and plants, its sources, acute and long-term impacts on the environment and human health, and overall challenges posed by the global poisoning issue. Cadmium is among the elements that have been most broadly used by man over time, which has led to extensive pollution of surface soils, mainly associated with the mining and smelting of the metal and the addition of organic cadmium compounds to petrol. The release of cadmium into the atmosphere from various high-temperature processes has also led to surface contamination on a regional and even global scale. Cadmium is particularly firmly bound to humic matter in organic-rich soil and to iron oxides in mineral soil and is rather immobile in the soil unless present at very high concentrations. Plants grown on cadmium-rich soils incorporate cadmium, thus increasing the concentration of cadmium in crop plants. Cadmium thus enters the food chain through the consumption of plant material, whichposes important health risks to humans and animals. In this book, readers will find out about the latest mitigation strategies, including a multi-disciplinary approach to address cadmium contamination. Recent methods in cadmium detoxification, speciation, and molecular mechanisms are included, and the book offers the knowledge required for efficient risk assessment, prevention, and countermeasure. Divided into 3 parts, this book brings together expert contributions on cadmium toxicity. In the first part, readers will find out about the different sources and distribution of cadmium in soil and plant ecosystems. The second part of the book outlines the health risks linked to cadmium toxicity, and in the final part, readers will discover sustainable cadmium toxicity mitigation strategies and potential applications of recent biological technology in providing solutions. This book is a valuable resource for students, academics, researchers, and environmental professionalsdoing fieldwork on cadmium contamination throughout the world.

The solvent-free approach provides green and alternative synthetic methods for obtaining diverse bioactive heterocycles. The solvent is frequently the primary component of synthetic protocol and contributes to significant waste. Additionally, its removal processes are energy intensive and substantial. This book explores different solvent-free procedures for efficiently synthesising heterocyclic analogues of immense biological importance and other applications.

In an era of increasing specialization, the need for cross-disciplinary dialogue demands an integrated approach that transcends the artificial boundaries between disciplines.'Impending Inquisitions in Humanities and Sciences'presents a groundbreaking tapestry of cutting-edge research across the spectrum of humanities and sciences. This volume presents a meticulously curated selection of research papers presented at the conference, a forum where scholars from diverse fields – English, Mathematics, Physics, and Chemistry – converged to engage in rigorous dialogue and push the boundaries of knowledge. From the nuanced interpretations of literary texts to the elegant formulations of mathematical models, from the awe-inspiring revelations of physics to the meticulous experiments of chemistry, each contribution challenges assumptions and provokes fresh perspectives. This collection serves as a valuable resource for scholars, students, and academic fraternity with an insatiable curiosity about the world around us.

This book presents the integrating of economics and urban geography to create a framework of cooperation around the idea of urban economic stability. It explores these disciplines through the economic lens and creates a collaborative environment for addressing the global challenges caused by the COVID-19 pandemic and future global shocks. Environmental advocates and proponents of economic growth are increasingly at odds—having looked at the economic impact of the decline of the environment as well as the environmental loss that occurs with unchecked growth and urbanization. The outbreak of the COVID-19 pandemic changed the global scene. The world shook in its foundations, as a number of countries'lockdown affected not only the global economy but also society and the environment. The global community has seen the negative impact of COVID-19 on our economies. There have been steep declines in gross domestic product, job losses have been in the millions, and people have seen their incomes fall. An unplanned shutdown has taken its toll and has been a shock to the economies of the world. Past shocks and how they have impacted urban economies as well as for how long are core to bettering our understanding of present and future urban economic change. The underlying economic factors that make a shock more damaging to certain economies or industries, as well as understanding these vulnerabilities, help entities recover from economic shocks and allow them to better understand how impacts on individual businesses can be implemented. The pandemic revealed the need to adopt a global development approach, taking into consideration four dimensions: global value chains, debt, digitalization, and the environment. Topics related to the causation and lockdown are explored through a number of case studies from around the world.

Green Solutions for Degradation of Pollutants is a compilation of reviews on environmental remediation by sustainable techniques. The book helps readers understand the potential of such techniques in resolving the growing problem of environmental pollutants.The editors have compiled 13 comprehensive reviews on green remediation techniques such as microbial bioremediation, nano-bioremediation, phytoremediation, and green-nanoremediation for the remediation of a variety of pollutants, including wastewater, microplastics, metals and other contaminants. Materials highlighted in the chapters include carbon quantum dots, plant extracts, metallic and organic nanoparticles.Green Solutions for Degradation of Pollutants is a reference book for readers who need to comprehend the practical application of green remediation techniques.

Environmental conditions and processes are one of the major pillars on which the human well-being rests. It is the core responsibility of the society to preserve and enhance better conditions for the human well-being. Indeed, there are several evolving unmet needs in public health. Emerging and re-emerging infectious diseases and a surge in the incidence of non-communicable diseases, including cardiovascular diseases (CAD), chronic respiratory diseases, and metabolic diseases have been impediments to sustainable well-being. Many factors are critical in the global surge in the rate and incidence of cardiovascular diseases. These include the shift from acute to chronic conditions, the shift from single risk factor vs. multiple influences, aging population, global health disparities, exposure to lower harmful influences over a longer period, etc. However, the epigenetic factors due to unhealthy environment play a most significant role in the underlying pathogenesis of cardiovascular diseases. Unfortunately, this has been ignored for a long time and realized lately to expand and disseminate knowledge to general population, expand research activities to investigate the cellular and molecular mechanisms, and develop better preventive and treatment strategies. The most significant environmental impoverishment in the pathogenesis of cardiovascular diseases include different genetical, chemical, physical, and biological influences, but not limited to, socio-economic status and lack of nutrients, nutritional aspects including habits, diets and additives, inhaled and ingested pollutants, exhaust gas and gasoline products, tobacco smoke, water pollution, alcohol consumption, soil and mineral pollution, solvents, pesticides, microplastics, non-critical usage of drugs, climate change, extreme atmospheric conditions, extremes in noise and temperature, electromagnetic influences, microwaves and radiation, outdoor light pollution, mental stressors, lack of or over exercise, microbiota and microbiological agents like SARS CoV-2 virus, etc.

This contributed volume covers all aspects of small indigenous fish for nutritional and livelihood security. The availability, descriptions and identification of common small indigenous fish provides potential and prospects of fish production from inland open water system. In addition, individual chapters are added on growth, feeding, diseases and health management of these small fishes. Essential information is provided on packaging and transport of these fishes. Specific chapters provide information on nutritional value of fishes, value addition and product development by using small indigenous fish species in different regions of the country. Further topics include small fishes of ornamental value, indigenous technical knowledge, climate change impact, conservation and management of small indigenous fish diversity. This book supports the academicians, farmers, entrepreneurs and fisheries professionals involved in gaining the knowledge and skills needed to contribute in nutritional and livelihood security of the nation.

This book comprehensively covers critically investigated information on medicinal plants prioritized for their anti-allergy properties. It offers insights into strategies related to the distribution, mechanism of action, and assessment of antiallergic medicinal plants, and also delves into crucial aspects of modern biotechnological tools, addressing their implementation challenges, presenting innovative approaches through case studies, and exploring opportunities for nanotechnologies. These elaborated discussions aim to raise awareness and bridge the gap between human health and the biodiversity of antiallergic medicinal plants. As the book navigates the uncertainties of plant-based medicines in the post-COVID-19 era, it provides real-world applications showcasing the specific utility of medicinal plants through advanced biotechnological insights. This book covers several medicinal plants associated with antiallergy, exploring their modes of action, available secondary metabolites,and estimation methods. It also emphasizes all modern biotechnological interventions aimed at propagating, multiplying, and conserving this unique treasure trove of medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. Increasing demand in both developing and developed countries resulted in the expanding trade of medicinal plants and has serious implications for the survival of several plant species, with many under threat of becoming extinct. This book describes various approaches to conserving these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication and cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as allergic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, and other traditional medical practitioners.

This book collates a wide spectrum of topics relevant to contemporary research achievement in sustainable utilization of plant genetic resources and conservation of plant genetic diversity within the framework of different crop systems. It introduces the status of crop genetic diversity and provides prospects for conservation of crop genetic diversity for sustainable agriculture. Plant genetic diversity is crucial for food security and agro-ecosystem maintenance paving ways to achieve sustainable agriculture development. This necessitates, consciously and judiciously, the conservation of all existing plant genetic resources for sustainable use in a variety of applications for human welfare. The wild and traditional landraces have generated an increased interest as a repertoire of valuable traits for breeding and improvement of cultivated germplasm. Internationally, concerted actions and policies toward for the conservation and management of plant genetic diversity are mounting, fromthe organization levels to national policies as deemed appropriate for the sustainable development goals. This needs an understanding of genetic diversity of different crops, ecological drivers and the structural changes within genetic diversity due to climate change. It is also equally important to evolve knowledge on what, how and where to conserve the existing plant genetic resources for present and future use. Assessment of the genetic diversity presents in a wild and traditional agro-ecosystem is another step towards effective utilization. In the past few years, advanced breeding tools have been developed which have offered great promise for efficient modification of targeted traits. This book consolidates current knowledge in the above core areas of plant genetic diversity and conservation. It is an essential reference for professionals, researchers, policy makers and commercial entrepreneurs concerned with plant genetic diversity and breeding to achieve enhanced agricultural productivity and sustainability of food resources to ensure food security. The book is also invaluable for graduate students involved in agriculture research.

This book describes the complex interplay between Earth's surface processes (erosion and sedimentation) and human interactions. Intensive as well as extensive research has been undertaken to infer modern sedimentation processes and to infer the mode of stratigraphic sequence building. However, the effort to understand the influence of sedimentation processes on society and the human impact on sedimentation is long overdue. This is a new upcoming multidisciplinary research field that is beyond the scope of leading traditional Earth and Environmental Science journals. To fill in the prodigious gap in the knowledge base, this book includes in-depth reviews and new data-based case studies from Asia, involving multidisciplinary research. It covers case studies of risk management of various hazards and risk management systems at regional, national, and local levels. The book proposes a comprehensive approach to reducing future risks by collaborating with various stakeholders and preparingfor the most effective responses towards complicated hazards, minimizing social damage. This publication will help researchers in the field of Environment and Earth surface processes, disaster risk reduction, and geoscientists to have a better idea of the current trend of research in the field and will provide updated synthesis on this important topic.

Reverse Vaccinology: Concept, Methods and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. Reverse vaccinology promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur's principles have failed, and it is explained in detail in this book.The book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, data bases, network analysis, machine learning, and NGS driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and member of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines.? Explains the fundamentals of reverse vaccinology and how it can save time in the development of new vaccines? Focuses on the efforts to develop a vaccine candidate against various pathogens using computational approaches? Presents databases and web servers for conducting reverse vaccinology? Describes the screening process of potential vaccine candidate through machine learning

This book focuses on the transformation of Bangladesh in respect to its people, geography, economy and environment. The authors discuss current problems such as vulnerability caused by environmental degradation in Bangladesh but also opportunities of this rapidly changing country. The book explains how the country is rapidly transforming from a rural subsistence agrarian based economic system to a new economic partner contributing to global processes. Bangladesh is presented as an example for the changes in the Global South, where a mismatch is often observed in linking resources and activities with environmental sustainability, possibly due to insufficient base-line knowledge. As faster growth is marginalizing resources to increase the GDP, the sustainability of resource exploitation is being questioned. The authors describe the vulnerable situation caused by possible sea-level rise, soil degradation, biodiversity loss, climate extremities, urbanization, and population displacement. This volume offers comprehensive knowledge about the geography and environment of Bangladesh and aims to help readers further investigate the issues and work on solutions. The book appeals to academics, professionals and students at all levels interested in Bangladesh as well as environmental problems and geographical issues in a rapidly transforming country.

In diesem Band berichten die Autoren aus führenden Labors, die sich mit Stammzelltheranostik beschäftigen, über die neuesten Fortschritte auf dem Gebiet der Stammzellforschung. Das Buch befasst sich mit vielen Aspekten der stammzellbasierten Therapie und den Fortschritten in der Stammzelltherapie bei Leber-, Augen- und Herz-Kreislauf-Erkrankungen sowie bei Krebs. Dieser Band ist eine Fortsetzung der von Prof. Khawaja Husnain Haider bereits herausgegebenen Bücher zur stammzellbasierten Therapienostik. Es ist ein ideales Buch für Forscher, die sich mit der Entwicklung von Arzneimitteln sowie mit regenerativer Medizin und stammzellbasierter Therapie beschäftigen. Die sekundäre Zielgruppe umfasst Medizinstudenten, Ärzte, Zellpharmakologen, die Arzneimittelindustrie und Forscher, die Stammzellen als Ex-vivo-Krankheitsmodelle für die Arzneimittelentwicklung verwenden.

This book comprises the proceedings of the 4th International Conference on Machine Intelligence and Signal Processing (MISP2022). The contents of this book focus on research advancements in machine intelligence, signal processing, and applications. The book covers the real-time challenges involved while processing big data analytics and stream processing with the integration of smart data computing services and interconnectivity. It also includes the progress in signal processing to process the normal and abnormal categories of real-world signals such as signals generated from IoT devices, smart systems, speech, and videos and involves biomedical signal processing: electrocardiogram (ECG), electroencephalogram (EEG), magnetoencephalography (MEG), electromyogram (EMG), etc. This book proves a valuable resource for those in academia and industry.

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more.Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment.Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests.Expert, internationally recognized chapter authors present guidelines representing different practices and points of view.Analytical criteria focus on the medical usefulness of laboratory procedures.Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world.Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase.NEW! 19 additional chapters highlight various specialties throughout laboratory medicine.NEW! Updated, peer-reviewed content provides the most current information possible.NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+.NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

COVID-19 in Alzheimer's Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer's disease, with special emphasis on age, gender, ethnic background, and lifestyle. Bringing this focus on neurodegenerative disease in one comprehensive resource, this volume is an essential reference for neuroscientists, clinicians, biomedical scientists, and all others working or interested in the field. Discusses Alzheimer's disease and dementia as morbidities for COVID-19 Describes SARS-CoV-2 structure, function, and biology Examines impact on elderly with chronic conditions including hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases Covers the effect of race, gender, and sex as additional risk factors

This book is a comprehensive collection of information about the features, functions, and services of aquatic macrophytes. As primary producers, aquatic macrophytes form the basis of food webs, play a major role in highly productive aquatic ecosystems, and have a significant impact on ecosystem functions and services. Macrophytes are also known to strongly influence the micro-climate and biogeochemical processes occurring in the littoral zones of marine ecosystems and the sediment dynamics of freshwater systems. They also serve as highly effective carbon sinks and play an important role in carbon sequestration. This book deals with various aspects of aquatic macrophytes, including nutrient recycling, biogeochemical processes, biomass production, wetland ecosystems, water resource management, carbon sequestration, environmental clean-up, and bioenergy production. Additionally, it presents the current status of aquatic macrophytes and discusses the impact of climate change on these plants. The book also highlights the major challenges associated with harnessing the benefits provided by aquatic macrophytes as ecosystem services. The book holds value and relevance for academicians and scientists working in the related domain. Additionally, it will serve as a valuable resource for students and researchers working in the field of ecology, biogeochemistry, wetland conservation, phytoremediation, elements biomonitoring, wastewater management, bioenergy production, etc.

This volume comprises the select peer-reviewed proceedings of the International Conference on Advances and Applications of Artificial Intelligence and Machine Learning 2022 (ICAAAIML 2022). It aims to provide a comprehensive and broad-spectrum picture of state-of-the-art research and development in the areas of artificial intelligence, machine learning, deep learning, and their advanced applications in computer vision and blockchain. It also covers research in core concepts of computers, intelligent system design and deployment, real-time systems, WSN, sensors and sensor nodes, software engineering, image processing, and cloud computing. This volume will provide a valuable resource for those in academia and industry.

This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors'group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings.

Metabolomics: A Path Towards Personalized Medicine integrates environmental factors of genomics, transcriptomics and proteomics, providing a bridge to resolve gaps between fundamental science and applications in clinical medicine and population health. The concept of personalized medicine or precision medicine is of great interest in biomedical research as it helps bring about new drug discovery and biomarker identification. In addition, it helps clinicians prescribe the right medicine to the right person with maximum efficacy and minimum toxicity, allowing clinicians to further predict the susceptibility to disease onset of vulnerable populations.The book is ideally suited for researchers and postgraduate students who are interested in clinical and non-clinical studies where metabolites are used for the identification of disease and therapeutic targets. - Gives insights on the importance of personalized medicine in clinical and research environments - Provides the principles of metabolomics - Presents applications of metabolomics in biomarker identification and drug discovery

This book describes the contributing aspects of contemporary developments related to sustainable agricultural resources and assessment of sustainable agriculture in developing nations. The issues like food crisis and declining agro-productivity, post-pandemic food security, zonation and mapping technique viewing food crisis, biotechnology and sustainable agricultural, scaling hunger indices, health hazard and food crisis, changing climate and food availability, consumer load and fertilizer usage, growing demand and increasing usage of harmful chemical in agro-fields are regarded as serious concerns. Thereafter, the scope of sustainable agricultural potentiality (SAP) modeling, amidst the arena of deforestation and encroachment of new cultivable land, impact of pandemic on sustainable agriculture, using wastewater as non-sustainable agricultural practice, applying geospatial techniques on extreme weather susceptibility and agro-production, soil erosion and poor agricultural production, questioning shifting cultivation on the issue of sustainability, meteorological drought and irrigational gaps, occupational mobility and loss of agricultural heritage, farm-excreta burning and air quality index (AQI), GI-Science and sustainable agro-management, community preparedness in food crisis management, multi-criteria hunger index (MCHI), climate change declining sustainable agro-production are worth some. Almost the entire world has recently suffered from several natural and human-induced problems, among which food crisis and unsustainable agriculture throw significant challenges to human society. Contrastingly, if modern technology and means, with advanced monitoring and calibration methodology and policy guidance, can help, it will undoubtedly reduce half of the world's problems and ensure the future survival of human society. In addition, this approach also can minimize the other partially linked problems, like climate change and food shortage, livelihood crisis, environmental refugees, international trade balance, global food supply chain interruption, the ever-expanding gap between rich and poor, and so on. Therefore, properly nurturing the knowledge on the application of GI-Science for an agriculturally sustainable society and their monitoring and management can curtail the gap between science, policy, and the ground-level scenario concerned.

This is an earnest, humble and hard-working attempt to bring the latest knowledge in the field of critical care medicine within arms reach of the practitioners of the craft in the field, at the bedside.

Diagnosis and Treatment of Fungal Infections, 3rd Edition contains the latest research and clinical evidence on fungal infections in humans. Updated again by globally recognized experts, this concise text is divided into sections dedicated to the patient approach, laboratory and radiological diagnosis, systemic antifungal agents, mycoses, and instructive cases. It is a concise but comprehensive resource for use in conjunction with patient care duties and in teaching. It is the perfect guide for hospital-based primary care physicians, oncologists, critical care specialists, and infectious disease fellows with limited training or experience in the identification and management of fungal infections.

This book comprises selected proceedings of the 5th International Conference on Water Resources 2021 (ICWR 2021) focusing on innovations and preparations to face the water-related challenges. Focus is given in the area of quantitative and qualitative water resource analyses comprising forecasting, modeling, and water governance. The contents are useful to researchers, educators, practitioners, and policymakers alike.

This book discusses fundamental aspects of super absorbent polymers (SAPs), insight into the synthesis and modification of SAPs as well as their potential applications in different domains.SAPs are bio-based material that has attracted much interest due to their unique structural properties, biodegradability, biocompatibility, etc. The book exhibits a unique combination of SAP designing, synthetic strategies, properties and chemistry along with SAP's application in the field of drug delivery, firefighting and biosensors, agriculture, etc. Various approaches to make these products a cost-effective and sustainable are discussed precisely in this book. Additionally, the approaches from the perspective of academic organization and research laboratories, many readers are able to learn the insights of the connection between super absorbent polymers in the agriculture field by reducing seedling mortality owing to their water storage capacity in soil. This book written byeminent researchers can be a useful reference for graduate, post-graduate students and researchers working in the file of super absorbent polymers, polymer technology, hygiene industry, etc.

This book comprehensively reviews the phytochemistry, functional properties, and health-promoting effects of bioactive compounds found in oil processing by-products, and it also explores the food and non-food applications of these by-products. Several oilseeds, vegetables, and fruits are cultivated for their oils and fats, wherein the oil extraction industry generates a huge amount of waste (meal or cake). The valorisation of this waste would be very beneficial not only from the economic and environmental perspectives, but also for the potential applications in food, cosmetics and pharmaceutical industries, in which phytochemicals derived from vegetable oil and oilseed processing by-products play an important role in, for instance, extending the shelf life of several products and providing added-value properties with their antioxidant and antimicrobial properties. In this work, expert contributors discuss about the added-value of biowaste from common and non-traditional vegetable oils and oilseeds processing, as well as fruit oils processing, and offer an extensive overview of the different bioactive compounds found in extracts from oil processing by-products and their chemical composition. The book also collects several examples in which oil processing by-products are integrated into industrial activities such as food production, livestock production and in pharmaceutical and cosmetics industries. Professionals and scholars alike interested in the recycling of agro-industrial wastes derived from vegetable oil and oilseed processing by-products will find this book a handy reference tool.

This book addresses current topics on pathogenic Vibrio spp. from a comprehensive and holistic perspective. Here, experts in the field provide timely chapters, ranging from genomics, pathogen emergence, and epidemiology to pathogenesis, virulence regulation and host colonization. Questions addressed include: How does climate change affect the spread of these bacteria? What is the status of current vaccines? Are there novel therapeutic options to treat Vibrio infections? Is there likelihood of emergence of new pathogenic strains or species? Can insights from mathematical models and epidemiology lead to prediction of pathogen outbreaks?Recent decades have seen a steady increase in Vibrio spp. infections originating in aquatic and marine habitats, driven by higher human population densities, warming of polluted oceans, natural and human-made disasters, and mass seafood production. These conditions increase the likelihood of pathogenic Vibrio spp. coming into contact with humans, making their study even more timely and relevant as these problems escalate over time. This book is a valuable resource for health management professionals, experienced microbiologists/ microbial ecologists, and early career scientists alike who want to learn more about these important environmental human pathogens. The ideas and technologies presented in this book for preventing, controlling, and monitoring Vibrio spp. infections contribute to the UN Sustainable Development Goal 3: Good Health and Well-Being.

Discover the positive and helpful contributions made by microorganisms to various areas of human health, food preservation and production, biotechnology, industry, environmental clean up and sustainable agriculture. In Good Microbes in Medicine, Food Production, Biotechnology, Bioremediation and Agriculture, a team of distinguished researchers delivers a comprehensive and eye-opening look at the positive side of bacteria and other microbes. The book explores the important and positive roles played by microorganisms. Divided into five sections, Good Microbes examines the use of microorganisms and the microbiome in human health, food production, industrial use, bioremediation, and sustainable agriculture. Coverage spans from food allergies, skin disorders, microbial food preservation and fermentation of various beverages and food products, also from an ethnical point of view to beneficial use of microbes in biotechnology, industry, bioeconomy, environmental remediation such as resource recovery, microbial-based environmental clean-up, plant-microbe interactions in biorestauration, biological control of plant diseases, and biological nitrogen fixation. Provides basic knowledge on bacterial biology, biochemistry, genetics and genomics of beneficial microbes Includes practical discussions of microbial biotechnology, including the contribution of microbial biotechnology to sustainable development goals Features a comprehensive introduction and extensive index to facilitate the search for key terms. Perfect for scientists, researchers and anyone with an interest in beneficial microbes, Good Microbes in Medicine, Food Production, Biotechnology, Bioremediation and Agriculture is also an indispensable resource for microbiology graduate students, applied microbiologists and policy makers.

COVID-19 has brought us extensive research databases in the fields of biophysics, biology, and bioinformatics. To extract valuable structural bioinformatic information of SARS-CoV-2 structural and nonstructural proteins, it is necessary to work with large-scale datasets of molecular dynamics (MD) trajectories that need to be optimized. This monograph serves as a comprehensive guide to optimization-based MD studies of the molecular structures of SARS-CoV-2 proteins and RNA. The book begins by performing local optimization, taking into account the three-body movement and optimizing the noncovalent bonds of each molecular structure. The optimized structures reach a transition state that offers the best stability and lowest energy. The optimization process utilizes a hybrid strategy that combines mathematical optimization with various local search algorithms. This approach significantly reduces data volume while eliminating irrelevant bioinformatics data. To gain a thoroughunderstanding of molecular stability and the mechanism of action, it is essential to consider not only static NMR, X-ray, or cryo-EM structures but also dynamic information obtained through MD or Quantum Mechanics/Molecular Mechanics (QM/MM) simulations. These simulations capture the internal motions and dynamic processes of molecules. Furthermore, for each protein, the structural bioinformatics obtained from the optimized structure is validated by analyzing large-scale MD trajectory databases, which are openly and freely available online. The analysis includes key structural bioinformatics aspects such as salt bridge electrostatic interactions, hydrogen bonds, van der Waals interactions, and hydrophobic interactions specific to each SARS-CoV-2 molecular structure. The book also delves into discussions on drugs, vaccines, and the origins of the virus. Additionally, pandemic mathematical models, including those incorporating time delays, are explored. This book is particularly valuable for professionals working in practical computing roles within computational biochemistry, computational biophysics, optimization and molecular dynamics, structural bioinformatics, biological mathematics, and related fields. It serves as an accessible introduction to these disciplines and is also an excellent teaching resource for students.

This book presents high-quality peer-reviewed articles from the 2nd International Conference on Biomass Utilization and Sustainable Energy 2022 (ICoBiomasSE 2022) organized by the Centre of Excellence for Biomass Utilization (COEBU), Universiti Malaysia Perlis (UniMAP), Malaysia. The theme of the conference “Emerging Technology for Future Sustainability” is chosen in view of the current revolution and rapid developments in the field of biomass innovation towards sustainable development. The contents are broadly divided into five parts: (1) sustainable biomass resources for decarbonizing the economy, (2) biomass conversion technologies for bioenergy and biofuels, (3) biomass conversion to intermediates and products, (4) bioeconomy sustainability, impacts and policies and (5) bioenergy integration. It provides a platform for students, professionals, researchers, academicians, policymakers and industries working in the areas of biomass utilization and sustainable energy to solve long-standing environmental issues for a healthier planet.​

This book provides comprehensive knowledge and recent advancements in biotic stress tolerance in crop plants. Despite this, it also focuses on the relevance of these advancements in securing food for the future. Rapid population outburst along with the significant reduction in agricultural fields across the globe embarks a serious threat to meet the need for the foods for the future. Yield loss due to biotic ingression makes the situation more complicated. Rapid climate change also has altered pathogenesis in many common crop plants. In this regard, a systematic and comprehensive approach is urgently necessary for sustainable agricultural developments. The biotic stress tolerance in crop plants is distinct from that of model plants hence, demands more priority. Host-microbe interaction is a very interesting branch of research in plant science. Although many host-microbe systems had extensively been studied, the systematic assemblage of the same with crop plants is largely obscured. Additionally, the implication of all these techniques in employing food security of the mass is again scarce. Given the above, the present book tries to fill the gap of knowledge to facilitate the “lab-to-land transition” of the same. The chapters are designed to cover all the aspects related to crop plant biotic stress tolerance mechanism in the light of modern biotechnology and the implication of the same in food security. The in-depth information provided in different chapters not only improves knowledge in biotic stress in crop plants but endow future research in this field also.

This book features research papers presented at the 6th International Conference on Intelligent Sustainable Systems (ICISS 2023), held at SCAD College of Engineering and Technology, Tirunelveli, Tamil Nadu, India, during February 2–3, 2023. The book reports research results on the development and implementation of novel systems, technologies, and applications that focus on the advancement of sustainable living. The chapters included in this book discuss a spectrum of related research issues such as applications of intelligent computing practices that can have ecological and societal impacts. Moreover, this book emphasizes on the state-of-the-art networked and intelligent technologies that are influencing a promising development in the direction of a long-term sustainable future. The book is beneficial for readers from both academia and industry.

This global encyclopedic work serves as a comprehensive collection of global scholarship regarding the vast fields of public administration, public policy, governance, and management. Written and edited by leading international scholars and practitioners, this exhaustive resource covers all areas of the above fields and their numerous subfields of study. In keeping with the multidisciplinary spirit of these fields and subfields, the entries make use of various theoretical, empirical, analytical, practical, and methodological bases of knowledge.Expanded and updated, the second edition includes over a thousand of new entries representing the most current research in public administration, public policy, governance, nonprofit and nongovernmental organizations, and management covering such important sub-areas as: 1. organization theory, behavior, change and development; 2. administrative theory and practice; 3. Bureaucracy; 4. public budgeting and financial management; 5. public economy and public management 6. public personnel administration and labor-management relations; 7. crisis and emergency management; 8. institutional theory and public administration; 9. law and regulations; 10. ethics and accountability; 11. public governance and private governance; 12. Nonprofit management and nongovernmental organizations; 13. Social, health, and environmental policy areas; 14. pandemic and crisis management; 15. administrative and governance reforms; 16. comparative public administration and governance; 17. globalization and international issues; 18. performance management; 19. geographical areas of the world with country-focused entries like Japan, China, Latin America, Europe, Asia, Africa, the Middle East, Russia and Eastern Europe, North America; and 20. a lot more.Relevant to professionals, experts, scholars, general readers, researchers, policy makers and manger, and students worldwide, this work will serve as the most viable global reference source for those looking for an introduction and advance knowledge to the field.

This book focuses on the nature and properties of soils of Hindu Kush-Himalayas and their management for agricultural land use. It discusses all aspects of climatic variations and potential of resources in the Himalayan region including examples from Afghanistan, Bangladesh, Bhutan, China (Tibet), India, Myanmar, Nepal and Pakistan. Chapters cover the geology of the parent material of native soils, soils microbes, flora and fauna. Soil classification has been given in detail to better understand the nature of soils for judicious management strategies. The authors present land use practices and suggestions for changes in land use to benefit from the full potential of the soils in this region. Their ultimate aim is to find ways of feeding the ever-increasing population and raising the standard of life for the people living in the Himalayan mountain region.

This book presents selected papers from the 2022 7th Asia Conference on Environment and Sustainable Development, which was held in Kyoto, Japan, November 4–6, 2022. The event was co-sponsored by the International Network for Environmental and Humanitarian Cooperation, and technically supported by Yokohama National University and the National Institute for Environmental Studies, Japan. The book focuses on environmental restoration and ecological engineering, global environmental change and ecosystems management, environmental dynamics, wastewater and sludge treatment, air pollution and control, and environmental sustainability. The volume is a valuable resource for those in both academia and industry.

Under ongoing climate change, natural and cultivated habitats of major food crops are being continuously disturbed. Such condition accelerates to impose stress effects like abiotic and biotic stressors. Drought, salinity, flood, cold, heat, heavy metals, metalloids, oxidants, irradiation etc. are important abiotic stresses; and diseases and infections caused by plant pathogens viz. fungal agents, bacteria and viruses are major biotic stresses. As a result, these harsh environments affect crop productivity and its biology in multiple complex paradigms. As stresses become the limiting factors for agricultural productivity and exert detrimental role on growth and yield of the crops, scientists and researchers are challenged to maintain global food security for a rising world population.This two-volume work highlights the fast-moving agricultural research on crop improvement through the stress mitigation strategies, with specific focuses on crop biology and their response to climatic instabilities. Together with'Climate Resilient Agriculture, Vol 1: Crop Responses and Agroecological Perspectives', it covers a wide range of topics under environmental challenges, agronomy and agriculture processes, and biotechnological approaches, uniquely suitable for scientists, researchers and students working in the fields of agriculture, plant science, environmental biology and biotechnology.