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For nearly 30 years, Dr. Meir Kryger's must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women's health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders. Online access to additional resources, including 95 video clips and over 950 self-assessment questions.

Pulp and Paper Industry: Chemical Recovery examines the scientific and technical advances that have been made in chemical recovery, including the very latest developments. It looks at general aspects of the chemical recovery process and its significance, black liquor evaporation, black liquor combustion, white liquor preparation, and lime reburning. The book also describes the technologies for chemical recovery of nonwood black liquor, as well as direct alkali regeneration systems in small pulp mills. In addition, it includes a discussion of alternative chemical recovery processes, i.e. alternative causticization and gasification processes, and the progress being made in the recovery of filler, coating color, and pigments. Furthermore, it discusses the utilization of new value streams (fuels and chemicals) from residuals and spent pulping liquor, including related environmental challenges. - Offers thorough and in-depth coverage of scientific and technical advances in chemical recovery in pulp making - Discusses alternative chemical recovery processes, i.e., alternative causticization and gasification processes - Covers the progress being made in the recovery of filler, coating color, and pigments - Examines utilization of new value streams (fuels and chemicals) from residuals and spent pulping liquor - Discusses environmental challenges (air emissions, mill closure) - Presents ways in which the economics, energy efficiency, and environmental protection associated with the recovery process can be improved

A case-based guide with expert commentary Challenging Concepts in Respiratory Medicine, deals with contemporary clinical scenarios in respiratory medicine. Each chapter is based around a real-life case, and interspersed with the most up-to-date evidence, management strategies, guidelines and controversies in management. As the reader works through each case there are a number of'Clinical Tips','Learning Points'and'Landmark Trial Summaries'to enhance the learning process along with an'Expert Commentary'written by a nationally or internationally-renowned expert in that particular field. This will provide a unique inside track on how the experts approach these types of challenging cases. The approach taken in this series is highly attractive to those in training preparing for their specialist exams.

Abnormal Psychology in a Changing World makes complex abnormal psychology concepts accessible and stimulating. Authors Jeffrey Nevid, Spencer Rathus and Beverly Greene present illustrative case examples drawn from their own clinical and teaching experiences, leading you to recognize the human dimension of the study of abnormal psychology. Updated to reflect the latest advancements in the field, the 10th Edition highlights the ways in which personal technology is changing the study of abnormal psychology via the new Abnormal Psychology in the Digital Age feature.

Das umfangreiche Nachschlagewerk von Möller, Laux und Kapfhammer darf zu Recht als Standardwerk für Psychiatrie im deutschsprachigen Raum bezeichnet werden. Die aktuelle Auflage wurde komplett überarbeitet und aktualisiert, zahlreiche Autoren tragen mit ihrem Expertenwissen dazu bei, dass sowohl Ärzte in Weiterbildung als auch Fachärzte für Psychiatrie und Psychotherapie auf alle Fragen umfassende Antworten erhalten. Insgesamt vier Bände enthalten alle Grundlagen der Psychiatrie, Prinzipien der Diagnostik und Behandlung und selbstverständlich einen umfangreichen Teil zu den einzelnen Störungen.Von der Geschichte über Klassifikation, Diagnostik und Therapie aller Krankheitsbilder bis hin zu speziellen Aspekten der Psychiatrie finden Sie hier das gesamte Wissen auf aktuellem Stand.

The Wiley Handbook of Developmental Psychopathology offers a concise, up-to-date, and international overview of the study of developmental psychopathology. Examines the cognitive, neurobiological, genetic, and environmental influences on normal and abnormal development across the lifespan Incorporates methodology, theory, and the latest empirical research in a discussion of modern techniques for studying developmental psychopathology Considers the legal, societal, and policy impacts of changes to diagnostic categories in the light of the transition to DSM-5 Moves beyond a disorder-based discussion to address issues that cut across diagnostic categories

The novelty of this book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, psychological profile, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and on psychological resilience the authors hope that this book can lead to the development of better treatment strategies for functional recovery from brain damage.

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. - Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry - Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets - Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

In this thought-provoking text, a collection of respected authors with a wealth of academic and practice experience come together to challenge some of the prevailing ideas serving as the foundation for the current child and adolescent mental health services (CAMHS) structure.Providing a fresh new perspective on critical issues and seeking to stimulate reflection and debate; from managers and commissioners to newly qualified practitioners and students, this book will both challenge and energise readers, spurring them on to reconsider some of the pressing CAMH issues of our time.

Medical Neurobiology, Second Edition continues the work of Dr. Peggy Mason as one of the few single author textbooks available. Written in an engaging style for the vast majority of medical students who will choose to specialize in internal medicine, orthopedics, oncology, cardiology, emergency medicine, and the like, as well as the student interested in neurology, psychiatry, or ophthalmology, this textbook provides a sturdy scaffold upon which a more detailed specialized knowledge can be built. Unlike other neuroscience textbooks, this new edition continues to focus exclusively on the human, covering everything from neuroanatomy to perception, motor control, homeostasis, and pathophysiology. Dr. Mason uniquely explains how disease and illness affect one's neurobiological functions and how they manifest in a person. Thoroughly updated as a result of student feedback, the topics are strictly honed and logically organized to meet the needs of the time-pressed student studying on-the-go. This textbook allows the reader to effortlessly absorb fundamental information critical to the practice of medicine through the use of memorable stories, metaphors, and clinical cases. Students will gain the tools and confidence to make novel connections between the nervous system and human disease. This is the perfect reference for any medical student, biology student, as well as any clinician looking to expand their knowledge of the human nervous system. New To the Second Edition of Medical Neurobiology: · New sections on cerebral palsy, brain cancer, traumatic brain injury, neurodegenerative diseases, aphasia, and Kallmann syndrome; · Incorporates easy to understand visual guides to brain development, eye movements, pupillary light reflex, pathways involved in Horner's syndrome; · Presents real-life dilemmas faced by clinicians are discussed from both the medical point of view and the patient's perspective; and · Additional reading lists are provided at the end of each chapter that include first-hand accounts of neurological cases and scientific discoveries (e.g. HM). Key Features Include: · Written in an accessible and narrative tone; · Uses metaphors and clinical examples to help the reader absorb the fundamentals of neurobiology; and · Highly illustrated with over 300 figures and tables for full comprehension of topics covered.

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

The search for medicinal agents to improve emotional, behavioral, and psychiatric conditions of Homo sapiens has occurred for ages. The 20th century witnessed the development of psychopharmacologic agents, including stimulants in the 1930s (and 1950s), chlorpromazine in the 1950s, lithium, tricyclic antidepressants, benzodiazepines, SSRIs (1990s), and others. The proper use of these agents in the pediatric population continues to be an active study. Atypical antipsychotics have been approved by the FDA for children and adolescents though their safety and efficacy in the pediatric population but must be assiduously ascertained with ongoing research in the eternal iatric maxim of primum non nocere. The science of evidence-based pharmacotherapy for mental health disorders in children and adolescents is finally emerging. Exciting discoveries await the researchers of this still early 21st century lead by the crucial collaborative efforts of academicians, pharmaceutical scientists, and medical government authorities. Controversies regarding the use of various psychopharmacologic agents for the pediatric population continue in the 21st century, requiring further research and insightful judgment for its applications in this vulnerable population. Excessive and unnecessary psychopharmacologic agents should be avoided in the pediatric population with behavioral/emotional/psychiatric conditions/disorders. In this second edition, the authors present updated information about psychopharmacology in childhood and adolescence.

The Routledge Handbook of Metaphor and Language provides a comprehensive overview of state-of-the-art interdisciplinary research on metaphor and language. Featuring 35 chapters written by leading scholars from around the world, the volume takes a broad view of the field of metaphor and language, and brings together diverse and distinct theoretical and applied perspectives to cover six key areas: Theoretical approaches to metaphor and language, covering Conceptual Metaphor Theory, Relevance Theory, Blending Theory and Dynamical Systems Theory; Methodological approaches to metaphor and language, discussing ways of identifying metaphors in verbal texts, images and gestures, as well as the use of corpus linguistics; Formal variation in patterns of metaphor use across text types, historical periods and languages; Functional variation of metaphor, in contexts including educational, commercial, scientific and political discourse, as well as online trolling; The applications of metaphor for problem solving, in business, education, healthcare and conflict situations; Language, metaphor, and cognitive development, examining the processing and comprehension of metaphors. The Routledge Handbook of Language and Metaphor is a must-have survey of this key field, and is essential reading for those interested in language and metaphor.

Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource. - Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkers - Provides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposal - Provides an interdisciplinary approach that can be applied in everyday clinic and research efforts - Features chapters edited by leaders in the field around the globe—the broadest expert coverage available

Introduction to Neurogenic Communication Disorders, Second Edition introduces students to common adult communication disorders and associated neuroanatomy and neurophysiology.This accessible text provides foundational knowledge along with real examples and online videos. These illustrative patient profiles provide actual case examples of symptoms, deficits, and pathological behaviors. This textbook and video combination offers just what students need to thoroughly understand neurogenic communication disorders, as well as provide the student with a window into real-world practice. Video content is a key element of this valuable resource. Illustrative footage is included with every new print copy of Introduction to Neurogenic Communication Disorders, Second Edition or can be purchased separately.

An authoritative guide to understanding and treating depression in the medically ill Depression in Medical Illness is based on the fact that depression and medical illness are inextricably bound together and must be viewed through a single lens in order to truly understand, diagnose, and treat them. Throughout the book, the authors emphasize not simply a critical distillation and balanced summary of the available empirical data, but equally important, an active synthesis, formulation, and analysis of that evidence.This informs a contemporary biomedical understanding, as well as diagnostic and therapeutic approaches. All of the chapters are authored by members of the Department of Psychiatry at the world-renowned Brigham and Women's Hospital. In chapters devoted to specific medical disorders, psychiatrists with particular expertise in those areas have been joined by other eminent Brigham medical and surgical specialists or subspecialists. This makes these chapters valuable not just to psychiatrists and other mental health professionals, but to a wide range of medical specialists as well. Logically Organized Into Five Sections: Core Concepts – provides a conceptual and intellectual framework for understanding depressive illness in the context of medical illness Assessment and Treatment of Depression in Medically Ill Patients – discusses the general principles of depression diagnosis and treatment Depression in Medical Illness – Assesses what we know about depression when it is comorbid with the full range of major medical disorders Special Populations and Settings – Is devoted to special patient populations and the importance of the settings in which care is delivered New Directions – A fascinating glimpse into the future of the care of medically ill patients who are depressed

This handbook synthesizes and integrates the science of internalizing and externalizing childhood disorders with the diagnostic structure of the Diagnostic and Statistical Manual – 5th Edition (DSM-5) of the American Psychiatric Association. It offers a comprehensive overview of DSM-5 disorders in childhood, covering etiology, symptom presentation, assessment methods, diagnostic criteria, and psychotherapeutic and pharmacological approaches to treatment, prognosis, and outcomes. Clinical vignettes and empirical insights illustrate key concepts and diagnostic and treatment issues such as developmental, cultural, gender, and other considerations that may influence diagnosis and case formulation. In addition, chapters on psychosocial therapies offer robust guidelines for working with children and adolescents with DSM-5 disorders. The Handbook also addresses the shift from categorical to dimensional, diagnostic, and treatment systems, particularly focusing on the current shiftin funded research in childhood disorders. Topics featured in this Handbook include:Intellectual disabilities and global developmental delay.Depressive disorders in youth.Posttraumatic and acute stress disorders in childhood and adolescence.Autism spectrum and social pragmatic language disorders.Alcohol-related disorders and other substance abuse disorders.Parent-child and sibling relationships. Cognitive-behavioral interventions and their role in improving social skills.The Handbook of DSM-5 Disorders in Children and Adolescents is a must-have resource for researchers, professors, and graduate students as well as clinicians, professionals, and scientist-practitioners in clinical child and school psychology, pediatrics, social work, and educational psychology.

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Non-motor Parkinson's: The Hidden Face-Management and the Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson's disease, a key unmet need. Specific chapters in this updated release include Therapeutics and NMS in PD, Non-motor effects of conventional and transdermal therapies in PD, Infusion therapy, CDD and NMS in PD, DBS and NMS in PD, TMS and implications for NMS in PD, Botulinum toxin therapy and NMS in PD, and Nutrition and NMS in PD, amongst others. Including practical tips for non-specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective. - Presents a comprehensive textbook on the non motor aspects of Parkinson's disease - Includes practical tips and clinical algorithms, and is the only textbook to bring a holistic approach - Contains contributions from over 40 global opinion leaders in the field of movement disorders - Provides special chapters on exercise, personalized medicine, osteoporosis, genetics, treatment aspects and nutrition

This is the first volume to present individual chapters on the full range of developmental and acquired pragmatic disorders in children and adults. In chapters that are accessible to students and researchers as well as clinicians, this volume introduces the reader to the different types of pragmatic disorders found in clinical populations as diverse as autism spectrum disorder, traumatic brain injury and right hemisphere language disorder. The volume also moves beyond these well-established populations to include conditions such as congenital visual impairment and non-Alzheimer dementias, in which there are also pragmatic impairments. Through the use of conversational and linguistic data, the reader can see how pragmatic disorders impact on the communication skills of the clients who have them. The assessment and treatment of pragmatic disorders are examined, and chapters also address recent developments in the neuroanatomical and cognitive bases of these disorders.

This book comprises succinct, accessible clinical cases in neuropsychiatry. Each clinical case has a specific and practical learning point, concerned with assessment, diagnosis, treatment or general approach. Each case models clinical reasoning and shows how the'puzzle'in the case changed the future practice of the author. Neuropsychiatry Case Studies is divided into sections relating to specific areas of neuropsychiatry, including dementias, movement disorders, autoimmune encephalopathies and epilepsy, amongst others. This book is aimed at trainee doctors in neurology and psychiatry and will also be of interest to fully trained doctors, nurses, psychologists and other allied health professionals working in this area.​

La presente obra está dedicada al tema del sueño desde tres áreas del conocimiento: la biológica, la psicológica y la social. El estilo de los textos es formal y académicamente riguroso, pero los modelos, teorías y resultados científicos se presentan de manera clara y accesible. De este modo, los elementos y términos técnicos se explican con detalle en el cuerpo del texto o en pies de página y figuras. La naturaleza de los sueños abre el telón con los estudios introductorios de José Luis Díaz Gómez y Enrique Soto Eguibar, para dar lugar a los ensayos del área biológica. En esta primera parte, el libro cuenta con textos de María Corsi-Cabrera, Lourdes Cubero Rego, Fructuoso Ayala-Guerrero, Rodolfo Cebreros Paniagua, Anabel Jiménez-Anguiano, Óscar Prospero García y Markus F. Müller, entre otros. Posteriormente, en la segunda parte, aparecen los estudios de Alejandra Rosales- Lagarde, Rafael J. Salín-Pascual y Gabriela Aguilar Dávila. Y por último, en el área social, la cual también incluye textos sobre los sueños en el arte y las humanidades, se presentan los ensayos de Mercedes de la Garza Camino, Fernando Chico Ponce de León, Jean-Philippe Jazé, Jorge Comensal, Miguel Ángel Sebastián, Juan Carlos González González y Ernesto Sosa.

Did you know that Facebook use can affect grades, and that only about 1% of students in a research study could correctly draw the Apple logo? Written in an engaging style that speaks directly to readers with examples of psychological concepts drawn from daily life, this brief introductory text makes the study of psychology interesting while providing solid grounding in the subject's knowledge base to help you succeed in the course. With built-in learning aids, ESSENTIALS OF PSYCHOLOGY: CONCEPTS AND APPLICATIONS, 5th Edition features an effective learning system that helps you absorb and remember important information. In MindTap, the text's online learning experience, you'll fine author podcasts and videos that you can access from your smart phone, direct links to TEDTalks, interactive learning activities, cool apps, and more.

This book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind. It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair. The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.

The new, third edition of the Clinical Manual of Child and Adolescent Psychopharmacology has been thoroughly revised, yet its mission remains the same: to keep clinicians up-to-date on the latest research so that they can provide state-of-the-art care to their young patients. To this end, the book describes and explores those elements that are specific to pediatric psychopharmacology; this defines and positions the volume at the nexus of child and adolescent psychiatry, pediatrics, and pharmacology. A stellar roster of contributors addresses new treatments for youths with disruptive behavior disorders, mood disorders, anxiety disorders, pervasive developmental disorders, and psychotic illnesses and tackles some of the most important emerging issues in the field. For example, advances in understanding the long-term treatment effects of medications in pediatric populations are thoroughly reviewed, including not only maintenance studies that consider the durability of efficacy but also clinical trials of greater duration designed to specifically evaluate long-term safety. In addition, recent studies of combination therapies are examined, helping clinicians better understand how to treat the complicated patients that arrive every day at a prescribing clinician's office. Finally, because research designs now include a broader base of patient populations to make the data more applicable to everyday clinical practice, the book focuses on head-to-head studies with multiple active comparators.The book offers clinicians comprehensive, accessible information and boasts a multitude of helpful features: • The book is organized by diagnosis instead of agent class. This makes it a true clinical desktop reference that allows clinicians to quickly and efficiently search treatment options and the evidence base on a case-by-case basis. DSM-5 criteria and information on comorbidities are also included.• The American Academy of Child and Adolescent Psychiatry Practice Parameters are integrated into the discussion, where applicable, in support of standard of care.• The book has been updated to include the latest research at the time of publication.• A new chapter has been added to address eating disorders, an area where psychopharmacological research that may apply to children and adolescents is now being pursued.• Useful features to help the reader understand and retain the material include clinical summary points, easy to read tables, and current and carefully vetted references. The Clinical Manual of Child and Adolescent Psychopharmacology, Third Edition, is an indispensable guide to the substantive research that has been done in nearly every area of pediatric psychopharmacology, as well as the major improvements that have been made to the evidence-based practice of treating youths with psychiatric illness.

How does mental health impact public health?In 2001, the WHO recognized depressive disorders as the leading cause of disability worldwide. But most Americans who meet diagnostic criteria for major depression are untreated or undertreated. Luckily, recent advances have finally made it possible for the field of public health to address mental health in the population. Public Health Perspectives on Depressive Disorders fills a gap by identifying the tools and strategies of public health practice and by exploring their application to twenty-first-century public mental health policy and practice.By looking at depressive disorders through a public health lens, this book highlights the centrality of mental health to public health. Linking the available research on depressive illness at the population level with public mental health policy and practice, expert contributors set a research agenda that will help make mental health a central part of public health science and practice. This book is an invaluable resource for researchers and practitioners to develop, facilitate, and conduct pilot and feasibility studies of promising preventive and treatment interventions that might mitigate the progression toward major depression and other mental disorders among populations at risk.The first part of the book underscores the public health significance of depressive illness by focusing on the evidence provided by recent approaches to nosology, epidemiology, illness burden, and impact on overall health. The second part looks at the social and environmental influences on depressive disorders that are critical to future efforts to prevent illness and to promote mentally healthy communities. The third and longest part addresses the vulnerability of diverse groups to depressive illness and underscore best practices to mitigate risk while improving both the preventive and therapeutic armamentaria.

This book is an introduction to the uncertainties and incongruities about madness. It is aimed at all of those who are curious about this subject whether out of general inquisitiveness or because it is part of a formal course of study.Using case studies of real people in order to explain, humanise, and bring to life the subject, Peter Morrall critically analyses how madness has been and is understood, or perhaps misunderstood. By contrasting past and present people who have been perceived as mad and/or perceive themselves as mad, Morrall presents core ideas about madness and critiques their would-be robustness in explaining the specific madness of the person in question, as well as their general relevance to madness overall.Unlike many of its contemporaries, the book does not adhere to a perspective,but rather remains skeptical about the ideas of all who profess to understandmadness, whether these emanate from sociology, psychology, psychotherapy,anthropology, ‘anti'psychiatry, or the biological sciences of contemporary‘scientific-psychiatry'. This book will inform and stimulate the thinking of the reader, and challenge those with preconceived ideas about madness.

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Presenting everything parents and professionals need to know about tic disorders, this essential guide provides up-to-date information on the condition, diagnosis, its management, and how to support a child with a tic disorder. Written in clear, accessible language, it also covers common co-occurring conditions and difficulties.

A step-by-step resource for treating more than 40 prevalent issues with proven strategies This comprehensive handbook for evidence-based mental health and learning interventions with children and adolescents is distinguished by its explicit yet concise guidance on implementation in practice. With a compendium of proven strategies for resolving more than 40 of the most pressing and prevalent issues facing young people, the book provides immediate guidance and uniform step-by-step instructions for resolving issues ranging from psychopathological disorders to academic problems. Busy academics, practitioners, and trainees in schools and outpatient clinical settings will find this resource to be an invaluable desktop reference for facilitating well-informed decision-making. Unlike other volumes that ignore or merely reference the evidence base of various interventions, this book focuses on providing immediate, empirically supported guidance for putting these strategies into direct practice. Issues covered include crisis interventions and response, social and emotional issues, academic/learning issues, psychopathological disorders, neuropsychological disorders, and the behavioral management of childhood health issues. Each chapter follows a consistent format including a brief description of the problem and associated characteristics, etiology and contributing factors, and three evidence-based, step-by-step sets of instructions for implementation. Additionally, each chapter provides several websites offering further information about the topic. Featuring contributions from leading scholars and practitioners on each issue covered, this book will be a valuable resource for child clinical and school psychologists, counselors, social workers, and therapists as well as other health and mental health professionals whose primary practice is with children and adolescents. Key Features: Demonstrates step-by-step, evidence-based interventions for more than 40 common childhood issues Provides treatment procedures that can be immediately put into practice Covers a wide range of mental health and academic/learning issues for children and adolescents Relevance for both school-based and clinically-based practice Includes contributions by noted experts in the field

The leading reference in the field of geriatric care, Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 8th Edition, provides a contemporary, global perspective on topics of importance to today's gerontologists, internal medicine physicians, and family doctors. An increased focus on frailty, along with coverage of key issues in gerontology, disease-specific geriatrics, and complex syndromes specific to the elderly, makes this 8th Edition the reference you'll turn to in order to meet the unique challenges posed by this growing patient population. - Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy. - More than 250 figures, including algorithms, photographs, and tables, complement the text and help you find what you need on a given condition. - Clinical relevance of the latest scientific findings helps you easily apply the material to everyday practice. - A new chapter on frailty, plus an emphasis on frailty throughout the book, addresses the complex medical and social issues that affect care, and the specific knowledge and skills essential for meeting your patients'complex needs. - New content brings you up to date with information on gerontechnology, emergency and pre-hospital care, HIV and aging, intensive treatment of older adults, telemedicine, the built environment, and transcultural geriatrics. - New editor Professor John Young brings a fresh perspective and unique expertise to this edition.

The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. - Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain - Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases - Includes well-written overviews of the basics of endocannabinoid system structure and function - Contains well-illustrated material, with diagrams, charts, and tables - Explores compelling case studies and their application to chapters written by experts

Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition. These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson's disease, Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction. - Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction - Written by international authors who are preeminent researchers in the field - Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases

Creatine (á-N-methylguanidino acetic acid) is a naturally occurring nitrogenous organic acid synthesized in the kidneys, liver, pancreas and brain (in less quantity), or obtained from a regular diet or as ergogenic nutritional supplement. Creatine is a popular and widely used form of protein supplementation due to its efficacy in improving performance in healthy athletic populations via increased muscle mass and enhanced adenosine triphosphate (ATP) energy regeneration. Chapter One reviews the available findings at animal and cellular studies as well as clinical trials investigating the neuroprotective effect of creatine and the possible mechanisms underlying its effect, which may represent important advances in the management of central nervous system diseases. Chapter Two considers the potential efficacy of creatine as an anabolic and ergonomic therapy for RA patients. In Chapter Three, a low-dimensional antimony-doped tin oxide aggregated nanoparticles (ATO NPs) were synthesized using hydrothermal method in alkaline phase. In Chapter Four, data obtained from –omics technologies and dynamical modeling are executed and analyzed, given the exponential growth of these methodologies in biological scientific research. The relevance of both creatine kinase system and creatine metabolism itself, as part of the molecular system bioenergetics in several components of cell (i.e., cytoskeleton, mitochondria, nucleus, endoplasmic reticulum, etc.), deserve to be examined from a systemic view that covers ascending and descending causality.

The field of psychiatry is evolving rapidly specifically in the areas of classification of many psychiatric disorders, psychopharmacology and psychotherapeutics. The new Diagnostic and Statistical Manual of Mental Disorders: DSM-5 which was introduced in 2013 forms the basis of the new classification system in psychiatry. The American Board of Psychiatry and Neurology is also in the process of phasing in DSM-5 criteria to the board examination, such that by 2017 the examination material will exclusively reflect the new manual. As psychiatric trainees and psychiatrists prepare for their certification and recertification examinations using the new classification system, a new board review textbook is imperative to address these changes in order to prepare them for the certification examinations as well as for their clinical practice. To help with this process we have compiled a list of 1000 questions and answers in psychiatry and neurology using the most current information available in the field and using the DSM 5 classification system. This book has been specifically written for the busy professional who does not have the time to access numerous resources necessary to prepare for professional examinations.

An authoritative and comprehensive volume of knowledge and green technologies wholly focused on the future of the bioeconomy. The authors present data, show opportunities, discuss R&D findings, analyze strategies, assess the wider economic impact, showcase achievements, criticize policies and propose solutions for the green revolution in biofuels, biochemicals and biomaterials'production and power generation.A fascinating range of case studies from the US, China and many European countries are used to inform readers about the impact of this field on society and how various technologies are currently being implemented. Additionally, the role of industry on this green industrial revolution is outlined with contributions from several major companies such as DuPont (US), UPM-Kymmene Oy (Finland), Anhui BBCA Biochemical Co (China).

A review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic use.The cannabis plant has been used for recreational and medicinal purposes for more than 4,000 years, but the scientific investigation into its effects has only recently yielded useful results. In this book, Linda Parker offers a review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic uses.Parker describes the discovery of tetrahydocannbinol (THC), the main psychoactive component of cannabis, and the further discovery of cannabinoid receptors in the brain. She explains that the brain produces chemicals similar to THC, which act on the same receptors as THC, and shows that the endocannabinoid system is involved in all aspects of brain functioning. Parker reports that cannabis contains not only the psychoactive compound THC, but also other compounds of potential therapeutic benefit, and that one of them, cannabidiol (CBD), shows promise for the treatment of pain, anxiety, and epilepsy. Parker reviews the evidence on cannabinoids and anxiety, depression, mood, sleep, schizophrenia, learning and memory, addiction, sex, appetite and obesity, chemotherapy-induced nausea, epilepsy, and such neurodegenerative disorders as multiple sclerosis and Alzheimer's Disease. Each chapter also links the scientific evidence to historical and anecdotal reports of the medicinal use of cannabis.As debate about the medical use of marijuana continues, Parker's balanced and objective review of the fundamental science and potential therapeutic effects of cannabis is especially timely.

In recent decades, a growing number of children have been diagnosed with autism spectrum disorder (ASD), a condition characterized by, among other features, social interaction deficits and language impairment. Yet the precise nature of the disorder's impact on language development is not well understood, in part because of the language variability among children across the autism spectrum. The contributors to this volume — experts in fields ranging from communication disorders to developmental and clinical psychology to linguistics — use innovative techniques to address two broad questions: Is the variability of language development and use in children with ASD a function of the language, such that some linguistic domains are more vulnerable to ASD than others? Or is the variability a function of the individual, such that some characteristics predispose those with ASD to have varying levels of difficulty with language development and use? Contributors investigate these questions across linguistic levels, from lexical semantics and single-clause syntax, to computationally complex phonology and the syntax-pragmatics interface. Authors address both spoken and written domains within the wider context of language acquisition. This timely and broadly accessible volume will be of interest to a broad range of specialists, including linguists, psychologists, sociologists, behavioral neurologists, and cognitive neuroscientists.

Developmental Disorders of the Brain: Brain and Behaviour addresses disabilities that occur or have their roots in the early, developmental phase of life which are of utmost concern to parents, siblings, carers and teachers.This text describes the latest clinical and behavioral findings of disorders which largely or entirely involve the frontostriatal (basal ganglia) system including Tourette's, Obsessive-Compulsive and Attention-Deficit-Hyperactivity disorders, Schizophrenia, Autism, gambling and addiction, depression, and Conduct, Developmental Motor Co-ordination, and language disorders. Examples of disorders involving the frontocerebellar are also described such as Asperger's disorder, Williams, Fragile X, and Cerebellar Cognitive Affective syndromes, and Friedreich Ataxia. This book also discusses the relevant anatomy, physiology and pathology, and some of the major functions mediated by affected or relevant structures, together with accounts of the latest recording, brain imaging and stimulating techniques related to these kinds of disorders.Covering both frontostriatal and frontocerebellar, systems which control and direct normal behavior, and which can fail with often distressing consequences during development, as well as addressing behavioural, clinical, pathophysiological and technical aspects, this text is vital to understanding, diagnosis and management of developmental disorders of the brain. This text will be of great interest to clinicians, researchers, teachers and parents.

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug's effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. - Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points - Presents illustrations with at least six figures, tables, and diagrams per chapter - Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment - Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

Authoritative, easy-access coverage for Emergency Department clinicians who need answers NOW A Doody's Core Title for 2019! Essential for anyone practicing in an emergency department or acute care setting, this new edition of CURRENT Diagnosis & Treatment Emergency Medicine strikes the perfect balance between brevity and clinical necessity. It delivers exactly the amount of information needed for quick diagnosis, effective treatment, and improved outcomes – no more, no less. The book emphasizes immediate management of life-threatening problems, then covers the evaluation and treatment of specific diseases. The problem-based organization encompasses all aspects of emergency medicine, including common emergencies, trauma, neonatal and pediatric emergencies. • Market: Emergency physicians (38,000 board certified; 20,000 non-board certified), Emergency Medicine residents (4,000), Emergency Departments (5,000/USA), medical students (18,500) • NEW! Increased number of procedural diagrams, new coverage of emergency bedside ultrasound and procedural sedation; updates throughout • Extensive at-a-glance algorithms facilitate rapid management and diagnosis

This book presents recent research in intelligent information and database systems. The carefully selected contributions were initially accepted for presentation as posters at the 9th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2017) held from to 5 April 2017 in Kanazawa, Japan. While the contributions are of an advanced scientific level, several are accessible for non-expert readers. The book brings together 47 chapters divided into six main parts:• Part I. From Machine Learning to Data Mining.• Part II. Big Data and Collaborative Decision Support Systems,• Part III. Computer Vision Analysis, Detection, Tracking and Recognition,• Part IV. Data-Intensive Text Processing,• Part V. Innovations in Web and Internet Technologies, and• Part VI. New Methods and Applications in Information and Software Engineering. The book is an excellent resource for researchers and those working in algorithmics, artificial and computational intelligence, collaborative systems, decision management and support systems, natural language processing, image and text processing, Internet technologies, and information and software engineering, as well as for students interested in such research areas.

This practical, research-based book introduces and reviews the evidence-based measures used in the commissioning and auditing of services for people with ASD, where the ability to demonstrate the benefits and effects of support and intervention is increasingly important.

For more than 35 years, Kaufman's Clinical Neurology for Psychiatrists has been the only reference to focus on the must-know aspects of neurology for psychiatrists. Now in a revised 8th Edition, this classic text brings you up to date with essential knowledge in clinical neurology with new topics, new illustrations, and new questions to help you excel on the American Board of Psychiatry and Neurology examination. Explains each condition's neurologic and psychiatric features, easily performed office and bedside examinations, appropriate tests, differential diagnosis, and management options. Discusses timely, clinically-relevant topics such as traumatic brain injury, Alzheimer and non-Alzheimer dementias, other age-related neurologic conditions, neurologic illnesses that present with symptoms of autism, neurologic effects of illicit drug use, and current treatments. Correlates neurologic illnesses with the DSM-5. Includes nearly 2,000 multiple-choice questions both in print and online, – all written to help you succeed on the ABPN certifying exam. Features new and improved clinical illustrations throughout: life-like patient sketches, anatomy line drawings, CTs, MRIs, and EEGs that demonstrate clinical features.

Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.

Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neuroscience A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology All chapters fully revised and updated to reflect the increasing role of neurologists in acute care Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson's disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitationfor dementia, epilepsy, headaches, neuro-genetics and many more

This comprehensive resource covers the current thoughts and trends on narcolepsy, as well as cutting-edge evidence-based research. Updates from the previous edition include advances in diagnostic guidelines, treatments, protocols and clinical and psychosocial considerations. Aspects of narcolepsy relating to sleep medicine, neurology, psychiatry and public health are featured throughout the text. Narcolepsy, 2nd Edition provides clinicians and allied health professionals with patient management modalities, clinical and quality of life issues and best practices for health care delivery.

The third edition of the hugely successful Handbook of Child and Adolescent Clinical Psychology incorporates important advances in the field to provide a reliable and accessible resource for clinical psychologists. Beginning with a set of general conceptual frameworks for practice, the book gives specific guidance on the management of problems commonly encountered in clinical work with children and adolescents drawing on the best practice in the fields of clinical psychology and family therapy. In six sections thorough and comprehensive coverage of the following areas is provided:Frameworks for practiceProblems of infancy and early childhoodProblems of middle childhoodProblems of adolescenceChild abuseAdjustment to major life transitionsThoroughly updated throughout, each chapter dealing with specific clinical problems includes cases examples and detailed discussion of diagnosis, classification, epidemiology and clinical features. New material includes the latest advances in: child and adolescent clinical psychology; developmental psychology and developmental psychopathology; assessment and treatment programmes. This book is invaluable as both a reference work for experienced practitioners and as an up-to-date, evidence-based practice manual for clinical psychologists in training.The Handbook of Child and Adolescent Clinical Psychology is one of a set of 3 books published by Routledge which includes The Handbook of Adult Clinical Psychology: An Evidence Based Practice Approach, Second Edition (Edited by Carr & McNulty) and The Handbook of Intellectual Disability and Clinical Psychology Practice (Edited by Alan Carr, Christine Linehan, Gary O'Reilly, Patricia Noonan Walsh and John McEvoy).

Neurobiology of Language explores the study of language, a field that has seen tremendous progress in the last two decades. Key to this progress is the accelerating trend toward integration of neurobiological approaches with the more established understanding of language within cognitive psychology, computer science, and linguistics. This volume serves as the definitive reference on the neurobiology of language, bringing these various advances together into a single volume of 100 concise entries. The organization includes sections on the field's major subfields, with each section covering both empirical data and theoretical perspectives.'Foundational'neurobiological coverage is also provided, including neuroanatomy, neurophysiology, genetics, linguistic, and psycholinguistic data, and models. - Foundational reference for the current state of the field of the neurobiology of language - Enables brain and language researchers and students to remain up-to-date in this fast-moving field that crosses many disciplinary and subdisciplinary boundaries - Provides an accessible entry point for other scientists interested in the area, but not actively working in it – e.g., speech therapists, neurologists, and cognitive psychologists - Chapters authored by world leaders in the field – the broadest, most expert coverage available

The field of cognitive and behavioral neurology is rapidly changing. Almost daily discoveries deepen our understanding of various conditions affecting our cognitive function. Cognitive and behavioral neurology is becoming a very important integral part of the neurosciences. The amount of already available and newly discovered information is growing, and the management of it might sometimes seem overwhelming to healthcare providers and to those in training. It is paramount to gain solid knowledge in order to critically navigate through new discoveries. This book begins with an introduction to neuropathology of the most commonly encountered neurodegenerative conditions. The following chapter describes imaging biological marker studies of conditions such as Alzheimer's disease and Lewy body spectrum disorders. Further chapters describe the function and dysfunction of different cognitive domains. This book provides guidance to clinicians on how to approach progressive conditions in the clinic by evaluating cognitive domains affected, and understand which underlying pathology is more likely to cause it. That is the way practicing physicians approach it daily. Neurology and psychiatry residents, fellows, medical students and already practicing healthcare providers should find this book useful as an introduction to this exciting field of neurology.