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Ten years have elapsed since the printing of the second edition of this book. Since then there's been a veritable explosion of information coming mainly from the field of molecular diagnostics, which bear particular importance in the classification and treatment of Infantile enteropathies, disorders associated with immunodeficiencies, the classification of intestinal polyps and polyposis syndromes in childhood, cholestatic and metabolic disorders of childhood, liver tumors and transplantation pathology, all of which were major subjects explored in our previous editions. In this updated third edition, most of the chapters have been extensively revised to incorporate updated understanding in pathogenesis and terminology. For example, the widespread use of genetic panels and next generation sequencing in the diagnosis of cholestatic disorders of infancy and childhood, not widely available when the last edition was being prepared, prompted the writing of an entirely new chapter reflecting these advances by a new set of authors. Similarly, progress in diagnosis and classification of liver tumors justified an entirely new chapter on liver tumors that incorporates newer patient stratification in treatment protocols and reflects the new WHO classification of liver tumors. Pathology of Pediatric Gastrointestinal and Liver Disease 3rd Edition provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. It includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts.

This book provides short chapters with key learning points from experts within the area, about musculoskeletal conditions in patients with obesity. Each chapter will be structured in two parts: (a) the increasing musculoskeletal conditions caused by the obesity and (b) the difficulty of treating the musculoskeletal conditions in the presence of obesity. It is aimed at a multidisciplinary readership including clinicians, physiotherapists, rehabilitation specialists, general practitioners and sports physicians, and other allied health professionals involved in the treatment of musculoskeletal disorders.

This book is the first review book to use the multiple-choice question format in pediatric neurosurgery. More than 500 MCQs are provided in a convenient format that is suitable for self-study.The mission of the book is to help readers understand the content and maintain the knowledge, rather than merely finding answers for complicated questions. The strategy and the format of the questions provide a step-by-step, thorough explanation of each disease from the definition, associated anatomy, pathology, clinical features, radiology to surgical decision-making, and surgical tricks, providing a comprehensive and concise overview. Answers and definitions appear immediately below the questions to facilitate information retention. It is an important asset for residents across neurosurgical disciplines as it includes much of the pediatric neurosurgery knowledge that neurosurgical residents need to prepare for their certification tests. It is also useful for those seeking ways to solidify their knowledge or maintain their current certification. This book is an adjunct to the existing texts and does not intend to be the primary source of information; it rather aims to help readers identify their relevant strengths and weaknesses in the area.

Despite the advances in precision medicine and the progressive tailoring of multimodal therapies, surgery still remains the mainstay treatment in the majority of pediatric solid tumors and plays a key role in the multidisciplinary evaluation and management of pediatric oncology patients. The surgeons will face a variety of challenging situations in many aspects of the treatment of a child with cancer. Whether in the emergency department, evaluating a new patient or in the operating room, a clear and concise decision-making plan needs to be developed to assure optimal care and survival. The Survival Handbook in Pediatric Surgical Oncology is to provide an up-to-dated, portable, easy to read and schematic overview of the main topics of the surgeon's role in pediatric oncology, delivering a quick reference guide especially designed for pediatric surgery residents, fellows and young practitioners. The wide coverage of general aspects of the field, like epidemiology, basic oncology, anesthesia and imaging, will be completed with a detailed but brief analysis of most prevalent solid tumors. Other important topics will also be treated, like oncological emergencies and fertility considerations. The chapters will be in charge of key opinion leaders in every topic, looking to deliver only the crucial information, in order to help in the bedside decision making plan. This handbook will be an important partner for many pediatric surgeons around the world, because in this kind of disease it's crucial to act quickly and correctly in order to assure the right diagnosis and start treatment as soon as possible.

Keep current with the latest clinical practice guidelines and policies from the American Academy of Pediatrics (AAP), covering 37 conditions plus every AAP policy statement, clinical report, and technical report though December 2023.KEY FEATURES New: “Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents with Obesity” Printed text and eBook access, including full text of the new AAP clinical practice guideline and 2023 AAP policy statements, clinical reports, and technical reports Key Action Statements for all AAP clinical practice guidelines More than 600 policy statements, clinical reports, technical reports, and AAP endorsed policies Five-section organization for ease of use

This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner's guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists.

This edited volume encompasses chapters on novel and innovative research in the applications of leading digital technologies in an accessible and engaging way. By utilising cutting edge and ever progressive technology in visualization, it will enhance our understanding and application in our everyday lives. This volume shows how we can use Extended Reality, 3D animations and serious games to benefit the learner, educator, clinician, patient, parent and carer. Visualization techniques like Virtual, Augmented and Mixed Reality and show how they can be utilised to improve training and understanding of anatomy, surgery, and clinical assessment. This is covered specifically for emergency practitioners in enhancing their understanding of ECG's for potential myocardial infarction by using augmented reality. From a translational medicine perspective and pre-operative pediatric surgical planning, the benefits of augmented reality are examined as to what might be found intra-operatively from imaging techniques. Educational applications of digital technologies using serious games and Extended Reality are examined. We show how Mixed Reality can aid understanding in cellular anatomy for our learners and researchers alike. We also show how serious games can have applications in diverse areas like parasite infections and neuroanatomy education and training. Finally, from a clinical perspective, the use of 3D animations and their applications is discussed for vertebral fractures and increasing parent/carer awareness through interactive applications. Also, the use of 3D animations in cerebral magnetic resonance angiography for global education highlights the great benefits of these tools and technologies. There is something for the researcher, clinician, educator, patient, and carer as we explore novel technologies. These are applied locally, nationally and globally as we advance our understanding of the world changing influence that digital technologies have on our day-to-day life.

With a focus on evidence-based, contemporary, and clinically relevant information, this practical new resource provides a concise, clinical, and techniques-focused guide to the medical, endovenous, and surgical management of patients with acute and chronic venous disease.Internationally recognized chapter authors cover the general principles of the pathophysiology, diagnosis, indications, and decision-making around the management of acute and chronic venous disease. The text emphasizes endovenous and surgical techniques where applicable, and also addresses symptomatic peripheral venous insufficiency, deep venous thrombosis, and the care of patients with symptomatic central venous disease.Vascular surgeons will find this a valuable guide, providing insights into key techniques and approaches to the treatment of acute and chronic venous disorders. This book is an invaluable resource for vascular trainees preparing for examinations and for physicians in other specialities looking to expand their knowledge base.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of the female genital tract, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Gynecological is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. - Covers all areas of gynecologic pathology, organized into seven easy-to-reference anatomic sections: vulva, vagina, uterine cervix, uterine corpus, fallopian tube and broad ligament, ovary, and peritoneum - Includes all frequently encountered conditions plus extensive coverage of uncommon entities, such as inflammatory diseases of the vulva, discussed by experts in dermatopathology - Provides updated differential diagnoses and diagnostic pearls as well as extensive revisions based on the 2020 WHO Classification of Tumors: Female Genital Tumors, including staging issues and measurement standards - Reflects important molecular updates in endometrial carcinoma classifications as well as updated classifications for squamous and glandular tumors for the lower genital tract, both in situ and invasive - Updates ancillary techniques, newly encountered pitfalls, and advances in the molecular landscape of epithelial and mesenchymal tumors - Features more than 2,500 superb images in print and online, including many new gross and microscopic images as well as diagnostically relevant immunohistochemical and molecular findings - Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

This text aims to provide a comprehensive review of general emergency surgery, the branch of medicine that treats patients presenting to the hospital with a wide variety of emergency conditions. It includes a section focusing on clinical aspects, management, logistics, patient cohorts and perioperative considerations in the context of general emergency surgery and trauma. Other sections describe various conditions and diseases in specific anatomical structures to enable readers to easily find the information they need. Written and edited by international experts and opinion leaders in the field, this book is a valuable reference resource for general and emergency surgeons, trauma surgeons, emergency physicians and nurses. It will also be of interest to residents, students and all other healthcare professionals involved in the management of emergency surgical patients.

Designed with the busy practitioner in mind, ExpertDDx: Brain and Spine, third edition, quickly guides you to the most likely differential diagnoses based on key imaging findings and clinical information. This superbly illustrated resource covers more than 275 of the top differential diagnoses across a broad spectrum of central nervous system diseases, presenting parallel groups of anatomically based differentials, generic imaging patterns, modality-specific findings, and clinically based differentials for each area. Now fully revised and up-to-date, this practical reference clearly guides you through useful, actionable differential diagnoses that lead to definitive findings in every area of the brain and spine. - Presents multiple clear, sharp, succinctly annotated images for each diagnosis; a list of diagnostic possibilities sorted as common, less common, and rare but significant; and brief, bulleted text offering helpful diagnostic clues - Reflects changes in 2021 WHO CNS tumor grading and nomenclature - Contains newly identified entities, new differential diagnoses, and updated references - Shows both typical and variant manifestations of each possible diagnosis - Includes more than 7,000 high-quality print and online images - Features updated genetic information now available in Online Mendelian Inheritance in Man (OMIM) - Separates adult and pediatric DDx lists for even faster reference - Assists you in building either a definitive diagnosis from an imaging study or a carefully refined list of reasonable differential diagnoses

Balancing basic science with information on everyday clinical practice, Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 7th Edition, provides you with expert guidance and advances in the field so you can offer patients the most optimal diagnostic and surgical care. In two convenient volumes, Dr. William Jarnagin and his team of internationally recognized surgeons cover exactly what you need to know, including advances in diagnostic and surgical techniques, minimally invasive surgeries, new interventional diagnostic techniques, and all relevant diseases. This comprehensive, practical reference is designed to help you choose and perform the most appropriate procedures that will minimize inpatient hospital time, curtail costs, and reduce overall recovery time for your patients. - Presents cutting-edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in one highly regarded, authoritative reference. - Covers all surgical approaches, both open and minimally invasive. - Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform clinical decision-making. - Contains 161 chapters with updated references and additional figures—more than 1,500 illustrations in all. The imaging section has been reorganized to reflect a disease-based approach. - Includes new and expanded sections on advances in molecular characterization of benign and malignant HPB diseases, perioperative management, interventional techniques, minimally invasive surgery and robotics, and therapeutic advances for malignant disease. - Features a section dedicated entirely to operative technique, plus a new historical chapter authored by Professor Jacques Belghitti:'Hepatobiliary and Pancreatic Surgery: Historical Perspective.

Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in an easy-to-access format. Chapters cover the key topics of greatest and most frequent concern to clinicians treating newborns, delivering current, data-driven management and treatment advice in a single source relevant to the seasoned practitioner, fellow, or trainee. - A highly templated format makes it easy to find exactly the information you need. - Lavishly illustrated with photos, radiographs, drawings, and charts and graphs that clarify key concepts in a helpful and accessible way. - Evidence-based focus ensures that only the most reliable treatment protocols and clear-cut, data-driven guidance are included. - Coverage of all relevant topics in the NICU: skin lesions, congenital anomalies, architecture/development of neonatal intensive care units, pain control, anesthesia for newborn infants, and much more. - Ideal for every member of the NICU team: neonatologists, neonatology fellows, residents, and neonatal nurses, as well as all other clinicians working in the NICU, including PAs, occupational therapists, respiratory therapists, and others.

Neonatal Care: A Compendium of AAP Clinical Practice Guidelines and Policies, 2nd Edition, provides the most recent and trustworthy recommendations from the American Academy of Pediatrics (AAP) Committee on Fetus and Newborn as well as other relevant committees, sections, and councils. This compendium contains all of the collected AAP clinical practice guidelines, policy statements, and clinical and technical reports related to the quality care of newborns and infants. Find more than 50 different topics organized into 9 sections for easy reference, including the highly anticipated “Clinical Practice Guideline Revision: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.” Each statement or report contains an abstract overview, a concise presentation and critique of the available data, and a summary of the findings and/or recommendations, along with a current and comprehensive bibliography. TOPICS INCLUDE• Delivery and discharge• Newborn screening• High-risk infants and preterm birth• Respiratory support• Infections and vaccinations• Complications and issues• Safe sleep• SIDS and infant death• And more!

Principles and Practice of Assisted Reproductive Technology provides comprehensive information on the modern day approach to all aspects of ART. It is a well-designed and illustrated textbook, which covers the entire armamentarium of ART, in depth, from basic principles of reproductive anatomy, physiology, endocrinology and laboratory aspects of IVF to the latest scientific advances. The book also provides updated optimal information on evaluation and management of an infertile couple, complications of ART, outcomes following ART, ethical and legal issues in ART and ART guidelines. It is a unique compilation where each topic is written by experts who have relevant experience in that field. The third edition not only updates the previous chapters with the latest advances, but brings fresh perspective not only to socially relevant topics like addressing fertility issues in the LGBTQ and gender transformation but also the COVID-19 pandemic and newer advances like rejuvenation therapy. The book portends to be a valuable asset to the entire fraternity of reproductive medicine specialists.

This book focuses on the worldwide frequent and growing problem with its projective trajectory that encompasses pediatric overweight and obesity. Through the ten chapters it offers in the first four a comprehensive state of art of the bases of pediatric obesity in order to support the following ones with new and proved clinical issues, as recent complementary features on anthropometry and food intake and new safe treatments. This books discusses comorbidities, trajectories, prevention, extended periods and treatment. For effective prevention, clues are given to routinely screen all comorbidities that are already present in overweight or obese children but frequently overlooked.This volume will be of benefit to pediatricians, endocrinologists and all healthcare providers interested in the care of children and adolescents.

Covering both surgical and non-surgical pain, Acute Pain Management Essentials is a comprehensive, clinically oriented reference for the entire acute pain management team. Edited by Drs. Alan David Kaye and Richard D. Urman, this new title brings together the expertise of contributing authors from anesthesiology, medicine, surgery, and allied health professions to offer an interdisciplinary approach to this complex and fast-changing field. Beginning with an overview of basic principles, it then approaches pain management by organ system, by patient population, and by treatment modality, ending with review of subspecialty considerations and related topics.

This book celebrates the emergence of knowledge in the field of pediatric gastroenterology (GI) and is written for the primary care clinician to help update knowledge in this important area. The current and future shortage of pediatric gastroenterologists necessitates steady, rejuvenated information on GI disorders for primary care clinicians as they care for the child and adolescent with complex gastroenterologic dilemmas and disorders. Much has been learned about pediatric gastroenterology and hepatology in the 21st century as research continues around the world despite many challenges such as the 2019-2023 COVID-19 pandemic. This second edition of the editors/writers'discussion on pediatric gastroentologic (GI) and hepatic disorders reflect on such updated knowledge that considers medical and surgical perspectives including dealing with such complex complications as infection and pain.

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

This case-based book comprehensively covers the clinically significant problems that can occur in children in the immediate postoperative period after surgery after admission to Post Anesthesia Care Unit. Chapter authors first focus on how clinical monitoring and safety of post-op patients can and must continue after hand off to the PACU team and then describe 24 interesting clinical scenarios that needed urgent intervention in PACU. The goal of this book is to teach members of the perioperative teams around the globe how to keep anesthesia stat calls to a minimum. Anesthesia STAT! Acute Pediatric Emergencies in PACU features contributions from leaders in pediatric anesthesiology and be an indispensable guide for the perioperative and postoperative team in preventing potential problems during the post-anesthetic period.

Management of childhood cancer involves knowledge of multiple specialties and skillsets. Case-based learning, originating at Harvard Business School in 1920, is a well-established educational method. A good working definition of case-based learning in medical practice is by Thistlewaite et al.'The goal of case-based learning is to prepare students for clinical practice, through the use of authentic clinical cases. Case-based learning provides students with an opportunity to see theory in practice and real cases expose them to multiple opinions and counter points'.

This book presents 101 unique and extraordinary cases in interventional radiology (IR) and endovascular therapy. Extreme IR is an internationally recognized event that Dr. Ziv Haskal created and held in early 2000's at mountaintop venues, then at successive Society of Interventional Radiology annual conference meetings, and later, published monthly within the Journal of Vascular and Interventional Radiology (JVIR) for which he was editor-in-chief for 10 years. The ever-popular Extreme IR sessions at conferences have drawn more than 5,000 attendees. Cases are presented in a rapid-fire format designed to maximize relevancy, excitement, and unique knowledge. This book aims to replicate that experience for a wider audience. The book is divided into twelve sections, including venous, portal hypertension, and biliary, arterial, oncology, etc. cases. Most cases span two pages and include large, illustrative images with bullet-pointed text to present essential information in a concise and focused fashion. The global list of authors exemplifies the extraordinary breadth of the cases for interventional radiologists, endovascular specialists. It is ideal for interventional radiologists and endovascular specialists at all levels of seniority and training.

Fluorescence-guided surgery (FGS) is defined as a medical imaging technique that uses a fluorescent dye or a near-infrared emitting light source to identify anatomic structures during surgical procedures. In 2020 alone, over 1200 academic articles were published on the topic of fluorescence-guidance surgery, a sign that this modality is making significant inroads into surgical practice. The use of near-infrared imaging and FGS is a rapidly growing modality, allowing surgeons to see more intraoperatively, enhance surgical precision, and improve surgical decision-making and patient outcomes. This manual provides a comprehensive, state-of-the art review of this field and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in fluorescence-guided surgery, guiding patient management and stimulating investigative efforts. After initial chapters discussing the history of FGS and the current platforms and devices, it presents the most up-to-date data regarding the use of FGS in multiple surgical fields - colorectal, hepatic, endocrine, reconstructive, pediatric, among others - as well as in the treatment of specific conditions such as burns. Chapters are generously illustrated with full-color figures and intraoperative photographs, and selected chapters include video segments. Access to a comprehensive resource such as this is currently limited by the relatively new inroads that fluorescence-guided technology has made into surgery. The SAGES Manual of Fluorescence-Guided Surgery fills this gap in the literature.

This book provides a concise overview of neonatal imaging. After a short clinical introduction on the crucial role of imaging in diagnosing and treating neonatal conditions, it discusses the various methods (ultrasound, digital radiography, fluoroscopy, CT, and MRI) available and explains in detail how they have to be adapted for neonatal applications. Chapters feature imaging findings and differential diagnoses for the most common neonatal conditions. Additionally, some relevant aspects of foetal imaging are presented. Written by an interdisciplinary team, Imaging in Neonates is a practical resource for daily use in the ward for all medical professionals involved in treating neonates.

From challenges presented in everyday clinical practice to the complex cases without simple answers, Challenging Cases in Urological Surgery is an effective reference and revision aid for trainees and consultants alike. As part of the Challenging Cases series, cases are examined from a multidisciplinary approach considering all aspects of diagnostic, practical and evidence-based skills to provide a comprehensive and detailed demonstration of clinical investigation within real-world scenarios. With contributions from over 40 experienced and renowned consultants from the UK, the opinions within the'Expert Commentary'includes an insight into real world case management and problem solving in complex cases. Using the most up-to-date evidence and clinical presentations highlighted in the UK ISCP curriculum, this book features the use of'Clinical Tips','Evidence Base'and'Future Advances'text boxes to highlight critical information in an easy-to-read format for efficient and effective learning. This book is split into 15 comprehensive sections; these include Urinary Tract Infection, Bladder Cancer, Male Infertility and Sexual Dysfunction and Emergency Urology and Trauma among other key areas in the field of Urology. Each chapter is a case-based guide which provides readers with practical yet clinically relevant advice on management of urological surgery cases. With every-day clinical observations, controversial topics and challenging cases, this book is a highly valuable resource for all those interested in urological surgery, trainees in the field and those sitting postgraduate urology examinations.

This book provides a comprehensive account on individually rare, but collectively frequent diseases of the liver. In the first part, conditions such as hepatic vascular malformations, ischemic cholangiopathy, hepatic artery occlusion, sinusoidal conditions and Budd-Chiari syndrome are discussed among others. The second part examines the causes of vascular liver disease namely, coagulation disorders, neoplasm disorders, non-malignant blood disorders, systemic diseases and toxins, among others. The unique expertise of the authors, who are all members of the Vascular Liver Disease Disorders Group, an independent network of researchers with a common interest in Vascular Liver Diseases, are merged for an optimal pragmatic and individualized approach. This book is of interest to a broad range of experts, such as hepatologists, internists, radiologists and angiologists.

Andrology & Sexual Medicine is a comprehensive source for urologists, andrologists, sexologists and general practitioners. It contains general and up-to-date information about almost all topics within andrology and sexual medicine, and is a unique source that can be used for both exams and general daily practice. Easily accessible to clinicians and researchers and specialists, it tackles the controversial and complex topics of andrology and sexual medicine for urologists.

The heavily revised second edition of this essential textbook describes how to utilize a range of surgical techniques applicable to pediatrics. Chapters contain flowcharts to facilitate rapid assessment and decision-making. In addition, learning objectives and review questions are contained within each chapter to reinforce the key points covered. Topics covered include routinely encountered adolescent problems and neoplasms in children. Pediatric Surgery: Diagnosis and Treatment concisely describes how to apply a range of diagnostic and treatment techniques that are applicable to the pediatric patient in a variety of surgical scenarios for a range of diseases. Furthermore, it is an ideal resource for trainees and active practitioners taking board examinations.

This practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions considered are extremity soft tissue sarcomas, retroperitoneal soft tissue sarcomas, bone sarcomas, uterine sarcomas, chordomas, pediatric sarcomas, squamous cell carcinomas, basal cell carcinomas, melanomas, Merkel cell carcinomas, and cutaneous lymphomas. Detailed attention is devoted to the issues and considerations of relevance in everyday practice when treating these diseases. The use of multiple radiotherapy techniques and procedures, including IMRT, brachytherapy, radiosurgery, and particle therapy, is fully explained, and the role of radiotherapy in combination with chemotherapy and emerging therapeutics such as immunotherapy and biologic anticancer agents is also addressed. The book will be of high value for practicing radiationoncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, trainees, and other medical professionals.

Bösartige Tumoren der Geschlechtsorgane machen etwa 15 Prozent der malignen Erkrankungen bei Frauen aus. Wer Patientinnen mit jenen betreuen möchte, muss in der gynäkologischen Onkologie bewandert sein. In diesem Kompendium beschreiben erfahrene Kliniker die entsprechenden Krankheiten und geben einen Überblick über die derzeitigen Standards in Diagnostik und Therapie – unter Berücksichtigung der Leitlinien sowie der wissenschaftlichen Literatur.

Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers. - Presents an overview on liquid biopsy techniques and their applications in cancer diagnosis - Explains how to extract circulating tumor DNA, RNA and circulating tumor cells and extracellular vehicles from blood samples to identify the urology cancers, including testis, prostate, bladder and kidney - Includes several images and schematic diagrams that illustrate content and facilitate its comprehension

IAP Recent Advances in Pediatrics, Volume 2 (IAPRAP2), the biennial treatise, once again brings to the readers, the recent scientific advances in the field of pediatrics across different spheres.

Since the publication of the 7th edition of this book, there has been a remarkable increase in information in several clinical areas, including cardiology, immunology and oncology. This rapid knowledge expansion has led to practice changes for family physicians and other primary care providers. Patients are now discharged from tertiary care hospitals to their home communities with life sustaining left ventricular assist “heart pumps”. Hepatitis C, once an incurable illness, is now routinely cured. Oncology treatment regimens are increasingly becoming ambulatory and individualized. The decreased cost and increasing availability of health monitoring devices will make it possible for physicians to remotely check on the health status of their patients in their homes. With the ongoing and worsening shortage of family physicians across the US, the practice model for family medicine in the future may tend toward a family physician supervising a cast of mid-level providers as they care for a panel of patients, versus the physician providing the majority of care. All of these changes will require practice pattern changes and a need for up to date sources of information for the family physician. In addition, the “family” of family medicine academic organizations is undertaking a major review of the practice, training, funding and evaluation of all aspects of family medicine. Eight family medicine organizations have launched the “Family Medicine for America's Health” (FMAHealth) with the expressed purpose “to strategically align work to improve practice models, payment, technology, workforce and education, and research to support the triple aim”. This project has moved past the study phase and will soon move to the implementation phased. This book is organized into short, focused chapters almost exclusively dedicated to topics relevant to daily practice. All lead authors are themselves accomplished family physicianswho can specifically address the needs, concerns, and interests of this crucial profession. As one of the key reference textbooks for family medicine, it is very important to provide the most up-to-date knowledge to support learners and practitioners of family medicine in the face of rapidly expanding clinical knowledge and the extensive self-examination of family medicine. Family Medicine: Principles and Practice, 8th Edition, is a must-have reference for medical students, residents, practicing physicians, nurse practitioners and physician assistants with an active role in patient care.

This book covers all aspects of Wilms'tumor, the second most typical solid tumor in children. Its potential for complete cure underscores correct management of this tumor. To achieve this goal, the book aims to provide all necessary details for practicing Pediatric surgeons, Oncologists, Pediatricians, Urologists, and Medical students. Topics ranging from epidemiology, etiology, pathology, clinical features, diagnostic methods, surgery, chemotherapy, radiotherapy to cutting-edge inventions are described in great detail.Detailed descriptions of surgical techniques and their nuances will greatly benefit surgeons and surgical residents. Importantly, all the chapters are written by authors who have first-hand experience with clinical management. Thus the text ensures the practical application of theoretical details.

Updated and expanded, this Second Edition of Essentials of Clinical Radiation Oncology continues to provide a succinct and effective review of the most important studies in the field. Organized by disease topic and grouped by body part, each chapter employs structured sections for targeted information retrieval and retention. Chapters begin with a'Quick Hit'overview of each disease summarizing the most significant paradigms before moving into dedicated summaries on epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigm, and medical management. An evidence-based question-and-answer section concludes each chapter, which pairs commonly encountered clinical questions with answers connecting historical context and pertinent clinical studies to better inform decision-making and treatment planning. Providing the latest treatment paradigms and guidelines, this comprehensive second edition now outlines the evidence and must-know considerations for using radiation therapy with immunotherapy, the strategies for metastasis-directed therapy for oligometastatic disease, and much more. Written for the practicing radiation oncologist, related practitioner, and radiation oncology resident entering the field, this'one-stop'resource is the go-to reference for everyday practice. Key Features: Structured sections offer high-yield information for targeted review Cites need-to-know clinical studies and treatment guidelines in evidence-based question-and-answer format Each chapter has been reviewed and updated to include the most recent and relevant studies New chapters on spine tumors, thyroid cancer, sinonasal tumors, cholangiocarcinoma, renal cell carcinoma, multiple myeloma and plasmacytoma, miscellaneous pediatric tumors, and treatment of oligometastatic disease from underlying cancers Designed for quick reference with comprehensive tables on treatment options and patient selection, workup, and prognostic factors by disease site Purchase includes digital access for use on most mobile devices or computers

A new, definitive, state-of-the-art reference in the specialist field of paediatric surgical oncology. Key points and informative guidance on all aspects of cancer surgery for children make this a vital textbook for the surgery resident, surgical oncology specialist, nursing staff and cancer health care teams. The editorial team of world experts and international guest authorship listings guarantees that the textbook content provides a definitive treatise for a global audience of pediatric surgeons.Textbook coverage includes chapters on pediatric cancer epidemiology, chemotherapy, immunotherapy, radiotherapy, pathology, radiology and vascular access, following which the main theme sections feature all of the major pediatric solid tumours in a system-based chronology. A section devoted to rare tumours provides useful and pragmatic information for the oncology surgeon. Minimally invasive surgery is covered highlighting current concepts and clinical outcome(s) by leading experts in the field. Nutritional considerations for the pediatric cancer patient undergoing surgery are all discussed. Management of surgical complications, fertility considerations and long-term outcomes are an invaluable vital resource for the reader. Final sections'look to the future'by focusing on surgical innovation, including key chapters on navigational surgery and surgical robotics.• Includes all the latest developments in pediatric surgical oncology ensuring the reader is kept fully up to date.• Multi-disciplinary content reflects current best practice.• Comprehensive coverage provides a definitive reference guide.An authoritative seminal reference work for surgical residents in training, surgeons working in the field of pediatric oncology, medical oncologists, intensive care specialists, nursing staff and allied health care professionals.

This book offers comprehensive coverage of naturopathic medicine. The principles and values of this profession are already clearly stated (i.e., Find and Treat the Cause; Treat the Whole Person, etc.), but few are the textbooks that provide a clear exposition of what the approach is that differs from what is described as conventional or allopathic medicine. The toolkit – herbs or nutrients – then becomes the defining feature, but this is not the most important attribute. To paraphrase the historian of medicine Harris Coulter – in this approach the body reacts creatively to stressors – and the Empirical school or natural medicine approach is more focused on supporting adaptive responses than suppressing symptoms. Or to put it another way, naturopathic physicians certainly do things to ameliorate symptoms, but their real interest is to discern what disturbances to the determining factors of health lead to imbalances, physiological dysfunction, and are generating the symptoms. This is not an attempt to argue that all health issues can get better on their own or that conventional medical interventions aren't capable of producing stellar outcomes. Conventional medicine holds great value, but there remains a concurrent need for a naturopathic approach that helps rebuild the body.There is a need for an approach in medicine that works to support adaptive responses of the body, reduce maladaptive responses, address determining factors of health, and sometimes create temporary homeostasis with agents such as drugs (or certain natural medicines) can play to maintain life when the body's healing responses are insufficient. This book takes this approach and begins by examining what health is and then what states lead to disease. In terms of the basis of disease states, the book teaches about how the lack of coordination in the body's bioregulatory systems (hormones, nervous system, cell signaling) can lead to disease, as well as the impact of irreversible degeneration, genetic damage, chronic stress, etc. The book takes the reader to some of the more common and well described reasons for these states of dysfunction, including the body's inability to process environmental toxins and disruptions to the human microbiome. The book then teaches how to assess a patient, and how various natural therapies impact root causes of disease, the long term consequences, and the various clinical manifestations.The book then takes a systems approach – cardiovascular, pulmonary, etc. This is where most books on the subject start, but instead of breaking out a number of conditions and giving protocols of diet, supplements, herbs etc., the author examines how to restore stability and function to that system. There is in depth coverage of how to confront degenerative processes that make self-healing far more challenging, or perhaps not entirely attainable. The application of the model of healing outlined in previous chapters is applied to each system. Special topics are then covered, ranging from lifespan/primary care considerations to the role of research, the rise of advanced data analytics as decision assistance, to the environmental, cultural, and global determinants of health. Each chapter will additionally include tables that summarize key diagnosis or treatment points, arrayed in an order that reflects the model presented in the book.This is an ideal guide for students in naturopathic medicine, as well as physicians and medical professionals looking to learn more about this field aimed towards maximizing patient resilience.

Emphasizing safety, efficacy, and evidence, this is the only text representative of the multidisciplinary effort requisite to ensure delivery of optimal pediatric anesthesia care. Featuring the expert perspectives of over 120 professionals across disciplines, this highly anticipated text is designed to meet the needs of nurse anesthesia students and certified registered nurse anesthetists responsible for providing anesthesia for infants and children. Distinguished by its multidisciplinary, practical approach, this user-friendly text delivers a comprehensive survey of all key aspects of the field, including evidence-based techniques and current trends. With brief and consistent chapters organized by body system, this text offers readers a solid foundation in pediatric anatomy, physiology, pharmacology, and anesthetic care to ensure the delivery of best practices in the clinical arena. With patient safety at the forefront, brief procedural chapters review the indications, unique aspects of the preoperative evaluation, and a step-by-step guide to delivering anesthesia for a variety of common and complex procedures, as well as clinical pearls, complications management, and postoperative care considerations. More than 35 case studies illustrate application of anesthetic techniques in practice and foster critical thinking and discussion. Abundant figures and tables illustrate key points and aid in retention. Instructor resources include an instructor's manual with additional case studies, PowerPoints, and a test bank. Key Features: Presents the entire range of anesthetic procedures organized by body system Demonstrates advanced techniques and aids retention through case studies, illustrations, tables, and images Covers special topics including fetal surgery, neonatal emergencies, transplant surgery, pain management, ERAS protocols, non-operating room anesthesia, and ethical considerations Includes online resources for emergency medication dosing, age-based parameters, antibiotic prophylaxis, and case plan templates Includes an instructor's manual with additional case studies, PowerPoints, and a test bank.

This two-volume textbook provides a comprehensive review of both adult and pediatric gastrointestinal, hepatobiliary and pancreatic pathology. The 1st volume is dedicated to gastrointestinal tract pathology. The second volume of this book covers liver, biliary system, and pancreatic pathology. This book covers each aspect of gastrointestinal tract pathology in detail, including clinical presentation, endoscopic appearance, disease pathogenesis, gross and microscopic details of each lesion. Ancillary diagnostic methods, molecular subtypes, and prognostic workup have been detailed adequately. The book also covers diseases relevant to South-East Asia, in addition to diseases prevalent worldwide. It contains 24 chapters, categorized into four sections. Section I covers the general aspects of gastrointestinal pathology including normal anatomy of the gastrointestinal tract, endoscopic details relevant for gastrointestinal pathologists and histopathologists, grossing techniques, utility of and details of ancillary tests needed; section II covers all benign diseases in different anatomical parts of the gastrointestinal tract; section III covers preneoplastic lesions and malignancies of the gastrointestinal tract, including a separate chapter on updated molecular classifications of gastrointestinal tract tumors arising from different segments; section IV includes a unique chapter on setting up a gastrointestinal pathology laboratory. This textbook has been written and edited by experts in the field with proven academic and research excellence and include curated contents to provide lucid and updated information to the readers. The book features more than 800 photographs, line diagrams, endoscopic and radiology pictures, gross and microscopic images. It includes'Chapter Summary'at the end of each chapter and ‘Learning Tips'summarized after each major segment that helps the readers to reinforce the knowledge gained fromeach chapter. Chapters also contain case studies and/ or multiple-choice questions to enable readers to self-assess and learn from the explanations added. The textbook includes many unique chapters. It also covers cytological details and techniques relevant to gastrointestinal pathology. This comprehensive review of gastrointestinal pathology is a valuable resource for the faculties, gastrointestinal pathologists, cytologists, histopathologists, practicing pathologists, gastroenterologists, gastrointestinal surgeons, pathology fellows, postgraduates, clinical gastrointestinal fellows, and researchers in related fields.

This essential book is a unique, authoritative and clinically oriented text on pediatric ultrasound. It provides up-to-date information addressing all aspects of congenital and acquired disorders in children encountered in clinical practice. The easy-to-navigate text is divided into 20 chapters. Each chapter is organized to cover the latest ultrasound techniques, normal development and anatomy, anatomic variants, key clinical presentations, characteristic ultrasound imaging findings, differential diagnoses and relevant pitfalls. With more than 2400 images, examples of new technological developments such as contrast-enhanced ultrasound and elastography are included. Written by internationally known pediatric radiology experts and editorial team lead by acclaimed authors, Harriet J. Paltiel, MDCM and Edward Y. Lee, MD, MPH, this reference is a practical and ideal guide for radiologists, radiology trainees, ultrasound technologists as well as clinicians in other specialties with an interest in pediatric ultrasound.

Providing core information on pediatric surgery, this book serves as a supplement to standard pediatric surgical textbooks. It offers pearls of wisdom that will help those who participate in pediatric surgical care, as well as to provide state-of-the-art insights based on physiological principles, literature reviews, and clinical experience. This book is an ideal tool to help readers prepare for questions they will be asked on ward rounds, in the OR, or in oral exams. The depth of exploration is intended for medical students, residents in pediatrics and pediatric surgery, pediatric surgical trainees, pediatric nurse practitioners, primary care pediatricians, and family practitioners.

The eighth edition of the acclaimed text Operative Pediatric Surgery continues to provide a unique level of comprehensive detail on the full range of surgically treatable conditions presented in neonate and childhood as well as in utero. Written by expert international authors, all chapters cover both minimal access and open surgery, with operative techniques illustrated by both high-quality colour line artwork, operative photographs, and a library of video clips. Encompassing the full range of pediatric surgery operations that both trainee and experienced pediatric surgeons require, this established operative guide is the standard reference for the pediatric surgeon and will ensure that they can access the most up to date and authoritative information to benefit their clinical practice.• ensures authoritative coverage of all aspects of pediatric surgery•includes the latest operative techniques•reviews alternative surgical approaches•aids visualisation by the inclusion of over 1000 illustrations•establishes total confidence

This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

Pediatric Emergencies comprehensively covers the practical management of pediatric emergencies based on organ systems, with a strong emphasis on clinical relevance. Each chapter explores the background, classic clinical presentation, atypical clinical presentation, differential diagnosis, diagnostic confirmation, treatment, clinical algorithm, disposition, complications, and pitfalls of each topic. Clinical pearls included in each chapter can be used at the bedside, and case examples allow readers to compare and contrast pediatric complaints to adult presentations. More clinically focused than a traditional textbook, and more comprehensive than a typical clinical guide, Pediatric Emergencies is an ideal resource for emergency providers of various backgrounds and training, including emergency physicians, emergency medicine residents, pediatric emergency medicine fellows, pediatricians, and other primary care providers who work in urgent care settings.

This book addresses and summarizes the main andrological disorders (genital, reproductive or sexual diseases) that may originate in childhood or adolescence. Since many of the andrological diseases that occur in adulthood originate before the age of 18 and sometimes even during gestation, andrological evaluation is essential during childhood to highlight anomalies in the genital organs. During puberty, evaluation can help to monitor growth and secondary sex characteristics, and to assess e.g. the possible presence of an eunucoid habitus, gynecomastia, testicular hypotrophy or varicocele, a very common pathology in young people. During adolescence, the assessment of risk factors, such as those related to certain lifestyles, is of fundamental importance for primary prevention. Moreover, in late adolescence the focus shifts to preventing sexually transmitted infections, or to dealing with possible discomforts related to the sexual sphere. Finally, ensuring young people's genital and sexual health also means protecting their fertility. Written by respected experts in the field, this book constitutes an innovative resource, combining updated, reliable and comprehensive information with agile consultation in order to provide a streamlined approach to the care of children and adolescents with such disorders.

Pediatric Surgery provides an authoritative, up-to-date and comprehensive analysis of current practice in the field. It is divided into three topical volumes, with a total of seven sections focusing on general principles, newborn surgery, general pediatric surgery, tumor surgery, trauma, transplantation, and pediatric urology surgery. Detailed descriptions of surgical techniques and pre- and postoperative management are provided by experts from various parts of the world.The result is an international reference on the surgical management of both common and rare diseases of infants and children that will be an ideal source of information and guidance for pediatric surgeons, pediatric urologists, neonatologists, pediatricians, and all those seeking more detailed information on surgical conditions in children.The three topical volumes are as follows: General Principles and Newborn Surgery General Pediatric Surgery, Tumors, Traumaand Transplantation Pediatric Urology

Children and infants comprise up to 20% of emergency department visits, and emergency physicians must be knowledgeable in choosing the most appropriate imaging modality to arrive at an accurate diagnosis and provide optimal patient care. Written specifically for the non-specialist and those with limited pediatric training, Pediatric Imaging for the Emergency Provider provides expert guidance in this challenging area. Abundant high-quality imaging examples cover the full range of pediatric disorders you're likely to see, including trauma, musculoskeletal, pulmonary, ENT, cardiac, genitourinary, gastroenterology, neurological, and neonatal patients. - Presents more than 80 common and important rare cases, supported with 450+ images across relevant modalities including ultrasound, radiography, CT, and MRI. - Identifies key radiographic findings for various pediatric conditions including congenital heart lesions, surgical entities, infectious disease processes, and traumatic injuries. - Accompanies images with clear, concise text that makes it easy to grasp the most clinically significant points of each case. - Provides expert guidance on best practices in important areas of pediatric imaging such as sedation, ionizing radiation exposure reduction, and imaging modality selection.

This comprehensive book provides detailed practical advice on the diagnosis and surgical management of congenital and acquired conditions in infants and children. Following the great success of the first edition, the new edition has been fully updated to reflect the major developments in the field of the past decade. Advances in prenatal diagnosis, imaging, anaesthesia and intensive care as well as the introduction of new surgical techniques, including minimally invasive surgery and robotic technology that have radically altered surgical conditions are now discussed in the book. In addition new chapters have been added on surgical safety in children, surgical problems of children with disabilities and surgical implications of HIV infection in children among others. This is a superbly structured and richly illustrated guide aimed at trainees, young pediatric surgeons and general surgeons with interest in pediatric surgery. The book also serves as a handy, quick andeasy reference for those making decisions in daily practice. Pediatric Surgery, Diagnosis and Management features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields.

This volume is a “how-to guide” to treating thoracic trauma and emergencies for acute care surgeons. It highlights the diagnosis and management of thoracic disease and injuries, and each chapter includes algorithms that lead readers through the process of identifying and treating many common and some uncommon thoracic pathologies. The international team of authors provides readers with a unique and diverse approach to the operative and non-operative challenges encountered by ACS surgeons. The large number of figures offers readers insights into what they can expect to see when caring for these patients. The editors understand that the management of adults and children differ and have included a specific chapter on pediatrics. Given the broad audience and diverse settings in which the text can be used, the authors also provide details of care in limited-resource environments. The volume is a valuable tool for professionals interested in thoracic surgery and acute care surgery.

This book is a comprehensive and up-to-date compendium on all aspects of sarcomas of bone and soft tissues in childhood and adolescence. After introductory chapters on the history, epidemiology, and biology of pediatric sarcomas, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. The pathology and biology of this diverse group of tumors are extensively reviewed. Promising new treatment approaches are discussed, and strategies for the development of new agents are appraised. The major common pediatric sarcomas, including osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, are covered in detail. The authors are internationally recognized experts who offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of childhood and adolescent sarcomas and will prove invaluable to specialists, generalists, and trainees alike.