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The Handbook of Stress: Neuropsychological Effects on the Brain is an authoritative guide to the effects of stress on brain health, with a collection of articles that reflect the most recent findings in the field. Presents cutting edge findings on the effects of stress on brain health Examines stress influences on brain plasticity across the lifespan, including links to anxiety, PTSD, and clinical depression Features contributions by internationally recognized experts in the field of brain health Serves as an essential reference guide for scholars and advanced students

This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Annual Plant Reviews, Volume 2. This exciting new volume provides an up-to-date survey of the biochemistry and physiology of plant secondary metabolism. The volume commences with an overview of the biochemistry, physiology and function of secondary metabolism, followed by detailed reviews of the major groups of secondary metabolites: alkaloids and betalains, cyanogenic glucosides, glucosinolates and nonprotein amino acids, phenyl propanoids and related phenolics, terpenoids, cardiac glycosides and saponins. A final chapter discusses the evolution of secondary metabolism. This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolism. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 39, Functions and Biotechnology of Plant Secondary Metabolites, Second Edition, Edited by M. Wink, is also available.

Make your way through the epilepsy maze Epilepsy is a complex neurological condition. There are many modern treatment options, and treatment should nowadays be tailored to an individual patient. But identification of the best therapy can be a labyrinthine process. The Handbook of Epilepsy Treatment provides a practical pathfinder for treating epilepsy based on published evidence and the author's 30 years of specialist clinical experience. Direct in style but comprehensive in content, with ample tables and summaries, the Handbook of Epilepsy Treatment covers: Treatment of the different forms and causes of epilepsy Treatment in the different commonly encountered clinical situations Treatment in children, in adults, in the elderly, in women, in epilepsy syndromes and in those with special needs and requirements Epilepsy drugs – their pharmacology, kinetics, side effects, effectiveness and practical usage in the clinic Epilepsy surgery – the various types, the indications, assessment and outcome A succinct pharmacopeia summarizes the entire range of anti-epileptic medications with emphasis on effective prescribing in the clinical setting. The Handbook of Epilepsy Treatment will help you and your patient find the best path to control epilepsy for each individual's situation.

A practical reference to the medical and surgical treatment of epilepsy The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy. It is a definitive source of clinical information to guide clinical practice and rational therapy. Written and edited by leading experts, many actively involved with the International League Against Epilepsy, this new edition: covers the recent advances in the principles and approaches to epilepsy therapy, the introduction of new drugs and the development of new surgical techniques contains 26 completely new chapters and 61 new contributors includes pharmacological properties and prescribing information for all drugs used in the treatment of epilepsy features the important contribution of a new editor Jerome Engel Jr, Professor of Neurology at the University of California School of Medicine in Los Angeles.

'The second edition of the treatment of Epilepsy is a vital contribution to the field. The book's primary focus is on the medical and surgical evaluation and treatment of the disease. Experts around the globe who have made seminal contributions to the treatment of epilepsy have contributed to the book, which preserves its flow and focus extremely well...This book is highly recommended and is a solid reference for anybody who is involved in the evaluation and medical care of patients with epilepsy.'New England Journal of Medicine 352;7 There is a wide variety of different types of epilepsy and seizures and a large array of available treatments suited to differing clinical situations. Consequently, the successful treatment of epilepsy is a complex process involving careful and rational analysis of a large number of variables and is rarely achieved. In recent years, there have been rapid advances both in medical and surgical treatments and and the complexity of treatment has increased still further. There remain important unresolved issues and controversies. Most of the existing large books on the subject either concentrate too much on the biology and phenomenology of epilepsy at the expense of therapy or else fail to balance the medical and surgical treatments available. This book aims to be the definitive textbook on medical and surgical treatment of epilepsy and to act as a clinical reference book with a strong practical bias. It will take the form of a detailed review and distillation of the literature rather than a presentation of individual research and will provide answers to the diversity of questions encountered in day to day clinical practice. In this way, the clinician will be guided through the difficult decision-making processes involved in the successful diagnosis and therapy. After a concise summary of the recent scientific developments in epileptology and discussion of the classification and diagnosis of epilepsy, the large medical will cover in detail the indications, clinical pharmacology, pharmacokinetics, toxicity and outcome of drug treatment. The surgical section will cover indications, patient selection, pre-surgical assessment, surgical technique, anaesthesia, complications and outcome.

Plant secondary metabolites have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. The subject is multi-disciplinary with chemists, biochemists and plant scientists all contributing to our current understanding. In recent years there has been an upsurge in interest from other disciplines, related to the realisation that secondary metabolites are dietary components that may have a considerable impact on human health, and to the development of gene technology that permits modulation of the contents of desirable and undesirable components. Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet addresses this wider interest by covering the main groups of natural products from a chemical and biosynthetic perspective with illustrations of how genetic engineering can be applied to manipulate levels of secondary metabolites of economic value as well as those of potential importance in diet and health. These descriptive chapters are augmented by chapters showing where these products are found in the diet, how they are metabolised and reviewing the evidence for their beneficial bioactivity.