Search

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the'How'in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision'medicine'–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Endoscopic orbital procedures are at the forefront of today's multidisciplinary patient care and team approach to problem-solving. Endoscopic Surgery of the Orbit offers state-of-the-art, expert guidance on minimally invasive orbit techniques that promise a more streamlined approach to comprehensive patient care, improved patient satisfaction, and superior outcomes. This unique resource reflects the contemporary, unparalleled partnership between otolaryngology, neurosurgery, and ophthalmology that often also includes a cohesive team of clinicians from many other specialties. - Provides expert perspectives from thought leaders in various specialties, including otolaryngologists, ophthalmologists, neurosurgeons, endocrinologists, medical and radiation oncologists, radiologists, and pathologists. - Details the two-surgeon, multi-handed surgical techniques that have revolutionized the management of complex pathologies involving the orbit and skull base. - Covers the full breadth of endoscopic orbital procedures—from advanced intraconal tumor removal and intracranial techniques involving the optic nerve and optic chiasm to more routine endoscopic procedures such as orbital decompressions, E-DCR, fracture repair, and subperiosteal abscess drainage. - Reviews key topics such as neuromonitoring in orbital and skull base surgery, endoscopic surgery of the intraconal space for tumor resection, Transorbital NeuroEnodscopic Surgery (TONES), and reconstruction of the orbit. - Includes tips and pearls on safe and effective procedures as well as novel approaches and innovations in the equipment used to perform these popular procedures. - Provides superb visual reinforcement with more than 400 high-definition images of anatomy, imaging, and surgical techniques, as well as procedural videos.

'Venomous'Bites from'Non-Venomous'Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called'rear-fanged snakes'). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided'one-stop shopping'by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of'venom'and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term'venomous.'- Fills a gap in toxicological, medical, and herpetological literature by providing a comprehensive review of this entire assemblage of non–front-fanged snakes, with particular attention given to their capacity to cause harm to humans - Offers a patient-centered, evidence-based approach which is applied to analyzing documented case reports of bites inflicted by a broad representation of species - Provides expanded and updated detailed information on the clinical management of medically significant bites from non–front-fanged snakes, which is also methodically reviewed, and specific recommendations are provided - Includes updates of the fluid taxonomy of advanced snakes and also of terminology with particular regard to the definition of'venom'and the nonmedical criteria used to define the biological basis of the'venomous condition'in snakes and lizards

Meningiomas, Volume 170, Part Two, discusses tumors that arise from the coverings of the brain and spinal cord. In this updated volume of the Handbook of Clinical Neurology, experts in the field - from basic scientists to skilled neurosurgeons, provide up-to-date synopses of each topic as it relates directly to this class of tumor. Surgical and radiation therapy, which remain the mainstays of treatment, are a major focus, but coverage also includes potential molecular avenues for the development of effective medical treatments. This book serves as a comprehensive review of the neurosurgical issues surrounding this extremely common brain tumor. Few procedures in surgery are more immediately formidable than an attack upon a large tumor of this type, hence the greatest challenge of treatment is the need to complete tumor removal without creating new neurologic deficit. Provides current reviews of neurosurgical issues, such as endoscopic surgery, molecular biology of meningiomas, and the role of different radiation oncology treatment modalities and drug therapies Addresses multiple patient populations – children, elderly and those with multiple or radiation-induced tumor Offers a strong focus on anatomy and surgical approaches Edited work featuring leaders in neurosurgery and neuro-oncology around the globe – the broadest, most expert coverage available

Meningiomas, Volume 169, Part One, serves as a comprehensive review of the neurosurgical issues surrounding this extremely common brain tumor. Few procedures in surgery are more immediately formidable than an attack upon a large tumor of this type. In this volume of the Handbook of Clinical Neurology, experts in the field - from basic scientists to skilled neurosurgeons - have provided up-to-date synopses of each topic as it relates to this class of tumor. Surgical and radiation therapy, which remain the mainstays of treatment, are a major focus, but coverage also includes potential molecular avenues for the development of effective medical treatments. - Provides current reviews of neurosurgical issues, such as endoscopic surgery, molecular biology of meningiomas, and the role of different radiation oncology treatment modalities and drug therapies - Addresses multiple patient populations – children, elderly and those with multiple or radiation-induced tumors - Offers a strong focus on anatomy and surgical approaches - Features leaders in neurosurgery and neuro-oncology from around the globe – the broadest, most expert coverage available

This issue on endoscopic cranial base and pituitary surgery is led by experts in the field of Otolaryngology and Neurosurgery. Otolaryngologists/Head and Neck surgeons Dr. Raj Sindwani and Dr. Troy Woodard join with Neurosurgeon Dr. Pablo Recinos to present a comprehensive clinical approach. Topics include: Building an endoscopic skull base program (room setup and key equipment / IGS); Skull Base Anatomy (corridors, intra and extradural); Imaging in skull base surgery – CT, MRI, CT cisternogram, intraop CT; Sellar lesions / pathology; Principles of endoscopic pituitary surgery ; Reconstruction of skull base defects – free graft, pedicle, TPF, alloderm; Lumbar drain utility (role of intrathecal fluorescein); Hemostasis in Skull Base Surgery (control of smaller vessels, maneuvers to minimize bleeding – warm irrigations, HOB up, embolization); Management of ICA Injury (intraop options, late complications); Meningioma; Esthesioneuroblastoma; Cordoma; Sinonasal Malignancies of Skull Base; Craniopharyngioma; Endonasal approaches to the craniocervical junction; Medical complications of Pituitary/skull base surgery – (ie. SIADH, DI, Hypopit); Post-op management of skull base patient (postop Abx, imaging, debridements, topical irrigations, more...). Articles cover surgical procedure, surgical complications, and surgical anatomy as relevant to the clinical discussion.

Because the base of the skull has proven to be one of the most challenging regions of the body to access, treatment options were once limited for patients with tumors or lesions in this area. However, with recent advancements and breakthroughs in treatment, patients with skull base tumors now have an array of surgical options that can help them return to leading a normal and active life. The Endoscopic Endonasal Approach (EEA) is an innovative surgical technique used to remove brain tumors and lesions—some as large as softballs—all through the nose.