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Medications that may produce movement disorders are widely used. The resulting disorders are often highly disconcerting for the patient and their relatives, especially when the connection between medication and disorder is not recognized. However, ascribing an adverse drug effect to medication exposure is often difficult, especially when the side effect is rare. Covering various drugs - including the major classes of medications working primarily on the brain, specifically antipsychotics and antidepressants – this all-encompassing review of medication-induced movement disorders aids early recognition and improved treatment. The problem of what to do when the offending medication cannot be reduced is also reviewed. It discusses the best options for evaluation and treatment, including medical imaging and deep brain stimulation, and guides the clinician in managing the disorder, making this a vital reference for medical specialists and consultants in neurology and neuropharmacology and any clinician seeing patients on medications crossing the blood-brain barrier.

It is often implied that antipsychotic-induced extrapyramidal side-effects are irrelevant to modern psychiatric therapeutics, rendered historic by newer, better treatments. This myth arises from limited awareness of the depth and breadth of neurological disruption antipsychotics can mediate. This volume discusses the extensive clinical boundaries of acute dystonias, drug-induced parkinsonism, akathisia and tardive dyskinesia, providing demographic and epidemiological context while illustrating how prescribing choices impact powerfully on their development. This new edition has been thoroughly updated and rewritten to include recent data, expanded references and a new chapter on the concept of'atypical'antipsychotics. Written in a light, engaging style, liberally illustrated with clinical examples, it also invites readers to consider ongoing controversies - subjective drug effects, the relationship between'akathisia'and restless legs, the status of the concept of'atypicality', and so on. Informative reading for trainees as well as established practitioners in the fields of psychiatry, neurology, primary care and geriatrics.

This Clinical Handbook for the Management of Mood Disorders will equip clinicians with the knowledge to refine their diagnostic skills and implement treatment plans for mood disorders based on the most up-to-date evidence on interventions that work. Covering the widest range of treatments and techniques, it provides clear guidance for the management of all types and subtypes of both minor and major depression. Chapters cover the latest and most innovative treatments, including use of ketamine, deep brain stimulation and transcranial magnetic stimulation, effective integration of pharmacological and psychotherapeutic approaches, as well as providing a thought-provoking look at the future research agenda and the potential for reliable biomarkers. This is the most comprehensive review of depression available today. Written and edited by leading experts mostly from Columbia University, this is an essential resource for anyone involved in the care and treatment of patients with mood disorders.

The ever-improving emergency care of those who have suffered serious cerebrovascular disease has shifted the treatment objective towards helping sufferers regain independence - meaning that there is an increased need to understand, manage and treat the residual deficits. The Behavioral and Cognitive Neurology of Stroke focuses on the diagnosis and management of behavioral and cognitive problems in patients with cerebrovascular disease. Written to be practical for clinical use, the book contains diagnosis and management strategies for all disorders observed in stroke patients, including acute and later problems, and aiming to minimize long-term disability. All important information related to each disorder is summarized in key-point tables. Fully updated throughout and containing five new chapters, this new edition brings the book up to date with the major advances of the last five years. This book will be of value to all clinicians caring for stroke patients, neuroscientists, neuropsychologists, neurorehabilitationists and a wide range of therapists.

Epilepsy is a complex disease which has significant effects on the well-being and quality of life of patients. Obtaining good pharmacological control of seizures is often time-consuming, involving several changes of therapy. Treatment may last for several years. This introductory book covers all aspects of epilepsy, from basic mechanisms of seizures to diagnosis and management, as well as legal and social considerations. Combining a rigorous academic approach with an emphasis on practical issues, the content provides a clear, concise guide which walks the reader through day-to-day clinical decisions. From basic principles, pathology, physiology and neurochemistry to clinical neurophysiology, genetics, neuroimaging, differential diagnosis and treatment, each chapter offers detailed explanations, summary boxes and learning objectives. Recommended treatment plans enable the reader to offer quick and accurate therapy to patients. This is essential reading for neurologists – particularly trainees – and those providing primary care and allied health support for patients with epilepsy.

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Central Nervous System disorders have an enormous impact on individuals and on society as a whole. The development of better treatments is crucial and is a major focus of pharmaceutical and biotechnology companies. This book explains the complicated process of CNS drug development in a way that is engaging for any interested professional or student. Chapters cover each stage of drug development, from pre-clinical research through all phases of clinical trials, to reporting to the regulatory authorities. Other key issues covered include strategic considerations, regulatory constraints, dissemination of results and ethical considerations. The user-friendly format and style enable readers to find important information quickly and easily. Written and edited by experts from different sectors actively engaged in CNS drug development, this is a unique resource for drug developers, investigators, academics and clinicians.

The lifetime risk of developing bipolar II disorder is 5-7%, yet the condition is often poorly detected. Mood elevation states are less extreme than in bipolar I disorder although the depressive episodes are usually severe. When correctly treated, the outcome is positive, but bipolar II is often poorly managed, resulting in a high suicide rate. This is the only academic and clinical management review focusing entirely on bipolar II, scrutinizing history, epidemiology, burden and neurobiology and including an extensive clinical debate by international experts about effective management strategies. New chapters cover comorbidity, over-represented personality styles, illness'trajectories'and distinguishing bipolar II from personality-based emotional dysregulation states. Evidence for different clinical management options is reviewed in detail, two clinical management models are presented and then debated. This book is essential reading for all health professionals managing mood disorders and informative to patients seeking information about their condition and treatment options.

A large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.

Human migration is a global phenomenon and is on the increase. It occurs as a result of'push'factors (asylum, natural disaster), or as a result of'pull'factors (seeking economic or educational improvement). Whatever the cause of the relocation, the outcome requires individuals to adjust to their new surroundings and cope with the stresses involved, and as a result, there is considerable potential for disruption to mental health. This volume explores all aspects of migration, on all scales, and its effect on mental health. It covers migration in the widest sense and does not limit itself to refugee studies. It covers issues specific to the elderly and the young, as well as providing practical tips for clinicians on how to improve their own cultural competence in the work setting. The book will be of interest to all mental health professionals and those involved in establishing health and social policy.

Clinical Obsessive-Compulsive Disorders in Adults and Children is a complete, comprehensive overview of OCD, covering its underlying causes, manifestations and treatment. The book begins by covering the basic science of OCD and its biological basis and mechanisms. It discusses the treatment for both adults and children with an emphasis on providing information for clinicians to use in their everyday practice. Using the latest information regarding evidence-based treatments, it takes the reader through medication options, including behavioural therapy, support groups and recent developments in surgical treatment. The clinical manifestations of OCD are covered, as well as the differentiation between OCD and other neuropsychiatric disorders with similar presentations. Chapters on spectrum illnesses including body dysmorphic disorder, impulse control disorders such as trichotillomania, and hoarding are also included. This book will appeal to all mental health professionals, from practitioners to researchers, working in the field of compulsive disorders.

With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.

Bipolar disorder, or manic depression, is characterised by episodes of pathological mood states. The two poles are mania (with a predominant elated or irritable mood) and depression (with feelings of sadness, anxiety, guilt or hopelessness) but mixed states frequently occur. Episodes can last for many months and profoundly affect physical health, relationships and careers. Since diagnosis and management are difficult, this practical guide provides an overview of the disorder and detailed guidelines for treating the illness throughout its stages, from authors internationally renowned for their work in bipolar disorder. Also discussed are disease theories, mechanisms and key clinical trials, as well as chapters devoted to psychosocial treatments, substance misuse and insights from'lived experience'. In-depth analyses of selected population groups, including youth, the elderly and women, complement guidelines for clinical approaches in managing bipolar disorder. Comprehensive and detailed, this guide will prove invaluable to clinicians, general practitioners, psychiatrists and psychologists.

Inpatient units treat some of the most difficult psychiatric patients. This compact clinical manual is convenient for use on the ward and serves as a standard guide for treatment, addressing the common questions and issues that clinicians face in day-to-day psychiatric work with this challenging patient group. Chapters are organised around the diagnoses found on inpatient psychiatric units, with additional chapters addressing documentation and the care of young adult inpatients. Charts, tables and clinical hints amplify the text, allowing practising clinicians to find the information they need quickly and easily, and enabling students to master the field for board and end-of-clerkship exams. This practical manual is essential reading for practising psychiatrists, psychiatric residents and all psychiatric educators, as well as serving as an accessible reference for physicians in other specialties who consult on the psychiatric ward, psychiatric nurses and medical students.

Drs Eduardo D. Bruera and Russell K. Portenoy have completely revised and updated the widely respected Cancer Pain: Assessment and Management for the second edition of this unanimously praised book. This is a comprehensive, clinically oriented review of all aspects of the complex and multidimensional problem of cancer pain. The unique characteristics of cancer pain, including pathophysiology, clinical assessment, diagnosis, and pharmacological and nonpharmacological management are all discussed here in detail. Internationally recognized leaders in cancer pain research have contributed to many new chapters, including neuraxial analgesia, hospice and institution-based palliative care programs, bone pain, and cancer pain and palliative care in the developing world. Cancer Pain continues to be a scholarly but accessible text that is an essential resource for physicians, nurses, and medical students who treat suffering from cancer pain.

Latent inhibition is a phenomenon by which exposure to an irrelevant stimulus impedes the acquisition or expression of conditioned associations with that stimulus. Latent inhibition, an integral part of the learning process, is observed in many species. This comprehensive collection of studies of latent inhibition, from a variety of disciplines including behavioural/cognitive psychology, neuroscience and genetics, focuses on abnormal latent inhibition effects in schizophrenic patients and schizotypal normals. Amongst other things, the book addresses questions such as, is latent inhibition an acquisition or performance deficit? What is the relationship of latent inhibition to habituation, extinction, and learned irrelevance? Does reduced latent inhibition predict creativity? What are the neural substrates, pharmacology, and genetics of latent inhibition? What do latent inhibition research and theories tell us about schizophrenia? This book provides a single point of reference for neuroscience researchers, graduate students, and professionals, such as psychologists and psychiatrists.

Antipsychotic medications are a key treatment for schizophrenia and sales of antipsychotic drugs approach $20 billion per year, with fierce marketing between the makers of the drugs. The U.S. National Institute of Mental Health sponsored the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project to provide independent information about the comparative effectiveness of medications. CATIE was the largest, longest and most comprehensive study of schizophrenia to date. Conducted under rigorous double-blind conditions, Antipsychotic Trials in Schizophrenia presents the definitive archival results of this landmark study. The core of the book consists of chapters focused on specific outcomes that set the CATIE findings in a wider context. Also included are chapters on the design, statistical analyses and implications for researchers, clinicians and policy makers. Psychiatrists, psychiatric researchers, mental health policy makers and those working in pharmaceutical companies will all find this to be essential reading.

Since its discovery 50 years ago, brain dopamine has been implicated in the control of movement and cognition, and is concerned with diverse brain diseases such as Parkinson's disease, schizophrenia and drug addiction. This book is an illustrated biography of the dopamine molecule, from its synthesis in the brain to its signalling mechanisms and ultimately to its metabolic breakdown. Using colour illustrations of positron emission tomography (PET) scans, each chapter presents a specific stage in the biochemical pathway for dopamine. Writing for researchers and graduate students, Paul Cumming presents a compilation of all that has been learned about dopamine through molecular imaging, a technology which allows the measurement of formerly invisible processes in the living brain. He reviews current technical controversies in the interpretation of dopamine imaging, and presents key results illuminating brain dopamine in illness and health.

• Written specifically with sufferers and carers in mind, to help them understand and apply the basic concepts of cognitive therapy for psychosis. • Illustrates what it is like to have common psychosis and how people's lives can be restored using therapy. • Increases understanding of how the psychosis started, and the factors that worsen symptoms or increase the likelihood of relapse. • Helps the sufferer learn how to control symptoms and delay or prevent relapse. • Includes features and exercises to help sufferers explore their own beliefs and feelings to reflect on the way they cope. • Helps carers know what to say and what to do. • Provides a resource for mental health professionals working with patients, to introduce the approach, support ongoing therapy and make the most efficient use of appointment time.

Psychotic illness is managed and treated with best results when it is recognized at the earliest stages of a person developing the disorder, or when that person is identified as being at high risk of doing so. Describing a stage-specific model highlighting the risk, the clinical and biological factors present during the development of the illness, and the best treatments available for each of these stages, this new edition will guide practitioners and researchers in the adoption of carefully planned management strategies fully integrating treatment with prevention. Issues such as resistance to drugs and vocational recovery are covered, with related topics such as service organization and community education. This will be essential reading for all those involved in the care of people with early psychotic illness, or those responsible for the organization of services.

This is a book of psychiatry at its most practical level. It aims to answer the sorts of questions psychiatrists ask on a daily basis. What treatments are available for the condition that I think this patient has? What is the relative value of each of these treatments? Are there any other treatments that I should be considering if a first approach has failed? Is there any value in combinations of treatment? And, can I be sure that the evidence and recommendations I read are free from bias? The content is organised into three sections covering disease classification, the major treatment modalities and the application of these treatments to the wide range of psychiatric diagnoses. All professionals in mental health want to give the best treatments for their patients. This book provides clinicians with the knowledge and guidance to achieve this aim.

This is a major international textbook for psychiatrists and other professionals working in the field of mental healthcare. With contributions from opinion-leaders from around the globe, this book will appeal to those in training as well as to those further along the career path seeking a comprehensive and up-to-date overview of effective clinical practice backed by research evidence. The book is divided into cohesive sections moving from coverage of the tools and skills of the trade, through descriptions of the major psychiatric disorders and on to consider special topics and issues surrounding service organization. The final important section provides a comprehensive review of treatments covering all of the major modalities. Previously established as the Essentials of Postgraduate Psychiatry, this new and completely revised edition is the only book to provide this depth and breadth of coverage in an accessible, yet authoritative manner.

No one reacts or responds to a drug in exactly the same way, just as no two persons are exactly alike. Individual and ethnic differences in drug response have been consistently found in clinical practice. This book covers all the important factors that explain how and why drug treatments used in psychiatry affect individuals and ethnic groups differently. It will increase understanding of how biological differences interact with social, cultural and environmental factors to bring about overall effects of medications, particularly in individuals from various ethnicities. This book uniquely brings these varied aspects together to consider a holistic approach to drug therapy across diverse biological make-up and cultures. This information has direct practical use in the clinical setting.

Significantly expanded and updated from the first edition, this edition of Psychiatric Intensive Care is essential reading for all healthcare professionals and managers involved in the care of the mentally ill patient, particularly in the intensive care environment. It provides practical and evidence-based advice on the management of disturbed and severely ill psychiatric patients in secure hospital settings. New chapters were added covering multidisciplinary team working, and emphasising the interface of psychiatric intensive care with other mental health specialities; specifically, Interface with General Psychiatry, Interface with Learning Difficulties, Interface with the Child and Adolescent, Interface with Substance Misuse, Interface with Social Work, User and Carer Issues, Legal Issues and National Standards and Good Practice in Psychiatric Intensive Care. This book should be read by all mental health team members working with disturbed psychiatric patients on an inpatient basis, as well as by management staff responsible for establishing and running these services.

Bipolar depression is now known to exist as a spectrum of disorders rather than a single disease entity. Bipolar II Disorder exists on this spectrum as a condition where the depressive episodes are as severe as in Bipolar I Disorder, but where the mood elevation states are not as extreme. This unexpected combination can lead to a failure to detect a condition thought to affect up to 6% of the population. This book reviews, for the first time, our knowledge of this debilitating disorder, covering its history, classification and neurobiology. In a unique section, fourteen internationally recognised experts debate management strategies, building to some consensus, and resulting in treatment guidelines where no such advice currently exists. It should be read by all health professionals managing mood disorders and will be informative to those wishing to learn more about the condition.

Anorexia Nervosa and other eating disorders are arguably the most complex mental health problems that a child or adolescent may experience. Numbers seeking help are on the increase, and the complexity of these disorders challenges even the most experienced clinician. In this 2006 book, the experience of numerous practitioners with international reputations in the field is brought to bear on the broad range of issues a good clinician needs to know about, from the history of the disorder through to treatment, psychopharmacology, the psychotherapies, epidemiology, comorbidities, eating disorders in boys, and neuroimaging. The book is divided into parts detailing the scientific underpinnings, abnormal states, the evidence base for treatments, and finally public health issues, including service delivery models and perspectives on prognosis and outcomes. Clinicians encountering eating disorders will find this latest addition to the Cambridge Child and Adolescent Psychiatry series invaluable.

Many clinicians and researchers are convinced that there is an overlap between affective and schizophrenic spectra. In this book, an international team of experts discuss aspects of comorbidity, genetic models, clinical course, phenomenology and therapies. This is the first comprehensive overview of the schizoaffective spectra. Challenging cases presenting clinical and paraclinical features of both spectra are surprisingly numerous. Not only the phenomenology but also the course, outcome and treatment of such cases have their own characteristics. Recent research shows that the overlap also involves genetics and biological processes related to psychotic disorders. Within the overlap of affective and schizophrenic spectra it is possible to identify some groups of disorders having similar clinical and non-clinical features: the'schizoaffective'group,'Acute and Transient Psychotic Disorder'or'Brief Psychosis', and other groups found in so-called'Atypical Forms'.

The care of stroke patients has changed dramatically. As well as improvements in the emergency care of the condition, there have been marked advances in our understanding, management and rehabilitation of residual deficits. This book is about the care of stroke patients, focusing on behavioural and cognitive problems. It provides a comprehensive review of the field covering the diagnostic value of these conditions, in the acute and later phases, their requirements in terms of treatment and management and the likelihood and significance of long-term disability. This book will appeal to all clinicians involved in the care of stroke patients, as well as to neuropsychologists, other rehabilitation therapists and research scientists investigating the underlying neuroscience.

It is well established that people suffering from schizophrenia have a higher prevalence of serious physical illness and a higher mortality than the general population. This book provides the first comprehensive and systematic review of current research evidence on the prevalence of physical diseases in people with schizophrenia, a disorder afflicting approximately 1% of the global population, and a group with mortality rates twice as high as the general population. The epidemiological data described in this book will provide the basis for improved awareness of these problems and better treatment for patients. This is the first in a series of books addressing an issue emerging as a priority in the mental health field: the timely and proper recognition of physical health problems in people with mental disorders. They should be read by policy makers, service managers, mental health professionals and general practitioners.

Liaison psychiatry, the recognition and management of psychiatric problems in the general medical setting, is an essential component of many doctors'work. Depression, anxiety and somatization disorders occur in about 50% of cases presented to primary care physicians. The Handbook of Liaison Psychiatry was first published in 2007 and is a comprehensive reference book for this fast-growing subspecialty. A team of experts in the field cover the full range of issues, from establishing a service and outlining the commonest problems encountered in general hospitals and primary care, to assessment and treatment guidelines, working with specific units within the hospital setting, disaster planning and legal-ethical considerations. It will be essential reading for doctors and other professionals concerned with the psychological health of patients in acute general hospitals and in primary care.

How can the discoveries made in the biological sciences play a role in a discussion on the foundation of ethics? This book responds to this question by examining how evolutionism can explain and justify the existence of ethical normativity and the emergence of particular moral systems. Written by a team of philosophers and scientists, the essays collected in this volume deal with the limits of evolutionary explanations, the justifications of ethics, and methodological issues concerning evolutionary accounts of ethics, among other topics. They offer deep insights into the origin and purpose of human moral capacities and of moral systems.

Palliative care affirms the value of holistic support for persons facing death from advanced disease. Increasingly the approach of palliative care is seen as relevant not only to terminal cancer (its initial concern) but also to many other incurable conditions. To date, the major emphasis of specialist neurology has been on diagnosis, and the continuing long term management of the many major diseases has received far less attention. This handbook aims to provide succinct and practical advice on the management of major neurological disorders in both their supportive and terminal phases, recognizing that these conditions are increasing in prevalence in virtually every society as the proportion of elderly persons grows. It demonstrates how the discomforts encountered in dementia, stroke, Parkinson's disease, ALS, Huntington's disease, muscular dystrophies and multiple sclerosis can benefit from the same comprehensive approach to palliation as has evolved in specialist care for cancer.

People with serious mental illness no longer spend years of their lives in psychiatric institutions. In developed countries, there has been a major shift in the focus of care from hospitals into the community. However, whilst it means those with mental illness are not confined, it does not guarantee they will be fully integrated into their communities. The barriers to full citizenship are partly due to the disabilities produced by their illnesses and partly by stigmatising and discriminatory attitudes of the public. This book analyses the causes of these barriers and suggests ways of dismantling them. The book is constructed in two parts: the first relates to social inclusion and the second to occupational inclusion. Throughout, the text is annotated with quotes from consumers, to illustrate their experience of the issues discussed. The innovations outlined are described in sufficient detail for the reader to implement them in their own practice.

This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians, psychiatrists and general practitioners.

In full color throughout, this pragmatic guide for prescribing clinicians complements the conceptual approach of the best-selling Essential Psychopharmacology. Covering over 100 psychotropic drugs, each with four or more pages, Stephen Stahl gives all the information a prescribing clinician needs to treat patients effectively. For each drug the information comes in five brief, clear categories: general therapeutics, dosing and use, side effects, special populations, and pearls. Target icons appear next to key categories for each drug so that the prescriber can go easily and instantly to the information needed. There are several indices, one consisting of a comprehensive list of both generic and proprietary names for all the drugs featured, one categorizing the generic drugs by use, and one listing the drugs by class.

This book presents a comprehensive overview of recent advances in evidence-based pharmacological treatment of psychiatric disorders. There have been very significant developments in our understanding of the methods for systematically reviewing literature, assessing clinical trials and optimising decision making. The book explores these issues and applies the lessons learned to the practical management of major psychiatric conditions, addressing issues such as selecting the best first-line psychopharmacological intervention for a particular disorder, how long a particular intervention should be continued, and identifying the next-best treatment strategy should the first agent fail. Conditions covered include, amongst others, depression, schizophrenia, panic, PTSD, OCD, ADHD and eating disorders. The potential for complications as a result of adverse interactions between drugs is also examined. These issues lie at the heart of clinical psychopharmacology and the book will therefore appeal to all practising clinicians, whether in a primary care or a specialist mental health setting.

The field of child and adolescent psychopharmacology is rapidly growing, but psychopharmacological treatments for children cannot be straightforwardly extrapolated from adult studies, which presents clinicians with assessment and prescribing challenges. This important book synthesises research findings about drug treatment of a broad range of psychiatric disorders in children, including attention-deficit hyperactivity disorder, obsessive-compulsive disorder, major depression, schizophrenia, bipolar mania, aggression in pervasive developmental disorder, Tourette's syndrome and substance abuse. They examine the issues of tolerability and efficacy, and appropriate use, within a social and developmental context. For each disorder, pharmacotherapy is discussed in the wider context of neurobiology, etiology, diagnosis and treatment. This will be essential reading for all mental health professionals to inform practice and improve patient outcomes.

Parkinson's disease and parkinsonism are particular problems in the elderly, causing disability and impairing quality of life. This book covers the clinical features, diagnosis and management of Parkinson's disease in elderly people, dealing not only with the motor symptoms but also problems such as depression and autonomic nervous system dysfunction. It particularly stresses the importance of rehabilitation and total patient care. Topics covered include: • Differential diagnosis and epidemiology • Drug-induced parkinsonism and gait apraxia • The drug treatment of elderly patients • Cognitive impairment in elderly patients with Parkinson's disease • The multidisciplinary rehabilitation team Being a comprehensive, practical and enlightened account of Parkinson's disease in the elderly, and drawing on international experts, this book will appeal to clinicians in the various disciplines involved with neurological disease and rehabilitation in elderly people.

Antipsychotic drugs have revolutionised the management of major psychiatric disorders and the outcomes of those who suffer from them. They are, however, possessed of a range of adverse effects, amongst the most frequent and distressing of which are those resulting in disturbance of voluntary motor function. Extrapyramidal side effects - or E.P.S. - are still poorly recognised and not infrequently misattributed. Despite a vast research literature, there have been few attempts to bring together both the descriptive clinical elements of these disorders and major research conclusions pertinent to routine practice. This very readable and well illustrated 1999 book seeks to rectify this in the hope of increasing clinicians'awareness of the issues and acknowledgement of their impact. This is a task made more rather than less urgent with the emergence of drugs of lower liability but which may promote subtler abnormality than standard compounds.