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Intelligent Computing Techniques in Biomedical Imaging provides comprehensive and state-of-the-art applications of Computational Intelligence techniques used in biomedical image analysis for disease detection and diagnosis. The book offers readers a stepwise approach from fundamental to advanced techniques using real-life medical examples and tutorials. The editors have divided the book into five sections, from prerequisites to case studies.Section I presents the prerequisites, where the reader will find fundamental concepts needed for advanced topics covered later in this book. This primarily includes a thorough introduction to Artificial Intelligence, probability theory and statistical learning. The second section covers Computational Intelligence methods for medical image acquisition and pre-processing for biomedical images. In this section, readers will find AI applied to conventional and advanced biomedical imaging modalities such as X-rays, CT scan, MRI, Mammography, Ultrasound, MR Spectroscopy, Positron Emission Tomography (PET), Ultrasound Elastography, Optical Coherence Tomography (OCT), Functional MRI, Hybrid Modalities, as well as pre-processing topics such as medical image enhancement, segmentation, and compression. Section III covers description and representation of medical images. Here the reader will find various categories of features and their relevance in different medical imaging tasks. This section also discusses feature selection techniques based on filter method, wrapper method, embedded method, and more.The fourth section covers Computational Intelligence techniques used for medical image classification, including Artificial Neural Networks, Support Vector Machines, Decision Trees, Nearest Neighbor Classifiers, Random Forest, clustering, extreme learning, Convolution Neural Networks (CNN), and Recurrent Neural Networks. This section also includes a discussion of computer aided diagnosis and performance evaluation in radiology.The final section of Intelligent Computing Techniques in Biomedical Imaging provides readers with a wealth of real-world Case Studies for Computational Intelligence techniques in applications such as neuro-developmental disorders, brain tumor detection, breast cancer detection, bone fracture detection, pulmonary imaging, thyroid disorders, imaging technologies in dentistry, diagnosis of ocular diseases, cardiovascular imaging, and multimodal imaging. - Introduces Fourier theory and signal analysis tailored to applications in optical communications devices and systems - Provides strong theoretical background, making it a ready resource for researchers and advanced students in optical communication and optical signal processing - Starts from basic theory and then develops descriptions of useful applications

Reconstructing Olduvai: The Behavior of Early Humans at David's Site provides the necessary information for future generations of archaeologists to peer into the lifestyle of early humans. Much of what is known about these hominins originates from the detailed excavations that Mary Leakey carried out at Olduvai Gorge in Tanzania. Since then, work at Olduvai has produced a wealth of new fossils, resulting in the discovery of David's Site, the biggest early Pleistocene site in the world. Its exceptional preservation and size make it an invaluable paleoarcheological finding, and this book details the insights discovered therein about the dietary, technological, and social behaviors of hominins. Written by leaders of present-day excavations at Olduvai Gorge, this book is systematically divided into three parts to deliver a clear account of the research advancements at David's Site. Part I focuses on the presentation of the site and the description of its geological and paleoecological reconstruction. Part II examines hominin feeding habits, including how they brought, processed, and consumed animals at the site. Part III explores hominin technologies, including reconstruction of the stone-tool activities carried out at the site. Reconstructing Olduvai offers a much-needed update to the decades-old monographs focused on Olduvai Gorge, Tanzania, by providing novel information on the fossils, sites, technologies, and behaviors of early humans. It is an indispensable resource for students, academics, and researchers who share an interest in the evolution of early human behavior.• Describes the discovery and excavation of David's Site (DS) at Olduvai Gorge, Tanzania •Details the geological and paleoecological reconstruction of all Olduvai Gorge Bed I sites •Summarizes the impact of taphonomic analyses at Bed I sites on our understanding of early human behaviors •Explores the dietary habits and technologies of early Pleistocene hominins

Advances in Food and Nutrition Research, Volume 111 provides the latest on highly timely topics, including Understanding the Heterocyclic Aromatic Amine Research: An Overview and Recent Findings, Recent advances and challenges in the analysis of natural toxins, High Pressure Processing Plus Technologies: Enhancing the Inactivation of Vegetative Microorganisms, A discussion on A1-free milk: nuances and comments beyond implications to the health, Bioactive peptides as a novel strategy to prevent alcoholic liver injury, Hemp seed protein-derived short- and medium-chain peptides and their multifunctional properties, Condensed tannins – their content in plant foods, changes during processing, antioxidant and biological activities, and more. - Contains contributions that have been carefully selected based on the vast experience and expertise of the authors on the subject - Includes updated, in-depth, and critical discussions of available information, giving the reader a unique opportunity to learn - Encompasses a broad view of the topics at hand

Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more. - Includes contributions from a world-renowned editorial board and expert contributors with wide-ranging backgrounds in toxicology - Thoroughly updated with the latest advances in the science - Contains concise and accessible content, providing an authoritative reference resource for non-specialists and readers from undergraduate level upwards, as well as advanced healthcare providers - Covers new topics such as computational toxicology, alternatives to animal testing, pharmaceutical ingredients, artificial intelligence models of toxicological exposure and effects, wildfires and effects of their smoke, vaping, high throughput transcriptomics, and the effect of environmental chemicals on the microbiome

Vitamin D and Health, Volume 109 reviews the versatility of vitamin D in enhancing the immune system and its potential role in combating many chronic diseases. While vitamin D's role in enhancing bone health is well established, recent studies demonstrated the safety and efficacy of peri-operative vitamin D supplementation in cardiac patients and its impact on post-operative outcomes. Chapters in this new release include discussions on Vitamin D and Immune Function, Vitamin D and Bone Heath, Vitamin D and Cardiovascular Disease, Vitamin D and Cancer, Vitamin D and Diabetes, Vitamin D and Neurological Diseases, Vitamin D and Celiac Disease, and much more. - Provides the latest information on the possible mechanisms of action by the active metabolite of vitamin D, 1,25(OH) in immune cells - Covers the beneficial roles of vitamin D in bone health, cardiovascular disease, diabetes, cancers, and celiac disease - Discusses vitamin D's ability to reduce the risk of severity and death from viral diseases such as influenza, COVID-19, and the respiratory syncytial virus (RSV)

Clinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Drug repurposing for viral disease, Drug repurposing for bacterial infections, Drug repurposing for parasitic protozoan diseases, Drug repurposing for fungal infections, Drug repurposing for treating anxiety and depression, Drug repurposing for personalized medicine, Drug repurposing for cancer, Drug Repurposing: A multi targeted approach to treat cardiac disease from existing classical drugs to modern drug discovery, and much more. Additional chapters cover Drug repurposing in MASLD and MASH-cirrhosis: targets and treatment approaches based on pathways analysis, Drug repurposing for respiratory infections, Drug repurposing for rare disease, Drug repurposing for neurological disorders, Drug repurposing for metabolic disorders: scientific, technological and economic issues, Drug repurposing for regenerative medicine and cosmetics: scientific, technological and economic issues, and Exploring Cutting-Edge Omics-Driven Strategies for Drug Repurposing – An Insight into the Tools of the Trade. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Molecular Biology and Translational Science series - Includes the latest information on Clinical Applications of Repurposed Drugs

Childhood Obesity: From Basic Knowledge to Effective Prevention brings together field experts, taking a multifactorial approach to understand the scope and various causes of the issue and offer the latest in treatment and prevention strategies and resources. Beginning with basic concepts and definitions, chapters progress to cover worldwide prevalence and trends, genetic and epigenetic origins, metabolic programming, and neuroendocrine control of appetite and satiety. Further, this book examines social determinants and lifestyle behaviors contributing to risk factors as well as complications associated with childhood obesity. Final chapters discuss multidisciplinary treatment, strategies for prevention, and current worldwide policies aimed to address obesity in children. This fundamental reference is a vital resource for both researchers and practicing clinicians in pediatric medicine. - Provides a comprehensive approach to childhood obesity - Presents a multi-omics description of the early origins of childhood obesity - Includes innovative strategies to treat and prevent obesity in children

COVID-19 Management in the Brain and Body describes the management of patients with the novel coronavirus in their varied symptoms. Detailing this multisystem disease and the variety of organs and tissues affected, this volume features chapters on neurological systems, including brain cancer, brain embolism, and meningoencephalitis. Several systems are addressed, including conditions affecting hematological, hepatobiliary, gastrointestinal, and cardiovascular systems. Telemedicine and are also discussed. This volume is relevant for all clinicians working to ensure the best outcomes and patient care of patients with COVID-19. - Discusses the management of multisystem symptomatology, including the effects of COVID-19 on the neurological, respiratory, hematological, hepatobiliary, gastrointestinal, and cardiovascular systems - Includes select guidelines for clinics providing care for COVID-19 patients - Features individual chapter introductions, and a section on case studies to provide a comprehensive primer for each topic - Contains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

'Value Addition of Fruit Wastes: Extraction, Properties, and Applications provides the latest technologies used in fruit waste to extract, isolate, and characterize functional, active compounds and their diversified pharmacological, food, agricultural, and industrial applications. Divided in 3 sections, the book explores emerging technologies for extraction of functional components, thoroughly discusses value-added components and works as a guide to its applications. The book also covers fruit wastes for extracting starch to provide more cereal crops available as food, besides supporting the efficient utilization of fruit wastes to bring many more opportunities for extraction of functional components in a sustainable manner for food applications. Written by a team of experts in the field, this book provides technicians, researchers, food technology experts, food industry personnel, and academia with value addition to the fruit waste and a lot more opportunities for extraction of functional components in a sustainable manner for food applications. - Covers valorization approaches of fruit waste for starch, protein, fibers, and phenolics - Includes novel green techniques for the extraction of the functional compounds - Brings industrial applications of value-added functional compounds

Therapeutic Drug Monitoring 2nd Edition is an updated reference on TDM analytical techniques in diverse clinical settings. This new edition reviews the exciting new developments in the area, including seven new chapters covering immunoassay design and applications, combined chromatographic techniques in therapeutic monitoring, drug monitoring in alternative specimens, pharmacogenomics of anticancer drugs, pharmacogenomics testing for patient management, selected antifungal agents, pharmacodynamic monitoring, and therapeutic drug monitoring of selected anticoagulants. All remaining chapters in the first edition were thoroughly revised and updated. Therapeutic Drug Monitoring 2nd Edition is the ideal reference for clinical pathologists, pharmacologists, and toxicologists involved with TDM. Scientists working in diagnostic companies, developing reagents for monitoring therapeutic drugs will also find relevant information in this book. - Includes new chapters covering antifungal, anticoagulant, and anticancer drugs monitoring - Discusses limitations of current immunoassays, new and sophisticated chromatographic techniques, the clinical effectiveness of newer antiretroviral agents, anticonvulsants and antidepressants - Provides full coverage of pharmacogenomics and personalized medicine, principles of pharmacokinetics and pharmacodynamics, and the application of biomarkers in TDM

Casein: Structural Properties, Uses, Health Benefits and Nutraceutical Applications investigates casein properties, uses, and applications in food and non-food products, in addition to exploring its health benefits and uses in manufacturing, such as in cheese products, along with an in-depth discussion on the future scope, challenges, and market trends of this protein. Casein: Structural Properties, Uses, Health Benefits and Nutraceutical Applications is an excellent reference for food scientists, dairy researchers, pharmaceutical scientists, students and researchers studying related fields. - Provides comprehensive coverage of casein, the main milk protein that has many applications and uses - Includes suggested reading for further information - Addresses a wide-range of related topics, including non-food applications of casein

Cardio-Hepatology: Connections Between Hepatic and Cardiovascular Disease provides a direct relationship between the cardiac and hepatic pathologies providing the link between the heart and liver and showing how liver diseases predispose to impairment in heart functioning and vice versa. Considering the growing number of patients living (and living longer) with heart failure and/or congenital heart disease, it is important to know when and how to test for liver disease in this population, how to interpret abnormal test results, and what management is appropriate. Coverage includes what should be done for patients to limit, avoid, or postpone the impairment in the liver functioning induced by heart diseases and the impairment in the heart functioning induced by liver diseases, on the basis of scientific-exposed evidence and pathophysiology knowledge. This comprehensive, extended review of the medical literature is perfect for researchers interested in the connection between cardiology and hepatology as well as clinicians making therapeutic decisions for patients suffering from heart or liver chronic diseases. - Reviews and discusses all current knowledge about the interactions between heart and liver pathologies - Provides guidance on current topics surrounding the assessment of the liver in heart failure - Presents important clinical cardiovascular assessments in cirrhotic patients

The Science of Human Milk offers readily understandable, scientifically sound information related to the compositional features of human milk at different stages of lactation. The book also debunks many myths about human milk and provides an analysis of the differences in human milk and baby formulas, offering suggestions for how the latter can be improved. The correlation between human milk composition and infant physiology and metabolism, growth, development, health and disease is explored in detail, placing emphasis on preterm infants. In addition, the dynamic nature of human milk, including its microbes, immunology, metabolites, cell components and epigenetically active molecules are covered. Written for researchers working in nutrition and neonatology, as well as health care professionals working in related fields, this book is sure to be a welcomed reference. - Presents the various compositional aspects of human milk - Explores donor milk banks with particular attention paid to guidelines surrounding their uses - Discusses the sale of human milk on the internet and its safety

••Selected for Doody's Core Titles® 2024 in Nutrition•• Encyclopedia of Human Nutrition, Fourth Edition, a Four Volume Set, provides updated information on the foundations of nutrition science, along with the biology and functions of vitamins and other essential nutrients present in the human diet. The book's content offers a modern understanding of the links between diet and health effects, including diseases of recognized nutritional etiology. This overview of the genetic and molecular aspects of nutrient-health interrelationships includes important content on topics like nutrigenomics, metabolomics and the microbiome. In addition, the book provides global context, particularly on the issue of food production, sustainability and climate change. The new edition carries on the legacy of a reference work that comprehensively offers a one-source, integrated bank of information on all three areas – food, nutrition science and clinical nutrition. - Provides an excellent overview of the field of human nutrition - Includes interdisciplinary chapters written by experts from around the world – chapters written by academics and practitioners from various fields and regions ensure the knowledge within is easily understood by, and applicable to, a large audience - Ideal for scientists in the fields of food science, biology, physiology, agriculture and climate change

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren's syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource. - Gives an introduction on rheumatic diseases, from bench to bedside - Describes diagnostic laboratory tests in rheumatic diseases - Meets the needs of basic scientists, clinicians and translational scientists and industry partners - Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases

Chromatin Remodeling Complexes and Transcriptional Coregulators, Volume 53, the latest release in The Enzymes series highlights new advances in the field, with interesting new chapters that cover Perspectives on Chromatin Remodeling, The functions of ISWI-type remodelers in yeast, Conserved mechanisms of NuRD function in hematopoietic gene expression, The SIN3 complex as a metabolic epigenetic regulator, Soft repression and chromatin modification by conserved transcriptional corepressors, The NPAC-LSD2 complex in nucleosome demethylation, Role of intrinsically disordered domains in transcriptional regulation, and Regulation of the Recovery of Cancer from Therapy Exposure by Noncoding RNAs. - Provides the authority and expertise of leading contributors from an international board of authors - Updated release includes the latest information on Chromatin remodeling complexes and transcriptional coregulators - Presents the latest release in The Enzymes series

Encyclopedia of Condensed Matter Physics, Second Edition, Five Volume Set is an authoritative and comprehensive expansion of the classic 2005 work, delivering over 300 brand new or fully updated articles focused on core theoretical discoveries and modern applications. Meticulously planned and structured into approximately 60 sections, the book allows the user to quickly gain a solid footing in the key theoretical aspects of quantum mechanics, mechanics, electrodynamics, relativity, statistical mechanics and the elementary particles that form the core physics background for the field. The work also presents useful coverage of experimental techniques, materials processing, and materials systems, as well as applied topics. Novel topics, including topology in condensed matter, graphene, integer and fractional quantum Hall effect, and other nanoscale phenomena in optics, in semiconductors, and in superconductors are presented in unusual depth. The encyclopedia solves the problem that students and interdisciplinary researchers often have of finding clear, accessible foundational information to answer their initial questions on a topic. - Presents an authoritative, modern presentation of advances in graphene, topology, quantum effects, optics, semiconductors and superconductors, and many more areas - Meticulously organized into approximately 300 articles and 60 sub-sections, offering a thematically balanced and navigable portrait of an unusually diverse interdisciplinary field - Contains logical and consistent chapter templating and writing styles adopted throughout, including use of next generation pedagogic features

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment. - Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma - Includes overviews to help readers apply information in their research - Encompasses summarizing diagrams and real-world examples to facilitate comprehension and enhance the applicability of the content

••Selected for Doody's Core Titles® 2024 in Clinical Genetics•• Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. - Features chapter contributions from leading international scientists and clinicians - Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more - Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches - Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Atlas of Hybrid Imaging of the Thorax, Abdomen and Pelvis, Volume Two: Sectional Anatomy for PET/CT, PET/MRI and SPECT/CT provides a guide for interpreting PET and SPECT in relation to co-registered CT and/or MRI. In this atlas, exclusively dedicated to thorax, abdomen and pelvis, nuclear physicians and radiologists cover hybrid nuclear medicine based on their own case studies. The practical structure in two-page unit offers readers a navigational tool based on anatomical districts, with labeled and explained low-dose multiplanar CT or MRI views merged with PET fusion imaging on one side and enhanced CT or MRI on the other. This new format enables the rapid identification of hybrid nuclear medicine findings which are now routine at leading medical centers. Each chapter begins with three-dimensional CT and/or MRI views of the evaluated anatomical region, bringing forward sectional tables. Clinical cases, tricks and pitfalls linked to several PET or SPECT radiopharmaceuticals help introduce the reader to peculiar molecular pathways and improve confidence in cross-sectional imaging that is vital for accurate diagnosis and treatments. - Presents a compact, comprehensive, easy-to-read guide on sectional imaging and multiplanar evaluation of hybrid PET and SPECT - Includes more than 200 fully colored, labeled, high quality original images of axial, coronal and sagittal CT, contrast enhanced CT, PET/CT and/or PET/MRI - Displays clinical cases that showcase both common and unusual findings that nuclear physicians and radiologists could encounter in their clinical practice - Provides specific text boxes that explain anatomical variants, radiological advices and physiological findings linked to tracer bio-distribution

Metabolic Syndrome: From Mechanisms to Interventions covers all aspects of this complex and multifactorial disease, providing a cutting-edge understanding of the problem of MetS, with a particular focus on its prevention and clinical management. The book discusses practical implementable approaches to its reversal in clinical practice, encompassing the entire spectrum of MetS, from molecular understanding to clinical therapeutics and prevention. This book is a valuable resource for clinicians in multiple specialties, including endocrinologists, diabetologists, hepatologists, gynecologists and researchers in related fields who need a deep understanding of the full range of scientific and clinical aspects of metabolic syndrome. - Presents a holistic, preventative strategy involving each and every aspect of metabolic syndrome, from pathophysiologic to clinical management - Discusses recent research on the role of inflammation, adipokines and myokines in metabolic syndrome - Includes cutting-edge information on the impact of bariatric surgery and role of gut microbiota in MetS - Provides flowcharts and diagrams to simplify pathophysiologic aspects and their association between risk factors

Clinical Immunology not only introduces the reader to the human immune system, it also covers immunology from clinical manifestation to therapeutic approaches in a wide range of conditions. Each chapter describes an introduction, the clinical manifestations, the immunopathogenesis, diagnosis, lab tests and therapeutic approaches. The book guides clinicians, researchers and students to a better understanding of the matters of immunologic-based diseases that can lead to better decision-making for patients.Because of the growing knowledge regarding the function of immune system in health and disease conditions, clinicians, researchers and students increasingly require an exclusive scientific reference to guide them on matters of immunologic-based diseases. Accordingly, despite the existence of numerous high quality references in basic and cellular/molecular immunology which deeply explain different immunologic mechanisms, there is still a knowledge gap in the field of clinical immunology. - Provides essentials, updates clinical knowledge regarding immune system diseases, and cover different aspects of clinical immunology, from immunopathogenesis and etiology to diagnosis and treatment - Introduces the most advanced approaches and laboratory tests as well as their interpretation in the diagnosis of immune system disorders - Focuses on the practical use of clinical immunology, from bedside to bench and vice versa

Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more. This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest. - Provides a one-stop resource for students and early and experienced researchers on all aspects of quantitative perfusion MRI as written by experts in the field - Explains basic theory and MRI techniques - Presents a strong focus on the practical considerations that can make or break perfusion MRI - Includes applications in oncology, cardiology, neurology and body imaging

A volume in the series on Foundations and Frontiers of Enzymology, Enzymes Beyond Traditional Applications in Dairy Science and Technology presents the applications of enzymes in dairy science and technology. Broken into four sections, this book provides a brief account of traditional applications of indigenous milk enzymes, the actions of exogenous enzymes on milk proteins for generating bioactive peptides and lactose for value addition, and methods and approaches for ensuring milk quality or cleaning milk plants. This book is an excellent resource for postgraduate students, academics, food scientists, and dairy professionals engaged in milk processing. - Provides coverage on in-vitro generation and in-silico prediction of bioactive peptides by action of proteolytic enzymes on major milk proteins and peptides generated during fermentation and cheese manufacturing, and their downstream processing - Presents the enzymatic conversion of lactose into ß-galactooligosaccharides, or tagatose?or producing low lactose milk - Discusses indigenous enzymes in normal and mastitis milk - Covers regulatory policies on enzyme use in food science

Application of Natural Products in SARS-CoV-2 examines the potential for natural products to treat COVID-19, bringing together the most recent research. SARS-CoV-2 is a novel disease H54 that is still being researched despite being globally prevalent. There are still few proven treatments, so repurposing existing drugs and treatments is essential. While there have been many articles published on the subject, this book is the first to bring together data and research on the topic. It includes information about molecular mechanism, dosage and safety profiles, and an essential resource for all scientists and researchers working to combat SARS-CoV-2. - Collates known data and research on COVID-19 and natural products in a single and easy to find place - Includes information about molecular mechanism, dosage and safety profiles - Provides information from a diverse group of academics and industrial scientists

Image Atlas of COVID-19 covers this novel and emerging respiratory infectious disease. Although the gold standard for clinical diagnosis of COVID-19 remains the nucleic acid test for SARS-CoV-2, chest CT scans have been widely used in the diagnosis and treatment of COVID-19 as simple and fast diagnostic methods. The latter has proven crucial when faced with a large volume of symptomatic and asymptomatic patients. The imaging manifestations of COVID-19 have some specific characteristics, hence a better understanding of imaging findings is of great value for detecting lesions, evaluating lesion severity, diagnosis and differential diagnosis, and assessment of therapeutic options and prognosis. - Contains 61 confirmed cases of COVID-19, including a collection of over 400 DR, CT, PET/CT and PET/MRI scans in Henan Provincial People's Hospital (HPPH) - Organized into four chapters by clinical subtypes of COVID-19 - Details a large number of clinical images, with illustrations that are intended to demonstrate imaging findings of COVID-19 to serve as a reference manual for medical staff engaged in imaging and clinical work - Ideal as a training material for academic education

Chitosan: Novel Applications in Food Systems is a practical resource for those looking to understand new applications of chitosan in the food industry. The content presented is written by experts in the field who have worked on the latest application of chitosan-based research to help researchers and scientists understand how recent applications combined with traditional food preservation hurdles, or novel hurdles such as active packaging, irradiation and essential oils can improve methods of controlling microorganisms in foods. With an emphasis of potential of chitosan in food safety this reference briefly summarizes what chitosan-based research has already done for the industry, including potential applications. - Explains the role of chitosan nanoparticles to fight against food pathogens - Provides the latest developments on chitosan and food packaging, especially on active food packaging chitosan film production - Presents chitosan research as a natural antimicrobial to enhance food safety - Includes nutritional aspects of chitosan used in food applications

Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. - Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design - Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application - Features chapter contributions from international experts in the field

Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research. - Examines toxicological risk assessment in drug research - Discusses toxicity mechanisms - Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology - Offers clinical interventions and managed care as a result of toxic injury and acute poisoning

Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsic mechanisms regulate myeloid-derived suppressor cells through cytokine networks, Role of myeloid-derived suppressor cells in head and neck cancer, Role of myeloid-derived suppressor cells in breast cancer, Role of myeloid-derived suppressor cells in endometriosis, Role of myeloid-derived suppressor cells in ovarian cancer, Role of myeloid-derived suppressor cells in sarcoma, and more. - Contains chapters led by selected experts on the topic of myeloid-derived suppressor cells - Includes comprehensive and detailed knowledge on myeloid-derived suppressor cells in different diseases - Offers a wide range of perspectives on specific diseases

Dairy science includes the study of milk and milk-derived food products, examining the biological, chemical, physical, and microbiological aspects of milk itself, as well as the technological (processing) aspects of the transformation of milk into its various consumer products, including beverages, fermented products, concentrated and dried products, butter and ice cream. This encyclopedia includes information on the possible impact of genetic modification of dairy animals, safety concerns of raw milk and raw milk products, peptides in milk, dairy-based allergies, packaging and shelf-life and other topics of importance and interest to those in dairy research and industry. The Encyclopedia of Dairy Sciences, Five Volume Set is the only work available that covers in detail the entirety of dairy science, from husbandry of dairy animals, milk production, through the processing of milk into a myriad of dairy products and ingredients, to the effect of dairy foods on human health. The third edition of Encyclopedia of Dairy Sciences will retain the split that characterized the earlier editions - one-third primary production, two-thirds dairy food. Unlike earlier editions, in which articles were arranged in alphabetical order by topic, this edition will be optimally organized into 9 coherent sections. This new edition contains 500 articles, the vast majority of which has been significantly revised or is completely new. Only 40 chapters have been retained from the earlier edition as they cover basic science areas still relevant and important today. All articles have been reviewed by specialists in their area. - Comprehensive and authoritative introductory articles on all aspects of dairy science from on-farm aspects, to processing, to consumers - Content is written and edited by leading authorities from across the globe making this the go-to foundational reference in the dairy science community - Articles are intuitively and meticulously organized into 9 coherent sections on key topics, making it easier for the reader to access relevant information quickly

Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. - Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models - Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals - Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure - Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity - Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior

Nutritional Management of Renal Disease, Fourth Edition, offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease and serves as an in-depth reference source concerning nutrition and kidney disease. This classic translational reference provides correct diagnosis - and therefore correct treatment - of renal, metabolic, and nutritional disorders. Nephrologists, diebetologists, endocrinologists, dieticians, and nutritionists depend on a strong understanding of the molecular basis for the disease. This fourth edition includes thorough new case reports, offering expert advice on how to use the latest research and clinical findings in counseling patients about dietary and lifestyle options. Readers gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient. - Includes the latest comprehensive KDOQI clinical practice guidelines for the nutritional management of kidney disease from the National Kidney Foundation and the Academy of Nutrition and Dietetics, covering recommendations for each essential nutrient, as well as for some nonessential nutrients - Presents a comprehensive, translational look at all aspects of metabolic and nutritional disorders in one reference - Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to assimilate information and discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease - Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles

Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions. This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). - Covers clinical aspects of autoimmunity and translational immunology studies in autoimmunity in different clinical settings - Meets the needs of basic scientists, clinicians, translational scientists and industry partners - Supported by a systematic appraisal of the most recent evidence

Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. - Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems with a focus on human health effects - Includes information on sources, transport, and the transformation of metals in the environment - Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment, and prevention of 38 metallic elements and their compounds

Advances in Agronomy, Volume 172, the latest release in this leading reference on the topic, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors. - Includes numerous, timely, state-of-the-art reviews on the latest advancements in agronomy - Features distinguished, well recognized authors from around the world - Builds upon this venerable and iconic review series - Covers the extensive variety and breadth of subject matter in the crop and soil sciences

The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors. Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders. - Provides a detailed description of the wide spectrum of clinical disorders emanating from the dysfunction of the'master gland and the fundamental science underlying pituitary dysfunction - Brings together pituitary experts from all areas of research and practice who take readers all the way from bench research to genomic and proteomic analysis, clinical analysis, and new therapeutic approaches - Describes the mechanisms for disease pathogenesis, including both subcellular and extrinsic mechanisms that subserve normal and disordered pituitary hormone secretion and action

With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management. Cholesterol: From Biophysics and Biochemistry to Pathology and Pharmacology empowers researchers, students, and clinicians across various disciplines to advance new cholesterol-based studies, improve clinical management, and drive drug discovery. - Ties basic biology to clinical application and drug discovery - Provides methods and protocols for lab-based cholesterol research and clinical testing - Examines the latest pharmacological discoveries employed to tackle cholesterol related disorders - Includes chapter contributions from a wide range of specialists, uniting various disciplines

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Hematologic, Renal, and Immunologic Disorders, Seventh Edition thoroughly examines medical genetics and genomics as applied to hematologic, immunologic and endocrinologic disorders, with an emphasis on understanding the genetic mechanisms underlying these conditions, diagnostic approaches, and treatment methods. Here, genetic researchers, students and health professionals will find new and fully revised chapters on the genetics of red blood cell diseases, rhesus and other fetomaternal incompatibilities, immunodeficiency disorders, inherited complement deficiencies, celiac disease, and diabetes mellitus, as well as thyroid, parathyroid and gonad disorders, among other conditions. With regular advances in genomic technologies propelling precision medicine into the clinic, this book, which has served as the ultimate resource for clinicians integrating genetics into medical practice, continues to provide the most important information. With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world's most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, this updated edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies. - Fully addresses medical genetics and genomics as applied to hematologic, immunologic and endocrinologic disorders, with an emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches and treatment methods - Provides genetic researchers, students and health professionals with new and updated chapters on the genetic basis of, and treatment pathways for, red blood cell disorders, rhesus and other fetomaternal incompatibilities, immunodeficiency disorders, inherited complement deficiencies, celiac disease, diabetes mellitus, as well as thyroid, parathyroid and gonad disorders, among other conditions - Includes color images supporting identification, concept illustration and method processing - Features contributions by leading international researchers and practitioners of medical genetics - Includes a robust companion website that offers lecture slides, image banks and links to outside resources and articles to help readers stay up-to-date on the latest developments in the field

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. - Summarizes translational research on brain imaging for brain tumors - Discusses limitations of neuroimaging for diagnosis and treatment - Presents advanced imaging technologies, including CT, MRI, and PET - Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more

Metals and Metalloids in Soil-Plant-Water Systems: Phytophysiology and Remediation Techniques examines the impact of metal/metalloid contamination on the plant lifecycle, along with microbes present in soil. Highlighting uptake and translocation, the book also examines antioxidant, photosynthesis and growth characteristics of plants grown in metal contaminated soil. Beginning with an introduction to different sources of soil and water pollution, chapters assess the environmental cytotoxicity pollution impact on plants, as well as how the generation of reactive oxygen and nitrogen species in plant tissues is affected. The book also discusses various soil remediation methodologies, including the potential applications of metal oxidizing microbes and nanomaterials. This is an essential resource for researchers and students interested in plant physiology, soil science, environmental science and agriculture. - Provides a comprehensive overview of metal and metalloids speciation, fractionation, bioavailability and transfer to plants - Analyzes properties of plants grown with excess metals/metalloids in soils - Highlights applications of biochar and other biostimulants for sustainable metal/metalloid remediation

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75% of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15% 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. - Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity - Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target - Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context. - Presents a'one-stop'resource covering the entire scope of modern respiratory medicine - Brings together a truly global collaboration of some of the most authoritative voices in respiratory medicine - Provides chapters that are concise and accessible, with an authoritative introduction for non-specialists, as well as up-to-date, foundational content for those familiar with the field - Includes multimedia-rich content, including hundreds of clear and helpful illustrations that can be used as teaching aids

Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing. - Describes challenges in the diagnosis, management and treatment of autoimmune diseases - Highlights major difficulties in the diagnosis and management of autoimmune diseases - Reflects important remediable deficiencies in current management - Meets the needs of basic scientists, clinicians and translational scientists and industry partners

Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist. Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more. Summarizes the neurologic effects of both cancer and cancer treatment Provides scientific and clinical information relevant to research and treatment Identifies neurological complications by tumor type and tumor therapy Covers GI, lung, breast, gynecological, head and neck cancers, and more Includes radiotherapy, chemotherapy, immunotherapy, and new drugs Contains melanoma, lymphoma, sarcoma, myeloma, leukemia, and more

Bioactive Food Components Activity in Mechanistic Approach presents the role of functional foods and bioactive compounds in inflammation. This book focuses on bioactive compounds, including phenolics, prebiotics, carotenoids, tocopherols, bioactive peptides, probiotics, polyunsaturated and monounsaturated fatty acids, and describes their actions in several diseases, mainly obesity and co-morbidities, inflammatory bowel disease, cognitive decline and cancer, and aging. Intended for food, nutrition, and nutraceutical researchers, as well as those studying related fields, the book offers a mechanistic approach that is currently lacking in the market. - Explores the mechanistic approach of functional foods in health and disease - Contains definitions, case studies, applications, literature reviews, recent developments and text boxes - Provides coverage of phenolic compounds, prebiotics and probiotics, carotenoids, tocopherols, bioactive peptides, polyunsaturated and monounsaturated fatty acids, and sulfur compounds

The current practice of medicine is largely moving toward applying an evidence-based approach. Evidence-based medicine is the integration of best research evidence using systematic reviews of the medical literature and then translating it into practice by selecting treatment options for specific cases based on the best research. Clinicians rely on the availability of evidence and accordingly take decisions to provide best treatment to their patients. Clinical management of neurologically compromised patients is challenging and varied; for this reason, treating physicians including neuroanesthesiologists are always in search of best available evidence for patient management and care. Essentials of Evidence-Based Practice of Neuroanesthesia and Neurocritical Care highlights the various controversies that exist in the practice of neuroanesthesia and provides conclusive evidence-based solutions. This comprehensive resource succinctly discusses evidence-based practice of neuroanesthesia based on systematic reviews in clinical neuroscience research. Topics include neurophysiology: ICP or CPP thresholds; neuropharmacology: intravenous or inhalational anesthetics; and neuromonitoring: ICP monitoring. Evidence-based practice is now an integral part of neuroscience, and this book will help residents and trainees gain knowledge to apply it to their practice. Endorsements/Reviews:'Evidence based practice is facilitating changes at a rapid pace in neuroanesthesia and neurocritical care practice. Its practice is exceedingly crucial in neuroanesthesia and neurocritical care considering the criticality of the neurologically sick patients, which leaves little or no room for error for an acceptable outcome in them. Patient management in Neuroanesthesia and neurocritical care has many contentious issues because of rapidly evolving changes in their management which require treatment guided by the latest available evidence in literature. Dr. Hemanshu Prabhakar is a strong proponent of evidence based practice for the management of neurologically ill patients both for surgical procedures and their management in neurointensive care unit. Undoubtedly, this book will be of enormous benefits to the students as well as teachers of neuroanesthesia and neurocritical care sub-specialties.'-- Parmod Bithal, Editor-In-Chief, Journal of Neuroanaesthesiology and Critical Care (JNACC) - Highlights the various controversies that exist in the practice of neuroanesthesia and provides conclusive evidence-based solutions - Topics include neurophysiology: ICP or CPP thresholds; neuropharmacology: intravenous or inhalational anesthetics; and neuromonitoring: ICP monitoring - Provides residents and trainees with the knowledge to apply evidence-based practice of neuroanesthesia to their practice

Topological Insulator and Related Topics, Volume 108 in the Semiconductors and Semimental series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Majorana modes at the ends of one dimensional topological superconductors, Optical/electronic properties of Weyl semimetals, High magnetic fields to unveil the electronic structure, magnetic field-induced transitions, and unconventional transport properties of topological semimetals, New aspects of strongly correlated superconductivity in the nearly flat-band regime, Anomalous transport properties in topological semimetals, Pseudo-gauge field and piezo-electromagnetic response in topological materials, Topological Gapped States Protected by Spatial Symmetries, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Semiconductors and Semimetals series - Updated release includes the latest information on Topological Insulator and Related Topics

Biologically Active Peptides: From Basic Science to Applications for Human Health stands as a comprehensive resource on bioactive peptide science and applications. With contributions from more than thirty global experts, topics discussed include bioactive peptide science, structure-activity relationships, best practices for their study and production, and their applications. In the interdisciplinary field of bioactive peptides, this book bridges the gap between basic peptide chemistry and human physiology, while reviewing recent advances in peptide analysis and characterization. Methods and technology-driven chapters offer step-by-step guidance in peptide preparation from different source materials, bioactivity assays, analysis and identification of bioactive peptides, encoding bioactive peptides. Later, applications across disease areas and medical specialties are examined in-depth, including the use of bioactive peptides in treating obesity, diabetes, osteoporosis, mental health disorders, food allergies, and joint health, among other disorders, as well as bioactive peptides for sensory enhancement, sports and clinical nutrition, lowering cholesterol, improving cardiovascular health, and driving advances in biotechnology. - Discusses the latest advances in bioactive peptide chemistry, functionality and analysis - Offers step-by-step instruction in applying new technologies for peptide extraction, protection, production and encoding, as well as employing bioactive peptide sequencing and bioactivity assays in new research - Effectively links basic peptide chemistry, human biology and disease - Features chapter contributions from international experts across disciplines and applications

Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven. - Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives - Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response - Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause - Includes case studies and slides