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The field of medicinal/aromatic plant breeding is growing and changing?this resource will help you stay up to date! In this essential book, researchers from large and small laboratories and institutions throughout Europe and the Mediterranean region explore recent developments in the selection and breeding of aromatic and medicinal plants. They take varied approaches?from traditional breeding to the use of molecular markers?and complement them with up-to-date information on biodiversity and resource conservation. From the editors:?It is widely recognized that a strategy of `conservation through use,? by which plant collection via wild harvesting is replaced by controlled cultivation, is the best way forward if we are to balance human demands with the necessary conservation of the biodiversity represented by these species. That provides one major driving force for research in this field. Another concerns the very real need for improving the quality control of products on the market, both to satisfy consumer demand and to conform with the (justifiably) increasing requirements for standardization and precise identification of the composition of the plant materials being sold for human use. We hope that this volume will give readers a taste of the exciting developments in the field.? Breeding Research on Aromatic and Medicinal Plants examines: breeding for resistance and abiotic factors manipulating natural product accumulation through genetic engineering biochemical and molecular regulation of essential oil accumulation economic and legal considerations that breeders will encounter the ethical aspects of breeding these plants

Yeast Sugar Metabolism looks at the biomechanics, genetics, biotechnology and applications of yeast sugar. The yeast Saccharomyces cereisiae has played a central role in the evolution of microbiology biochemistry and genetics, in addition to its use of a technical microbe for the production of alcoholic beverages and leavening of dough.

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer's disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer's disease.Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer's agents Explains the role of phytomolecules and natural products in Alzheimer's therapy Reviews preclinical ways to assess drugs focusing on Alzheimer's disease Covers biomarker analysis for Alzheimer's disease Discusses the onset and progression of Alzheimer's disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

Image-based biomarkers that report on specific cell phenotypes in the body are highly valued for disease detection and monitoring cytotherapies. Towards this need, there is sustained scientific interest in fluorine-19 (19F) magnetic resonance imaging (MRI) for in vivo molecular–cellular imaging applications. The attraction of 19F tracer MRI is its ability to produce pure ‘hot-spot'images, an absence of false-positive signals, robust quantification, and tracer safety. For molecular–cellular applications, fluorine MRI does not require a pre-scan prior to tracer administration, thus offering several advantages over metal–ion-based proton (1H) contrast-agent approaches. Key applications of 19F MRI include cell tracking, inflammation detection, and biosensing. Fluorinated imaging tracers can also serve as therapeutic agents or drug-delivery vehicles. Over the past decade, the field of 19F MRI has seen remarkable innovation in tracer designs and detection methods as well as the realization of its clinical potential.This book is an interdisciplinary compendium detailing cutting-edge science and biomedical research in the emerging field of 19F MRI and includes technical issues, such as pulse sequence considerations and limits of detection of the techniques; synthesis of novel 19F MRI tracer agents; inflammation, cancer, and stroke imaging; regenerative brain repair; theranostic nanomedicine; and clinical perspectives. The book will appeal to investigators involved in MRI physics, biomedicine, immunology, pharmacology, and probe chemistry as well as general readers.

Service organizations are grappling with unprecedented challenges in maintaining and enhancing productivity. As the landscape evolves, traditional approaches to service operations become obsolete, necessitating a deep understanding of the intricate dynamics at play. Innovative Technologies for Increasing Service Productivity delves into this urgent issue, offering a comprehensive exploration of the trends and challenges confronting service industries. The book sheds light on the impact of digital transformation, emerging technologies, and disruptive business models, serving as a guide for navigating the complexities of service productivity in an ever-changing environment. As a groundbreaking solution, this book not only identifies challenges but provides various solutions for service organizations to thrive amidst technological disruption. Its unique selling points lie in the breadth of its coverage, spanning diverse service industries and dissecting the symbiotic relationship between technology and productivity. Offering practical strategies and tools, the book equips service professionals with the means to enhance productivity, quality, and customer experience. By connecting the gap between theoretical insights and practical implementation, it stands as a valuable resource for academics, researchers, and service managers seeking innovative solutions to the evolving landscape of service productivity. The objective of this work extends beyond merely highlighting problems—it contributes substantively to the literature on service productivity. By seamlessly weaving together research findings, case studies, and the best practices from global service industries, the book enriches the collective knowledge base. Moreover, its relevance is underscored by its examination of social, economic, and environmental factors influencing service operations, providing a comprehensive view that is indispensable for policymakers. In essence, Innovative Technologies for Increasing Service Productivity offers a transformative blueprint, empowering stakeholders to navigate and thrive in the era of digital service evolution.

This book contains the proceedings of the Cambridge Unsteady Flow Symposium, held on 4–5 March 2024 at the University of Cambridge. The book brings together internationally leading experts in computational fluid dynamics (CFD) and promotes discussions on numerical methods for unsteady flows. The book covers a wide range of topics related to CFD, including but not limited to, large-eddy simulations, unsteady flows in aerospace, high order methods, and mesh generation.

Offering a novel and interdisciplinary approach, this thought-provoking book critically analyses the notions of fragility and antifragility and addresses their connections and applications in planning theory, urban studies and architecture. It goes beyond the risk and resilience paradigm and proposes methodological and pragmatic strategies to cope with severe forms of uncertainty and socio-spatial inequalities.Showcasing expert contributions from leading scholars, this book illustrates how a specific research focus on fragility and antifragility may elucidate some key value-based facets of contemporary cities and regions in order to foster sustainability, innovation and justice. Chapters examine the theoretical and political dimensions of fragility and antifragility, exploring how these two opposing concepts can reimagine traditional rationality in public action and potentially reframe the methods used by architects, urban planners, and policy makers. Exploring conceptual, methodological and case-based aspects, this incisive book will be of great interest to academics and students within the fields of urban studies, cities and urban geography, architecture, social sciences, philosophy, technology and innovation studies. Its presentation of original accounts of antifragile plans, policies and projects will further benefit policy makers practising within these areas.

The book presents selected materials received as part of the International Scientific Conference “Digital Transformation on Manufacturing, Infrastructure and Service” (DTMIS 2022) and may be of interest to: Undergraduate, graduate students and postgraduate students in the areas of economics, business engineering, enterprise management, sustainable development; University professors teaching courses such as Digital Economy, Energy Economics, Knowledge Economics, Integrated Course Project, Public Administration, Management, and so on; Scientists conducting research in the field of digital transformation of industries, services, and construction, as well as managing complex processes in enterprises within the framework of a dynamic development of the external environment. This book contains a wide range of directions in the economy that are brought together under one trend - digital transformation.

The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

La vicenda di Anfitrione è tra i miti antichi più ripresi in età moderna: valoroso condottiero e sposo felice di Alcmena, l'eroe è vittima di un inganno perpetrato da Giove, che ne assume le sembianze per sedurne la sposa e generare con lei il semidio Ercole. Connesso da un lato all'archetipo del fanciullo divino, figlio di un dio e di una donna mortale, dall'altro al tema del doppio, il mito si è prestato a molteplici riletture. Tra i testi qui proposti – coincidenti con i momenti chiave della lunga storia di Anfitrione – la «tragicommedia» di Plauto si impone come ineludibile punto di partenza: commedia degli equivoci e degli inganni, incentrata sul «furto di identità» (nasce da qui il significato moderno di «sosia»), l'Anfitrione plautino è un esempio di come la cultura antica intendeva il tema del doppio. L'adulterio è invece al centro dell'Amphitryon di Molière, che rilegge il modello antico adattandolo alla realtà e ai gusti del suo tempo: sulle inquietudini del doppio prevale la beffa ai danni del marito tradito. Ancora diverso il testo di Kleist: apparentemente ispirato al fortunatissimo modello molieriano, in realtà se ne distacca radicalmente, sviluppando in modo originale il potenziale tragico della vicenda. Segnata dal conflitto tra apparenza e realtà, la commedia di Kleist appare perciò venata da una sottile amarezza. Infine, l'Amphitryon 38 di Giraudoux, meno noto al pubblico italiano, è forse la più brillante tra le varie riprese del mito nel Novecento: commedia degli equivoci lieve e ricca di humour, pone in primo piano il tema della coppia che miracolosamente resiste alle insidie del destino ed esalta il personaggio di Alcmena come donna padrona di se stessa e capace di gestire la propria vita.

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. - Provides up-to-date information on current molecular biomarkers research for cancer - Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient's survivorship - Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas

Come possono i personaggi imporsi di vivere dentro una scelta di una mortificazione perenne? Come può un uomo costringersi in un distacco dal mondo delle passioni e dei desideri, rifiutati in blocco come realtà assolutamente negative? Nel panorama di un mondo inteso come il campo da gioco di un destino ineluttabile e amaramente tragico, i romanzi di Deledda pongono subito un problema profondamente morale. Il peso della colpa infrange nell'io qualsiasi tentativo di vita esteriore e sociale, portandolo a una vertiginosa parabola finale aperta tra due possibilità: la tragica e presentita esperienza del nulla e la flebile luce drammatica del perdono. Assistiamo a una dimensione eminentemente deleddiana di sentire la vita e le sue urgenze, derivata di filato da un certo sentimento religioso, inteso lato sensu come rapporto col mistero e col destino. La scrittrice ci ricorda che il male esiste, così come esiste il peccato. La sua forza anti-ideologica novecentesca ci ribolle tra le mani, nella libertà tragica che lei dipinge. Una Deledda estrema che ci trascina in un misto di fascino e repulsione sino alle domande ultime dell'uomo.

This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes.The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians.

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

Dairy science includes the study of milk and milk-derived food products, examining the biological, chemical, physical, and microbiological aspects of milk itself, as well as the technological (processing) aspects of the transformation of milk into its various consumer products, including beverages, fermented products, concentrated and dried products, butter and ice cream. This encyclopedia includes information on the possible impact of genetic modification of dairy animals, safety concerns of raw milk and raw milk products, peptides in milk, dairy-based allergies, packaging and shelf-life and other topics of importance and interest to those in dairy research and industry. The Encyclopedia of Dairy Sciences, Five Volume Set is the only work available that covers in detail the entirety of dairy science, from husbandry of dairy animals, milk production, through the processing of milk into a myriad of dairy products and ingredients, to the effect of dairy foods on human health. The third edition of Encyclopedia of Dairy Sciences will retain the split that characterized the earlier editions - one-third primary production, two-thirds dairy food. Unlike earlier editions, in which articles were arranged in alphabetical order by topic, this edition will be optimally organized into 9 coherent sections. This new edition contains 500 articles, the vast majority of which has been significantly revised or is completely new. Only 40 chapters have been retained from the earlier edition as they cover basic science areas still relevant and important today. All articles have been reviewed by specialists in their area. - Comprehensive and authoritative introductory articles on all aspects of dairy science from on-farm aspects, to processing, to consumers - Content is written and edited by leading authorities from across the globe making this the go-to foundational reference in the dairy science community - Articles are intuitively and meticulously organized into 9 coherent sections on key topics, making it easier for the reader to access relevant information quickly

Advances in Biomolecular EPR, Volume 666 in the Methods of Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Magnetic Resonance Characterization of Physiologically Important Metal Ion Binding Sites in the Prion and Related Proteins, The catalytic role of metal-radical/protein-based radicals in heme enzymes, Rigid Cu2+-based spin labels for the study of higher-order DNA G-quadruplex structures, Orthogonal spin labeling and membrane proteins: increasing the information content and going towards in cell applications, Spectroscopic investigation of mono- and di-Mn-containing centers in biochemistry with an emphasis on application of paramagnetic resonance techniques, and more. Additional chapters cover In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance, an Update, EPR contributions to understanding molybdenum-containing enzymes, EPR spectroscopy of Type I reaction centers, Characterization of a substrate-derived radical in the NosN reaction during the biosynthesis of nosiheptide, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Includes the latest information on Advances in Biomolecular EPR

Improving Sustainable Practices in Viticulture and Enology provides an up-to-date view on the major issues concerning the sustainability of the wine supply chain. The book describes problems and solutions on the use of inputs (e.g., water, energy) and emphasizes the roles and limitations of implementing circularity in the sector. It identifies some of the most relevant metrics while pinpointing the most critical issues concerning the environmental impacts of wine's supply chain (vineyards, wineries, trading). This is a novel reference to help the industry excel in production while improving current environmental practices. Professionals in industry, academics, environmentalists and anyone interested in gaining knowledge in sustainable solutions and practices in viticulture and wine production will find this resource indispensable. - Suggests and discusses solutions to overcome challenges imposed by adverse climate conditions - Presents innovative technologies that have an impact on the efficiency of resources and recycling - Includes technological tools for more precise monitoring and management in the wine supply chain

Tuberculosis is an important concern in numerous countries across the globe. Training is usually focused on pulmonary tuberculosis, and the nuances of diagnosis and management of extrapulmonary tuberculosis, including abdominal tuberculosis, are not usually emphasized. This book details the varied presentations and mimics of tubercular involvement of the abdomen and the gastrointestinal system..The book provides clear guidance to the clinicians to diagnosis and manage the varied forms of abdominal tuberculosis. The chapters also touch on areas of controversy and confusion. Chapters are focused on each of the sites (intestinal, peritoneal, gastroduodenal, hepatobiliary, and pancreatic), modalities for evaluation (histology, microbiology, radiology, endoscopic ultrasound, nuclear medicine), differential diagnosis, and follow-up including response to treatment. Separate chapters have also been devoted to pediatric abdominal TB, therapy-related hepatitis, and considerations in immunocompromised states such as HIV. Therefore, this book will help practice clinicians and serve as a one-stop resource for graduate students in internal medicine and fellows training in gastroenterology.