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This book provides recent advances in the understanding of the central processes in the resolution of inflammation. It also describes the active, specialized pathways that bring the resolution of inflammation. Further, the book examines the key molecular and cellular events that are involved in the resolution of inflammation processes involved in tissue repair and regain of physiological function. Importantly, it sheds light on the cellular and molecular processes through which conventional inflammatory cytokines control mammalian tissue repair and regeneration. It also explores the perturbation of processes that are involved in the resolution of inflammation with aging and reviews clinical trials of anti-inflammatory and immunomodulatory therapies. Towards the end, the book discusses the role of inflammation in the development and progression of cancer. This book is an invaluable resource for scientists, academicians, and research scholars interested in the latest cutting-edge knowledge in the field of immunology, inflammation, inflammation resolution, and inflammatory diseases. ​

In this ground-breaking debut, Charli Clement combines their own experiences alongside unique short profiles from individuals with chronic illness, to provide an intimate and insightful look at the complexities of living as an autistic and chronically ill person. From navigating your diagnosis and healthcare, learning how to manage pain and your own sensory needs to dealing with ableism, medical misogyny and transphobia, Clement offers practical advice and delves into the unique challenges faced by individuals living in this intersection.With a focus on the unique neurodivergent experience and an exploration into disability pride and joy'All Tangled Up in Autism and Chronic Illness'is a necessary and empowering resource for autistic and chronically ill people as well as for family members, friends, and healthcare professionals.

This book describes what it is like to embody chaos and liminality in living with a physical chronic illness and how these experiences are related to the loss and remaking of one's sense of self. It also encourages readers to listen closely to the figurative language people use in trying to articulate the unspeakable. Focusing upon a wide array of narrative fragments gathered from first-person literary work and research, the author portrays how a conglomerate.

Advances in modern medicine have altered how patients experience chronic illness and end-of-life care, and the quality of life of both patients and their loved ones has frequently been questioned. Palliative care programs are specifically designed to help patients cope more effectively with serious conditions while prioritizing quality of life. This text describes occupational therapy's distinct purpose in chronic condition management, palliative care, and hospice, and provides a guide for thoughtful, patient-centered service delivery.

The second edition of this popular textbook provides a comprehensive overview to chronic illness care, which is the coordinated, comprehensive and sustained response to chronic diseases and conditions by health care providers, formal and informal caregivers, healthcare systems, and community-based resources. This unique resource uses an ecological framework to frame chronic illness care at multiple levels, and includes sections on individual influences, the role of family and community networks, social and environmental determinants, and health policy. The book also orients how chronic care is provided across the spectrum of health care settings, from home to clinic, from the emergency department to the hospital and from hospitals to residential care facilities. The fully revised and expanded edition of Chronic Illness Care describes the operational frameworks and strategies that are needed to meet the care needsof chronically ill patients, including behavioral health, care management, transitions of care, and health information technology. It also addresses the changing workforce needs in health care and the fiscal models and policies that are associated with chronic care. Several new chapters are included in the second edition and reflect the significant changes that have occurred in health care due to the COVID-19 pandemic. Chapters covering vaccinations, virtual care, and care of COVID-19 associated chronic conditions have been added. The revised textbook builds on the first edition's content that covered providing care to special population groups, such as children and adolescents, older adults, and adults with intellectual and developmental disabilities, by including care approaches to adults with severe and persistent mental health disorders, the LGBTQ+ community, incarcerated persons, immigrants and refugees, and military veterans. Finally, chapters on important and emerging topics, such as natural language processing and health inequities and structural racism have also been added.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) – what they are, their burden, their determinants and how they can be prevented and controlled.Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action.Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

This book contributes to the emerging field of men's health studies, delving into how men incorporate, adapt, negotiate, or reject health care practices to perform masculinities in social interactions. By moving beyond the simplistic association between men, masculinity and the adoption of ‘risky'or ‘unhealthy'practices, this book draws from recent critical perspectives on the study of men's health, seeking to challenge and problematize the relationship between masculinities and health. The text presents original empirical findings derived from qualitative and digital research examining the different ways in which men (re)negotiate their masculinities after the onset of a chronic illness, focusing on diabetes as a strategic case study. Living with a chronic illness implies that those gender practices that are usually taken for granted suddenly become unachievable and impose a reconfiguration of the masculine self, as well as a negotiation of the very meaning of masculinity. The volume aims to critically examine this interactive process of (re)negotiation, while also reflecting on men, masculinities and their health on a more general level. This book serves as a valuable resource for students and scholars in social sciences working on the intersection of gender and health, as well as for health professionals seeking a deeper understanding of the connection between men, gender and health.

This fourth edition brings together a diverse range of experts in nutrition-related areas to discuss recent thinking and discoveries in nutrition, especially in relation to topics that have the greatest capacity to improve human health and nutritional implementation. An overview of nutrition science in the third decade of the twenty-first century reveals that much water has flown under the bridge of the advancing river that is nutrition research and practice. With these large accumulations of developments in the field of nutrition, the need for a new edition of this book is obvious. Our vastly improved nutrition knowledge gives us the capability of preventing a sizable fraction of the chronic diseases that afflict the people of our world, but only if these discoveries can be translated into effective action at the population level. Nutritional Health endeavours to address the needs of those who would most benefit from up-to-date information on key areas in the field of nutrition.The book starts with a discussion of the nature of nutritional research then moves into an overview of the most important aspects of the complex interactions between diet, its nutrient components, and their impacts on disease states, and on those health conditions that increase the risk of chronic diseases. Parts three and four discuss diet and include new chapters on the Mediterranean diet, the DASH diet, the flexitarian diet, and the low-carbohydrate diet. The final two parts of the book discuss emerging trends in nutrition science, such as gut microbiome and sustainable diet, and areas of controversy in nutrition, such as the influence of the food industry and dietary supplements. Up to date and comprehensive, Nutritional Health: Strategies for Disease Prevention, Fourth Edition offers physicians, dietitians, and nutritionists a practical, data-driven, integrated resource to help evaluate the critical role of nutrition.

60%-80% of all outpatients worldwide have a chronic disease, and this fact demonstrates that an essential part of primary care practice will be the prevention, treatment, and rehabilitation of chronic illnesses. The medical literature, which states that the cost, mortality, and morbidity rates will decrease when the healthcare service is improved, has led to writing this comprehensive and up-to-date book. In addition to the sections where you can find detailed information about each stage of chronic disease follow-up, the book includes up-to-date information accompanied by guidelines and ways to be followed in clinical practice, including primary prevention.

Chronic kidney disease (CKD) is a major global public health problem, affecting nearly one in seven adults in the United States alone. It is a disease that integrates chronic illness at several levels, and the progressive condition is associated with high rates of co-morbidity. This text provides a comprehensive, current state-of-the art review of this field, serving as a valuable resource for primary care providers and non-nephrology clinicians that treat patients with CKD. It is comprised of 24 chapters focused on specific aspects of the disease. The first 2 chapters provide a bit of background on the disease, describing the anatomy and physiology of the kidney as well as the definition and epidemiology of the disease. The following 3 chapters discuss the detection, prevention and progression of the disease. The next 6 chapters describe the relationship of the disease with other conditions and most common co-morbidities such as diabetes and hypertension. The chapters, that follow focus on the CKD associated complications and the CKD within special populations such as the elderly and minorities as well as dietary restrictions and drug dosing. The book concludes with discussion on preparation for renal replacement therapy and preemptive organ transplantation as an alternative to dialysis in the management of the advanced CKD. Written by experts in the field, Approach to Chronic Kidney Disease is a comprehensive guide for clinicians, especially primary care providers including residents and fellows in training, who take care of chronic kidney disease patients. It is also a useful tool for researchers dealing with this challenging field.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety.Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses'What-Why-When-How'highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the EditorsJoy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies.Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

A NEW YORK TIMES BESTSELLERFINALIST FOR THE 2022 NATIONAL BOOK AWARD FOR NONFICTIONNamed one of the BEST BOOKS OF 2022 by NPR, The New Yorker, Time, and Vogue“Remarkable.” –Andrew Solomon, The New York Times Book Review'At once a rigorous work of scholarship and a radical act of empathy.”—Esquire'A ray of light into those isolated cocoons of darkness that, at one time or another, may afflict us all.” —The Wall Street Journal'Essential.'—The Boston GlobeA landmark exploration of one of the most consequential and mysterious issues of our time: the rise of chronic illness and autoimmune diseasesA silent epidemic of chronic illnesses afflicts tens of millions of Americans: these are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O'Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier. Drawing on her own medical experiences as well as a decade of interviews with doctors, patients, researchers, and public health experts, O'Rourke traces the history of Western definitions of illness, and reveals how inherited ideas of cause, diagnosis, and treatment have led us to ignore a host of hard-to-understand medical conditions, ones that resist easy description or simple cures. And as America faces this health crisis of extraordinary proportions, the populations most likely to be neglected by our institutions include women, the working class, and people of color. Blending lyricism and erudition, candor and empathy, O'Rourke brings together her deep and disparate talents and roles as critic, journalist, poet, teacher, and patient, synthesizing the personal and universal into one monumental project arguing for a seismic shift in our approach to disease. The Invisible Kingdom offers hope for the sick, solace and insight for their loved ones, and a radical new understanding of our bodies and our health.