Search

Con il catalogo I libretti italiani a stampa dalle origini al 1800, pubblicata dal 1990 al 1994 da Bertola & Locatelli a Cuneo, Claudio Sartori ha donato alla ricerca sulla storia dell'opera e dell'oratorio una base completamente nuova. Rispondendo alle richieste degli studiosi di rendere nuovamente disponibile questo opus magnum, Don Juan Archiv Wien e Hollitzer Verlag pubblicano una ristampa e un'edizione e-book, con un ritratto dell'autore e della sua opera realizzato da Federica Riva. With his catalogue I libretti italiani a stampa dalle origini al 1800, published by Bertola & Locatelli in Cuneo between 1990 and 1994, Claudio Sartori laid a completely new foundation for the research of the history of operas and oratorios. Responding to the requests of scholars to make this opus magnum available again Don Juan Archiv Wien and Hollitzer Verlag publish a reprint and an e-book edition, including a portrait of the author and his work by Federica Riva.

Con il catalogo I libretti italiani a stampa dalle origini al 1800, pubblicata dal 1990 al 1994 da Bertola & Locatelli a Cuneo, Claudio Sartori ha donato alla ricerca sulla storia dell'opera e dell'oratorio una base completamente nuova. Rispondendo alle richieste degli studiosi di rendere nuovamente disponibile questo opus magnum, Don Juan Archiv Wien e Hollitzer Verlag pubblicano una ristampa e un'edizione e-book, con un ritratto dell'autore e della sua opera realizzato da Federica Riva. With his catalogue I libretti italiani a stampa dalle origini al 1800, published by Bertola & Locatelli in Cuneo between 1990 and 1994, Claudio Sartori laid a completely new foundation for the research of the history of operas and oratorios. Responding to the requests of scholars to make this opus magnum available again Don Juan Archiv Wien and Hollitzer Verlag publish a reprint and an e-book edition, including a portrait of the author and his work by Federica Riva.

Auf der Grundlage des neuen Kirchenverständnisses des Papsttums entwarfen die Inquisitoren des 13. Jahrhunderts eine Kultur rigider Alternativentscheidungen über religiöse Zugehörigkeit, die Laien keinen Raum zwischen Ketzerei und Orthodoxie mehr ließen. Doch die italienische Bevölkerung reagierte mit Widerstand und teils mit offener Kritik auf mehreren Ebenen: Einerseits protestierte sie gegen die Kriminalisierung ihrer Entscheidungen für verschiedene religiöse Optionen. Andererseits wehrten sich auch die Kommunen. Da die Inquisition so eine Praxis des Entscheidens schuf, die bereits etablierte Strukturen massiv unter Druck setzte, wurden Diskursivierungen der Einbettung von Recht und Religion erzwungen und so weiterwirkende Dynamiken eingeleitet.

Neurotransmitters are usually considered to be endogenous substances that are released from neurons, act on receptor sites that are typically present on membranes of postsynaptic cells and produce a functional change in the properties of the target cell. They are essential features of the nervous systems of all animals, and numerous chemicals can act as neurotransmitters either intentionally (e.g. pesticides) or unintentionally (neurotoxins). The most common forms of neurotoxicity are the death of neurons, degeneration of axons, damage to glial cells and interference with the axonal membrane or neurotransmission. Important neurotoxins are found among pesticides, metals, solvents, natural substances, and industrial chemicals. Environmental chemicals may also contribute to the pathology of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Neurotransmitters and Toxicology will be particularly appealing to toxicologists interested in neurotoxicology in various sub-disciplines, as well as neuro-chemists interested in pathology and disease mechanisms associated with neurotoxicants.

Exploring Ethical Dimensions of Environmental Sustainability and Use of AI is a comprehensive and insightful book that delves into the ethical implications and challenges that emerge at the intersection of environmental sustainability and the utilization of artificial intelligence (AI). With a focus on key ethical dimensions such as transparency, equity, privacy, autonomy, unintended consequences, and trade-offs, this book aims to provide a thorough understanding of the responsible deployment and development of AI in the realm of environmental sustainability. By addressing the ethical aspects and challenges involved, this book contributes to the development of ethical guidelines and frameworks that align AI technologies with the vision of a sustainable and equitable future. Researchers will find immense value in this book as it offers a holistic exploration of the ethical implications, filling a critical gap in the existing literature. Policymakers can gain valuable insights to inform the creation of ethical guidelines and regulations governing AI use in sustainable initiatives. Practitioners, including professionals working in environmental organizations or technology companies, will acquire practical knowledge to guide their decision-making and implementation of AI-driven solutions. The book covers various topics ranging from AI applications in conservation and sustainable resource management to climate change mitigation, responsible AI development, ethical challenges in environmental monitoring, AI in sustainable agriculture, energy solutions, waste management, biodiversity conservation, AI-enabled smart cities, water management, human-AI collaboration, AI ethics governance, and the future of AI and environmental sustainability.

Explore and advance bioinformatics and systems biology tools for crop breeding programs in this practical resource for researchers Plant biology and crop breeding have produced an immense amount of data in recent years, from genomics to interactome and beyond. Bioinformatics tools, which aim at analyzing the vast quantities of data produced by biological research and processes, have developed at a rapid pace to meet the challenges of this vast data trove. The resulting field of bioinformatics and systems biology is producing increasingly rich and transformative research. Bioinformatics for Plant Research and Crop Breeding offers an overview of this field, its recent advances, and its wider applications. Drawing on a range of analytical and data-science tools, its foundation on an in-silico platform acquired multi-omics makes it indispensable for scientists and researchers alike. It promises to become ever more relevant as new techniques for generating and organizing data continue to transform the field. Bioinformatics for Plant Research and Crop Breeding readers will also find: A focus on emerging trends in plant science, sustainable agriculture, and global food security Detailed discussion of topics including plant diversity, plant stresses, nanotechnology in agriculture, and many othersApplications incorporating artificial intelligence, machine learning, deep learning and more Bioinformatics for Plant Research and Crop Breeding is ideal for researchers and scientists interested in the potential of OMICs, and bioinformatic tools to aid and develop crop improvement programs.

Nationalism, Religious Violence, and Hate Speech in Nineteenth-Century Western Europe critically analyses the role played by different memories of past religious violence in public debates in nineteenth-century Europe.Looking back, European societies often did not seek to overcome their differences and create a framework of peaceful coexistence among various religions and denominations, but rather, more frequently, to fuel intra- and inter-religious hatred. Moreover, various violent pasts were mobilised to define what and who was intolerant, in order to mark the'other'as intolerant and therefore incompatible with societal values. To examine conflicting memories of violence and hatred, this book focuses on commemorations, statues, publications, and public polemics surrounding past religious violence. Three elements serve as a framework to explain the conflictive nature of these memories of intolerance: the age of commemorations, the culture wars, and the second confessional age. The authors explore cases in France, Germany, Italy, Spain, Switzerland, the United Kingdom, and the Low Countries, covering Catholicism, Protestantism, Anglicanism, Islam, and Judaism. The book focuses on iconic victims such as Giordano Bruno and Michael Servetus, collective massacres, and discourses surrounding religious hatred in events such as the Crusades. The cases of religious violence remembered in the nineteenth century span the Middle Ages and the intense period of religious violence known as the confessional age.This book will appeal to students and scholars of politics, religious tolerance and freedom, hate speech, nationalism, religious history, and European history.

Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. - Provides a current, expansive, and well-documented resource on chromatin and epigenetics - Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease - Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward

This book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix “epi” (meaning “upon,” “above,” or “beyond”) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 μm. This protein-DNA complex is known as chromatin. The content of this book is linked to the “Molecular Medicine and Genetics” course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks “Mechanisms of Gene Regulation” and “Human Epigenomics.” It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms.

The Cell Biology textbook covers the fundamental principles and concepts of cellular biology. The book explores the structure, function, and organization of cells, as well as the mechanisms of cell division, differentiation, and communication. It also covers the molecular biology of cells, including DNA replication, transcription, and translation. This book is an invaluable resource for understanding the complexities of cellular biology.

Body contouring surgeries are pretty common among plastic surgeons and the Brazilian Plastic Surgery is one of the most recognized in terms of innovations. This book proposes a new approach for treatment of all body abnormalities in order to achieve aesthetic improvement. Written by Brazilian expert contributors, it addresses all body segments related to body contouring, such as breast, abdomen, dorsum, buttocks, lower and upper limbs, and also body lifting techniques after large weight loss. Associated surgeries, new invasive and non-invasive techniques and technologies such as: robotics, lasers, ultrasound, among others will be carefully described in 59 chapters. The work will also discuss the behavior of lipografting to improve body contouring as well as the importance of isolated medial tight lifting. Body contouring - Current Concepts and Best Practices is richly illustrated by images and will be a reference book for plastic surgeons worldwide.

This 4th edition of Handbook of Solvents, Volume 2, contains the most comprehensive information ever published on solvents as well as an extensive analysis of the principles of solvent selection and use. The book begins with a discussion of solvents used in over 30 industries which are the main consumers of solvents. The analysis is conducted based on the available data and contains information on the types (and frequently amounts) of solvents used and potential problems and solutions. Picking up where Handbook of Solvents, Volume 1 leaves off, Handbook of Solvents Volume 2 provides information on the methods of analysis of solvents and materials containing solvents, with 2 sections containing standard and special methods of solvent analysis, followed by a discussion of residual solvents left in the final products. The environmental impact of solvents, such as their fate and movement in the water, soil, and air, fate-based management of solvent-containing wastes, and ecotoxicological effects are discussed as are solvents'impact on tropospheric air pollution. The next 2 chapters are devoted to the toxicology of solvents and regulations aiming to keep solvent toxicity under control. The analysis of the concentration of solvents in more than 15 industries, specific issues related to the paint industry, and characteristics of the environment in automotive collision repair shops are followed by a thorough discussion of regulations in the USA and Europe. Following chapters show examples of solvent substitution by safer materials, with an emphasis on supercritical solvents, ionic liquids, deep eutectic solvents, and agriculture-based products, such as ethyl lactate. Discussion of solvent recycling, removal, and degradation includes absorptive solvent recovery, comparison of results of recovery and incineration, and application of solar photocatalytic oxidation. The book concludes with an evaluation of methods of natural attenuation of various solvents in soils and modern methods of cleaning contaminated soils. - Assists in solvent selection by providing key information and insight on environmental and safety issues - Provides essential best practice guidance for human health consideration - Discusses the latest advances and trends in solvent technology, including modern methods of cleaning contaminated soils, selection of gloves, suits, and respirators

This book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease.

Tauchen Sie ein in die Welt der Epigenetik, die Ihnen erklärt, wie Sie Ihre Gesundheit fördern und das Beste aus sich selbst herausholen können. Zunächst führt Sie das Werk in die molekularen Grundlagen ein, wie jede einzelne Zelle funktioniert und Information über ihre Umgebung verarbeitet. Letzteres hat sehr viel mit Epigenetik zu tun, die ein zentrales Thema in diesem Buch ist. Die Epigenetik, die für die Identität der mehr als 400 verschiedenen Zelltypen unseres Körpers entscheidend ist, hat auch einen dynamischen Aspekt. Sie lernen, wie intrazellulärer Signalübertragungswege über extrazelluläre Signale aktiviert werden und damit Transkriptionsfaktoren und Chromatin-modifizierenden Enzymen beeinflussen. Viele dieser Signale stammen direkt oder indirekt von unserer Ernährung. Letztere ist das wichtigste externe Signal, dem wir täglich ausgesetzt sind. Das führt zum zweiten zentralen Thema dieses Buches, der Nutrigenomik. Die Nahrung, die wir täglich zu uns nehmen, ist weit mehr als eine Ansammlung von Kohlenhydraten, Proteinen, Lipiden, Vitaminen und Mineralien, die Energie und Bausteine für unseren Körper liefert. Das faszinierende Fachgebiet der Nutrigenomik beschreibt die Wechselwirkung zwischen Nahrungsmolekülen, ihren Metaboliten und unserem (Epi)genom. Viele Nahrungsbestandteile, wie beispielsweise ungesättigte Fettsäuren, aktivieren direkt Transkriptionsfaktoren oder verursachen Veränderungen in den Konzentrationen von Metaboliten. Diese beeinflussen wiederum die Aktivität von Chromatin-modifizierenden Enzymen. Auf diese Weise „sprechen“ Moleküle unseres Frühstücks, Mittagessen oder Abendessen mit unserem Genom bzw. Epigenom. Tauchen Sie ein in die faszinierende Welt der Selbstheilung und Verantwortung für Ihre Gesundheit!

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. - Summarizes our current understanding of Multiple Sclerosis - Discusses clinical features and available biomarker monitoring - Focuses on mechanisms that drive disease pathogenesis

This book is a comprehensive overview of the forest bioenergy, from feedstock production to end products. The book presents the state of the art of forest biomass production, assessment, characterization, and conversion into heat and power. It starts with forest sources of biomass and potential availability. Continues with the characterization of the forest stands and the availability of biomass for energy per stand structure, including stands managed for timber, non-wood products, and energy plantations. It follows with biomass evaluation and monitoring considering data sources, modeling methods, and existing models. are also addressed. After the initial focus on forest biomass production and estimation, this resource is assessed as a feedstock for energy conversion. Not only current, but also emerging biofuels obtained from forest biomass are considered. Established and emerging conversion technologies for the production of bio-heat and bio-power are examined and the impacts of the conversion systems presented.

This book examines Naples's patron saint, Gennaro, the history of his blood relic, and the mystery of its periodical liquefaction.Three times a year, Neapolitans gather to witness the recurring phenomenon of the liquefaction of San Gennaro's blood. From the seventeenth century to the present, crowds have prayed to the city's patron for protection from fires, earthquakes, plagues, droughts, and the fury of Mt. Vesuvius. In the “miraculous” moment of transposition from solid to liquid, the faithful seek respite from the ills of the world in the saintly blood, a visual reminder of the blood of Christ spilled for their salvation. In Naples, the periodical liquefaction of San Gennaro's blood is not officially recognized as miraculous by the Catholic Church, which now more cautiously refers to it as a prodigy. Nevertheless, for centuries, this phenomenon has been called “a miracle” in liturgical texts approved by the ecclesiastical authority and in the words of bishops, cardinals, popes, and saints. However, not everyone agreed. This volume follows the efforts of theologians, alchemists, charlatans, and scientists who, through the centuries, have tried to answer questions such as: Is the liquefaction of San Gennaro's blood really a miracle? If not, how is it possible to explain a phenomenon that occurs only on dates liturgically relevant to the saint?The Natural History of a Neapolitan Miracle will be of great value to those interested in Religious Studies, Italian Studies, Medieval and Early Modern Studies, as well as the History of Science, Anthropology, and Ethnography.

Il libro che vi accingete a leggere custodisce il meglio delle magie e dei misteri che emanano dalle leggendarie terre del Quarnero e dell'Istria. Esseri malefici, diavoli, streghe, custodi di tesori, fate e santi: in questo libro troverete ogni sorta di personaggio o di stregoneria. Incontrerete diavoli, orchi e vampiri, ma anche esorcizzatori, folletti e altri strambi personaggi. Verrete attirati dalle leggende di Attila e Orlando, dei giganti Zidòvi. Viaggerete attraverso il folklore con danze e canti, troverete anche ninne-nanne per bambini, scioglilingua e filastrocche. Questo immenso patrimonio popolare, accumulato nei secoli, è arrivato fino a noi attraverso la memoria di chi, di generazione in generazione, lo ha trasmesso oralmente ai posteri. Il grande merito di Giacomo Scotti è stato quello di aver viaggiato dai litorali ai monti per raccoglierlo e custodire il prezioso tesoro di una terra davvero magica.

Der Lago Maggiore, eingehegt von den letzten Alpenausläufern, verwöhnt bereits mit mediterranem Klima. Noble Villen mit Palmengärten, charmante Fischerdörfer und verträumte Inseln bilden die Kulisse für einen abwechslungsreichen Urlaub. Kultur, Shopping und Genuss lassen sich in mondänen Städten wie Locarno und Verbania erleben. Hier kann man durch mittelalterliche Gassen oder entlang der Uferpromenade flanieren, ein'gelato'probieren und herrlich baden. Der zweitgrößte See Italiens ist bestens geeignet für Wassersportbegeisterte, während in den Höhenlagen verschlungene Wanderwege zu Klöstern und Einsiedeleien mit traumhaftem Ausblick auf den See und die umliegenden Berge locken. Dieser aktuelle Reiseführer ist der ideale Begleiter, um alle Facetten der Region Lago Maggiore selbstständig zu entdecken: - Die interessantesten Orte, Sehenswürdigkeiten und Attraktionen ausführlich vorgestellt und bewertet - Die schönsten Naturerlebnisse und Ausflugsziele - Die reizvollsten Badestellen rund um den See - Die prächtigsten Villen und Gärten - Die besten Hotspots zum Bootfahren, Segeln, Angeln und Surfen - Unterwegs mit Auto, Bus oder Fahrrad - Die ganze Bandbreite der Tessiner, lombardischen und piemontesischen Küche - Shoppingtipps für lokale Produkte von Gorgonzola bis Wein - Tipps zur Wahl der Unterkunft sowie außergewöhnliche Unterkunftskonzepte: von der eleganten Villa bis zur Agriturismo-Unterkunft - Die erstaunlichsten Bräuche und Feiern - Besonderheiten der Flora und Fauna - Das Locarno Film Festival und die bewegte Geschichte einer Künstlerkolonie: spannende Tipps, Exkurse und Hintergrundinfos - Alle praktischen Infos zu Anreise, Preisen, Touren, Events, Hilfe im Notfall, Verkehrsmitteln, Wetter... - Kleine Sprachhilfe Italienisch mit den wichtigsten Vokabeln für den Reisealltag

In this book, Diana Bullen Presciutti explores how images of miracles performed by mendicant saints-reviving dead children, redeeming the unjustly convicted, mending broken marriages, quelling factional violence, exorcising the demonically possessed-actively shaped Renaissance Italians'perceptions of pressing social problems related to gender, sexuality, and honor. She argues that depictions of these miracles by artists-both famous (Donatello, Titian) and anonymous-played a critical role in defining and conceptualizing threats to family honor and social stability. Drawing from art history, history, religious studies, gender studies, and sociology, Presciutti's interdisciplinary study reveals how miracle scenes-whether painted, sculpted, or printed-operated as active agents of'lived religion'and social negotiation in the spaces of the Renaissance Italian city.

The book summarizes the role of multiple enzyme targets and strategies to design and develop noveldrug candidates for Alzheimer's disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume.The chapters highlight current information scientists have unraveled about the origin, pathogenesis andprevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.

This book explains the fundamental characteristics and biofunctionality of Alzheimer's Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer's Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer's disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer's disease treatment.

This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox).The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI). - Covers metal carcinogens - Includes discussions on the mechanisms of cancer formation - Provides updates on the diverse mechanisms that drive cancer formation by metals

This book is a compilation of selected papers from the 10th PIANC Smart Rivers Conference (Smart Rivers 2022). The work focuses on novel techniques for inland waterways and navigation structures. The contents make valuable contributions to academic researchers, engineers in the industry, and regulators of aviation authorities. As well, readers will encounter new ideas for realizing Green Waterways and Sustainable Navigations. This is an open access book.

This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

Alcohol: No Ordinary Commodity is a collaborative effort by an international group of addiction scientists to improve the linkages between addiction science and alcohol policy. It presents, in a comprehensive, practical, and readily accessible form, the accumulated scientific knowledge on alcohol research that has a direct relevance to the development of alcohol policy on local, national, and international levels. It provides an objective basis on which to build relevant policies globally and informs policy makers who have direct responsibility for public health and social welfare. By locating alcohol policy primarily within the realm of public health, this book draws attention to the growing tendency for governments, both national and local, to consider alcohol misuse as a major determinant of ill health, and to organize societal responses accordingly. The scope of the book is comprehensive and global. The authors describe the conceptual basis for a rational alcohol policy and present new epidemiological data on the global dimensions of alcohol misuse. The core of the book is a critical review of the cumulative scientific evidence in seven general areas of alcohol policy: pricing and taxation, regulating the physical availability of alcohol, modifying the environment in which drinking occurs, drinking-driving countermeasures, marketing restrictions, primary prevention programs in schools and other settings, and treatment and early intervention services. The final chapters discuss the current state of alcohol policy in different parts of the world and describe the need for a new approach to alcohol policy that is evidence-based, global, and coordinated. A valuable resource for those involved in addiction science and drug policy, as well as those in the wider fields of public health, health policy, epidemiology, and practising clinicians.

In times of emergency, communication plays a crucial yet problematic role. While this may seem obvious nowadays, even before the emergence of modern media, the methods of gathering, elaborating and transmitting information had a significant influence on the perception of risk and decision-making processes. The book examines how government bodies and different social actors handled emergencies in the Hispanic Monarchy, from the late sixteenth to the early nineteenth centuries. It features case studies from the Hispanic Monarchy's European, American and Asian territories, exploring the narrative strategies used in news-sheets and gazettes, the impact of disasters on information networks, how they interacted with political and social dynamics, and the effect of conflicting interpretations of extreme events.

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs - Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution - Features chapter contributions from leading experts in the field

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. - Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction - Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists - Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding - - Includes chapter contributions from leading global experts

The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in “Molecular Medicine and Genetics”, “Molecular Immunology”, “Cancer Biology” and “Nutrigenomics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8). “Molecular Immunology: How Science Works” (ISBN 978-3-031-04024-5), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist's terms.

This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.

This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. - Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics - Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine - Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout - Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction - Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

En paraissant une trentaine d'années après la confirmation du Missel Romain pour les Diocèses du Zaïre, ce livre évalue la réception de la manière zaïroise de célébrer l'eucharistie et envisage l'avenir de la liturgie congolaise. À des degrés divers, les auteurs interrogent les pratiques et les conceptions liturgiques en vigueur en RDC. Ils font le point sur le développement actuel de la liturgie de la messe dans ce pays, dégagent les nouveaux enjeux liturgiques et sacramentels qui émergent du contexte sociopolitique, culturel et religieux actuel, et balisent les voies de l'avenir de l'inculturation de la liturgie en vue d'un agir chrétien prophétique.

l volume raccoglie i testi delle relazioni tenute nel corso delle diverse giornate di studio promosse e organizzate dalla Provincia di Calabria dei Frati Minori Cappuccini sul tema Gli inizi della riforma cappuccina in Calabria, che si sono tenute tra Cosenza, Lamezia Terme e Belvedere Marittimo dal 14 maggio 2018 al 24 maggio 2019. L'anno 2018 è stato significativo per tutti i membri della Provincia: il Ministro provinciale fr. Pietro Ammendola, con Lettera Circolare del 22 aprile 2018 indirizzata a tutti i frati, ha indetto il V Centenario della presenza cappuccina in Calabria, sottolineando come il carisma cappuccino sia “una ricchezza e un patrimonio spirituale inestimabile che appartiene alla nostra terra di Calabria”. Gli eventi organizzati nel corso dell'anno celebrativo prevedevano giornate di studio volte a mettere in risalto come il movimento di riforma si proponesse di vivere intensamente l'originario ideale francescano di preghiera, fraternità, povertà e austerità, e manifestazioni religiose che consentissero a tutti di esprimere al meglio il proprio legame spirituale con il carisma dei Cappuccini di ieri, di oggi e di sempre. Gli Atti sono impreziositi da due contributi supplementari, che non sono stati presentati nel corso degli incontri di studio, ma che pure offrono interessanti informazioni sulla riforma cappuccina calabrese. La pubblicazione è inoltre accompagnata da una attenta raccolta di Brani scelti dalle antiche cronache sull'origine dei Cappuccini in Calabria e da un Repertorio iconografico che ripropone le tavole iconografiche dei primi frati calabresi tratte dai Flores Seraphici sive icones vitae et gesta virorum illustrium in eodem Ordine capuccinorum ed utilizzate nella Mostra di stampe allestita per ogni evento celebrato.

Lissabon, das Herz Portugals, besticht mit Charme und Lebensart. Die'weiße Stadt'am Rio Tejo, eingebettet zwischen Hügeln und Flusslandschaft, bietet eine großartige kulturelle Vielfalt und hat sich dennoch die Balance zwischen Tradition und Moderne bewahrt. Hier kann man in das bunte Treiben der Altstadt eintauchen oder sich an Orten der Ruhe, etwa in den botanischen Gärten von Belém, vom Alltag erholen. An der Atlantikmündung locken Ausflugsziele wie Cascais und Sintra. Gekrönt wird der Aufenthalt von vorzüglichem Essen und einem guten Wein – auch davon gibt es in Lissabon reichlich. Dieser aktuelle Stadtführer ist der ideale Begleiter, um alle Seiten der portugiesischen Hauptstadt selbstständig zu entdecken: - Die wichtigsten Sehenswürdigkeiten und Museen der Stadt sowie weniger bekannte Attraktionen und Viertel ausführlich vorgestellt und bewertet - Faszinierende Architektur zwischen Altstadtgassen und Expo-Gelände - Abwechslungsreiche Stadtspaziergänge durch die interessantesten Viertel - Erlebnisvorschläge für einen Kurztrip und darüber hinaus - Shoppingtipps von der Modeboutique bis zum Azulejo-Geschäft - Die besten Lokale der Stadt und allerlei Wissenswertes über die portugiesische Küche - Die pulsierende Klub- und Musikszene von den Docas bis zum Fado-Konzert - Pessoa, Camões, Saramago: portugiesische Literaten von Weltruhm - Mit Ausflügen in die idyllischen Küstenvororte Cascais und Estoril sowie zum pittoresken Märchenschloss von Sintra - Ausgewählte Unterkünfte von preiswert bis ausgefallen - Detaillierte und verlässliche Reisetipps: Anreise, Preise, Stadtverkehr, Touren, Events, Hilfe im Notfall... - Hintergrundartikel mit Tiefgang: Geschichte, Mentalität der Bewohner, Leben in der Stadt... - Kleine Sprachhilfe Portugiesisch mit den wichtigsten Vokabeln für den Reisealltag

This book provides a concise overview of the latest controversies and advances in men's health. It covers the male anatomy, physiology, and the metabolic syndromes that most commonly affect males. A range of benign and malignant conditions affecting the prostate, testes, rectum and colon are detailed. Chapters feature an easy-to-follow format and feature learning objectives to highlight the key concepts in each chapter aiding the reader to develop a thorough understanding of fundamental aspects in men's health.Men's Health and Wellbeing features insightful reviews of controversies and recent developments in men's health, and is a valuable resource for all trainee and practicing medical professionals who treat these patients.

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

This book aims to approach the epidemiology, diagnosis and management of infectious complications related to the use of biologic and targeted therapies. The first part is a general overview on the epidemiology and prevention of infections with the use of these agents. Timelines, pre-treatment evaluation, use of vaccines and travel counseling. In the second part, we will analyze the specific risk of infections associated with the use of the most important agents. The third part approach the problem on a syndromic point of view. For example, how to evaluate pulmonary infiltrates in a patient receiving biologic agents. This part III includes the most difficult and conflicting syndromes that clinicians may face when evaluating these patients.This book is intended not only for infectious diseases specialists, but also for different medical specialties prescribing biologic and targeted therapies.

The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.

Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research. - Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics - Features chapter contributions from leading international contributors - Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research

Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Updated release includes the latest information on Helicase Enzymes

Praeneste, l'odierna Palestrina, nel Latium vetus ha una lunga storia di comunità indipendente risalente al tempo della Repubblica. In epoca imperiale e nella tarda antichità, la città rimase attraente e vivace: era ben collegata con altre città dell'impero Romano, e il santuario della Fortuna era assiduamente frequentato, come peraltro già lo era stato in epoca repubblicana. Gli oggetti e le iscrizioni presentati in questo volume, dagli specchi alle statue e ai sigilli, attestano tutti i periodi anzidetti. Concentrandosi, tra l'altro, sui siti di ritrovamento e sui gruppi di oggetti, questo volume è molto di più di un resoconto del lavoro preliminare sul previsto fascicolo Praeneste di CIL XIV e di studi puntuali sull'epigrafia di una città del Lazio. Il volume offre infatti un contributo importante e aggiornato alla ricerca archeologica e storica su Palestrina ed è corredato da un importante apparato illustrativo.

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding. - Clear, readable explanations provide a concise story about how cells function at the molecular level. - An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology. - Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases. - Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation. - Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.

Grotte, chiese, foreste e menhir: la mappa dei luoghi magici della Sardegna La Sardegna è una delle regioni italiane più misteriose, eppure pochi altri territori al mondo possono vantare una tale concentrazione di meraviglie naturalistiche e non: dalle grotte, le cascate e i canyon fino alle chiese romaniche, le torri costiere e gli innumerevoli menhir e nuraghi, l'isola offre al visitatore un vero e proprio universo di bellezze da scoprire. Gianmichele Lisai, grande esperto della storia e della cultura della Sardegna, ci conduce in un viaggio alla scoperta dei luoghi magici e fantastici di questo incredibile territorio. Dalle fatate domus de janas e le enigmatiche tombe dei giganti, passando per boschi millenari e paesaggi indimenticabili, fino a piccoli e preziosi musei e a rarità artistiche e architettoniche, questo libro propone una carrellata di cinquanta tappe obbligate per chiunque voglia assaporare la magia e il mistero di una terra ancora piena di segreti. dalle meraviglie naturali a quelle architettoniche, passando per i resti di civiltà misteriose: i luoghi magici dell'isola Tra i luoghi presenti nel volume: Alghero (Sassari), la grotta di Nettuno Austis (Nuoro), sa Crabarissa Baunei (Ogliastra), cala Goloritzé Collinas (Medio Campidano), il “pozzo sacro” di su Angiu Esterzili (Cagliari), sa Domu'e Orgia Fluminimaggiore (Sulcis-Iglesiente), il tempio di Antas Iglesias (Sulcis-Iglesiente), il pan di Zucchero Morgongiori (Oristano), la grotta sacra di Scaba'e Cresia Orgosolo (Nuoro), s'Elighe'e Tureddu Orune (Nuoro), la fonte sacra di Su Tempiesu Pau (Oristano), il sentiero dell'ossidiana Quartucciu (Cagliari), la tomba di giganti di Is Concias Ulassai (Ogliastra), la cascata di Lequarci Villasimius (Cagliari), la Madonna del naufrago Gianmichele LisaiÈ nato a Ozieri, in provincia di Sassari, nel 1981. Editor e autore, con La Newton Compton ha pubblicato una quindicina di volumi. Ha vinto il premio Gualtiero De Angelis per la cultura sarda (Voci tra le onde 2021). Con Antonio Maccioni ha pubblicato Il giro della Sardegna in 501 luoghi; Guida curiosa ai luoghi insoliti della Sardegna, Luoghi segreti da visitare in Sardegna e Breve storia della Sardegna. Curatore di diversi volumi anche per «La Nuova Sardegna», ha un sito web dedicato ai suoi libri e alla sua isola: gianmichelelisai.com

This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.Key Features Provides historical context of the contributions of the model system Includes contributions from an international team of leading scholars Presents topics spanning cell biology, developmental biology, genomics, and disease model Describes recent experimental advances Incorporates richly illustrated diagrams and color images Related TitlesGreen, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)Faber, J. & P. D. Nieuwkoop. Normal Table of Xenopus laevis (Daudin): A Systematical & Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis (ISBN 978-0-8153-1896-5)Jarret, R. L. & K. McCluskey. The Biological Resources of Model Organisms (ISBN 978-1-0320-9095-5)The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis has been a key area of biological inquiry for decades. The next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution. Transcriptome analysis has evolved from the detection of single RNA molecules to large-scale gene expression profiling and genome annotation initiatives. Written by a team of global experts, key topics in Transcriptome Profiling include transcriptome characterization, expression analysis of transcripts, transcriptome and gene regulation, transcriptome profiling and human health, medicinal plants transcriptomics, transcriptomics and genetic engineering, transcriptomics in agriculture, and phylotranscriptomics. - Presents recent development in the tools and techniques in transcriptomic characterization - Integrates expression analysis of transcripts and gene regulation - Includes the application of transcriptomics in human health, genetic engineering and agriculture