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Published in 1997 as the first single-authored book on critical care neurology, The Practice of Emergency and Critical Care Neurology serves as a comprehensive guide to managing all aspects of critically ill neurologic patients. Following patients from the moment they enter the emergency department, this textbook demonstrates how specialists in the neurosciences assume full responsibility for patient care. Edited succinctly for relevance, this book differs from conventional textbooks by following the time course of clinical complexities as they emerge and change, instead of focusing on just the theoretical aspects of the field. Great emphasis is placed on the management of unstable and deteriorating patients. As any patient presents a unique, complex problem, the book pays special care in describing the considerations behind the rapid-fire decisions that comprise the work environment of the neurointensivist. In this new third edition, all chapters have been revised with added information and, in some, new concepts and ideas. Key features of this new edition include: 1. Additional chapters on the basics of neuroimaging and its interpretation; basic pharmacology issues in the intensive care setting (e.g., drug interactions and side effects); intoxications; the principles of critical care ultrasound and its relevance in the NeuroICU and the principles of neuro palliation including neuroethics 2. Rich illustrations using color photos of patients and drawings of important basic concepts of mechanisms in diseases of neurocritical care 3. Fully updated and comprehensive reference list 4. Narrated instruction video of the coma FOUR score

Recovered in 1755 during excavations in the Villa dei Papiri in Herculaneum, the prosciutto sundial is the earliest known portable Roman sundial. Palm-sized and in the shape of an Italian cured ham, its silver-plated cast bronze form cleverly combines an accurate modelling of a prosciutto with a relatively sophisticated scientific device capable of capturing the seasonal hours of the zodiacal year by employing the pig's tail to cast the sun's shadow onto the dial. This book explores the significance of this curious object's discovery in the Villa dei Papiri and offers the first comprehensive survey of its reception and analysis by drawing on contemporary correspondence and manuscripts, travel journals, popular accounts, archaeological studies, and scientific and horological assessments. Christopher Parslow shows how the prosciutto sundial is a rare example of an ancient artifact that has attracted the attention of a very broad audience, from archaeologists, art historians, and philologists to astronomers, philosophers, and sundial aficionados. The backdrop to its history features bitter infighting in the Bourbon court, clandestine descriptions circulating on the international scholarly network, and jockeying for preeminence among scholars in the learned foreign academies. Despite this long history, no scholar has treated the prosciutto adequately in full or analyzed it correctly because they lacked crucial evidence available only by examining the actual object in detail. Parslow addresses that shortcoming by providing results obtained through a 3D model to offer the first empirical analysis since the initial assessment by the Bourbon court of the prosciutto's remarkably accurate capabilities as a timepiece.

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids. - Highlights fundamental concepts with advanced exploration of phenolic acids - Provides in-depth coverage on the design and development of novel drugs from natural phenolic acids - Reviews the changing role of phenolic acids

This book contains four chapters reviewing hydrazine and its applications. Chapter One overviews derivatives of hydrazine as massive sources of pharmaceutically bioactive drugs. Chapter Two looks to hydrazine derivatives such as pyrazole, pyridazine, etc as a source of pharmaceutically bioactive drugs. Chapter Three explores the use of carbon based nanomaterials for the electrochemical determination of hydrazine. Chapter Four reviews a nano-composite materials approach to hydrazine detection.

This book provides a broader understanding of infectious diseases and hearing loss prevention and treatment in children. In addition to all the common infections, the book covers the prion diseases, the autoinflammatory syndromes, and diseases of unknown etiology. A specific chapter is dedicated to cochlear implant infections. The final part reviews the available therapeutic agents. Written by international experts, the book will appeal to a wide readership, from ENT and pediatrics trainees, to practitioners and researchers in these disciplines.

The recent progress in analytical methods, aided by bringing in a wide range of other disciplines, opens up the study to a broader field, which means that biogeography now goes far beyond a simple description of the distribution of living species on Earth.Originating with Alexander von Humboldt, biogeography is a discipline in which ecologists and evolutionists aim to understand the way that living species are organized in connection with their environments. Today, as we face major challenges such as global warming, massive species extinction and devastating pandemics, biogeography offers hypotheses and explanations that may help to provide solutions.This book presents as wide an overview as possible of the different fields that biogeography interacts with. Sixteen authors from all over the world offer different approaches based on their specific areas of knowledge and experience; thus, we intend to illustrate the vast number of diverse aspects covered by biogeography.

Schrifttragende Artefakte sind einer Vielzahl von Praktiken ausgesetzt, durch die sie in der einen oder anderen Form beschädigt werden. Dabei können die Absichten, Hintergründe und Kontexte dieser Praktiken stark variieren, sodass durch die Zeiten hindurch in verschiedenen kulturellen Kontexten, Situationen und Diskursen vielfältige Ausprägungen zu beobachten sind. Solche Fälle sind keineswegs darauf beschränkt, Missbilligung gegenüber Inhalten oder Autoren auszudrücken oder das Andenken an Personen auszulöschen. Anhand von detailliert aufgearbeiteten Fallbeispielen, die vom antiken Ägypten, Mesopotamien und dem Mittelmeerraum über das alte China, das europäische Mittelalter und die Neuzeit sowie islamische Traditionen bis zum heutigen Bali reichen, werden verschiedene Facetten der unterschiedlichen Praktiken und ihrer Motivationen erarbeitet und eine übergreifende Systematik entwickelt. Ziel ist es, eine an praxeologischen Kriterien orientierte Phänomenologie von Schriftzerstörung aufzustellen. Das Hauptaugenmerk liegt auf Praktiken in non-typographischen Gesellschaften, also in Kulturen, in denen Schriftdokumente nicht mittels Buchdruck und vergleichbaren Verfahren fast beliebig vervielfältigt, sondern von Hand einzeln angefertigt wurden.

É possível afirmar que o jogo é indispensável ao desenvolvimento físico, psicológico, moral e até mesmo social da criança - como será cada vez mais necessário a uma existência equilibrada e otimista do adulto. Como formas do afeto das pessoas e do calor das coisas, o jogo e o brinquedo são tão necessários à criança quanto o ar ou o alimento. Cabe à família proporcioná-los. À escola ajudá-los. Esse imperativo imediato se reveste de uma obrigação de longo alcance, uma vez que a prática dos jogos infantis é a melhor preparação para que o homem de amanhã se consagre alegremente ao lazer.

Cave organisms are the ‘monsters'of the underground world and studying them invariably raises interesting questions about the ways evolution has equipped them to survive in permanent darkness and low-energy environments. Undertaking ecological studies in caves and other subterranean habitats is not only challenging because they are difficult to access, but also because the domain is so different from what we know from the surface, with no plants at the base of food chains and with a nearly constant microclimate year-round. The research presented here answers key questions such as how a constant environment can produce the enormous biodiversity seen below ground, what adaptations and peculiarities allow subterranean organisms to thrive, and how they are affected by the constraints of their environment. This book is divided into six main parts, which address: the habitats of cave animals; their complex diversity; the environmental factors that support that diversity; individual case studies of cave ecosystems; and of the conservation challenges they face; all of which culminate in proposals for future research directions. Given its breadth of coverage, it offers an essential reference guide for graduate students and established researchers alike.

Encyclopedia of Caves, Third Edition, provides detailed background information to anyone with a serious interest in caves. This includes students, both undergraduate and graduate, in the earth, biological and environmental sciences, and consultants, environmental scientists, land managers and government agency staff whose work requires them to know something about caves and the biota that inhabit them. Caves touch on many scientific interests in geology, climate science, biology, hydrology, archaeology, and paleontology, as well as more popular interests in sport caving and cave exploration. Case studies and descriptions of specific caves selected for their special features and public interest are also included. This book will appeal to these audiences by providing in-depth essays written by expert authors chosen for their expertise in their assigned subject. - Features 14 new chapters and 13 completely rewritten chapters - Contains beautifully illustrated content, with more than 500 color images of cave life and features - Provides extensive bibliographies that allow readers to access their subject of interest in greater depth

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in surgical critical care. The book reviews up to date data regarding the management of common problems that arise in the Surgical Intensive Care Unit. The protocols, care bundles, guidelines and checklists that have been shown to improve process measures, and in certain circumstances, are discussed in detail. The text also discusses several well designed randomized prospective trials conducted recently that have altered the way we care for surgical patients with traumatic brain injury, hemorrhagic shock, acute respiratory distress syndrome, and sepsis. This book provides the practicing physician with a clinically oriented practical approach to handle basic and complex issues in the Surgical Intensive Care Unit. This text will serve as a very useful resource for physicians dealing with critically ill surgical patients. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. This text will become an invaluable resource for all graduating fellows and practicing physicians who are taking the surgical critical care board examinations.

Partez à la découverte de la facture instrumentale avec ce Grand Article Universalis!Les instruments actuels de la musique savante occidentale sont souvent considérés comme des archétypes de la facture. Pourtant, bien des particularités ne s'expliquent que par référence à des instruments appartenant à d'autres civilisations et à ceux du passé. Les aménagements importants qui ont...Un ouvrage spécialement conçu pour le numérique afin d'en savoir plus sur la facture instrumentaleÀ PROPOS DES GRANDS ARTICLES D'UNIVERSALISLa collection des Grands Articles d'Universalis rassemble, dans tous les domaines du savoir, des articles écrits par des spécialistes reconnus mondialement et édités selon les critères professionnels les plus exigeants.Une sélection thématique, effectuée parmi les nombreux articles qui composent l'Encyclopaedia Universalis, permet au lecteur curieux d'en savoir plus sur un sujet précis et d'en faire le tour grâce à des ouvrages conçus pour une lecture en numérique.À PROPOS DE L'ENCYCLOPAEDIA UNIVERSALISÉcrite par plus de 7 400 auteurs spécialistes de renommée internationale et riche de près de 30 000 médias (vidéos, photos, cartes, dessins…), Encyclopaedia Universalis offre des réponses d'une grande qualité dans toutes les disciplines et sur tous les grands domaines de la connaissance. Elle est la référence encyclopédique du monde francophone.

Research in the 20th and 21st centuries into historical performance practice has changed not just the way performers approach music of the 17th and 18th centuries but, eventually, the way audiences listen to it. This volume, beginning with a 1915 Saint-Sa lecture on the performance of old music, sets out to capture musicological discussion that has actually changed the way Baroque music can sound. The articles deal with historical instruments, pitch, tuning, temperament, the nexus between technique and style, vibrato, the performance implications of musical scores, and some of the vexed questions relating to rhythmic alteration. It closes with a section on the musicological challenges to the ideology of the early music movement mounted (principally) in the 1990s. Leading writers on historical performance practice are represented. Recognizing that significant developments in historically-inspired performance have been led by instrument makers and performers, the volume also contains representative essays by key practitioners.

This work has been devoted to the exploitation of the synthesis of transition metal hydrazine cinnamates using transition metals salts, hydrazine hydrate and cinnamic acid. The study includes a detailed presentation of coordination complexes, chemistry of hydrazine, cinnamic acid and transition metals, their applications, and various metal hydrazine carboxylates. The scope and objectives of the study are also discussed. The specifications of all the materials used in the study and the details of the different experimental techniques employed in this study are elaborated. The main part of the book illustrates the synthesis and characterization of the different metal hydrazine cinnamates and the methods used for this.

Les méningites sont des maladies rares. Cependant, l'éventail du spectre de gravité est large, allant du redoutable purpura fulminans d'origine méningococcique à la méningite virale guérissant sans traitement. Tout médecin a connu ou connaîtra la crainte de manquer ce diagnostic. La meilleure défense est d'avoir une vision globale et pragmatique de cette pathologie. C'est ce que propose cet ouvrage en balayant l'ensemble de la thématique : quand suspecter une méningite, comment réaliser une ponction lombaire selon les bonnes pratiques, comment analyser les résultats du liquide cérébrospinal, quelles en sont les principales étiologies bactériennes, virales, mais aussi parasitaires et les particularités dans la population pédiatrique, quelle est la place des biomarqueurs, sans oublier la prise en charge des céphalées post-rachicentèse et la prophylaxie entourant un cas index d'infection invasive à méningocoque.Cet ouvrage de référence est destiné aux médecins urgentistes, généralistes, pédiatres mais également aux autres spécialistes et permet d'avoir une vue circulaire et réaliste de la question.Rédigé par une équipe pluridisciplinaire d'urgentistes, anesthésistes, réanimateurs, infectiologues, pédiatres, il s'inscrit dans la collection « Références en médecine d'urgence » comme une aide pratique au quotidien.

The Chronic EarThere are many different ways to treat complex chronic middle ear disease, with ongoing advancements being made globally. Diverse approaches are necessitated for variations in patient age, degree of infection, extent of middle ear remodeling, inflammation severity, and underlying mechanisms of Eustachian tube dysfunction. Addressing multinational and clinical nuances, the editors have compiled 48 chapters with eclectic perspectives from otology experts in 13 countries. The surgical anatomy of the middle ear cleft and mastoid and underlying pathophysiological mechanisms of chronic otitis media are clinically challenging. Articles cover anatomy, physiology, disease characterizations and manifestations, clinical evaluation, office management, surgical procedures, and new horizons. Traditional and newer hybrid techniques for systematic disease and inflammatory conditions are presented in roundtable format, for example, underlay fascia tympanoplasty as well as the use of cartilage and bioengineered materials.Selected Key Topics:Applied middle ear anatomy and physiologyPathologic mechanisms of chronic otitis media Office evaluation, management and surgical decision makingMastoid cavity obliteration and canal wall reconstructionChallenges in tympanoplasty and ossicular chain reconstructionTraditional and hybrid tympanomastoid surgeryHearing implants in the chronic earThis is an exceptional teaching tool for ear surgeons in training as well as a must-have clinical resource for practicing otolaryngologists.

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. - Enhanced encyclopedic format with drug monographs now organized alphabetically - Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions - Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing - Extensive bibliography with over 40,000 references - A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

Le Dictionnaire des Musiques réunit plus de six cents articles empruntés au fonds de l'Encyclopaedia Universalis et aborde tous les aspects de la musique : les formes et les genres (sonate, rhapsodie, valse, madrigal…), l'écriture et la théorie (gamme, arrangement, tempérament, rubato...), les voix et l'art lyrique (baryton, contre-ténor, bel canto, Covent Garden, Scala de Milan…), les traditions musicales (Afrique noire, Moyen-Orient, Asie du Sud-Est...), la musique contemporaine (aléatoire, concrète, minimaliste, sérielle...), tous les instruments (arc musical, piano, célesta, tympanon, flûte...), les courants musicaux d'aujourd'hui (rock, raï, hip-hop...), le jazz, le blues, la world music, la musique de film, les festivals… Un inépuisable inventaire des musiques passées et présentes, avec un accent mis sur les musiques savantes, sous la conduite des guides les plus qualifiés. Un index facilite la consultation du Dictionnaire des Musiques, auquel ont collaboré plus de cent auteurs, parmi lesquels François Bayle, Philippe Beaussant, Gérard Condé, Alain Féron, Paul Méfano, Alain Pâris, Marc Vignal…

Extrait du Dictionnaire des Musiques, précédemment paru dans la même collection, le Dictionnaire des Instruments de musique est dédié à tous les instruments, passés ou présents, proches ou lointains, par lesquels s'exprime la musique. Le sommaire comprend quelque 200 articles, d'ACCORDÉON à YUEQIN (luth chinois), en passant par CASTAGNETTES, COR DES ALPES ou GAMELAN, mais aussi par ALTO, CLAVECIN ou VIOLONCELLE. Illustré et très documenté, ce dictionnaire vous invite à découvrir, ou à mieux comprendre, l'histoire de ces instruments si divers, leur facture, les modes de jeu, les styles musicaux et les répertoires qui leur sont associés. Un index facilite la consultation du Dictionnaire des Instruments de musique, auquel ont collaboré 28 auteurs parmi lesquels Juliette Garrigues, Eugène Lledo, Michel Philippot…

Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.