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Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications, the intersection of deep learning and genetics opens up new avenues for advancing our understanding of the genetic code, gene regulation, and the broader genomics landscape. The book not only covers the most up-to-date advancements in the field of deep learning in genetics and genomics, but also a wide spectrum of (sub) topics including medical and clinical genetics, predictive medicine, transcriptomic, and gene expression studies. In 21 chapters Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications describes how AI and DL have become increasingly useful in genetics and genomics research where both play a crucial role by accelerating research, improving the understanding of the human genome, and enabling personalized healthcare. From the fundamentals concepts and practical applications of deep learning algorithms to a wide range of challenging problems from genetics and genomics, Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications creates a better knowledge of the biological and genetics mechanisms behind disease illnesses and improves the forecasting abilities using the different methodologies described. This title offers a unique resource for wider, deeper, and in-depth coverage of recent advancement in deep learning-based approaches in genetics and genomics, helping researchers process and interpret vast amounts of genetic data, identify patterns, and make discoveries that would be challenging or impossible using traditional methods. - Brings together fundamental concepts of genetics, genomics, and deep learning - Includes how to build background of solution methodologies and design of mathematical and logical algorithms - Delves into the intersection of deep learning and genetics, offering a comprehensive exploration of how deep learning techniques can be applied to various aspects of genomics

Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations.The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.

This book is a collection of high-quality peer-reviewed research papers presented at the Ninth International Conference on Cyber-Security, Privacy in Communication Networks (ICCS 2023) held at Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK, during 11–12 December 2023. This book presents recent innovations in the field of cyber-security and privacy in communication networks in addition to cutting edge research in the field of next-generation communication networks.

This book explains the translational aspects of ethnomedicinal plants of different geographical regions including India by explaining the medicinal properties against several diseases, genomic evolution in changing environments, metabolic profiling for biomarker discovery, the role of non-coding RNA in the synthesis of secondary metabolites, genome-wide transcriptome profiling, application of pluripotent stem cells for drug discovery, the importance of high-throughput omics, and genome-editing techniques. In addition, some of the chapters have been designed to describe the role of artificial intelligence, plant database, and network-based drug discovery to explore the medicinal importance of compounds as well as challenges and opportunities in drug discovery from ethnomedicinal plants. The book serves as a great source of information for the students, researchers/scientists of diverse fields such as pharmacognosy, plant physiologists, biotechnologists, and pharmaceutical scientists etc., working in the areas of phytotherapy from ethnomedicinal plants.

This 4th edition of Handbook of Solvents, Volume 2, contains the most comprehensive information ever published on solvents as well as an extensive analysis of the principles of solvent selection and use. The book begins with a discussion of solvents used in over 30 industries which are the main consumers of solvents. The analysis is conducted based on the available data and contains information on the types (and frequently amounts) of solvents used and potential problems and solutions. Picking up where Handbook of Solvents, Volume 1 leaves off, Handbook of Solvents Volume 2 provides information on the methods of analysis of solvents and materials containing solvents, with 2 sections containing standard and special methods of solvent analysis, followed by a discussion of residual solvents left in the final products. The environmental impact of solvents, such as their fate and movement in the water, soil, and air, fate-based management of solvent-containing wastes, and ecotoxicological effects are discussed as are solvents'impact on tropospheric air pollution. The next 2 chapters are devoted to the toxicology of solvents and regulations aiming to keep solvent toxicity under control. The analysis of the concentration of solvents in more than 15 industries, specific issues related to the paint industry, and characteristics of the environment in automotive collision repair shops are followed by a thorough discussion of regulations in the USA and Europe. Following chapters show examples of solvent substitution by safer materials, with an emphasis on supercritical solvents, ionic liquids, deep eutectic solvents, and agriculture-based products, such as ethyl lactate. Discussion of solvent recycling, removal, and degradation includes absorptive solvent recovery, comparison of results of recovery and incineration, and application of solar photocatalytic oxidation. The book concludes with an evaluation of methods of natural attenuation of various solvents in soils and modern methods of cleaning contaminated soils. - Assists in solvent selection by providing key information and insight on environmental and safety issues - Provides essential best practice guidance for human health consideration - Discusses the latest advances and trends in solvent technology, including modern methods of cleaning contaminated soils, selection of gloves, suits, and respirators

SARS-CoV-2, the coronavirus responsible for COVID-19, wreaked havoc on the world; it could both spread easily and mutate rapidly, leading to the decrease in the effectiveness of newly developed vaccines over time. The detection of these mutated variants and the development of more efficient vaccines requires significant effort and increased knowledge in this field. This new book, SARS-CoV-2 Variants and Global Population Vulnerability: Diagnostic Strategies, Vaccine Development, and Therapeutic Management, provides detailed and systemic information regarding the biology and immunophysiology of SARS-CoV-2 and highlights the global vulnerability of the world population to SARS-CoV-2 infection and COVID-19.The book covers different aspects pertaining to the SARS-CoV-2 variants and their relation to global vulnerability. Chapters discuss the diagnostics, vaccine development, and therapeutic management starting from the zoonotic origin, organization, and transmission of SARS-CoV-2, lifestyle and immunophysiology of the virus, detection and diagnosis techniques, and analytical techniques. The book also observes the global impact of Delta and Omicron SARS-CoV-2 variants. It looks at the drug repurposing and new drug discovery routines for the emerging variants. It presents strategies for fast-track vaccine development, the roles of nasal vaccines and nucleic acid vaccines for COVID-19 management, monoclonal antibody therapy for the diseases management, along with the use of dietary supplements and nutraceuticals, herbal drugs, and other alternative remedies for COVID-19 management. The book also considers the social and environmental impacts of SARS-CoV-2 variants and the current challenges, outlining aspects that can help in developing more efficacious means for controlling SARS-CoV-2 in the future.Key highlights: Discusses SARS-CoV-2 variants, diagnosis strategies, vaccine development, and the therapeutic management of the disease Provides comprehensive coverage of SARS-CoV-2 virus and variants With its unique and thorough take on the subject, this book is an important resource of know-how for investigators working in this area. Professionals from the pharmaceutical industry as well as students, research scholars, doctors, and other healthcare professionals will find this book of particular value.

The world is addressing the insistent challenge of climate change, and the need for innovative solutions has become paramount. In this period of technical developments, artificial intelligence (AI) has emerged as a powerful instrument with enormous prospects to combat climate change and other environmental subjects. AI's ability to process vast amounts of data, identify patterns, and make intelligent predictions offers unprecedented opportunities to tackle this global crisis. High-Performance Computing (HPC) or super-computing environments address these large and complex challenges with individual nodes (computers) working together in a cluster (connected group) to perform massive amounts of computing in a short period. Creating and removing these clusters is often automated in the cloud to reduce costs. Computer networks, communication systems, and other IT infrastructures have a growing environmental footprint due to significant energy consumption and greenhouse gas emissions. To address this seemingly self-defeating conundrum, and create a truly sustainable environment, new energy models, algorithms, methodologies, platforms, tools, and systems are required to support next-generation computing and communication infrastructures. Harnessing High-Performance Computing and AI for Environmental Sustainability navigates through AI-driven solutions from sustainable agriculture and land management to energy optimization and smart grids. It unveils how AI algorithms can analyze colossal datasets, offering unprecedented insights into climate modeling, weather prediction, and long-term climate trends. Integrating AI-powered optimization algorithms revolutionizes energy systems, propelling the transition towards a low-carbon future by reducing greenhouse gas emissions and enhancing efficiency. This book is ideal for educators, environmentalists, industry professionals, and researchers alike, and it explores the ethical dimensions and policies surrounding AI's contribution to environmental development. It tackles the unintended consequences of AI, providing a comprehensive guide to harnessing AI for sustainable outcomes. Readers will discover how AI can catalyze sustainable farming practices, optimize energy distribution, and combat deforestation. Moreover, the text probes the profound impacts of AI on the Earth, both guided and unguided, offering a balanced perspective on its potential and challenges. Its chapters cover diverse facets, from the role of HPC and open climate data in water and natural resource management to the design principles for environmentally sustainable computing. It unravels the implications of global warming on data center power consumption, introduces intelligence models for computing resource management, and explores the applications of blockchain in energy management and trading agricultural products.

Nowadays, the field of microbiology is undergoing a revolutionary change due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-related problems, exploring the interaction between microorganisms and the surrounding environment. It also helps to extract novel microbial metabolites which have been used in various fields like medical, food and agricultural industries. As the pace of innovation in Microbiology is accelerating, the use of AI in these industries will be beneficial. AI will not only show its extraordinary potential in expanding the market of antibiotics, food, and agriculture but also offer an eco-friendly, safer, and profitable solution to the respective industries. It would be challenging to search out specific features and discuss future research on AI in microbiology with a wide perspective. - Uncovering extended functions of AI in Microbiology. - Production and development of novel drug targets through AI. - Challenges for using and selecting appropriate AI tools in health, agriculture and food sector

'Machine Learning Algorithms Using Scikit and TensorFlow Environments assists researchers in learning and implementing these critical algorithms. Covering key topics such as classification, artificial neural networks, prediction, random forest, and regression analysis, this premier reference source is ideal for industry professionals, computer scientists, researchers, academicians, scholars, practitioners, instructors, and students'--

Millets are ancient grains that have been cultivated by humans for centuries, and they have recently emerged as a crucial staple food in numerous cultures owing to their abundant essential nutrients and their resilience to changing climates, requiring fewer resources for growth. In the face of the current climate crisis, the spotlight on millets as a cornerstone of sustainable societies has intensified. The Role of Women in Cultivating Sustainable Societies Through Millets delves into the significance of millets in sustainable agriculture and the indispensable role that women play in their cultivation and promotion. This book seeks to advocate for the cultivation and consumption of millets as a pathway to constructing sustainable societies. However, it goes beyond mere cultivation, as it critically recognizes and highlights the pivotal role of women in this transformative process. Drawing from millennia of historical perspectives, the book examines how women have been key agents of change in millet cultivation, shaping its cultivation techniques, preservation, and the propagation of traditional knowledge across generations. While elucidating the nutritional and environmental merits of millets, the book also draws attention to the socioeconomic aspects of this agricultural industry. It explores how the cultivation and promotion of millets have contributed to the economic empowerment of women, fostering equitable growth and prosperity within communities. The book also offers valuable insights into crop monitoring and management, providing readers with practical applications for integrating millets into existing agricultural practices. To further solidify the book's foundation, it includes compelling case studies, illustrating successful real-world applications of millet cultivation and its socio-economic impact, making this book a timely and essential resource for students, researchers, academicians, and industry professionals alike.

This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.

Schultz/Schultz/Maragnes'THEORIES OF PERSONALITY, 12th EDITION, discusses major theorists and theories. This text not only clearly presents a diverse array of theories of personality, but also does so in a way that is easy to read and that includes details of the theorists'lives and personalities. Additionally, it includes details of psychological research conducted with real people. Students are invited to reflect on the newly presented information, especially as it applies in their own lives, via the Pause for Reflection feature.

To cope with the competitive worldwide marketplace, organizations rely on business intelligence to an increasing extent. Cyber security is an inevitable practice to protect the entire business sector and its customer. This book presents the significance and application of cyber security for safeguarding organizations, individuals'personal information, and government.The book provides both practical and managerial implications of cyber security that also supports business intelligence and discusses the latest innovations in cyber security. It offers a roadmap to master degree students and PhD researchers for cyber security analysis in order to minimize the cyber security risk and protect customers from cyber-attack. The book also introduces the most advanced and novel machine learning techniques including, but not limited to, Support Vector Machine, Neural Networks, Extreme Learning Machine, Ensemble Learning, and Deep Learning Approaches, with a goal to apply those to cyber risk management datasets. It will also leverage real-world financial instances to practise business product modelling and data analysis.The contents of this book will be useful for a wide audience who are involved in managing network systems, data security, data forecasting, cyber risk modelling, fraudulent credit risk detection, portfolio management, and data regulatory bodies. It will be particularly beneficial to academics as well as practitioners who are looking to protect their IT system, and reduce data breaches and cyber-attack vulnerabilities.

Singapore and New Zealand are island nations that share many similarities and have enjoyed close relations for almost sixty years. Both face global challenges in today's less stable world. Twenty-seven prominent experts cover a wide range of topics, from Singapore's and New Zealand's history, foreign policy, trade relations, economy, sustainability and climate policies, to creative sectors, museums and ageing populations. Other distinguished authors highlight the close cooperation in defence, trade and business.The Editor, Dr Anne-Marie Schleich, was a German career diplomat posted to Singapore from 1982 to 1985 and was the German Ambassador to New Zealand from 2012 to 2016. She is now an Adjunct Senior Fellow at the S. Rajaratnam School of International Studies, NTU, Singapore.

This series of books is a result of collaboration between the Chinese Academy of Sciences and relevant national departments. This book provides a comprehensive summary and analysis of the current state and future trends of e-Science in China, with a focus on strategic developments, application practices, and infrastructure construction. This book showcases the recent progress, achievements, and new situations in China's e-Science in the past two years, and offer detailed cases for reference. The content is rich and offers valuable insights for the future development of research informatization.

Linking Neuroscience and Behavior in COVID-19 examines the impact of the virus and pandemic on behavior and mental health. Chapters look at those with pre-existing conditions, including dementia and multiple sclerosis, and how the pandemic has burdened them further. There is also discussion on the mental health consequences the pandemic has had and continues to have on the broad populace, including depression and anxiety, as well as neurological effects of the virus itself. Finally, managing care and treatment of conditions - those preceding, caused by, or emerging for the first time during the pandemic are also detailed. - Discusses the impact of the COVID-19 pandemic and the virus itself on behavior and psychology - Examines comorbidities including Parkinson's disease, neuroinflammation, and autism spectrum disorders - Outlines the management and care for coexisting conditions including brain tumors, multiple sclerosis, and ischemic stroke - Features chapters on the severe damage to the nervous system which may be caused by SARS-CoV-2 infection including myelitis - Contains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitablefor antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers. ​

This edited volume presents perspectives from computer science, information theory, neuroscience and brain imaging, aesthetics, social sciences, psychiatry, and philosophy to answer frontier questions related to artificial intelligence and human experience. Can a machine think, believe, aspire and be purposeful as a human? What is the place in the machine world for hope, meaning and transformative enlightenment that inspires human existence? How, or are, the minds of machines different from that of humans and other species? These questions are responded to along with questions in the intersection of health, intelligence and the brain. It highlights the place of consciousness by attempting to respond to questions with the help of fundamental reflections on human existence, its life-purposes and machine intelligence. The volume is a must-read for interdisciplinary and multidisciplinary researchers in humanities and social sciences and philosophy of science who wish to understand the future of AI and society.

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This encyclopedia covers the definitions, concepts, methods, theories, and application of evidence-based pharmaceutical public health and health services research. It highlights why and how this field has a significant impact on healthcare. The work aims to synthesize baseline knowledge as well as the latest and cutting-edge research-based information. The encyclopedia collates information on public health, health services research, evidence-based pharmacy practice and its impacts on patients, decision-makers and consumers. This reference work discusses all aspects of policy and practice decisions on medicines use, access and pharmacy services by covering broad aspects related to pharmacy practice, public health and health services research. The aim is to develop high-quality content, which will be a must-read and be used as a reference source at all pharmacy and medical schools in the world. The health services research investigates the impact of social factors, organizational policies, financing systems, medical technologies and personal influence on access, quality and cost of healthcare concerning the quality of life of the patients. This reference work fundamentally promotes the evidence-based evaluation of healthcare services and thus will improve the better access and delivery of healthcare services. Also, pharmacy, medical and health services students and researchers need a broad understanding of pharmaceutical public health, evidence-based approaches to delivering care, changing professional and patient behavior and undertaking research in these areas. In general, there is a need to build research capacity and capability in the pharmacy profession.EDITOR-IN-CHIEF:Professor Zaheer-Ud-Din Babar, University of HuddersfieldSECTION EDITORS:Filipa Alves da Costa, University of LisbonZubin Austin,University of TorontoDalia Dawood, National Institute for Health and Care ExcellenceAndy Gray, University of Kwa Zulu-NatalRachele Hendricks-Sturrup, Duke Margolis Center for Health PolicyJason Hsu, Taiwan Medical UniversityRabia Hussain, Universiti Sains MalaysiaChristine Y. Lu, Harvard Medical School and Harvard Pilgrim Health Care InstituteMohamed Izham Mohamed Ibrahim, Qatar UniversityPrasad Nishtala, University of BathDerek Charles Stewart, College of Pharmacy, Qatar UniversityFatima Suleman, University of Kwa Zulu-NatalZaheer-Ud-Din Babar, University of Huddersfield

This book provides relevant theoretical frameworks and the latest empirical research findings in Operations Research (OR) and Management Science (MS) as applied to sustainability. Its goal is to identify and describe ways in which OR and MS have been applied to and influenced the development of sustainability. Many of the issues we face today stem from the interconnectivity of the economy, society, and the environment, and from how both the economy and society are affecting the environment. In response, there have been a range of local and global efforts to advance society without harming the natural environment. The book showcases how OR/MS can help to address these issues, specifically with regard to renewable energy, smart industry, smart cities, transportation, smart homes and devices, etc. This book is intended for professionals in the fields of energy, engineering, information science, mathematics and economics, and for researchers who wish to develop new skills in connection with sustainability, or whose work involves sustainability.

This edited volume discusses the biopolitics and shock economy of COVID-19, emphasizing medical perspectives and the socioeconomic dynamics of the pandemic and the ensuing institutional responses. Written by an international, multidisciplinary group of academic and professional experts, chapters embrace a wide range of topics such as: medical perspectives on COVID-19; application of geospatial technology; infectivity, immunogenicity, and disease as important factors for adoption of relevant biopolitical measures; shock economy; COVID-19-induced transaction costs; social support and resilience of inhabitants of marginalized areas; business resilience factors; entrepreneurship; and digital transformation. Jointly addressing global examples of biopolitical governance and overarching macroeconomic effects of the pandemic, this volume will be of interest to academics across disciplines as well as policymakers and practitioners on the ground.

Recent discoveries in microbiology are hard to grasp for those unfamiliar with scientific jargon, and the research data can be overwhelming even for those working in other scientific fields. This book aims to remedy this situation by presenting the most interesting findings and current trends in microbiology in an easy-to-read and understandable format. The first part tells the story of the beginnings of microbiology itself and introduces the reader to the founders of this fascinating research discipline. The second part focuses on communication between microorganisms and how they organize themselves into fascinating microbial cities called “biofilms”. The reader also learns how bacteria exchange genetic material - mechanisms that are the root of the emergence of multidrug-resistant superbugs, pathogens that pose a major burden to human health and our healthcare systems. The third part is devoted to the latest techniques being used by scientists to study, control, and manipulate microorganisms for our benefit. The final part links the first three parts together and highlights how infectious diseases, including coronaviruses, can be transmitted from animals to humans, how global warming is affecting emerging diseases, and provides information on the actions that need to be taken to get ahead of pathogenic microbes and future pandemics. This comprehensive, state-of-the-art book is intended for anyone interested in microbiology and epidemiology, from biology and biomedical students in schools and colleges, to patients suffering from infectious diseases who want to learn more about their condition. The concepts covered in this book contribute to UN Sustainable Development Goal 3: Health and Well-Being.

This book analyzes the factors that have sparked pandemics over the past 2000 years, from the Antonine Plague to COVID-19.It is noteworthy that the frequency of pandemics has increased over the past 2000 years. The authors identify three main drivers for the development of pandemics: transportation, human development, and changes in natural ecosystems. It is important to note that with the advent of the industrial age, the length of time it takes for a pandemic to develop has decreased. COVID-19 is certainly not the last pandemic we will face. Therefore, it is of paramount importance to learn from the past 2000 years to help educate general community and public health officials about pandemic risks and help governments prepare for the next pandemic.The book is also very useful in low and middle-income countries where, in the last several decades, viruses with potential for pandemics have originated. It's comprehensiveness and didactic stylemake this book a valuable read for government health agencies, private organizations, health care professionals and students.

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. - Highlights basic research in tissue specific stem cells, experiments with animal models, and clinical trials that are transforming the field of regeneration - Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research - Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases. - Details the pathophysiology of various classes of infections - Examines mechanisms of pathogenesis, immunity, and therapeutics in bacterial, viral, and eukaryotic infectious diseases - Discusses various aspects on herpes, COVID-19 infections, Mucormycosis, Omicron, vaccines, and therapeutics - Covers the salient features on zoonosis, prion disease, and diabetic foot infections - Provides therapeutic strategies of using new antibiotics, vaccines, bromhexine, boron compounds, structurally diverse phytotherapeutics, immune enhancers, and other modalities for treating infections

During last 30 years, hundreds of different development projects have been made all over the world. In Finland, gender equity in technology education has been one main theme since 1970. The results of this research show some positive signs in girls'attitudes towards technology. However, the results in psychomotor and cognitive areas are not as promising and it can be concluded that an ideal solution in Finnish technology education has not been found. At any rate, the problem of inequality in the field of technology seems to be far more complicated than was previously thought. Technology education is not only responsible for solving such a complex problem, but society as a whole.

Modern information and communication technologies make it easier for individuals to be involved in their own health and social care. They also facilitate contact between individuals and service providers and deliver more efficient tools for healthcare staff. Artificial Intelligence (AI) promises to bring even more benefits in the future, with more effectiveness and the provision of decision support. This book presents the proceedings of the 33rd Medical Informatics Europe Conference, MIE2023, held in Gothenburg, Sweden, from 22 to 25 May 2023. The theme of MIE2023 was ‘Caring is Sharing – Exploiting Value in Data for Health and Innovation', stressing the increasing importance of sharing digital-health data and the related challenges. The sharing of health data is developing rapidly, both in Europe and beyond, so the focus of the conference was on the enabling of trustworthy sharing of data to improve health. Topics covered include healthcare, community care, self-care, public health, and the innovation and development of future-proof digital-health solutions, and the almost 300 papers divided into 10 chapters also cover important advances in the sub domains of biomedical informatics: decision support systems, clinical information systems, clinical research informatics, knowledge management and representation, consumer health informatics, natural language processing, public health informatics, privacy, ethical and societal aspects among them. Describing innovative approaches to the collection, organization, analysis, and data-sharing related to health and wellbeing, the book contributes to the expertise required to take medical informatics to the next level, and will be of interest to all those working in the field.

This textbook is an introductory guide to applied machine learning, specifically for biology students. It familiarizes biology students with the basics of modern computer science and mathematics and emphasizes the real-world applications of these subjects. The chapters give an overview of computer systems and programming languages to establish a basic understanding of the important concepts in computer systems. Readers are introduced to machine learning and artificial intelligence in the field of bioinformatics, connecting these applications to systems biology, biological data analysis and predictions, and healthcare diagnosis and treatment. This book offers a necessary foundation for more advanced computer-based technologies used in biology, employing case studies, real-world issues, and various examples to guide the reader from the basic prerequisites to machine learning and its applications.

Dal primo viaggio di Colombo per il Nuovo Mondo alle prime guerre d'Italia, fino alla pace di Cateau-Cambrésis e allo scoppio delle guerre di religione; l'epoca ricostruita dal volume non è solo ricca di eventi drammatici, ma segna l'inizio di un nuovo capitolo della storia universale. Hauser e Renaudet individuano due correnti maggiori che, come forze che agiscono al di sopra dei fatti particolari, attraversano l'intero periodo, producendo un'eco trasformatrice in tutti i paesi europei: il Rinascimento e la Riforma. Si tratta di due vere e proprie rivoluzioni, la prima dell'intelligenza e delle arti, la seconda della religione, della morale e infine della fede stessa. Due movimenti che, solo grazie a questa profonda analisi storica, sono conoscibili come rappresentazioni di una medesima affermazione dell'individuo, manifestazioni della sua emancipazione dalle costrizioni collettive ereditate dal Medioevo.

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world's healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body.This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic.This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

Libro especializado que se ajusta al desarrollo de la cualificación profesional y adquisición del certificado de profesionalidad'HOTR0408. COCINA'. Manual imprescindible para la formación y la capacitación, que se basa en los principios de la cualificación y dinamización del conocimiento, como premisas para la mejora de la empleabilidad y eficacia para el desempeño del trabajo.

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer´s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin´s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized.Key Features: Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior Describes potential behavioral and pharmacological approaches to support brain insulin signaling

This book contains best selected research papers presented at ICTCS 2021: Sixth International Conference on Information and Communication Technology for Competitive Strategies. The conference will be held at Jaipur, Rajasthan, India, during December 17–18, 2021. The book covers state-of-the-art as well as emerging topics pertaining to ICT and effective strategies for its implementation for engineering and managerial applications. This book contains papers mainly focused on ICT for computation, algorithms and data analytics, and IT security. The book is presented in two volumes.

Bioinspiration is recognized by the World Health Organization as having great promise in transforming and democratizing health systems while improving the quality, safety, and efficiency of standard healthcare in order to offer patients the tremendous opportunity to take charge of their own health. This phenomenon can enable great medical breakthroughs by helping healthcare providers improve patient care, make accurate diagnoses, optimize treatment protocols, and more. Unfortunately, the consequences can be serious if those who finance, design, regulate, or use artificial intelligence (AI) technologies for health do not prioritize ethical principles and obligations in terms of human rights and preservation of the private life. Advanced Bioinspiration Methods for Healthcare Standards, Policies, and Reform is the fruit of the fusion of AI and medicine, which brings together the latest empirical research findings in the areas of AI, bioinspiration, law, ethics, and medicine. It assists professionals in optimizing the potential benefits of AI models and bioinspired algorithms in health issues while mitigating potential dangers by examining the complex issues and innovative solutions that are linked to healthcare standards, policies, and reform. Covering topics such as genetic algorithms, health surveillance cameras, and hybrid classification algorithms, this premier reference source is an excellent resource for AI specialists, hospital administrators, health professionals, healthcare scientists, students and educators of higher education, government officials, researchers, and academicians.

Now in four convenient volumes, Field's Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field's Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.

Clinical Management of Pediatric COVID-19: An International Perspective and Practical Guide provides the most current international research and clinical characteristics of pediatric patients with SARS-CoV-2 infection. Coverage ranges from epidemiology including origin, route of transmission, incubation period, mortality and susceptibility risk factors; to pathogenesis, including difference between the adult and pediatric populations. Diagnosis is covered with special attention to the difference between adult and pediatric patients as well as the differences between newborns, children and adolescents. The book presents current complications, including multisystemic inflammatory syndrome as well as treatment therapies including antiviral and immunomodulatory therapies for this age group. Finally, immunization efficacy and safety are examined. This is the perfect reference to provide guidance to pediatricians on the diagnosis and treatment of SARS-CoV-2, as well as a valuable source of the latest research about the pediatric population for further study. - Provides the latest findings on the clinical characteristics of pediatric patients with SARS-CoV-2 infection - Elucidates the differences between pediatric COVID-19 and its adult counterpart, outlining the correct clinical course for infants, children and adolescents - Covers both recent clinical practice as well as current research specific to the pediatric population

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin's role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book's complete coverage of organ systems and diseases where Angiotensin plays a key role. - Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19 - Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction - Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels

International Encyclopedia of Education, Fourth Edition updates readers on emerging interests and developments in the field. The book presents comprehensive reviews of research in various areas, but also includes illustrations/examples from regions, nations, locations--situated and contrastive (i.e., rather than exemplars serving transferability rather than generalizability avoiding standardization and homogenizations). In so doing, this encyclopedia can serve topic-specific purposes as well as be enlisted in a fashion which binds together separate entries. Sections provide comprehensive reviews and the state of research, theory and practice in a fashion that is both historic and developmental. - Provides comprehensive reviews of research in various areas, including illustrations/examples from regions, nations, locations--situated and contrastive (i.e. rather than exemplars serving transferability rather than generalizability avoiding standardization and homogenizations) - Addresses the state of research, theory and practice in a fashion that is both historic and developmental - Presents a critical accounting of not only what educational scholars have achieved, but also current challenges

'AI Tools for Protecting and Preventing Sophisticated Cyber Attacks illuminates the most effective and practical applications of artificial intelligence (AI) in securing critical cyber infrastructure and internet communities worldwide. The book presents a collection of selected peer-reviewed chapters addressing the most important issues, technical solutions, and future research directions in cyber security. Covering topics such as assessment metrics, information security, and toolkits, this premier reference source is an essential resource for cyber security experts, cyber systems administrators, IT experts, internet and computer network professionals, organizational leaders, students and educators of higher education, researchers, and academicians'--

This handbook analyzes and develops methods and models to optimize solutions for energy access (for industry and the general world population alike) in terms of reliability and sustainability. With a focus on improving the performance of energy systems, it brings together state-of-the-art research on reliability enhancement, intelligent development, simulation and optimization, as well as sustainable development of energy systems. It helps energy stakeholders and professionals learn the methodologies needed to improve the reliability of energy supply-and-demand systems, achieve more efficient long-term operations, deal with uncertainties in energy systems, and reduce energy emissions.Highlighting novel models and their applications from leading experts in this important area, this book will appeal to researchers, students, and engineers in the various domains of smart energy systems and encourage them to pursue research and development in this exciting and highly relevant field.

For the past 17 years, Pediatric Hypertension has served as the definitive reference text on hypertension in children and adolescents. Each edition has incorporated the latest research on the pathophysiology, clinical significance and management of hypertension in the young, and has incorporated the most current consensus guidelines on diagnosis and management. The years since publication of the fourth edition have seen further advances in the field that merit publication of an updated, expanded text, including: Analysis of the implications of updated hypertension guidelines on identification of youth at highest cardiovascular risk Additional data on the proximate effects of high blood pressure in children in adolescents Further understanding of the links between high blood pressure in youth and surrogate markers of adult cardiovascular disease The fifth edition is a readable, informative text that provides a comprehensive guide to the diagnosis, management and therapy of hypertension in children and adolescents, and presents new data that very clearly indicate that the origins of adult cardiovascular disease are rooted in pediatric hypertension. It will, as a result, be very important for therapeutic decisions and will also be highly relevant for those in internal medicine, who care for the millions of adults who have hypertension, cardiovascular disease and kidney disease. In this sense, the book fulfills the longstanding goal of showing that hypertension that begins in childhood is important to track, diagnose and treat, and that the present understanding of adult hypertension necessitates the study of blood pressure in youth. The fifth edition has a similar structural format to the prior editions and covers all aspects of pediatric hypertension, from basic science research to the most recent clinical information.

This book aims to serve the critical interests of the global community by supplying the most current knowledge and understanding of Covid-19 epidemiology, treatment, and prognoses. There was much uncertain and contradictory information published in the first year of the novel coronavirus. The dynamics of COVID-19 have now been realized, including the type of antibodies produced in infected patients and their limited lasting endurance. This book will set the record straight on the concept of “herd immunity” and explore the current vaccine trials taking place in different countries. This comprehensive book will illuminate recent advances regarding COVID-19 and offer a possible roadmap on how to move forward. Frontiers of COVID-19: A Pathophysiology and Epidemiology Roadmap of Novel Coronavirus Disease will be a vital and forward-looking guide for infectious disease clinicians, scientists and researchers, and students at the graduate level.

Companies that use innovative training and development practices are likely to report better financial performance than their competitors that do not. Training and development also help a company develop the human capital needed to meet competitive challenges. Many companies now recognize that learning through training, development, and knowledge management helps employees strengthen or increase their skills directly impacting their job performance, satisfaction, and career advancement. The 9th edition covers and addresses the changes in training and development from an employer and employee perspective - adding value to the employer and employee. Based on the author's extensive experience in teaching training and development courses to both graduate and undergraduate students, Employee Training and Development, Ninth Edition, retains the lively writing style, inspiring examples, and emphasis on new technology and strategic training from previous editions.

Spendere meno e in modo più consapevole, per il benessere del pianeta e del nostro conto corrente. In una parola, risparmiare: che significa essere creativi, conoscere meglio sé stessi e i propri bisogni, scoprire che alcune spese si possono ridurre, affrontare in modalità diverse o anche annullare grazie alla condivisione, al noleggio, al fai da te. Con leggerezza e abbondanza di informazioni, questa guida offre suggerimenti pratici e concreti per risparmiare su tutti i tipi di acquisto e di necessità, senza proporre solo la via della rinuncia e del sacrificio, ma indicando come usare al meglio il denaro e come trovare soluzioni nuove ai problemi della realtà quotidiana. Le cinque sezioni del testo (Alimenti, Persona, Casa, Cultura, Flora e fauna) sono arricchite da box con curiosità e consigli di lettura sugli aspetti che ciascun lettore avrà piacere di approfondire. Ogni capitolo si apre con una citazione letteraria, a ricordarci che fare la spesa, comprare un elettrodomestico o prenotare un viaggio sono necessità a cui nessuno può sottrarsi, neppure i personaggi di fantasia.

Data, informatics, and technology are now among the most important aspects inspiring health professionals and informaticians to improve healthcare for the benefit of patients. This book presents the proceedings of the 19th annual International Conference on Informatics, Management, and Technology in Healthcare (ICIMTH 2021), held as a virtual event due to COVID-19 pandemic restrictions on 16 and 17 October 2021 in Athens, Greece. The ICIMTH conferences are a series of scientific events which bring together scientists working in the field of biomedical and health informatics from around the world. The 2021 conference examined the field of biomedical and health informatics in a very broad framework, presenting the research and application outcomes of informatics from cell to populations, and including a number of technologies such as imaging, sensors and biomedical equipment, as well as management and organizational aspects, including legal and social issues and the setting of research priorities in health informatics. A significant number of the papers included here relate to the COVID-19 pandemic. Providing an insight into the latest developments in biomedical and health informatics, the book will be of interest to all those working in the field.

Learn MANAGEMENT YOUR Way with MGMT! Extensively updated to reflect the latest research in the field, MGMT makes concepts and theories accessible and relevant with timely, interesting examples of their applications at real businesses. Now available with MindTap, the digital learning solution designed to help you think and act like a manager. MGMT's easy-reference, textbook presents course content through visually engaging chapters as well as Chapter Review Cards that consolidate the best review material into a ready-made study tool. With the textbook or on its own, MindTap for MGMT allows you to learn on your terms. Read or listen to textbook and study with the aid of instructor notifications, flashcards and practice quizzes. Track your scores and stay motivated toward your goals. Whether you have more work to do or are ahead of the curve, you'll know where you need to focus your efforts.

The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened a two-day virtual public workshop to address knowledge gaps in the understanding of promising approaches to manipulate the immune system and/or the regenerative medicine product to improve outcomes of tissue repair and regeneration in patients. The workshop, titled'Understanding the Role of the Immune System in Improving Tissue Regeneration,'explored the role of the immune system in the success or failure of regenerative medicine therapies. Participants considered potential strategies to effectively'prepare'patients'immune systems to accept regenerative therapies and increase the likelihood of successful clinical outcomes and also discussed risks associated with modulating the immune system. This Proceedings of a Workshop highlights the presentations and discussions that occurred during the workshop.