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Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy. Offers a comprehensive and authoritative guide to all aspects of the subject internationally Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics Shows the latest developments in research in genomics and in practice with the digital clinic

Genetic Programming Theory and Practice brings together some of the most impactful researchers in the field of Genetic Programming (GP), each one working on unique and interesting intersections of theoretical development and practical applications of this evolutionary-based machine learning paradigm. Topics of particular interest for this year's book include powerful modeling techniques through GP-based symbolic regression, novel selection mechanisms that help guide the evolutionary process, modular approaches to GP, and applications in cybersecurity, biomedicine, and program synthesis, as well as papers by practitioner of GP that focus on usability and real-world results. In summary, readers will get a glimpse of the current state of the- art in GP research.

This book gathers papers presented during the 5th International Conference on Electrical Engineering and Control Applications (ICEECA 2022), held on November, 15–17, 2022, Khenchela, Algeria. It covers new control system models, troubleshooting tips, and complex system requirements, such as increased speed, precision, and remote capabilities. Additionally, the book discusses not only the engineering aspects of signal processing and various practical issues in the broad field of information transmission, but also novel technologies for communication networks and modern antenna design. The later part of the book covers important related topics such as fault diagnosis and fault-tolerant control strategies for nonlinear systems and alternative energy sources. This book is intended for researchers, engineers, and advanced postgraduate students in the fields of control and electrical engineering, computer science, signal processing, as well as mechanical and chemical engineering.

This book reflects the latest developments in sliding-mode control (SMC) and variable-structure systems (VSS), comprising contributions by leading researchers and an international range of experts. Such contributions highlight advances in various branches of the field—conventional and higher-order SMC with continuous- and discrete-time implementation and theory and applications both receive attention.The book consists of six parts. In the first, new SMC/VSS algorithms are proposed and their properties are analyzed. The second part focuses on the use of observers to solve the estimation and output-feedback control problems. The third part discusses the discretization aspects of SMC algorithms. Parts IV and V provide important insights on the use of adaptation laws for non-overestimated control gains and chattering alleviation. The last part examines the applications of these SMC/VSS ideas to real-world systems. Sliding-Mode Control and Variable-Structure Systems introduces postgraduates and researchers to the state of the art in the field. It includes theory, methods, and applications relevant to workers in disciplines including control, automation, applied mathematics, electrical and mechanical engineering, instrumentation, electronics, computer science, robotics, transportation, and power engineering. Its clear style and deep exposition help readers to keep in touch with tools that are, thanks to the robustness and insensitivity to perturbations of the SMC/VSS paradigm, among the most efficient for dealing with uncertain systems.

This book is a collection of the high-quality research articles in the field of computer vision and robotics which are presented in International Conference on Computer Vision and Robotics (ICCVR 2022), organized by BBD University Lucknow India, during 21 – 22 May 2022. The book discusses applications of computer vision and robotics in the fields like medical science, defence and smart city planning. This book presents recent works from researchers, academicians, industry, and policy makers.

'Cyber Trafficking, Threat Behavior, and Malicious Activity Monitoring for Healthcare Organizations provides a comprehensive review of techniques and applications of industry 5.0-enabled intelligent healthcare centric cyber security. The goal of this book is to close the gap between AI and cyber security. Covering topics such as malicious activity, dark web, and smart healthcare systems, this premier reference source is an essential resource for healthcare administrators, IT managers, system developers, system architects, IT specialists, students and educators of higher education, librarians, researchers, and academicians'--

This book is a collection of high-quality research work on cutting-edge technologies and the most-happening areas of computational intelligence and data engineering. It includes selected papers from the International Conference on Computational Intelligence and Data Engineering (ICCIDE 2022). It covers various topics, including collective intelligence, intelligent transportation systems, fuzzy systems, Bayesian network, ant colony optimization, data privacy and security, data mining, data warehousing, big data analytics, cloud computing, natural language processing, swarm intelligence and speech processing.

Bringing clarity to the emerging model of precision medicine within the diabetes field, and expanding upon how it will lead to the development of specifically tailored treatment for patients and even macro strategies in public health, this unique book explores the realm of biomarkers in the era of big data. Various experts in their respective areas discuss the current practice to illuminate how creating a more discreet profile of patients and even substratum of populations will lead to more refined therapies targeted towards the phenotype and genotype of the patient.Embracing a multidisciplinary team science approach, this book demonstrates how precision medicine in diabetes can mine a web of data toward diabetes risk stratification and treatment options. The authors skillfully articulate how the construction of various prediction-based models can revolutionize clinical decision-making, and they examine the challenges and pitfalls of integrating disparate sources of information and how the collection of data and cooperation among stakeholders will be key to the future of precision medicine in diabetes treatment. Topics include personalized approaches to the management of both type 1 and type 2 diabetes, various macro and microvascular complications of diabetes, inpatient management of glycemia, nutrition, exercise, advances in diabetes technology and others.Ideal for clinical endocrinologists and other professionals involved in the management of diabetes and its complications, Precision Medicine in Diabetes is first of its kind to address this paradigm-shifting topic in a comprehensive way.

The Encyclopedia of Systems and Control collects a broad range of short expository articles that describe the current state of the art in the central topics of control and systems engineering as well as in many of the related fields in which control is an enabling technology. The editors have assembled the most comprehensive reference possible, and this has been greatly facilitated by the publisher's commitment to continuously publish updates to the articles as they become available in the future. Although control engineering is now a mature discipline, it remains an area in which there is a great deal of research activity, and as new developments in both theory and applications become available, they will be included in the online version of the encyclopedia. A carefully chosen team of leading authorities in the field has written the well over 300 articles, 50 of them new in the second edition. The topics range from basic principles of feedback in servomechanisms to advanced topics such as the control of Boolean networks and evolutionary game theory and this range has also been expanded to include material on such subjects as the Internet of Things, quantum control and smart grids. Because the content has been selected to reflect both foundational importance and subjects that are of current interest to the research and practitioner communities, a broad readership that includes students, application engineers, and research scientists will find entries that are of interest.

This book presents innovative research works to demonstrate the potential and the advancements of computing approaches to utilize healthcare centric and medical datasets in solving complex healthcare problems. Computing technique is one of the key technologies that are being currently used to perform medical diagnostics in the healthcare domain, thanks to the abundance of medical data being generated and collected. Nowadays, medical data is available in many different forms like MRI images, CT scan images, EHR data, test reports, histopathological data and doctor patient conversation data. This opens up huge opportunities for the application of computing techniques, to derive data-driven models that can be of very high utility, in terms of providing effective treatment to patients. Moreover, machine learning algorithms can uncover hidden patterns and relationships present in medical datasets, which are too complex to uncover, if a data-driven approach is not taken. With the help ofcomputing systems, today, it is possible for researchers to predict an accurate medical diagnosis for new patients, using models built from previous patient data. Apart from automatic diagnostic tasks, computing techniques have also been applied in the process of drug discovery, by which a lot of time and money can be saved. Utilization of genomic data using various computing techniques is another emerging area, which may in fact be the key to fulfilling the dream of personalized medications. Medical prognostics is another area in which machine learning has shown great promise recently, where automatic prognostic models are being built that can predict the progress of the disease, as well as can suggest the potential treatment paths to get ahead of the disease progression.

An ideal resource for both pediatricians and endocrinologists, Sperling's Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today's clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you're preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient. - Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests. - Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta. - Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine. - Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment. - Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.

The past few years have seen the attention and rapid developments in event-triggered sampled-data systems, in which the effect of event-triggered sensor measurements and controller updates is explored in controller analysis and design.This book offers the first systematic treatment of event-triggered sampled-data control system design using active disturbance rejection control (ADRC), an effective approach that is popular in both theoretic research and industrial applications. Extensive application examples with numerous illustrations are included to show how the event-triggered ADRC with theoretic performance guarantees can be implemented in engineering systems and how the performance can be actually achieved. For theoretic researchers and graduate students, the presented results provide new directions in theoretic research on event-triggered sampled-data systems; for control practitioners, the book offers an effective approach to achieving satisfactory performance with limited sampling rates.

Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices).Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation

This book presents the proceedings of The 2020 International Conference on Machine Learning and Big Data Analytics for IoT Security and Privacy (SPIoT-2020), held in Shanghai, China, on November 6, 2020. Due to the COVID-19 outbreak problem, SPIoT-2020 conference was held online by Tencent Meeting. It provides comprehensive coverage of the latest advances and trends in information technology, science and engineering, addressing a number of broad themes, including novel machine learning and big data analytics methods for IoT security, data mining and statistical modelling for the secure IoT and machine learning-based security detecting protocols, which inspire the development of IoT security and privacy technologies. The contributions cover a wide range of topics: analytics and machine learning applications to IoT security; data-based metrics and risk assessment approaches for IoT; data confidentiality and privacy in IoT; and authentication and access control for data usage in IoT. Outlining promising future research directions, the book is a valuable resource for students, researchers and professionals and provides a useful reference guide for newcomers to the IoT security and privacy field.

This book presents outstanding contributions in an exciting, new and multidisciplinary research area: the application of formal, automated reasoning techniques to analyse complex models in systems biology and systems medicine. Automated reasoning is a field of computer science devoted to the development of algorithms that yield trustworthy answers, providing a basis of sound logical reasoning. For example, in the semiconductor industry formal verification is instrumental to ensuring that chip designs are free of defects (or “bugs”). Over the past 15 years, systems biology and systems medicine have been introduced in an attempt to understand the enormous complexity of life from a computational point of view. This has generated a wealth of new knowledge in the form of computational models, whose staggering complexity makes manual analysis methods infeasible. Sound, trusted, and automated means of analysing the models are thus required in order to be able to trust their conclusions. Above all, this is crucial to engineering safe biomedical devices and to reducing our reliance on wet-lab experiments and clinical trials, which will in turn produce lower economic and societal costs. Some examples of the questions addressed here include: Can we automatically adjust medications for patients with multiple chronic conditions? Can we verify that an artificial pancreas system delivers insulin in a way that ensures Type 1 diabetic patients never suffer from hyperglycaemia or hypoglycaemia? And lastly, can we predict what kind of mutations a cancer cell is likely to undergo? This book brings together leading researchers from a number of highly interdisciplinary areas, including: · Parameter inference from time series · Model selection · Network structure identification · Machine learning · Systems medicine · Hypothesis generation from experimental data · Systems biology, systems medicine, and digital pathology · Verification of biomedical devices “This book presents a comprehensive spectrum of model-focused analysis techniques for biological systems...an essential resource for tracking the developments of a fast moving field that promises to revolutionize biology and medicine by the automated analysis of models and data.”Prof Luca Cardelli FRS, University of Oxford

The world of medical technologies is undergoing a sea change in the domain of consumer culture. Having a grasp on what appeals to consumers and how consumers are making purchasing decisions is essential to the success of any organization that thrives by offering a product or service. As such, it is vital to examine the consumer-centered aspects of medical technological developments that have a patient-centered focus and allow patients to take part in their own personal health and wellness. Consumer-Driven Technologies in Healthcare: Breakthroughs in Research and Practice is a critical source of academic knowledge on the use of smartphones and other technological devices for cancer therapy, fitness and wellness, chronic disease monitoring, and other areas. The tracking of these items using technology has allowed consumers to take control of their own healthcare. Highlighting a range of pertinent topics such as clinical decision support systems, patient engagement, and electronic health records, this publication is an ideal reference source for doctors, nurse practitioners, hospital administrators, medical professionals, IT professionals, academicians, and researchers interested in advancing medical practice through technology.

Biotechnology can be defined as the manipulation of biological process, systems, and organisms in the production of various products. With applications in a number of fields such as biomedical, chemical, mechanical, and civil engineering, research on the development of biologically inspired materials is essential to further advancement. Biotechnology: Concepts, Methodologies, Tools, and Applications is a vital reference source for the latest research findings on the application of biotechnology in medicine, engineering, agriculture, food production, and other areas. It also examines the economic impacts of biotechnology use. Highlighting a range of topics such as pharmacogenomics, biomedical engineering, and bioinformatics, this multi-volume book is ideally designed for engineers, pharmacists, medical professionals, practitioners, academicians, and researchers interested in the applications of biotechnology.

Originally published in 1989, presenting a new perspective on cognitive therapy in neuropsychology, these papers examine a cognitively-oriented, single-case methodology in neuropsychological rehabilitation. The recommended strategy is in-depth analysis of the precise nature of the impaired as well as the preserved processing components in the individual patient. The objective is to design a therapeutic course based on individual patient needs that is justified by the theoretical interpretation of the location of the deficit in his or her cognitive architecture.

Originally published in 1987, Aphasia Therapy surveys the approaches to aphasia treatment from throughout the world that have been taken both in the past and in the present day. The authors critically examine the assumptions underlying different approaches, and show their effects on modern clinical practices. Finally, the book offers new perspectives on some contemporary issues in aphasia therapy, the effectiveness of treatment, and the relationship between an analysis of a patient's problems and the processes of treatment. Aphasia Therapy is divided into three parts: Part 1 illustrates some approaches to treatment in the period up to World War II – for instance, a didactic approach which emphasised the importance of repetition; the second part considers the different kinds of approaches to therapy that have developed since then – seven'schools'of treatment are identified; Part 3 considers whether there is evidence that treatment of aphasia is effective: the authors argue that in future, aphasia treatment must involve the development and evaluation of specific treatment methods that are theoretically motivated by a coherent analysis of the individual patient's problems.Students, postgraduates, and practising clinicians in speech therapy will find this volume of great interest, as will neuropsychologists and clinical psychologists.

Recent developments in model-predictive control promise remarkable opportunities for designing multi-input, multi-output control systems and improving the control of single-input, single-output systems. This volume provides a definitive survey of the latest model-predictive control methods available to engineers and scientists today. The initial set of chapters present various methods for managing uncertainty in systems, including stochastic model-predictive control. With the advent of affordable and fast computation, control engineers now need to think about using “computationally intensive controls,” so the second part of this book addresses the solution of optimization problems in “real” time for model-predictive control. The theory and applications of control theory often influence each other, so the last section of Handbook of Model Predictive Control rounds out the book with representative applications to automobiles, healthcare, robotics, and finance. The chapters in this volume will be useful to working engineers, scientists, and mathematicians, as well as students and faculty interested in the progression of control theory. Future developments in MPC will no doubt build from concepts demonstrated in this book and anyone with an interest in MPC will find fruitful information and suggestions for additional reading.

This book gathers selected, extended and revised contributions to the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018), and the 3rd Conference on Imaging and Visualization, which took place on 26-29 March, 2018, in Lisbon, Portugal. The respective chapters highlight cutting-edge methods, e.g. new algorithms, image analysis techniques, and multibody modeling methods; and new findings obtained by applying them in biological and/or medical contexts. Original numerical studies, Monte Carlo simulations, FEM analyses and reaction-diffusion models are described in detail, together with intriguing new applications. The book offers a timely source of information for biologists, engineers, applied mathematicians and clinical researchers working on multidisciplinary projects, and is also intended to foster closer collaboration between these groups.

Glucose Monitoring Devices: Measuring Blood Glucose to Manage and Control Diabetes presents the state-of-the-art regarding glucose monitoring devices and the clinical use of monitoring data for the improvement of diabetes management and control. Chapters cover the two most common approaches to glucose monitoring–self-monitoring blood glucose and continuous glucose monitoring–discussing their components, accuracy, the impact of use on quality of glycemic control as documented by landmark clinical trials, and mathematical approaches. Other sections cover how data obtained from these monitoring devices is deployed within diabetes management systems and new approaches to glucose monitoring. This book provides a comprehensive treatment on glucose monitoring devices not otherwise found in a single manuscript. Its comprehensive variety of topics makes it an excellent reference book for doctoral and postdoctoral students working in the field of diabetes technology, both in academia and industry. - Presents a comprehensive approach that spans self-monitoring blood glucose devices, the use of continuous monitoring in the artificial pancreas, and intraperitoneal glucose sensing - Provides a high-level descriptions of devices, as well as detailed mathematical descriptions of methods and techniques - Written by experts in the field with vast experience in the field of diabetes and diabetes technology

This volume constitutes the refereed proceedings of the 6th Workshop on Engineering Applications, WEA 2019, held in Santa Marta, Colombia, in October 2019.The 62 revised full papers and 2 short papers presented in this volume were carefully reviewed and selected from 178 submissions. The papers are organized in the following topical sections: computer science; computational intelligence; bioengineering; Internet of things; power applications; simulation systems; optimization.

ITiB'2018 is the 6th Conference on Information Technology in Biomedicine, hosted every two years by the Department of Informatics & Medical Devices, Faculty of Biomedical Engineering, Silesian University of Technology. The Conference is organized under the auspices of the Committee on Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. The meeting has become an established event that helps to address the demand for fast and reliable technologies capable of processing data and delivering results in a user-friendly, timely and mobile manner. Many of these areas are recognized as research and development frontiers in employing new technology in the clinical setting. Technological assistance can be found in prevention, diagnosis, treatment, and rehabilitation alike. Homecare support for any type of disability may improve standard of living and make people's lives safer and more comfortable. The book includes the following sections: Ø Image Processing Ø Multimodal Imaging and Computer-aided Surgery Ø Computer-aided Diagnosis Ø Signal Processing and Medical Devices Ø Bioinformatics Ø Modelling & Simulation Ø Analytics in Action on the SAS Platform Ø Assistive Technologies and Affective Computing (ATAC)

Neuropsychology is the study of the relationship between behaviour, emotion, and cognition on the one hand, and brain function on the other. Psychology Library Editions: Neuropsychology (12 Volume set) presents titles, originally published between 1981 and 1993, covering a variety of areas within neuropsychology, a relatively new discipline at the time, as it firmly established itself within the field of psychology. It includes contributions from well-respected academics, many still active in neuropsychology today.

This brief introduces recursive modeling techniques that take account of variations in blood glucose concentration within and between individuals. It describes their use in developing multivariable models in early-warning systems for hypo- and hyperglycemia; these models are more accurate than those solely reliant on glucose and insulin concentrations because they can accommodate other relevant influences like physical activity, stress and sleep. Such factors also contribute to the accuracy of the adaptive control systems present in the artificial pancreas which is the focus of the brief, as their presence is indicated before they have an apparent effect on the glucose concentration and so can be more easily compensated. The adaptive controller is based on generalized predictive control techniques and also includes rules for changing controller parameters or structure based on the values of physiological variables. Simulation studies and clinical studies are reported to illustrate the performance of the techniques presented.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician's performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

These two volumes constitute the Proceedings of the 7th International Workshop on Soft Computing Applications (SOFA 2016), held on 24–26 August 2016 in Arad, Romania. This edition was organized by Aurel Vlaicu University of Arad, Romania, University of Belgrade, Serbia, in conjunction with the Institute of Computer Science, Iasi Branch of the Romanian Academy, IEEE Romanian Section, Romanian Society of Control Engineering and Technical Informatics (SRAIT) - Arad Section, General Association of Engineers in Romania - Arad Section, and BTM Resources Arad. The soft computing concept was introduced by Lotfi Zadeh in 1991 and serves to highlight the emergence of computing methodologies in which the accent is on exploiting the tolerance for imprecision and uncertainty to achieve tractability, robustness and lower costs. Soft computing facilitates the combined use of fuzzy logic, neurocomputing, evolutionary computing and probabilistic computing, leading to the concept of hybrid intelligent systems. The rapid emergence of new tools and applications calls for a synergy of scientific and technological disciplines in order to reveal the great potential of soft computing in all domains. The conference papers included in these proceedings, published post-conference, were grouped into the following areas of research: • Methods and Applications in Electrical Engineering • Knowledge-Based Technologies for Web Applications, Cloud Computing, Security Algorithms and Computer Networks • Biomedical Applications • Image, Text and Signal Processing • Machine Learning and Applications • Business Process Management • Fuzzy Applications, Theory and Fuzzy Control • Computational Intelligence in Education • Soft Computing & Fuzzy Logic in Biometrics (SCFLB) • Soft Computing Algorithms Applied in Economy, Industry and Communication Technology • Modelling and Applications in Textiles The book helps to disseminate advances in selected active research directions in the field of soft computing, along with current issues and applications of related topics. As such, it provides valuable information for professors, researchers and graduate students in the area of soft computing techniques and applications.

This book constitutes the refereed proceedings of the 16th International Symposium on Automated Technology for Verification and Analysis, ATVA 2018, held in Los Angeles, CA, USA in October 2018.The 27 full papers presented together with 5 short papers and 3 invited talks were carefully reviewed and selected from 82 submissions. The symposium is dedicated to the promotion of research on theoretical and practical aspects of automated analysis, verification and synthesis by providing a forum for interaction between the regional and the international research communities and industry in the field.

Process Systems Engineering brings together the international community of researchers and engineers interested in computing-based methods in process engineering. This conference highlights the contributions of the PSE community towards the sustainability of modern society and is based on the 13th International Symposium on Process Systems Engineering PSE 2018 event held San Diego, CA, July 1-5 2018. The book contains contributions from academia and industry, establishing the core products of PSE, defining the new and changing scope of our results, and future challenges. Plenary and keynote lectures discuss real-world challenges (globalization, energy, environment and health) and contribute to discussions on the widening scope of PSE versus the consolidation of the core topics of PSE. - Highlights how the Process Systems Engineering community contributes to the sustainability of modern society - Establishes the core products of Process Systems Engineering - Defines the future challenges of Process Systems Engineering

An important resource that puts the focus on the chemical engineering aspects of biomedical engineering In the past 50 years remarkable achievements have been advanced in the fields of biomedical and chemical engineering. With contributions from leading chemical engineers, Biomedical Engineering Challenges reviews the recent research and discovery that sits at the interface of engineering and biology. The authors explore the principles and practices that are applied to the ever-expanding array of such new areas as gene-therapy delivery, biosensor design, and the development of improved therapeutic compounds, imaging agents, and drug delivery vehicles. Filled with illustrative case studies, this important resource examines such important work as methods of growing human cells and tissues outside the body in order to repair or replace damaged tissues. In addition, the text covers a range of topics including the challenges faced with developing artificial lungs, kidneys, and livers; advances in 3D cell culture systems; and chemical reaction methodologies for biomedical imagining analysis. This vital resource: Covers interdisciplinary research at the interface between chemical engineering, biology, and chemistry Provides a series of valuable case studies describing current themes in biomedical engineering Explores chemical engineering principles such as mass transfer, bioreactor technologies as applied to problems such as cell culture, tissue engineering, and biomedical imaging Written from the point of view of chemical engineers, this authoritative guide offers a broad-ranging but concise overview of research at the interface of chemical engineering and biology.

This volume presents the proceedings of the CLAIB 2016, held in Bucaramanga, Santander, Colombia, 26, 27 & 28 October 2016. The proceedings, presented by the Regional Council of Biomedical Engineering for Latin America (CORAL), offer research findings, experiences and activities between institutions and universities to develop Bioengineering, Biomedical Engineering and related sciences. The conferences of the American Congress of Biomedical Engineering are sponsored by the International Federation for Medical and Biological Engineering (IFMBE), Society for Engineering in Biology and Medicine (EMBS) and the Pan American Health Organization (PAHO), among other organizations and international agencies to bring together scientists, academics and biomedical engineers in Latin America and other continents in an environment conducive to exchange and professional growth.

Babies of women with diabetes are nearly five times more likely to be stillborn and almost three times more likely to die in the first three months. The incidence of gestational diabetes mellitus in the U.S. is high—between 3 and 7 percent—and rising. The condition is often complicated by other risk factors such as obesity and heart disease. The Textbook of Diabetes and Pregnancy presents a comprehensive review of the science, clinical management, and medical implications of gestational diabetes mellitus, a condition with serious consequences that is on the increase in all developed societies. This new edition supports the latest initiatives and strategies of the International Federation of Gynecology and Obstetrics (FIGO) and adds chapters on noncommunicable diseases, obesity, bariatric surgery, and epidemiology outside Western cultures. Written by a cadre of experts, the book provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.

Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

This book tackles the problem of overshoot and undershoot in blood glucose levels caused by delay in the effects of carbohydrate consumption and insulin administration. The ideas presented here will be very important in maintaining the welfare of insulin-dependent diabetics and avoiding the damaging effects of unpredicted swings in blood glucose – accurate prediction enables the implementation of counter-measures. The glucose prediction algorithms described are also a key and critical ingredient of automated insulin delivery systems, the so-called “artificial pancreas”.The authors address the topic of blood-glucose prediction from medical, scientific and technological points of view. Simulation studies are utilized for complementary analysis but the primary focus of this book is on real applications, using clinical data from diabetic subjects.The text details the current state of the art by surveying prediction algorithms, and then moves beyond it with the most recent advancesin data-based modeling of glucose metabolism. The topic of performance evaluation is discussed and the relationship of clinical and technological needs and goals examined with regard to their implications for medical devices employing prediction algorithms. Practical and theoretical questions associated with such devices and their solutions are highlighted.This book shows researchers interested in biomedical device technology and control researchers working with predictive algorithms how incorporation of predictive algorithms into the next generation of portable glucose measurement can make treatment of diabetes safer and more efficient.

Stemming from environmental, genetic, and situational factors, chronic disease is a critical concern in modern medicine. Managing treatment and controlling symptoms is imperative to the longevity and quality of life of patients with such diseases. The Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions features current research on the diagnosis, monitoring, management, and treatment of recurring diseases such as diabetes, Parkinson's disease, autoimmune disorders, and others. This handbook is intended for practitioners and researchers across various disciplines including, but not limited to, biology, biomedical engineering, computer science, and information and communication technologies. Aimed at identifying new disease determinants and the way in which new technologies can contribute to improved health outcomes, this handbook covers a variety of topics, including wearable and mobile technologies, capillaroscopy imaging, diagnostic and monitoring methods, and disease prediction modeling, among others.

Une vingtaine de spécialistes se sont réunis pour écrire le deuxième tome de la nouvelle édition du Traité de neuropsychologie clinique de l'adulte qui porte sur la revalidation des troubles cognitifs et comportementaux consécutifs à une atteinte cérébrale.Un complément évident du tome 1 sur l'évaluationÉcrit avec un égal souci de clarté dans l'exposé, le tome 2 réaffirme l'importance de maintenir un lien fort et explicite entre les cadres théoriques et les pratiques cliniques. Sensibles à l'évolution des pratiques, les auteurs ont pris soin de présenter les pistes nouvelles ouvertes par la recherche et les initiatives de terrain.L'ouvrage n'a pas d'équivalent en langue françaisePar son ampleur, par la richesse de sa documentation et par le nombre de domaines couverts, cet ouvrage est unique en langue française. Il aborde l'ensemble des domaines de la revalidation avec une double préoccupation : l'analyse critique et sans complaisance des méthodes de revalidation conjuguée au souci d'interroger la finalité des pratiques rééducatives, avec une centration sur la qualité de vie des patients.Une deuxième édition sensiblement augmentée par rapport à la précédenteCet accroissement reflète le développement considérable des pratiques de revalidation. Sur le plan des méthodes, une ouverture est faite aux méthodes d'activation directe du cerveau et aux techniques de réalité virtuelle. Une attention particulière est également apportée aux travaux des neurosciences sur la plasticité cérébrale tandis que la plupart des chapitres font écho aux études qui tentent de valider les interventions en s'inspirant des critères fondés sur des données probantes. Une place importante est enfin accordée au vieillissement cognitif et à la démence en insistant sur l'urgence qu'il y a à développer des prises en charge intégrant toutes les dimensions de la personne : ses ressources cognitives bien entendu, mais aussi sa vie affective et son insertion sociale.Ce livre et les travaux qu'il présente rappelleront aux cliniciens que la revalidation neuropsychologique n'est pas qu'une enfant des neurosciences, elle relève aussi de la psychologie et des sciences sociales.

CONTENTS: SESSION: SIMULATION AND NUMERICAL METHODS SESSION: VISUALIZATION, GRAPHICAL USER INTERFACE, TOOLS AND TECHNIQUES SESSION: MODELING

Prolonged life expectancy along with the increasing complexity of medicine and health services raises health costs worldwide dramatically. Whilst the smart health concept has much potential to support the concept of the emerging P4-medicine (preventive, participatory, predictive, and personalized), such high-tech medicine produces large amounts of high-dimensional, weakly-structured data sets and massive amounts of unstructured information. All these technological approaches along with “big data” are turning the medical sciences into a data-intensive science. To keep pace with the growing amounts of complex data, smart hospital approaches are a commandment of the future, necessitating context aware computing along with advanced interaction paradigms in new physical-digital ecosystems. The very successful synergistic combination of methodologies and approaches from Human-Computer Interaction (HCI) and Knowledge Discovery and Data Mining (KDD) offers ideal conditions for the vision to support human intelligence with machine learning. The papers selected for this volume focus on hot topics in smart health; they discuss open problems and future challenges in order to provide a research agenda to stimulate further research and progress.

Expert authors present an up-to-date overview of health law as it affects the professionals, institutions, and entities that deliver and finance health care in the United States. Considers the law's response to quality and error through institutional and professional regulation, and malpractice litigation against professionals, hospitals, and managed care organizations. Surveys tax, corporate, and organizational issues. Explores the government's efforts to control costs and expand access through Medicare and Medicaid. Examines government attempts to police anticompetitive activities, fraud, and abuse. And considers the legal and ethical issues involving death, human reproduction, medical treatment decision making, and medical research. The Affordable Care Act, HIPAA, HITECH, and other new statutory and regulatory changes of the past few years are thoroughly incorporated in all aspects of the legal discussion.

The current epidemic of diabetes, obesity and related disorders is a driving force in the development of new technologies. Technological advances offer great new opportunities for the treatment of these chronic diseases. This review presents an update of developments that promise to revolutionize the treatment of diabetes. It examines hospital and outpatient care, intensive insulin therapy, blood glucose monitoring and innovative steps towards the construction of an artificial pancreas. Providing a comprehensive overview on the latest advances, this volume of Frontiers in Diabetes will be of particular interest to all healthcare providers involved in the daily management of patients with diabetes or related diseases.

This book constitutes the refereed proceedings of the 6th International Conference on Runtime Verification, RV 2015, held in Vienna, Austria, in September 2015. The 15 revised full papers presented together with 4 short papers, 2 tool papers, 4 tutorials, 3 invited talks, and 2 software competition papers were carefully reviewed and selected from 45 submissions.The discussion of the conference centers around two main aspects. The first is to understand wether the runtime verification techniques can practically complement the traditional methods proving programs correct before their execution, such as model checking and theorem proving. The second concerns with formal methods and how their application can improve traditional ad-hoc monitoring techniques used in performance monitoring, hardware design emulation and simulation, etc.

Linguistics and Aphasia is a major study of recent developments in applying psycholinguistics and pragmatics to the study of acquired language disorders (aphasia) and their remediation. Psycholinguistic analyses of aphasia interpret disorders in terms of damaged modules and processes within what was once a normal language system. These analyses have progressed to the point that they now routinely provide a model-based rationalefor planning patient therapy. Through a series of case studies, the authors show how the psycholinguistic analysis of aphasia can be assessed for its effectiveness in clinical practice.Pragmatic approaches to the study of aphasia are of more recent origin. Ruth Lesser and Lesley Milroy evaluate their considerable significance to the study of aphasia and their relevance to practical issues of diagnosis and treatment. Controversial analysis, in particular, offers a fruitful and productive framework within which to assess the functional adequacy of the language used by aphasic speakers in everyday contexts.

New York Trial Answer Book Techniques, law, and forms for trial preparation and presentation. The latest edition of New York Trial Notebook adds hundreds of new case citations, dozens of new tips, and many new and substantially revised sections. Turn to New York Trial Notebook for clear, concise explanations, practice tips, and recent case-based illustrations covering everything from preparing the case for trial through post trial motions. Lawyers no longer have as many opportunities to polish their trial skills. Small cases rarely reach courtrooms, and specialists and public defenders now handle the criminal cases that used to keep civil lawyers trial-ready. However, the procedures and cases governing New York courtrooms — and the techniques that work in them — must still be learned and remembered. Here is the solution. Courtroom veterans Ed Birnbaum, Carl Grasso, and Justice Ariel Belen have blended their hard-won trial lessons with the law and rules governing New York trials in an accessible single volume called New York Trial Notebook. This practical work is heavily-supported with 2,000 cases containing parenthetical descriptions and pinpoint citations, more than 80 forms in print and via Digital Access, and dozens of practice tips. New York Trial Notebook delivers: Expert witness disclosure Eve-of-trial preparation Expert witness testimony Jury selection Trial tips Cross examination of lay witnesses And much, much more. You'll receive detailed answers to the questions that frequently arise in the home stretch before trial, and that arise in the courtroom – qualification and cross-examination of experts, making and meeting objections, persuasive openings and closings, pretrial motions and motions during trial, jury selection and instruction.

This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. - Builds upon and enhances the reader's existing knowledge of modeling methodology and practice - Editors are internationally renowned leaders in their respective fields - Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

The three volume set LNCS 8834, LNCS 8835, and LNCS 8836 constitutes the proceedings of the 20th International Conference on Neural Information Processing, ICONIP 2014, held in Kuching, Malaysia, in November 2014. The 231 full papers presented were carefully reviewed and selected from 375 submissions. The selected papers cover major topics of theoretical research, empirical study, and applications of neural information processing research. The 3 volumes represent topical sections containing articles on cognitive science, neural networks and learning systems, theory and design, applications, kernel and statistical methods, evolutionary computation and hybrid intelligent systems, signal and image processing, and special sessions intelligent systems for supporting decision, making processes,theories and applications, cognitive robotics, and learning systems for social network and web mining.

New research by international contributors on Modeling, Simulation, and Visualization Methods

This volume is the first of the new series Advances in Dynamics and Delays. It offers the latest advances in the research of analyzing and controlling dynamical systems with delays, which arise in many real-world problems. The contributions in this series are a collection across various disciplines, encompassing engineering, physics, biology, and economics, and some are extensions of those presented at the IFAC (International Federation of Automatic Control) conferences since 2011. The series is categorized in five parts covering the main themes of the contributions:· Stability Analysis and Control Design· Networks and Graphs· Time Delay and Sampled-Data Systems· Computational and Software Tools· ApplicationsThis volume will become a good reference point for researchers and PhD students in the field of delay systems, and for those willing to learn more about the field, and it will also be a resource for control engineers, who will find innovative control methodologies for relevant applications, from both theory and numerical analysis perspectives.

The congress's unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by two leading experts. The themes address specific topics of medicine and technology that provide multiple and excellent opportunities for exchanges.