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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. - Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations

Written by internationally renowned experts, the 4rd edition of this book provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into seven volumes: Basic Principles, Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, Retinoblastoma, and Eyelid Tumors. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors'private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncology's clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition includes several hundred new images and videos to improve comprehension of procedures and techniques. This volume provides diagnosis and therapy for retinal tumors, including vitreoretinal lymphoma and paraneoplastic disorders.

This book presents comprehensive coverage of the RASopathies, one of the largest known recognizable patterns of malformation syndromes, affecting approximately 1 in 1,000 people. These syndromes include neurofibromatosis type 1, Noonan syndrome, Noonan syndrome with multiple lentigines, Costello syndrome, cardio-facio-cutaneous syndrome, Legius syndrome, capillary malformation-arteriovenous malformation syndrome, SYNGAP1 syndrome and central conducting lymphatic anomalies. Noted physician and authority Katherine Rauen and an assembly of the top international experts present detailed discussions of both the science and clinical implications of these fascinating disorders. The major topics covered in this book include the syndromes and genes, the RAS pathway, phenotypic features, animal modeling and treatments. The book will appeal to a wide audience, including clinicians and basic scientists alike such as medical geneticists, genetics counsellors, oncologists, neurologists, cardiologists, dermatologists, behavioralists, orthopedists, ophthalmologists, neuroscientists, RAS biologists, and signal transductionists. This book is also intended for advocate leaders, trainees, and families with RASopathies.

This book is designed to have a comprehensive review of the spectrum of diseases involving orbital apex and periorbital skull base and the up-to-date advancement in different treatment modalities. Management of diseases at the orbital apex and periorbital skull base has always been a challenge. Multiple specialties are involved, including skull base neurosurgeon, oculoplastic ophthalmologist, otorhinolaryngologist, head and neck surgeon, oncologist, neurologist and radiologist. However, frequently it results into a “no-man's land”, as no single specialty is entirely familiar with this complex and overlapping anatomical territory. Cranial nerves, carotid artery, and cavernous sinus are just one of the few examples of important anatomical structures that pass through. However, this has often been managed by one specialty especially during surgical planning and operation, resulting in biases in choices of approach and surgical strategies. We believe that this interesting yet complex region deserves special attention with a well-orchestrated multi-disciplinary effort. Traditionally, surgical treatments for diseases in this region involve different types of craniotomy and orbitotomy. In this book, it covers the advancement in imaging modalities, medical therapies, operative instruments, radiation therapy namely stereotactic radiosurgery or radiotherapy, management of diseases in orbital apex and periorbital skull base evolve and improve with time. Minimally invasive surgery in terms of mastering neuro-endoscopy contributes to the intervention advancement.

The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues (2nd Edition) addresses diabetes from a comprehensive, multidisciplinary perspective. Its purpose is to integrate state-of-the-art information on diabetes from specialists in various disciplines, including epidemiology, public health, pathophysiology, non-pharmacologic and pharmacologic treatment, patient support, acute and chronic complications, new and unproven therapies, and prevention. The main benefit of “The Diabetes Textbook” is its integrative approach. The book is therefore intended for three main types of readers: 1) physicians and health professionals seeking a comprehensive approach to diabetes; 2) those with previous expertise in a specific professional area who want to expand their knowledge; and 3) those interested in learning about topics not previously covered, who will find the contents of “The Diabetes Textbook” both enriching and innovative. The Diabetes Textbook is intended for a broad readership, including professors of medicine and related disciplines (nursing, nutrition, psychology); general physicians; internists and specialists, e.g. in ophthalmology, endocrinology, cardiology, obstetrics and gynecology, pediatrics, geriatrics, epidemiology and public health. To address these readers'needs, the second edition is divided into the following eleven sections: 1) Magnitude of the Problem from an Individual and Social Context, 2) Diagnosis, Classification and Mechanisms of Disease, 3) Global Experiences in Diabetes Care, 4) Basic Components of Management: Patient-Centeredness, Evidence-Based Medicine, and Outcomes, 5) Resources of Support for Persons with Diabetes, 6) Drug Therapy, 7) Cardiovascular Risk Factors, 8) Acute Complications, 9) Chronic Complications, 10) Diabetes in Special Populations, and 11) Novel Therapeutic Approaches: Evidence-Based and Non-Proven, and Diabetes Prevention.

This book discusses the new era of modern retinal laser therapy and its clinical applications. While the photocoagulation era universally presupposed the therapeutic necessity of laser-induced retinal damage, the modern retinal laser therapy is equally opposed to this idea. The evidence for this sea-change in the understanding of retinal laser is well presented within this book, and the conceptual and clinical consequences are discussed with particular emphasis on the emergence of retinal laser therapy as the first reasonable preventive and restorative intervention for the most important retinal disorders. Finally, the future of modern retinal laser therapy is highlighted with respect to coming technological advances, remaining challenges, and the place of retinal laser in the management of retinal disease. This book is an essential resource for all ophthalmic residents and clinicians seeking a clear and concise guide to modern retinal laser therapy in their everyday practice.

The main theme of “Recent Advances in Ophthalmology-16” is Artificial Intelligence in Ophthalmology as envisaged by late Dr Hari Vallabh Nema. Artificial intelligence (AI) technology utilizes computational methods to mimic human behavior and thought process. Its application includes assisting a medical practitioner to understand the disease in a better way and take correct decisions. Moreover, it is a sophisticated and reliable diagnostic tool that can be used to detect an ophthalmic disease and monitor the treatment response.

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a “Who's Who” in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients'ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

This book presents the latest knowledge and expert guidance on all aspects of inherited retinal diseases, including molecular genetics, diagnosis, clinical features, general principles of treatment, novel treatment methods, and genetic counseling. Recent years have witnessed great advances in understanding of the genetic and cytological background of these diseases. Genetic analysis methods such as next generation sequencing have remarkably reduced the cost and time required for massive analysis of patients'samples. Studies on gene therapy and stem cell therapy have been successfully carried out in animal models, and gene therapy is now available for Leber congenital amaurosis caused by RPE65 mutations. Against this background, Inherited Retinal Disease will be an invaluable up-to-date resource for ophthalmologists, medical students, and researchers in ocular inflammation. In addition to supplying essential information on each individual disorder, it features many interesting cases contributed by global leaders in the field as well as clinical photographs obtained with newer imaging techniques and numerous images of rare but clinically important diseases.

Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.

This book focuses on Gems of Ophthalmology—Cataract Surgery. Cataract surgery is a procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens. This book consists of 27 chapters. The present book covers a wide range of topics on cataract surgery such as Manual small-incision cataract surgery, dye-enhanced cataract surgery, Pediatric cataract Surgery and IOL Implantation, etc. A number of chapters on phacoemulsification in difficult situations such as posterior polar cataract, white cataract, hard cataract, and cataract surgery in small pupil, subluxated lens and compromised cornea have also been included for the benefit of young cataract surgeons. The chapter on Dropped nucleus or nuclear fragment cautions the cataract surgeon where to stop. Femtosecond laser (FL) has made its inroads in cataract surgery also. FL clear corneal incision, capsulotomy and softening of nucleus make phacoemulsification easy and provide excellent results. The book is concise and information on cataract surgery is presented in an easily readable form. It is profusely illustrated. Postgraduate students, residents, and general ophthalmologists can learn not only how to perform a safe cataract surgery but also to tackle difficult cases.

This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.

This second volume continues with a focus on the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book's editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asianeye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume II will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.

The diversity of procedures that characterize modern refractive surgery makes it, both for the beginner and the experienced surgeon, necessary to have well established guidelines to face refractive complications. This lavishly illustrated guide is written by international opinion leaders with extensive experience in the practice of refractive surgery. It offers the reader practical pearls to the solution and prevention of the different complications of corneal and refractive surgery.This book provides ophthalmic surgeons with appropriate solutions for the most frequent problems they would face in their daily practice. Surgical complications are described and illustrated from their pathogenesis to various treatment modalities. Complications covered include: Intraoperative complications (e.g. those encountered during femtosecond laser, SMILE and LASIK, corneal refractive surgery, refractive lens exchange, and intraocular refractive procedures); early post-operative complications and late post-operative complications.

This book, besides reviewing basic and clinical aspects of Behçet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet's disease. Behçet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​

This richly illustrated book is intended as a gold standard for the refractive surgeon. It complements the authors'successful previous book, Management of Complications in Refractive Surgery, by providing detailed practical information on the management of specific cases. Worldwide leaders in the field document a wide range of challenging cases drawn from their own clinical practice. These cases relate to the planning of refractive laser treatment; intra operative complications when using LASIK (Microkeratome and Femtosecond) and various surface treatments, including PRK, PTK and EpiLASIK; early and late postoperative complications with these treatments and a range of other complications that may arise during or after refractive surgery. This book will be an indispensable aid for the refractive surgeon and will assist in decision making when the surgeon is confronted by a difficult case.

Although there are numbers of textbooks regarding refractive surgery in the market, readers feel that they cannot find all what they need in only one book. They also feel that they have to read much to find what exactly they are looking for. And in spite of the vast number of refractive surgery courses conducted during conferences, the audience may feel that they do not get answers to all the questions that rise in their mind. In addition, during daily practice, refractive surgeons may wish to own a quick reference in their hands that is well ordered and easy to deal with. All the above reasons were behind writing this handbook. To make information easily accessible, simple language was used, a tabulated text was written, and a step-by-step systematic methodology was applied. Together with comprehensive illustrations, clinical aspects were integrated into basics to make use of any tiny information. To reach this goal, this handbook was composed of five steps consisting of nine chapters. Step one consists of four chapters dealing with corneal imaging and its clinical application in refractive surgery. Step two has one chapter discussing major refractive procedures. Step three has one chapter describing rules and recommendations in refractive surgery. Step four is a start-off step, consisting of two chapters, dealing with approaching the candidate and discussing refractive surgery complications. Step five presents clinical case-study.

The diversity of procedures that characterize modern refractive surgery makes it, both for the beginner and the experienced surgeon, necessary to have well established guidelines to face refractive complications. This lavishly illustrated guide is written by international opinion leaders with extensive experience in the practice of refractive surgery. It offers the reader practical pearls to the solution and prevention of the different complications of corneal and refractive surgery. Complications covered include: Intraoperative complications, e.g. intraocular refractive surgery, femtosecond laser, LASIK and EPILASIK, refractive lens exchange, corneal refractive surgery, early post-operative complications and late post-operative complications. All complications are described and lavishly illustrated from its pathogenesis to its treatment modalities. It provides ophthalmic surgeons with the most adequate solutions for the most frequent problems they face in their daily practice.

Title from ebook title screen (viewed on June 4, 2004).

Title from e-book title screen (viewed on June 4, 2004)