77 results on '"Terstappen, Georg C."'
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2. Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling
3. A call for better understanding of target engagement in Tau antibody development
4. A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
5. Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
6. A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells
7. Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels
8. Strategies for delivering therapeutics across the blood–brain barrier
9. Trafficking of JC virus-like particles across the blood–brain barrier
10. Combining experimental strategies for successful target deconvolution
11. Cloud-Point Extraction of Gangliosides using Nonionic Detergent C14EO6
12. Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs
13. Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study
14. Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells
15. Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems
16. Drug Distribution into Peripheral Nerve
17. Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example
18. Label-free detection of small-molecule binding to a GPCR in the membrane environment
19. Targeting mutant huntingtin for the development of disease-modifying therapy
20. Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades
21. Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625
22. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin
23. P2-297: Increased expression of a single-pass transmembrane glycoprotein and its ligand in Alzheimer's disease brain
24. Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity
25. Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
26. Screening technologies for ion channel drug discovery
27. A Primer on Screening Data Management
28. How to Achieve Confidence in Drug Discovery and Development: Managing Risk (from a Reductionist to a Holistic Approach)
29. Robust MS quantification method for phospho-peptides using 18O/16O labeling
30. Small molecule drug discovery for Huntington's Disease
31. Not a dilemma: target deconvolution in drug discovery
32. Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders
33. Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors
34. P2‐462: SEN12333 (WAY‐317538), a novel alpha7 nicotinic receptor agonist with neuroprotective efficacy: Implication for neurodegenerative diseases therapy
35. P2-163: Thimet oligopeptidase expression is increased in Alzheimer's disease brain
36. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity
37. Functional screening of α7 nicotinic receptor ligands
38. Functional Properties of α7 Nicotinic Acetylcholine Receptors Co-expressed with RIC-3 in a Stable Recombinant CHO-K1 Cell Line
39. Sequential detergent fractionation of primary neurons for proteomics studies
40. Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification
41. Target deconvolution strategies in drug discovery
42. In vitro screening strategies for nicotinic receptor ligands
43. Huntington's disease: from experimental results to interaction networks, patho-pathway construction and disease hypothesis
44. Fishing for new Alzheimer’s drug targets in large proteomics and transcriptomics datasets using expert‐curated pathways and predicted interaction networks.
45. Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
46. Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules
47. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
48. P2-062: A new cellular-based approach for target validation in neurodegenerative diseases
49. Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology
50. Ion Flux and Ligand Binding Assays for Analysis of Ion Channels
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