63 results on '"Simon, Adam J."'
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2. Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
3. Sports Concussion And Mild Traumatic Brain Injury Assessment Is Enhanced With Portable, Non-invasive Biosensor Arrays
4. Exploration of EEG features of Alzheimer’s disease using continuous wavelet transform
5. P4-048: BIOMARKER STABILITY IN CSF: PRE-ANALYTICAL FACTORS IN A PROSPECTIVE COLLECTION
6. Stochastic Dynamic Modeling of the Human Brain EEG Signal
7. Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease
8. Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform
9. Reference measurement procedures for Alzheimer’s disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42
10. Power based analysis of single-electrode human EEG recordings using continuous wavelet transform
11. Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels
12. P1‐112: A brain computer interface to detect Alzheimer's disease
13. Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product
14. A novel pathway for amyloid precursor protein processing
15. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex
16. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers
17. P1-187: Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain
18. Modeling Effect of a γ-Secretase Inhibitor on Amyloid-β Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism
19. SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition
20. Application of an End-to-End Biomarker Discovery Platform to Identify Target Engagement Markers in Cerebrospinal Fluid by High Resolution Differential Mass Spectrometry
21. Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing
22. First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
23. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase
24. Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates
25. Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects
26. Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease
27. P3-094: Three novel CSF assays expand a core panel of CSF biomarkers: BACE activity, oligomeric Aβ and homocysteine assessed in pathologically confirmed Alzheimer subjects within the Oxford project to investigate memory and aging (Optima) cohort
28. O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates
29. O3‐02–06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease
30. P3-263: The kinesin light chain 1 polymorphism rs8702 is associated with elevated CSF levels of secreted forms of amyloid precursor protein
31. P3-077: Cerebrospinal fluid levels of Alzheimer's disease biomarkers in term and pre-term newborn infants
32. In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
33. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors
34. Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1
35. Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)
36. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors
37. Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid
38. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation
39. Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)
40. A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels
41. Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.
42. Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model
43. P2-165: A multi-analyte panel of six CSF biomarkers classifies AD and control in pathologically confirmed Alzheimer subjects within the OPTIMA cohort
44. P4–315: Pharmacodynamic changes in plasma Aβ40 following peripheral antibody treatment in transgenic mice
45. P2-069: Nonhuman primate model for prediction of human Aβ effects. Targeting γ-secretase: Effects of enzyme inhibition vs. modulation of cleavage specificity on CSF and plasma Aβ in conscious rhesus monkeys
46. Biochemical and cell-based assays for characterization of BACE-1 inhibitors
47. Compounds That Bind APP and Inhibit Aβ Processing in Vitro Suggest a Novel Approach to Alzheimer Disease Therapeutics
48. Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex
49. Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)
50. A cell-based β-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication
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