300 results on '"Nepom, Gerald"'
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2. C-peptide and metabolic outcomes in trials of disease modifying therapy in new-onset type 1 diabetes: an individual participant meta-analysis
3. Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes
4. Idiotypic Networks in Tumor Immunity
5. Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial
6. Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy
7. FOXP3+regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues
8. Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial
9. Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool
10. IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function
11. HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success
12. Synergistic targeting of immunologic pathways to empower durable tolerance therapies
13. Translating lessons learned on the role of HLA in immunological responses in LEAP to peanut OIT Trials: IMPACT and POISED
14. Multiple FLG variants drive eczema severity in the LEAP study participants
15. HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy
16. Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes
17. Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy
18. Approaches to Establishing Tolerance in Immune Mediated Diseases
19. Uncovering Pathways to Personalized Therapies in Type 1 Diabetes
20. Characterizing T-Cell Autoimmunity
21. Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
22. 277-OR: Teplizumab Reverses the Loss of C-Peptide in Relatives at Risk for Type 1 Diabetes (T1D)
23. 250-OR: Hypoproliferative CD8 Effector Memory (EM) Subsets Are Linked to Preservation of C-Peptide in Alefacept-Treated Recent-Onset Type 1 Diabetes (T1D) Subjects
24. Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
25. Contributors
26. Major Histocompatibility Complex and Autoimmunity
27. Tetramer Analysis of Human Autoreactive CD4‐Positive T Cells
28. HLA and Rheumatoid Arthritis
29. HLA and Type I Diabetes
30. Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis
31. Genetic Determinants of Peanut-Specific IgG4 in The Learning Early About Peanut Allergy (LEAP) Study
32. Effects of Combined Treatment with Cat Allergen Immunotherapy and Tezepelumab on Nasal Allergen Challenge
33. Development of peanut allergy is associated with coding SNPs in the C-terminus of the IL-33 receptor that impact signaling and TH2 effector function
34. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
35. A composite immune signature parallels disease progression across T1D subjects
36. Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes
37. 1746-P: Differential Depletion and Expansion of Autoreactive CD8+ T Cell Subsets after Alefacept Treatment in Type 1 Diabetes (T1D)
38. The MALT1 locus and peanut avoidance in the risk for peanut allergy
39. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
40. Molecular Genetics of Autoimmunity
41. Is DQB2 Functional Among Nonhuman Primates?
42. HLA-DQ and Diabetes Mellitus: A Genetic and Structural Paradigm for Models of Disease Susceptibility
43. Humanized in vivo Model for Autoimmune Diabetes
44. Humanized in vivo Model for Autoimmune Diabetes
45. Humanized in vivo Model for Autoimmune Diabetes
46. Synchronous immune alterations mirror clinical response during allergen immunotherapy
47. Looking behind the data curtain
48. Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes
49. Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
50. Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes
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