33 results on '"McGeough, Matthew D."'
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2. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
3. Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis
4. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
5. The effect of a fennel seed extract on the STAT signaling and intestinal barrier function
6. The Effect of a Fennel Extract on the STAT Signaling and Intestinal Barrier Function
7. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis
8. ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model
9. Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy
10. Mutations in topoisomerase IIβ result in a B cell immunodeficiency
11. NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice
12. The Effect of Fennel ( Foeniculum vulgare) on the JAK/STAT Pathway and Intestinal Barrier Function
13. NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL‐17 and TNF in mice
14. Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis
15. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies
16. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate
17. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
18. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
19. Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism
20. Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart
21. Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction
22. NLRP3 mediates osteolysis through inflammation‐dependent and ‐independent mechanisms
23. Abstract 14850: Independent Role of the Priming and Triggering of the NLRP3 Inflammasome in the Heart
24. NLRP3 inflammasome activation is required for fibrosis development in NAFLD
25. ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma
26. Functional consequences of EpCam mutation in mice and men
27. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
28. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies
29. Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models
30. Mo1982 Epcam Deficient Mice Demonstrate Intestinal Permeability Defects
31. Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice
32. Epcam Deficient Mice Show Significant Morbidity and Pathology Resembling Congenital Tufting Enteropathy
33. Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
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