181 results on '"Kelley, David E."'
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2. Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index
3. Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
4. Muscle insulin resistance in type 1 diabetes with coronary artery disease
5. Diabetes
6. Mechanisms of Insulin Resistance in Obesity
7. Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
8. PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy
9. Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states
10. Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
11. Clinical Evaluation of MK ‐2640: An Insulin Analog With Glucose‐Responsive Properties
12. Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS
13. Using [2H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies
14. GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia
15. Insulin secretory effect of sitagliptin: assessment with a hyperglycemic clamp combined with a meal challenge
16. Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes
17. Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts
18. Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299–308
19. Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass
20. A glucose-responsive insulin therapy protects animals against hypoglycemia
21. Engineering Glucose Responsiveness Into Insulin
22. Photooxidation of Organic Wastes Using Semiconductor Nanoclusters
23. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model
24. Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation
25. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
26. Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation
27. GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
28. Reply to Letter to the Editor: “The art of quantifying glucose metabolism”
29. Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers
30. Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys
31. Metabolic improvements following Roux-en-Y surgery assessed by solid meal test in subjects with short duration type 2 diabetes
32. Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys
33. Changes in skeletal muscle and organ size after a weight-loss intervention in overweight and obese type 2 diabetic patients
34. Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus
35. Physiological Expression of AMPKγ2 Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice
36. The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys
37. Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice
38. Linearity of β-cell response across the metabolic spectrum and to pharmacology: insights from a graded glucose infusion-based investigation series
39. Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population
40. Glucagon receptor antagonism induces increased cholesterol absorption
41. Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions
42. Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions
43. Tracer-based estimates of protein flux in cases of incomplete product renewal: evidence and implications of heterogeneity in collagen turnover
44. Partial Meal Replacement Plan and Quality of the Diet at 1 Year: Action for Health in Diabetes (Look AHEAD) Trial
45. Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats
46. Ectopic Fat and the Metabolic Syndrome
47. Free Fatty Acids, Insulin Resistance, and Ectopic Fat
48. Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes
49. Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling
50. Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
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