84 results on '"Guchhait, Sankar K."'
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2. Molecular medicinal insights into scaffold hopping-based drug discovery success
3. Late‐Stage CH Activation–Functionalization of Drugs, Natural Products, and Biomolecules: In View of Molecular Property and Mechanistic Pathway
4. A Core‐Linker‐Polyamine (CLP) Strategy Enables Rapid Discovery of Antileishmanial Aminoalkylquinolinecarboxamides That Target Oxidative Stress Mechanism
5. Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents
6. Synthesis of Heterocyclic‐Fused Furans and Dihydrofurans via (4+1)‐Annulation with Ylide: Exploration of Unique Reactivity Behavior of α‐Carbonyl Sulfoxonium Ylide
7. A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones
8. Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies
9. Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects
10. Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles
11. Microtubule‐targeting agents impair kinesin‐2‐dependent nuclear transport of β‐catenin: Evidence of inhibition of Wnt/β‐catenin signaling as an important antitumor mechanism of microtubule‐targeting agents
12. C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules
13. C‐12 Binds to Tubulin at the Colchicine‐binding Site and Target Microtubules by Preferentially Binding to GTP‐bound Tubulin
14. Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα
15. Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
16. Synthesis of Polyfunctionalized Pyrroles via a Tandem Reaction of Michael Addition and Intramolecular Cyanide-Mediated Nitrile-to-Nitrile Condensation
17. Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
18. A Combretastatin Analogue C12 Binds to Colchicine Site in Tubulin, Inhibits Spindle Microtubule Dynamics, Activates Mitotic Checkpoint and Induces Apoptosis in Cancer Cells
19. Synthesis of Polysubstituted 2-Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α-Bromoalkenones
20. A nitrile-stabilized ammonium ylide as a masked C–CN synthon in heterocyclization with amidine–imine: 3-component assembly to fused pyrimidine scaffolds
21. Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines
22. Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα
23. ChemInform Abstract: A Reaction of 1,2‐Diamines and Aldehydes with Silyl Cyanide as Cyanide Pronucleophile to Access 2‐Aminopyrazines and 2‐Aminoquinoxalines.
24. Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2-a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents
25. ChemInform Abstract: Oxidative Dearomatization of Indoles via Pd-Catalyzed C-H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones.
26. Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism
27. Oxidative Dearomatization of Indoles via Pd-Catalyzed C–H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones
28. Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety
29. ChemInform Abstract: Pd‐Catalyzed Ag(I)‐Promoted C3‐Arylation of Pyrido[1,2‐a]pyrimidin‐4‐ones with Bromo/Iodo‐Arenes.
30. A reaction of 1,2-diamines and aldehydes with silyl cyanide as cyanide pronucleophile to access 2-aminopyrazines and 2-aminoquinoxalines
31. ChemInform Abstract: Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C-O Bond Activation-Arylation.
32. Pd-Catalyzed Ag(I)-Promoted C3-Arylation of Pyrido[1,2-a]pyrimidin-4-ones with Bromo/Iodo-Arenes
33. Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C–O Bond Activation–Arylation
34. Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors
35. ChemInform Abstract: Desilylative Activation of TMSCN in Chemoselective Strecker—Ugi Type Reaction: Functional Fused Imidazoles as Building Blocks as an Entry Route to Annulated Purines.
36. Scaffold-hopping and hybridization based design and building block strategic synthesis of pyridine-annulated purines: discovery of novel apoptotic anticancer agents
37. ChemInform Abstract: α,β-Epoxy Esters in Multiple C-O/C-N Bond-Breaking/Formation with 2-Aminopyridines; Synthesis of Biologically Relevant (Z)-2-Methyleneimidazo[1,2-a]pyridin-3-ones.
38. Desilylative activation of TMSCN in chemoselective Strecker–Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines
39. Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents
40. Structural Elaboration of a Natural Product: Identification of 3,3′‐Diindolylmethane Aminophosphonate and Urea Derivatives as Potent Anticancer Agents
41. Indenoindolone derivatives as topoisomerase II–inhibiting anticancer agents
42. ChemInform Abstract: C-H Bond Functionalization under Metalation-Deprotonation Process: Regioselective Direct Arylation of 3-Aminoimidazo[1,2-a]pyrazine.
43. One-pot preparation of isocyanides from amines and their multicomponent reactions: crucial role of dehydrating agent and base
44. ChemInform Abstract: One‐Pot, Three‐Step Copper‐Catalyzed Five‐/Four‐Component Reaction Constructs Polysubstituted Oxa(Thia)zolidin‐2‐imines.
45. ChemInform Abstract: Intramolecular Oxidative Coupling of 3‐Indolylarylketones with Pd(II)‐Catalysis under Air: Convenient Access to Indenoindolones.
46. C–H Bond Functionalization Under Metalation–Deprotonation Process: Regioselective Direct Arylation of 3-Aminoimidazo[1,2-a]pyrazine
47. ChemInform Abstract: CuSO4-Glucose for in situ Generation of Controlled Cu(I)-Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization Toward Synthesis of N-Fused Imidazoles.
48. Intramolecular oxidative coupling of 3-indolylarylketones with Pd(II)-catalysis under air: convenient access to indenoindolones
49. ChemInform Abstract: Friedel—Crafts 3‐(2‐Bromobenzoylation) of Indoles and Intramolecular Direct Arylation: An Efficient Route to Indenoindolones.
50. CuSO4–Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles
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