230 results on '"Fairlamb, Alan H."'
Search Results
2. Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases
3. Surmounting structural barriers to tackle endemic infectious diseases
4. Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity
5. Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
6. Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties
7. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi
8. Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
9. New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
10. The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
11. Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis
12. Substituted Aminoacetamides as Novel Leads for Malaria Treatment
13. Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
14. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
15. Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity
16. Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
17. Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome
18. Antitrypanosomatid Pharmacomodulation at Position 3 of the 8‐Nitroquinolin‐2(1H)‐one Scaffold Using Palladium‐Catalysed Cross‐Coupling Reactions
19. Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
20. A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism
21. Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
22. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
23. Melarsoprol Resistance in African Trypanosomiasis
24. Characterisation of a putative glutamate 5‐kinase from Leishmania donovani
25. Screening a protein kinase inhibitor library against Plasmodium falciparum
26. Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani
27. Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
28. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
29. Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
30. Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
31. The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei
32. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
33. The N-myristoylome of Trypanosoma cruzi
34. Correction: Corrigendum: Drug resistance in eukaryotic microorganisms
35. Drug resistance in eukaryotic microorganisms
36. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
37. Erratum: Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis
38. The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
39. Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase
40. Author response: The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
41. Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases
42. Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
43. Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei
44. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity
45. A novel multiple-stage antimalarial agent that inhibits protein synthesis
46. Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study
47. Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay
48. Homoserine and quorum‐sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect‐stage Trypanosoma brucei
49. Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
50. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
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