116 results on '"Cotgreave, Ian"'
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2. A safer and more sustainable by design perspective in biocatalytic amide-bond coupling of in silico controlled chemical space
3. hERG-Toxicity Prediction using Traditional Machine Learning and Advanced Deep Learning Techniques
4. In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values
5. The Development of Diaryl Chalcogenides and α-(Phenylselenenyl) Ketones with Antioxidant and Glutathione Peroxidase-Mimetic Properties
6. APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke
7. Pharmacology, Formulations, and Adverse Effects
8. Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
9. Assessing exposure of semi-volatile organic compounds (SVOCs) in car cabins: Current understanding and future challenges in developing a standardized methodology
10. Pre-validation of choriogenin H transgenic medaka eleutheroembryos as a quantitative estrogenic activity test method
11. Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 Infection
12. Blueprint for a self-sustained European Centre for service provision in safe and sustainable innovation for nanotechnology
13. [17] S-Glutathionylation of glyceraldehyde-3-phosphate dehydrogenase: Role of thiol oxidation and catalysis by glutaredoxin
14. N-Acetylcystei ne: Pharmacological Considerations and Experimental and Clinical Applications
15. Studies on the Reversibility of Protein S-Thiolation in Human Endothelial Cells
16. [48] N-acetylcysteine
17. Critical Events in the Toxicity of Redox Active Drugs
18. Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy
19. Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) – A comparison with lysosomotropic drugs
20. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals
21. Human Disposition and Pharmacokinetics of Some Substituted Methylxanthine Bronchodilator Drugs
22. Approaches for Determining Ethylenediamine and its Metabolites: Use of [14C]- and [D4]-Ethylenediamine
23. Strategic focus on 3R principles reveals major reductions in the use of animals in pharmaceutical toxicity testing
24. Strategic Focus on 3R Principles Reveals Major Reductions in the Use of Animals in Pharmaceutical Toxicity Testing
25. Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes
26. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans
27. Mitochondrial toxins are detected in the spermatozoa motility assay
28. Isoform specific ALT measurement during liver and skeletal muscle damage
29. ChemInform Abstract: Novel Water-Soluble Diorganyl Tellurides with Thiol Peroxidase and Antioxidant Activity.
30. H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
31. Barriers to Validation
32. PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes
33. Isoforms of alanine aminotransferases in human tissues and serum—Differential tissue expression using novel antibodies
34. Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
35. Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells
36. Determination of site-specificity of S-glutathionylated cellular proteins
37. Vitamin D fails to prevent serum starvation- or staurosporine-induced apoptosis in human and rat osteosarcoma-derived cell lines
38. Biological stress responses to radio frequency electromagnetic radiation: are mobile phones really so (heat) shocking?
39. Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA
40. Modelling of Normal and Premalignant Oral Tissue by using the Immortalised Cell Line, SVpgC2a: A Review of the Value of the Model
41. The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation
42. DNA ADDUCTS OF BENZO[A]PYRENE- AND DIBENZO[A,L]PYRENE-DIOL EPOXIDES IN HUMAN LUNG EPITHELIAL CELLS: KINETICS OF ADDUCT REMOVAL, EFFECTS ON CELL CYCLE CHECKPOINTS, AND GENE EXPRESSION
43. Cyclodextrin-Derived Diorganyl Tellurides as Glutathione Peroxidase Mimics and Inhibitors of Thioredoxin Reductase and Cancer Cell Growth
44. Human skeletal muscle interstitial glutathione levels are elevated in comparison to adipose tissue and blood plasma
45. Analytical developments in the assay of intra- and extracellular GSH homeostasis: Specific protein S-glutathionylation, cellular GSH and mixed disulphide compartmentalisation and interstitial GSH redox balance
46. Visualization of the compartmentalization of glutathione and protein‐glutathione mixed disulfides in cultured cells
47. Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection
48. Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis
49. Tributyltin Causes Cytochrome c Release from Isolated Mitochondria by Two Discrete Mechanisms
50. Differentiation‐specific alterations to glutathione synthesis in hormonally stimulated release from human skeletal muscle cells
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