50 results on '"Bettencourt Brian"'
Search Results
2. Development of RNAi Therapeutics
3. Spider phylosymbiosis: divergence of widow spider species and their tissues’ microbiomes
4. A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
5. Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
6. An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria
7. Phase 2 Open-Label Extension Study (OLE) of Patisiran, an Investigational RNAi Therapeutic for Familial Amyloid Polyneuropathy (FAP) (S38.003)
8. Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis
9. ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients
10. Serial scanning with technetium pyrophosphate (99mTc-PYP) in advanced ATTR cardiac amyloidosis
11. Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study
12. Rapid progression of familial amyloidotic polyneuropathy
13. Phase 2 open-label extension study of patisiran, an investigational RNAi therapeutic for the treatment of familial amyloid polyneuropathy (S9.003)
14. Abstract 666: RNAi Therapeutics Targeting Human Angiotensinogen (hAGT) Ameliorate Preeclamptic Sequelae in an Established Transgenic Rodent Model for Preeclampsia
15. Mapping Genotype Distributions in the UnisexualAmbystomaComplex
16. 850c RNAi Therapeutics Ameliorate Liver Disease Associated with Alpha-1-Antitrypsin Deficiency
17. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
18. Aln-TMP: A Subcutaneously Administered RNAi Therapeutic Targeting Tmprss6 For The Treatment Of β-Thalassemia
19. Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
20. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
21. Evaluation of exogenous siRNA addition as a metabolic engineering tool for modifying biopharmaceuticals
22. RNAi-Mediated Inhibition of Tmprss6 Elevates Hamp1 Expression and Reduces Serum Iron Levels in Mice
23. RNAi-Mediated Inhibition of Activated Protein C- A New Approach for Hemophilia Treatment
24. Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia
25. Organization and evolution of hsp70clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments
26. Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
27. In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)
28. Duplicate Gene Evolution Toward Multiple Fates at the Drosophila melanogaster HIP/HIP-Replacement Locus
29. Natural Variation in Drosophila Stressed Locomotion Meets or Exceeds Variation Caused by Hsp70 Mutation: Analysis of Behavior and Performance
30. Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models
31. Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4Receptor Ligands
32. Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists
33. Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70null flies
34. Polyglutamine expansion in Drosophila: thermal stress and Hsp70 as selective agents
35. A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection
36. Comparative genome sequencing of Drosophila pseudoobscura: Chromosomal, gene, and cis-element evolution
37. Compensated Deleterious Mutations in Insect Genomes
38. Modification of Heat-Shock Gene Expression in Drosophila melanogaster Populations via Transposable Elements
39. Response To Natural And Laboratory Selection At The Drosophila Hsp70 Genes
40. Rapid Concerted Evolution via Gene Conversion at the Drosophila hsp70 Genes
41. RESPONSE TO NATURAL AND LABORATORY SELECTION AT THE DROSOPHILA HSP70 GENES
42. Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in “Evolution Canyon,” Israel
43. Hsp70 Duplication in the Drosophila melanogaster Species Group: How and When Did Two Become Five?
44. A DROSOPHILA MELANOGASTER Strain From Sub-Equatorial Africa Has Exceptional Thermotolerance But Decreased Hsp70 Expression
45. Evolution of Thermotolerance and Variation in the Heat Shock Protein, Hsp70
46. Experimental Evolution of Hsp70 Expression and Thermotolerance in Drosophila melanogaster
47. EXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER
48. Conformational Integrity and Ligand Binding Properties of a Single Chain T-cell Receptor Expressed in Escherichia coli
49. Affinity and kinetics of the interactions between an αβ T-cell receptor and its superantigen and class II-MHC/peptide ligands
50. Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*
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