102 results on '"Beekman, Jeffrey M"'
Search Results
2. Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense Mutations
3. Colonization of vancomycin-resistant Enterococcus faecium in human-derived colonic epithelium: Unraveling the transcriptional dynamics of host-enterococcal interactions
4. Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis
5. OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion
6. Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations
7. Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis
8. CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes
9. Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
10. Current and future CFTR therapeutics
11. Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders
12. Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19
13. Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis
14. Readthrough compounds for nonsense mutations: bridging the translational gap
15. Establishment and characterization of a newPseudomonas aeruginosainfection model using 2D airway organoids and dual RNA sequencing
16. High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing
17. Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids
18. The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion
19. Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids
20. Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
21. The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression
22. Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient
23. Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression
24. In depth characterization of vaccine breakthrough infections with SARS-CoV-2 among healthcare workers of a Dutch academic medical center
25. CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy
26. Breast development in a 7 year old girl with CF treated with ivacaftor: An indication for personalized dosing?
27. Lumacaftor/ivacaftor in people with cystic fibrosis with an A455E–CFTR mutation
28. Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
29. Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells
30. Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
31. A new era for people with cystic fibrosis
32. An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay
33. Comparison of Organoid Swelling and In Vivo Biomarkers of CFTR Function to Determine Effects of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation
34. Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation
35. Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in intestinal organoids
36. R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids
37. Correction of CFTR function in intestinal organoids to guide treatment of cystic fibrosis
38. Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations
39. Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids
40. CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank
41. Responsible use of organoids in precision medicine: the need for active participant involvement
42. Activating alternative chloride channels to treat CF: Friends or Foes?
43. Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids
44. High-resolution 3D imaging of fixed and cleared organoids
45. Intestinal organoids to model cystic fibrosis
46. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis
47. R560S: A class II CFTR mutation that is not rescued by current modulators
48. Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
49. Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants
50. Long‐term expanding human airway organoids for disease modeling
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