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20. The mode of action of thiazolidinedionesThis paper is based on a presentation given at the satellite symposium, ‘Are all glitazones the same? Addressing insulin resistance as a fundamental issue’, held at the 35th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Brussels, Belgium on 28 September 1999. This paper was updated relative to the issue of hepatotoxicity because of the US Food and Drugs Administration (FDA) analyses and the subsequent removal of troglitazone from the US market.