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Magnusiomyces capitatus is an uncommon opportunistic fungal pathogen primarily affecting immunocompromised individuals. While rare, cases have been reported in immunocompetent patients. We present a documented case of Magnusiomyces capitatus invasive infection in an immunocompetent patient with no previous medical history. This case shows that invasive fungal infections by Magnusiomyces capitatus might affect even the immunocompetent patients. [ABSTRACT FROM AUTHOR]

Two cases of fungemia caused by Magnusiomyces capitatus, an arthroconidial yeast-like fungus, in non-hematologic immunocompromised patients are described. Both patients died before definite diagnosis of M. capitatus was made. The report highlights that pending confirmation of the isolate by phenotypic and/or molecular methods, the characteristic morphologic features observed in Gram-stained smears of blood culture positive bottles can lead to early preliminary diagnosis, thus significantly reducing time required for initiating appropriate antifungal therapy. [ABSTRACT FROM AUTHOR]

Résumé Les infections fongiques disséminées à Magnusiomyces capitatus sont rares et surviennent exclusivement chez les patients immunodéprimés. Nous rapportons le premier cas chez un patient transplanté hépatique ayant fait un choc réfractaire sur fongémie avec un rejet chronique et thrombose porte. Malgré un traitement antibactérien et un traitement empirique antifongique par caspofungine, le patient est décédé d’une défaillance multiviscérale. Ultérieurement, l’examen mycologique des hémocultures, du liquide de lavage broncho-alvéolaire et des urines s’est révélé positif à M . capitatus , identifié par spectrométrie de masse et confirmé par séquençage. La souche était résistante à la caspofungine et au fluconazole. Le meilleur traitement semble être l’association amphotéricine B et voriconazole ou amphotéricine B et 5 fluorocytosine. Summary Disseminated fungal infections due to Magnusiomyces capitatus are rare, occurring exclusively in immunocompromised patients. We report the first case in a liver transplant patient with chronic rejection and portal thrombosis who had a M . capitatus fungemia with a refractory septic shock. Despite an antibacterial and antifungal treatment with caspofungin empirical treatment, the patient died from multiple organ failure. Subsequently, mycological examinations of blood cultures, bronchoalveolar lavage fluid and urine were positive to M . capitatus identified by mass spectrometry and confirmed by sequencing respectively. The stain was resistant to caspofungin and fluconazole. The best treatment appears to be the combination of amphotericin B and voriconazole or amphotericin B and 5 fluorocytosine. [ABSTRACT FROM AUTHOR]