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Understanding tendon mechanobiology is important for gaining insight into the development of tendon pathology and subsequent repair processes. The aim of this study was to investigate how experimentally observed mechanobiological adaptation of rat Achilles tendons translate to changes in constitutive mechanical properties and biomechanical behavior. In addition, we assessed the ability of the model to simulate tendon creep and stress-relaxation. A three dimensional finite element framework of rat Achilles tendon was implemented with a fibre-reinforced poro-visco-hyper-elastic constitutive model. Stress-relaxation and creep data from Achilles tendons of Sprague Dawley rats that had been subjected to both daily loading and a period of reduced loading were used to determine the constitutive properties of the tendons. Our results showed that the constitutive model captures creep and stress-relaxation data from rat Achilles tendons for both loaded and unloaded tendons with good accuracy (normalized root mean square error between model and experimental data were 0.010–0.027). Only when the model parameters were fitted to data from both mechanical tests simultaneously, were we able to also capture similar increase in elastic energy (increased stiffness) and decreased viscoelasticity in response to unloading, as was reported experimentally. Our study is the first to show that experimentally observed mechanobiological changes in tendon biomechanics, such as stiffness and viscoelasticity, can be designated to mechanical quantities in a constitutive model. Further investigation in this direction has potential to discriminate tissue components responsible for specific biomechanical response, and enable targeted treatment strategies for tendon health. Image 1 [ABSTRACT FROM AUTHOR]

Copyright of Revista de la Sociedad Química del Perú is the property of Sociedad Quimica del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We compare two approaches for building a statistical proxy model (metamodel) for CO 2 geologic sequestration from the results of full-physics compositional simulations. The first approach involves a classical Box-Behnken experimental design with a quadratic polynomial response surface. The second approach used a space-filling maxmin Latin Hypercube sampling design with the choice of four different meta-modeling techniques: quadratic polynomial, kriging, multivariate adaptive regression spline (MARS) and additivity and variance stabilization (AVAS). Simulations results for CO 2 injection into a reservoir-caprock system with 9 design variables (and 97 samples) were used to generate the data for developing the proxy models. The fitted models were validated with an independent data set for three different performance metrics: total storage efficiency, CO 2 plume radius and average reservoir pressure. The Box-Behnken–quadratic polynomial metamodel performed the best, followed closely by the maximin LHS–kriging metamodel. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Textile & Apparel / Tekstil ve Konfeksiyon is the property of Tekstil ve Konfeksiyon and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: Effect of alkaline metal salts on the solvent extraction of platinum from leached spent dehydrogenation catalysts (Pt/Al2O3) in aqua-regia by the Trioctylphosphine oxide (TOPO) has been investigated. Best salting out effect was achieved using KCl as the additive salt in which process upto 90% of Platinum extraction achieved. Response Surface methodology utilized in order to design the experiments, model the extraction process for platinum and aluminum as well as; optimize the whole process. It was shown that solvent extraction of platinum by TOPO was kinetically fast and the needed equilibrium time for it was less than 30seconds. In the present study, proposed models for platinum and aluminum extractions were reported and optimum conditions determined which led to the highest separation factors. [Copyright &y& Elsevier]