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[Display omitted] • Betaxanthin reduces metabolic dysfunction in postmenopausal mouse models. • Betaxanthin decreases lung tumor growth in postmenopausal mouse models Betaxanthin mitigates pre-existing lung tumor growth in postmenopausal obese mouse model. • Betaxanthin inhibits lung cancer cell proliferation and migration in response to insulin challenge. • Betaxanthin suppresses tumor growth in the setting of hyperinsulinemia. • Betaxanthin improves SIRT3 expression levels in the lung tumor. Metabolic disturbances associated with obesity increase the risk and advancement of various tumor forms, including postmenopausal lung cancer, in humans. Betaxanthin, a type of yellow-orange pigment found in certain plants, particularly in some flowers, fruits, and vegetables, can be utilized to inhibit the growth of tumors and lessen the metabolic dysfunctions brought on by obesity. However, the functional role of betaxanthin (BET) in suppressing lung cancer progression and its potential mechanisms are still not fully understood. In this study, we examined the regulation of BET in obese mice with postmenopausal lung cancer receiving a high-fat diet (HFD). Initially, we found that BET could significantly mitigate the metabolic dysfunction that a high-fat diet causes in mice. Improved histological changes in the mammary fat pad, lower hepatic lipid deposition, and improved glucose tolerance and insulin resistance demonstrated this. Following that, BET treatment inhibited the formation of lung neoplasms in in-situ cancer animal models that were stimulated by HFD. Furthermore, in a postmenopausal mouse model fed HFD, BET significantly reduced the growth of pre-existing lung tumors, as well as attenuating metabolic abnormalities. Notably, in vitro research revealed that BET co-culture significantly reduced the proliferation and migration of mouse lung cancer cells, whereas insulin exposure increased these processes. Research on animals verified that lung cancer progressed due to hyperinsulinemia; however, BET treatment might inhibit this condition in postmenopausal mice on a high-fat diet. BET could up-regulate sirtuin 3 (SIRT3) expression levels in tumor, liver, and mammary fat pad tissues in postmenopausal mice with HFD-induced obesity, according to a bioinformatic and molecular biology study. Crucially, eradicating SIRT3 expression completely eliminated BET's inhibitory effects on insulin-stimulated cancer cell proliferation and migration. This suggests that increasing SIRT3 expression may be required for BET to perform its anti-tumor function against lung cancer in conditions of hyperinsulinemia. Our findings showed that by modifying SIRT3 signaling, BET consumption is probably effective in the prevention and treatment of obesity-related lung cancer. [ABSTRACT FROM AUTHOR]

Betalain profile and content by HPLC–TOF-MS/MS method and antioxidant capacity by four in vitro assays in thirteen varieties and root parts of red beet were determined. Red beetroot tissues contained thirty betalains, constituting of eighteen betacyanins and twelve betaxanthins. Among the betalains identified, betanin and isobetanin (betacyanins) and vulgaxanthin I (betaxanthins) were predominant. In varieties and root parts, betalain contents were 10.26–17.15 mg/g dm and 7.20–17.24 mg/g dm, respectively, differing significantly across varieties and root parts ( P  <   0.05). Among the root parts, peel was noted for the highest betalain concentration. Red beetroot extracts scavenged radicals, and their antiradical potential differed significantly across varieties and root parts ( P  <   0.05). Additionally, red beetroot antioxidant capacity was positively and significantly correlated with betalain content (P < 0.05). This study demonstrates that red beetroot varieties have their own betalain fingerprint as well as specific antioxidant capacity, which are also dependent on root part. [ABSTRACT FROM AUTHOR]

Polyphenols and betalain pigments respond property’s antioxidants benefic for the human health (Will Strike et al., 2002; Lecerf, 1999 ). The item present shows procured results for strengths in polyphenols and in betalains to the time in fruits and in their juice for the period 2008–2009. Our searches show that rate in polyphenols is more increased in the entire fruit than in only the juice. We have equally remarked that the red prickly pear contains amounts of polyphenols more raised than those of the yellow variety. This study has permitted us equally to value betalain pigments extracted from fruity juice. These are the betalains present in the epidermis and the pulp of the prickly pear confers on it its color varying from yellow to purple. Results show that yellow and red prickly pears contain imported strengths in betalains. Our work shows that the red prickly pear contains betaxanthin pigments in excess of the indicaxanthin that permits to valorize human’s potential spring of genuine colorings. Betalains and polyphenols are antioxidants that contribute to nutritional prickly pears’ quality and to their products of transformation. [ABSTRACT FROM AUTHOR]