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1. Phaeosphaerins A–F, Cytotoxic Perylenequinones from an Endolichenic Fungus, Phaeosphaeriasp.

Author

Li, Gang, Wang, Haiying, Zhu, Rongxiu, Sun, Lingmei, Wang, Lining, Li, Ming, Li, Yaoyao, Liu, Yongqing, Zhao, Zuntian, and Lou, Hongxiang

Abstract

Six novel phototoxins, phaeosphaerins A–F (1–6), together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeriasp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.

Published
2012
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