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[Display omitted] With the development of information technology, electromagnetic interference (EMI) has become a problem that people have to face. Electromagnetic wave absorbing (EMWA) materials is the key to solve this problem. In recent years, one-dimensional (1D) nanofiber EMWA materials have become a research hotspot because of their characteristics that can enhance the loss of electromagnetic waves (EMW). Electrospinning is a simple and effective method to prepare 1D fiber materials, which has the advantages of short preparation period and continuous collection, and has been paid more and more attention. When EMWA materials are used in complex, extreme environments (oceans, acid rain, etc.), they can cause extensive corrosion, resulting in a decrease in absorbing performance. Therefore, it is necessary to design multi-functional EMWA materials such as corrosion resistance. In this paper, the research progress on EMW absorption and corrosion resistance of 1D nanofibers prepared by electrospinning technology in recent years are reviewed. The effect of different fillers on EMW absorption and the effect of different post-treatment methods on the multifunction of the EMWA materials are analyzed. Finally, the advantages and disadvantages of composite EMWA materials prepared by electrospinning technology in different environments are summarized, and suggestions and prospects are put forward. [ABSTRACT FROM AUTHOR]

Photothermal therapy (PTT) shows promise in cancer treatments due to its good spatiotemporal selectivity and minimal invasiveness. However, PTT has some problems such as excessive heat damage to normal tissues, tumor thermo-resistance caused by heat shock proteins (HSPs), and limited efficacy of monotherapy. Here, we construct a patch named “partitioned microneedles” (PMN-SNAP/CuS), which separates the “catalyst” bovine serum albumin-based copper sulfide nanoparticles (CuS@BSA NPs) and the “reactant” S-nitroso-N-acetylpenicillamine (SNAP) into different regions of microneedles, for enhancing mild PTT (mPTT) of melanoma. PMN-SNAP/CuS showed an excellent photothermal effect, Fenton-like catalytic activity, and nitric oxide (NO) generation ability. The combination of NO and reactive oxygen species (ROS) produced by PMN-SNAP/CuS effectively blocked the synthesis of HSPs at the source and enhanced the efficacy of mPTT. Both in vitro and in vivo results proved that PMN-SNAP/CuS significantly enhanced the inhibition of melanoma under 808 nm laser irradiation. In conclusion, our partitioned microneedle strategy based on the combination of enhanced mPTT and gas therapy (GT) provides a promising approach to enhance the therapeutic effect on melanoma.

Hydrogels are promising materials for wound protection, but in wet, or underwater environments, the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their application. In this study, inspired by the structural characteristics of strong barnacle wet adhesion and combined with solvent exchange, a robust wet adhesive hydrogel (CP-Gel) based on chitosan and 2-phenoxyethyl acrylate was obtained by breaking the hydration layer and resisting swelling. As a result, CP-Gel exhibited strong wet adhesion to various interfaces even underwater, adapted to joint movement and skin twisting, resisted sustained rushing water, and sealed damaged organs. More importantly, on-demand detachment and controllable adhesion were achieved by promoting swelling. In addition, CP-Gel with good biosafety significantly promotes seawater-immersed wound healing and is promising for use in water-contact wound care, organ sealing, and marine emergency rescue.

Small extracellular vesicles (sEVs) hold considerable promise for drug delivery due to their natural origin and inherent qualities. However, their clinical application is impeded by two main challenges: low yield and potential side effects. Therefore, it is crucial to obtain substantial quantities of sEVs that adhere to rigorous biosafety standards to ensure successful translation into clinical practice. To address this need, we propose exploring optimized methods for sourcing and separating sEVs, taking inspiration from clinical blood transfusion. In particular, we have identified blood sEVs as a viable alternative and developed a novel separation technique for their isolation. Our approach involves incubating dopamine solution with serum, resulting in the formation of polydopamine (PDA) nanoparticles on the surface of blood sEVs. These nanoparticles have minimal impact on blood sEVs, facilitating their easy separation under standard centrifugal conditions with high purity. This innovative technique enables the development of nanocarriers using blood sEVs with efficient drug-loading capabilities and enhanced pharmacokinetics. Additionally, the incorporation of PDA nanoparticles imparts a photothermal effect to the nanomedicines, enabling the integration of chemotherapy and photothermal therapy. Moreover, the photothermal effect holds the potential to facilitate the membrane fusion of sEVs and cells. In summary, our straightforward surface functionalization technique utilizing PDA effectively isolates blood sEVs and enables chemo-thermal tumor therapy. This approach significantly enhances the feasibility of translating sEV-based nanomedicines into clinical applications.

The Yungang Grottoes are an exceptional representation of ancient Buddhist rock sculptures in China, serving as a cultural treasure trove of the Chinese nation. They bear significant relevance not only in the realms of history, religion, and art, but also in sports, offering profound connotations and remarkable research value. This study, from the relatively under-explored perspective of martial arts history, uses the methods of literature review, field study, image analysis, and tripartite evidence to investigate the martial arts statues found in the Yungang Grottoes. By comprehensively cataloging, summarizing, and exploring the quantity, subject matter, layout, aesthetic form, and cultural imagery of the martial art statues, the research found that there are 163 martial arts statues in the Yungang Grottoes, covering the themes of archery, boxing, strongman lifting, and weaponry. The " image" of their macro - layout and micro - movements, serving as an intuitive and irreplaceable proof, reflects the historical evolution of Chinese martial arts during the Northern Wei Dynasty. It showcases the aesthetic beauty of unity between Buddhism and martial arts and the distinctive " meaning" of the fusion of various ethnicities during the Southern and Northern Dynasties. [ABSTRACT FROM AUTHOR]

The energy conversion efficiency of a triboelectric nanogenerator (TENG) is severely limited by the charge density of triboelectric materials, while drastic and unavoidable charge decay happens during contact due to the insufficient charge retention capacity of positive triboelectric materials. Here, elaborately synthesized acid-ion-doped pyridine-based polybenzimidazole processing with strong charge retention capability is demonstrated to couple with negatively corona-polarized electrets. As illustrated by thermal stimulation and an ion mass spectrometer, the formation of acid-ion chimerism processes high activation energy for stored charges, and the selective anion migration can compensate the escape of polarized charge. Accordingly, the charge density can reach up to 596 μC m–2and the charge retention rate reaches 49.7%, which is so far the highest intrinsic charge density obtained in the open air. Thus, the ionic chimerism strategy provides an effective way to suppress the charge escaping in the open air and gives a great expandable avenue for the material challenges of TENG’s practical deployment.

In recent years, the full-touch human–machine interface (HMI) mode has been widely used in vehicles built by Tesla. This interaction mode replaces the conventional physical interaction modality with a screen, and it has a good sense of technological experience. However, it is unclear whether this mode will make the driver's lateral control more challenging than the conventional mode (CM). To investigate this issue, two most common secondary tasks were designed: dialing and navigation entry tasks and real-world road experiments were conducted using two instrumented vehicles. The vehicle operating parameters and the driver manual data were collected in different modes, respectively. Interestingly, the opposite results were found regarding the effect of the full-touch mode (FTM) on the driver's lateral control ability in different secondary tasks. Compared with the CM, the lateral control ability decreased less during the dialing task relative to the baseline driving in the FTM, while the lateral control ability decreased more in the FTM during the navigation entry task. In addition, drivers’ lateral control decreased further as task difficulty and driving speed increased regardless of mode. This study provides a theoretical basis for the development of laws and regulations regarding full-touch HMI mode.

A novel photochemical difluoromethylation of quinoxalin-2(1H)-ones under catalyst-free conditions was achieved with difluoroacetic anhydride and pyridine N-oxide. The green and mild reaction conditions as well as readily attainable difluoroacetic anhydride provide a useful protocol to prepare C3-difluoromethylated quinoxalin-2(1H)-ones.

Metal–organic frameworks (MOFs) are network-like frameworks composed of transition metals and organic ligands containing oxygen or nitrogen. Because of its highly controllable composition and ordered porous structure, it has broad application prospects in the field of material synthesis. In this work, Zn4(PYDC)4(DMF)2∙3DMF (ZPD) was synthesized via a hydrothermal method. Self-doped nitrogen porous carbon ZPDC-T was then prepared by one-step carbonization. The results show that the self-doped nitrogen porous carbon ZPDC-850 has a micro/mesoporous structure with a specific surface area of 1520 m2g−1and a nitrogen content of 6.47%. When a current density is 1.0 A g−1, its specific capacitance is 265.1 F g−1. After 5000 times of constant current charging and discharging, the capacitance retention rate was 79.2%. Thus, self-doped nitrogen porous carbon ZPDC-850 exhibits excellent electrochemical properties and good cyclic stability. Therefore, the self-doped nitrogen porous carbon derived from MOFs can be a promising electrode material for supercapacitors.

This study investigates the open-circuit fault diagnosis problem in the inverter of the inductive power transfer (IPT) systems. A novel rough-set-theory-based (RST-based) method is proposed to diagnose and locate the open-circuit faults for the first several attempts. First, the system structure of the IPT systems and the operation principle of the inverter are described. Then, by using the proposed rough-sets-theory-based method, a minimum set of necessary variables is obtained from some measurable parameters, which are used to generate the diagnostic rules. Implemented through a set of basic logic units, these rules result in a digital logic circuit for diagnosing inverter open-circuit faults in IPT systems. It should be emphasized that the proposed method not only enables fault diagnosis but also facilitates fault localization. Importantly, it is not constrained by inverter parameters or types. Finally, the simulation and experiment examples are carried out and the results show the effectiveness of the proposed methods.

Let Abe an infinite dimensional simple unital stably finite C*-algebra and Bbe a large subalgebra of A. In this paper, we show that Bhas local weak comparison if Ahas local weak comparison, and Ahas local weak comparison if M2(B)has local weak comparison. As a consequence, we are able to prove that Ahas weak comparison if and only if Bhas weak comparison.

The dynamics of the teleconnection between the Indian Ocean Dipole (IOD) in the tropical Indian Ocean and El Niño-Southern Oscillation (ENSO) in the tropical Pacific Ocean at the time lag of one year are investigated using lag correlations between the oceanic anomalies in the southeastern tropical Indian Ocean in fall and those in the tropical Indo-Pacific Ocean in the following winter-fall seasons in the observations and in high-resolution global ocean model simulations. The lag correlations suggest that the IOD-forced interannual transport anomalies of the Indonesian Throughflow generate thermocline anomalies in the western equatorial Pacific Ocean, which propagate to the east to induce ocean-atmosphere coupled evolution leading to ENSO. In comparison, lag correlations between the surface zonal wind anomalies over the western equatorial Pacific in fall and the Indo-Pacific oceanic anomalies at time lags longer than a season are all insignificant, suggesting the short memory of the atmospheric bridge. A linear continuously stratified model is used to investigate the dynamics of the oceanic connection between the tropical Indian and Pacific Oceans. The experiments suggest that interannual equatorial Kelvin waves from the Indian Ocean propagate into the equatorial Pacific Ocean through the Makassar Strait and the eastern Indonesian seas with a penetration rate of about 10%–15% depending on the baroclinic modes. The IOD-ENSO teleconnection is found to get stronger in the past century or so. Diagnoses of the CMIP5 model simulations suggest that the increased teleconnection is associated with decreased Indonesian Throughflow transports in the recent century, which is found sensitive to the global warming forcing.

Neuronal cell damage is a major cause of cognitive impairment in Alzheimer’s disease (AD). Multiple factors, such as amyloid deposition, tau hyperphosphorylation, and neuroinflammation, can lead to neuronal cell damage. Therefore, the development of multi-target drugs with broad neuroprotective effects may be an effective strategy for the treatment of AD. Natural products have become an important source of drug discovery because of their good pharmacological activity, multiple targets, and low toxicity. In this study, we screened a natural compound library and found that the fat-soluble sesquiterpene natural compound isolinderalactone (Iso) extracted from the dried root pieces of Lindera aggregatahad the ability to alleviate cellular damage induced by β-amyloid-1–42 (Aβ1–42). The role and mechanism of Iso in AD have not yet been reported. Herein, we demonstrated that Iso significantly reduced the level of apoptosis in PC12 cells. Besides, Iso treatment reduced amyloid deposition, neuron apoptosis, and neuroinflammation, ultimately improving the cognitive dysfunction of APP/PS1 (APPswe/PSEN 1dE9) mice. Notably, Iso-10 mg/kg showed superior improved effects in APP/PS1 mice compared with the positive control drug donepezil-5 mg/kg. Mechanistically, the results of RNA sequencing combined with Western blots showed that Iso exerted its therapeutic effect by inhibiting the c-Jun N-terminal kinase (JNK) signaling pathway. Taken together, our findings suggest that Iso is a potential drug candidate for the treatment of AD.

• The C-BiOCl/Bi 2 S 3 (C-BOC/BS) composites are successfully prepared. • C-BOC/BS show good photoelectrochemical (PEC) and photocatalytic (PC) properties. • The optimized 5C-BOC/5BS composite is used as a PEC sensor for Cr(VI) detection. • Efficient Cr(VI) removal is achieved via adsorption and PC reduction by 5C-BOC/5BS. Novel C-BiOCl/Bi 2 S 3 composites are prepared by hydrothermal C doping in BiOCl and in-situ growth of Bi 2 S 3 on C-BiOCl. Compared with BiOCl, C-BiOCl has a larger exposed surface area and can effectively absorb visible light. The construction of a heterojunction in C-BiOCl/Bi 2 S 3 further promotes the separation and transfer of photogenerated carriers. With improved photoelectric properties, the optimized 5C-BiOCl/5Bi 2 S 3 is applied as a dual-functional composite for photoelectrochemical (PEC) detection and photocatalytic (PC) reduction of Cr(VI). The 5C-BiOCl/5Bi 2 S 3 shows a linear range of 0.02–80 μM for PEC cathodic detection of Cr(VI) with a detection limit of 0.01628 μM. Additionally, 99.5% of Cr(VI) can be removed via absorption and PC reduction by 5C-BiOCl/5Bi 2 S 3 , with the reduction rate constant (k) 336 times higher than that of BiOCl. [ABSTRACT FROM AUTHOR]

The encapsulation of various guest molecules into the pores of metal–organic frameworks (MOFs) to form hybrid materials has attracted significant attention due to their unique spatial distribution and certain preferential geometry of the guests inside the MOFs. This arrangement often results in the guests exhibiting unique physical and chemical properties due to their intramolecular interactions with the host. In this article, five viologen derivatives were introduced as guests in a Zn-MOF with different benzene ring lengths, resulting in the formation of host–guest three-dimensional (3D) MOFs. The five compounds exhibited guest-dependent emission wavelength, color, and excellent photochromic behavior upon ultraviolet (UV) light radiation due to the distinct electronic transfer and π···π stacking interactions between the viologen guests and the host framework. This study provides a host–guest strategy for designing color-tunable luminescent and highly sensitive photochromic materials.

In recent years, neuromorphic processors are widely used in many scenarios, showing extreme energy efficiency over traditional architectures. However, almost all existing neuromorphic hardware are following the heterogeneous computing methodology without Instruction Set Architecture (ISA), leading to inflexibility in programming. In this paper, we first propose a RISC-V Neuromorphic Extension (RVNE) to enable fine-grained and flexible homogeneous programming for neuromorphic algorithms while utilizing SNN sparsity from different levels of granularity and computing flows. Based on RVNE, we next implement a neuromorphic micro-architecture that is tightly coupled to the CPU pipeline to accelerate neuromorphic computing. To demonstrate the proposed homogeneous neuromorphic architecture, we implement a prototype processor called NeuroRVcore based on RISC-V ISA and an open-source RISC-V core. The evaluation results show that RVNE achieves a 2.8 × −4.3 × reduction in code density compared with the general-purpose ISAs. Compared with the state-of-the-art neuromorphic processor, the proposed homogeneous computing reduces energy consumption by 3.4%−22.5% while enabling fine-grained and flexible homogeneous programming.

Video-based human-object interaction recognition is a challenging task since the state of objects as well as their correlations change constantly in the video. Existing methods mainly use 3DCNN or use separate components (e.g., GCN + RNN) to model the spatial correlation or the temporal correlation respectively, but ignore modeling spatio-temporal correlations simultaneously and long-term temporal dynamics of objects. In this paper, we propose a novel model, named Spatio-Temporal Interaction Graph Parsing Networks (STIGPN), for human-object interaction recognition in videos. STIGPN captures both spatial and temporal correlations simultaneously and thus can capture intra-frame and inter-frame dependencies efficiently and effectively. To model long-term temporal dynamics of objects, we introduce spatio-temporal feature enhancement, which can improve the detection of the salient human-object interaction pairs. We explore three types of spatio-temporal graph convolutions to simultaneously capture the spatio-temporal correlations and assess their effectiveness as the basic building block of STIGPN. Extensive experiments on CAD-120, Something-Else and Charades datasets show that our proposed solution leads to competitive results compared with the state-of-the-art methods. Code for STIGPN is available at: https://github.com/NingWang2049/STIGPN2

Background: Herpes simplex keratitis (HSK) is the most common but serious infectious keratitis with high recurrence. It is predominantly caused by herpes simplex virus type 1 (HSV-1). The spread mechanism of HSV-1 in HSK is not entirely clear. Multiple publications indicate that exosomes participate in the intercellular communication process during viral infections. However, there is rare evidence that HSV-1 spreads in HSK by exosomal pathway. This study aims to investigate the relationship between the spread of HSV-1 and tear exosomes in recurrent HSK. Methods: Tear fluids collected from total 59 participants were included in this study. Tear exosomes were isolated by ultracentrifugation, then identified by silver staining and western blot. The size was determined by dynamic light scattering (DLS). The viral biomarkers were identified by western blot. The cellular uptake of exosomes was studied using labelled exosomes. Results: Tear exosomes were indeed enriched in tear fluids. Collected exosomes own normal diameters consistent with related reports. The exosomal biomarkers existed in tear exosomes. Labelled exosomes were successfully taken up by human corneal epithelial cells (HCEC) in large numbers in a short time. After cellular uptake, HSK biomarkers were detectable by western blot in infected cells. Conclusions: Tear exosomes should be the latent sites of HSV-1 in recurrent HSK and might be involved in the spread of HSV-1. Besides, this study verifies HSV-1 genes can be indeed transferred between cells by exosomal pathway, providing new inspiration for the clinical intervention and treatment as well as the drug discovery of recurrent HSK.

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Although the biosynthesis of rifamycin has been studied for three decades, the biosynthetic formation of the naphthalenic ring remains unclear. In this study, by deletion of all post-PKS modification genes, we identified macrolactam precursors released from rifPKS. Isolated prorifamycins (M3and M4) have a benzenic chromophore and exist in two sets of macrocyclic atropisomers. The transformation from prorifamycins to benzenoid (5) and naphthalenoid (6) was suggested to be a non-enzymatic process, which is an off-PKS assembly.

The internet of things (IoT) has become a key support object for Chinese strategic emerging industries. It is of great practical significance to promote the construction of the internet of things. Driven by national policies, the development of the internet of things in China has achieved certain results, but it also faces many problems. For example, there are few theoretical and empirical studies on the internet of things economy. In this context, from the perspective of big data, this paper studies the development model and influencing factors of the internet of things economy, and takes Jiangsu Province as an example to put forward development strategies. This article studies the three-stage development model of the IoT economic big data ecosystem: the primary stage, the growth and maturity stage, and the integration stage. On the basis of the research on the development model, the general evaluation method of the economic development model of the internet of things from the perspective of big data is studied, and the general model of strategy selection is established.

In this article, the chance-constrained $H_{\infty }$ state estimation problem is investigated for a class of time-varying neural networks subject to measurements degradation and randomly occurring deception attacks. A novel energy-constrained deception attack model is proposed, in which both the occurrence of the attack and the selection of released faked packet are random and the energy of the deception attack is introduced, calculated, and analyzed quantitatively. The main purpose of the addressed problem is to design an $H_{\infty }$ estimator such that the prefixed probabilistic constraints of the system error dynamics are satisfied and the $H_{\infty }$ performance is also ensured. Subsequently, the explicit expression of the estimator gains is derived by solving a minimization problem subjected to certain recursive inequality constraints. Finally, a numerical example and a practical three-tank system are utilized to demonstrate the correctness and effectiveness of the proposed estimation scheme.

Transdermal cancer therapy faces great challenges in clinical practice due to the low drug transdermal efficiency and the unsatisfactory effect of monotherapy. Herein, we develop a novel bubble pump microneedle system (BPMN-CuS/DOX) by embedding sodium bicarbonate (NaHCO3) into hyaluronic acid microneedles (MNs) loaded with fucoidan-based copper sulfide nanoparticles (Fuc-CuS NPs) and doxorubicin (DOX). BPMN-CuS/DOX can generate CO2bubbles triggered by an acidic tumor microenvironment for deep and rapid intradermal drug delivery. Fuc-CuS NPs exhibit excellent photothermal effect and Fenton-like catalytic activity, producing more reactive oxygen species (ROS) by photothermal therapy (PTT) and chemodynamic therapy (CDT), which enhances the antitumor efficacy of DOX and reduces the dosage of its chemotherapy (CT). Simultaneously, DOX increases intracellular hydrogen peroxide (H2O2) supplementation and promotes the sustained production of ROS. BPMN-CuS/DOX significantly inhibits melanoma both in vitroand in vivoby the combination of CDT, PTT, and CT. In short, our study significantly enhances the effectiveness of transdermal drug delivery by constructing BPMNs and provides a promising novel strategy for transdermal cancer treatment with multiple therapies.

The DNA damage repair of tumor cells limits the effect of photothermal therapy (PTT), and high temperatures induced by PTT can damage adjacent normal tissues. To overcome these limitations, we developed a novel composite hydrogel (OLA-Au-Gel) based on chitosan (CS) and β-glycerophosphate (β-GP), which encapsulated olaparib-liposomes (OLA-lips) and CS-capped gold nanoparticles (CS-AuNPs). OLA-Au-Gel achieved the combination of mild PTT (mPTT) by CS-AuNPs and tumor DNA damage repair inhibition by OLA. The hydrogel showed good biocompatibility, injectability, and photothermal response. Under near-infrared laser irradiation, OLA-Au-Gel inhibited the proliferation of tumor cells, induced the generation of reactive oxygen species in vitro, and effectively inhibited the growth of breast tumors in vivo. OLA-Au-Gel shows a promising application prospect for inhibiting tumor development and improving the antitumor effect. Collectively, we propose a novel strategy for enhanced antitumor therapy based on the combination of mPTT and DNA damage repair inhibition.

SHR-A1201 is an antibody–drug conjugate (ADC) that combines trastuzumab with DM1 (a chemotherapeutic agent) using a chemical connector. This phase I study investigated the safety, tolerability and pharmacokinetics of SHR-A1201 in patients with human epidermal growth factor receptor 2-positive advanced breast cancer. This phase I study enrolled patients in a traditional 3 + 3 dose-escalation design to receive a single dose of SHR-A1201 (1.2 mg/kg, 2.4 mg/kg, 3.6 mg/kg or 4.8 mg/kg). The observation period of dose-limiting toxicity (DLT) was 21 days. A total of 12 patients were enrolled and received SHR-A1201. Most treatment-emergent adverse events (TEAEs) were grade 1 or 2 in severity, with elevated aspartate aminotransferase (75%), thrombocytopenia (75%), and nausea (66.7%) being reported most frequently. The common grade 3 TEAEs were thrombocytopenia and decreased lymphocyte count, and there were no grade 4 or above TEAEs. There were no serious adverse events or drug-related deaths. One DLT occurred in one patient treated with SHR-A1201 4.8 mg/kg (asymptomatic grade 3 increased γ-glutamyltransferase). The maximum tolerated dose of SHR-A1201 was not lower than that of T-DM1 (3.6 mg/kg). A total of 8.3% (1/12) of patients had ADA-positive reactions 504 h after administration, but no differences were observed in the type, incidence, or severity of TEAEs between patients with and without ADA. SHR-A1201 exhibited the pharmacokinetics characteristics of typical ADCs. An encouraging antitumor effect was observed in the 4.8 mg/kg dose group. SHR-A1201 was well tolerated and safe in patients with advanced HER2-positive breast cancer. The pharmacokinetics parameters showed a linear trend, and the immunogenicity results met the clinical expectations.