19 results on '"Zeng, Chunhua"'
Search Results
2. Tunable Schottky barrier in graphene/XAg4Y (X, Y = S, Se, Te) heterostructures
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Ye, Yujiao, Gao, Lei, Xue, Yufei, Fan, Xiao, Ren, Weina, Shai, Xuxia, Wei, Tingting, Zeng, Chunhua, and Wang, Hua
- Abstract
•Graphene/XAg4Y (X, Y = S, Se, and Te) possess different graphene/X interface, resulting in various Schottky barrier heights and contact types.•Schottky barrier heights and contact types can be modulated by the vertical strain and external electric field.•The mechanism of the tunable Schottky barrier via the vertical strain and external electric field are investigated.•Vertical strain or external electric field underlies that the relative Dirac-cone position of graphene in heterostructures can be tuned.
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- 2023
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3. ‘CandidatusLiberibacter asiaticus’ secretory protein SDE3 inhibits host autophagy to promote Huanglongbing disease in citrus
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Shi, Jinxia, Gong, Yinan, Shi, Hongwei, Ma, Xiaoding, Zhu, Yuanhong, Yang, Fan, Wang, Dan, Fu, Yating, Lin, Yu, Yang, Naiying, Yang, Zhuhui, Zeng, Chunhua, Li, Weimin, Zhou, Changyong, Wang, Xuefeng, and Qiao, Yongli
- Abstract
ABSTRACTAntimicrobial acroautophagy/autophagy plays a vital role in degrading intracellular pathogens or microbial molecules in host-microbe interactions. However, microbes evolved various mechanisms to hijack or modulate autophagy to escape elimination. Vector-transmitted phloem-limited bacteria, CandidatusLiberibacter (Ca. Liberibacter) species, cause Huanglongbing (HLB), one of the most catastrophic citrus diseases worldwide, yet contributions of autophagy to HLB disease proliferation remain poorly defined. Here, we report the identification of a virulence effector in “Ca. Liberibacter asiaticus” (Las), SDE3, which is highly conserved among the “Ca. Liberibacter”. SDE3expression not only promotes the disease development of HLB and canker in sweet orange (Citrus sinensis) plants but also facilitates Phytophthoraand viral infections in Arabidopsis, and Nicotiana benthamiana(N.benthamiana). SDE3 directly associates with citrus cytosolic glyceraldehyde-3-phosphate dehydrogenases (CsGAPCs), which negatively regulates plant immunity. Overexpression of CsGAPCsand SDE3significantly inhibits autophagy in citrus, Arabidopsis, and N.benthamiana. Intriguingly, SDE3 undermines autophagy-mediated immunity by the specific degradation of CsATG8 family proteins in a CsGAPC1-dependent manner. CsATG8 degradation is largely rescued by treatment with an inhibitor of the late autophagic pathway, E64d. Furthermore, ectopic expression of CsATG8senhances Phytophthoraresistance. Collectively, these results suggest that SDE3-CsGAPC interactions modulate CsATG8-mediated autophagy to enhance Las progression in citrus.Abbreviations:ACP: asian citrus psyllid; ACD2: ACCELERATED CELL DEATH 2; ATG: autophagy related; Ca. Liberibacter: CandidatusLiberibacter; CaMV: cauliflower mosaic virus; CMV: cucumber mosaic virus; Cs: Citrus sinensis; EV: empty vector; GAPC: cytosolic glyceraldehyde-3-phosphate dehydrogenase; HLB: huanglongbing; H2O2: hydrogen peroxide; Las: liberibacter asiaticus; Laf: liberibacter africanus; Lam: liberibacter americanus; Pst: Pseudomonas syringaepv. tomato; PVX: potato virus X; ROS: reactive oxygen species; SDE3: sec-delivered effector 3; TEM: transmission electron microscopy; VIVE : virus-induced virulence effector; WT: wild-type; Xcc: Xanthomonas citrisubsp. citri;
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- 2023
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4. Features of BSCL2 related congenital generalized lipodystrophy in China: long-term follow-up of three patients and literature review.
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Su, Xueying, Lin, Yunting, Liu, Li, Mei, Huifen, Xu, Aijing, Zeng, Chunhua, Sheng, Huiying, Cheng, Jing, Shao, Yongxian, Zheng, Ruidan, Ting, Tzer Hwu, Zhang, Wen, and Li, Xiuzhen
- Abstract
Congenital generalized lipodystrophy (CGL) is a group of rare autosomal inherited diseases characterized by a widespread loss of adipose tissue. The main purpose of this study was to evaluate the features of Chinese patients with CGL2. Three patients diagnosed with CGL2 from our center were reviewed. Data on clinical features, results of laboratory analyses, and previous treatments were retrospectively collected. This study also reviewed studies that reported patients diagnosed with CGL2 in the last 30 years. All patients presented a lack of subcutaneous fat, hypertriglyceridemia, reversed triangular faces, acanthosis nigricans, and hepatomegaly within the first six months of life. All three patients developed splenomegaly, and mental retardation in later life. Dietary control dramatically lowered triglyceride levels in all patients. One patient presented with diabetes mellitus at 1 year-old. Although combined therapy with low fat diet and metformin maintained normal levels of blood lipid and glucose, this patient developed hypertrophic cardiomyopathy at the age of three. By a literature review on all Chinese cases with CGL2, it is known that classic manifestations such as hypertriglyceridemia, hepatomegaly and diabetes mellitus can occur shortly after birth, and early diagnosis and treatment can improve quality of life. In this cohort, the most frequent variations are c.782dupG and c.974dup in the BSCL2 gene. However, the same genotype may have different clinical phenotypes in patients with CGL2. This study not only described the clinical and genetic features of three patients with CGL2 in China, but also reviewed literature about CGL2 around the world. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Features of BSCL2 related congenital generalized lipodystrophy in China: long-term follow-up of three patients and literature review
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Su, Xueying, Lin, Yunting, Liu, Li, Mei, Huifen, Xu, Aijing, Zeng, Chunhua, Sheng, Huiying, Cheng, Jing, Shao, Yongxian, Zheng, Ruidan, Ting, Tzer Hwu, Zhang, Wen, and Li, Xiuzhen
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- 2023
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6. Emerging group-11 monochalcogenide MX (M = Cu, Ag, Au; X = S, Se, Te) monolayers: Two-dimensional polarized metals and visible-light-driven photocatalysts
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Xue, Yufei, Gao, Lei, Ye, Yujiao, He, Shihao, Jiang, Li, Tian, Yuan, Ren, Weina, Shai, Xuxia, Wei, Tingting, Zeng, Chunhua, and Wang, Hua
- Abstract
Two-dimensional (2D) transition metal chalcogenides have garnered significant research interest owing to their novel properties and potential applications. In this paper, we report a novel class of group-11 chalcogenide MX (M = Cu, Ag, Au; X = S, Se, Te) monolayers based on first-principles calculations, which demonstrate significant application potential as polarized metals and visible-light-driven photo-catalysts. ι-CuS, ι-AgS ι-AgTe, η-CuSe, and η-CuTe were found to be metals, while β-AgSe, α-AuS, α-AuSe, and α-AuTe were observed to be semiconductors with a bandgap of 1.46, 2.14, 1.77, and 1.37 eV respectively. Interestingly, the work functions of the bottom and top sides of ι-CuS, ι-AgS, and ι-AgTe differed owing to the out-of-plane inversion asymmetry of the ι phase. Moreover, these metallic MX monolayers were used to form graphene-based metal-metal heterostructures; accordingly, the work function of graphene could be modulated from 4.35 eV to the range of 3.87–5.04 eV. For semiconducting MX monolayers, a-phase and β-phase monolayers just satisfied the band edge requirement for the H+/H2and H2O/O2reaction at pH 0/7, respectively. Further investigations on the α-AuSe/α-AuTe heterostructure demonstrated its great application potential as a Z-scheme photocatalyst in visible-light-driven overall water splitting with appropriate band alignment, enhanced optical absorbance and high solar-to-hydrogen energy conversion efficiency (20.47%). Benefitting from these excellent properties, 2D group-11 chalcogenide MX monolayers can be potentially used as polarized metals and visible-light-driven water splitting photocatalysts.
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- 2023
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7. Anisotropic Chalcogenide Perovskite CaZrS3: A Promising Thermoelectric Material.
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Song, Xiefei, Shai, Xuxia, Deng, Shukang, Wang, Jinsong, Li, Jie, Ma, Xinru, Li, Xiaorui, Wei, Tingting, Ren, Weina, Gao, Lei, Fu, Yunchang, Wang, Hua, and Zeng, Chunhua
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- 2022
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8. A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.
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Jiang, Xiaoling, Liu, Huazhen, Shao, Yongxian, Peng, Mingzhi, Zhang, Wen, Li, Duan, Li, Xiuzhen, Cai, Yanna, Tan, Ting, Lu, Xinshuo, Xu, Jianan, Su, Xueying, Lin, Yunting, Liu, Zongcai, Huang, Yonglan, Zeng, Chunhua, Tang, Ya-ping, and Liu, Li
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PHENYLALANINE ,MISSENSE mutation ,MICE ,MOTORS ,SYMPTOMS ,DISABILITIES - Abstract
Abstract Background GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism, neurotransmitter synthesis, nitric oxide production and so on. Though improvements could be achieved by tetrahydrobiopterin and neurotransmitter precursor levodopa supplementation, residual motor and mental deficits remain in some patients. An appropriate GTPCH deficiency animal model with clinical symptoms, especially the motor impairments, is still not available for mechanism and therapy studies yet. Objectives and methods To investigate whether the heterozygous GTPCH missense mutation p.Leu117Arg identified from a patient with severe infancy-onset dopa-responsive motor impairments is causative and establish a clinical relevant GTPCH deficiency mouse model, we generated a mouse mutant mimicking this missense mutation using the CRISPR/Cas9 technology. Series of characterization experiments on the heterozygous and homozygous mutants were conducted. Results The expressions of GTPCH were not significantly changed in the mutants, but the enzyme activities were impaired in the homozygous mutants. BH4 reduction and phenylalanine accumulation were observed both in the liver and brain of the homozygous mutants. Severer metabolic disturbance occurred in the brain than in the liver. Significant reduction of neurotransmitter dopamine, norepinephrine and serotonin was observed in the brains of homozygous mutants. Live-born homozygous mutants exhibited infancy-onset motor and vocalization deficits similar to the disease symptoms observed in the patient, while no obvious symptoms were observed in the young heterozygous mutant mice. With benserazide-levodopa treatment, survival of the homozygous mutants was improved but not completely rescued. Conclusions The GTPCH p.Leu117Arg missense mutation is deleterious and could cause tetrahydrobiopterin, phenylalanine and neurotransmitter metabolic disturbances and infancy-onset motor dysfunctions recessively. This is the first GTPCH deficiency mouse model which could be live-born and exhibits significant motor impairments. The different extents of BH4 reduction and phenylalanine accumulation observed between liver and brain in response to GTPCH deficiency gives potential new insights into the vulnerability of brain to GTPCH deficiency. Highlights • The novel GCH1 missense mutation p.Leu117Arg is a deleterious recessive mutation. • Established the first GTPCH deficiency animal model with motor impairments • Severer BH4 reduction and phenylalanine accumulation in the brain than the liver [ABSTRACT FROM AUTHOR]
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- 2019
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9. Clinical features, molecular characteristics, and treatments of a Chinese girl with sitosterolemia: A case report and literature review.
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Su, Xueying, Shao, Yongxian, Lin, Yunting, Zhao, Xiaoyuan, Zhang, Wen, Jiang, Minyan, Huang, Yonglan, Zeng, Chunhua, Liu, Li, and Li, Xiuzhen
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GENETIC disorder diagnosis ,GENETIC disorder treatment ,HYPERCHOLESTEREMIA diagnosis ,GENETIC disorders ,CHOLESTYRAMINE ,CHINESE people ,DIAGNOSTIC errors ,LIPID metabolism disorders ,MEDICAL errors ,GENETIC mutation ,SYMPTOMS ,SEVERITY of illness index ,PHYTOSTEROLS ,FAMILIAL hypercholesterolemia ,SEQUENCE analysis ,GENETICS ,THERAPEUTICS - Abstract
Sitosterolemia is a rare autosomal recessive disease characterized by a significant increase in blood plant sterol levels. Clinical manifestations usually include xanthomas, hypercholesterolemia,premature atherosclerosis and hematological abnormalities. We report here a sitosterolemia patient who presented with multiple xanthomas and profound hypercholesterolemia since 3 years old. The girl was mistreated as familial hypercholesterolemia for 6 years until correct diagnosis was made by detecting serum plant cholesterol levels. Sequence analysis revealed compound heterozygous mutations in ABCG5 gene, including the previously reported mutation c.904+1G>A and a novel missense mutation c.1528C>A. Although cholestyramine therapy reduced cholesterol level in association with marked regress of the xanthomas, serum plant sterol levels still remain high. Our study suggests that patients develop severe hypercholesterolemia and xanthomas at early age should be suspected of sitosterolemia. In addition, we also describe a novel missense mutation in exon 11 of the ABCG5 gene, which enriches the genetic mutation spectrum of sitosterolemia. • Clinical, molecular characteristics, and treatments of a girl with sitosterolemia. • Describes a novel missense mutation c.1528C>A in the ABCG5 gene. • Reviews the characteristics of 26 Chinese patients with sitosterolemia. [ABSTRACT FROM AUTHOR]
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- 2019
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10. Two Chinese Patients of Auriculocondylar Syndrome 2: A Novel PLCB4Splicing Variant and 5-Year Follow-up
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Lin, Yunting, Zhang, Ye, Ma, Jian, Liu, Shu, Liu, Yongxi, Yang, Chaoxiang, Zeng, Chunhua, and Luo, Xianqiong
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Objective Auriculocondylar syndrome (ARCND) is a set of rare craniofacial malformations characterized by variable micrognathia, ear malformations, and mandibular condyle hypoplasia, and other accompanying features with phenotypic complexity. ARCND2 caused by pathogenic variants in the PLCB4gene is a very rare disease with less than 50 patients reported and only 36 different variants of the PLCB4gene recorded in HGMD. This study aims to enrich the patient resources, clinical data and mutational spectrum of ARCND2.Design Case series study.Setting Guangzhou Women and Children's Medical Center and Guangdong Women and Children Hospital.Patients Two Chinese patients with ARCND2.Main Outcome Measures Clinical, radiological and molecular findings.Results Both the two patients presented with craniofacial and ear malformations, and feeding difficulties. Whole exome sequencing identified two different variants of the PLCB4gene in these two patients with a heterozygous allele and a de novomode of inheritance respectively. Patient 1 carried a known pathogenic c.1861C > T(p.Arg621Cys) missense variant, whereas Patient 2 had a novel c.225 + 1G > A splicing variant. Sanger sequencing confirmed the presence of PLCB4variants in the proband and absence in the unaffected parents. These two PLCB4variants were suggested as disease-causing candidates for these two patients. During a 5-year follow-up, Patient 2 gradually manifested crowded teeth, underweight, motor delay and intellectual disability.Conclusions In this study, we report two Chinese patients with ARCND2, describe their clinical and mutational features, and share a 5-year follow-up of one patient. Our study adds two additional patients to ARCND2, reveals a novel PLCB4variant, and expands the phenotypic and genotypic spectrum.
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- 2024
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11. Strain effect on the electronic and optical properties of anisotropic Au2Te monolayer
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Gao, Lei, Jiang, Li, Xue, Yufei, Zeng, Chunhua, and Wang, Hua
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•Au2Te is mechanically stable and has excellent mechanical flexibility.•The highly anisotropic mechanical, electronic and optical properties indicate that it can be applied to direction-sensitive sensors.•The band gaps can be effectively tuned by uniaxial and biaxial strain.•The optical absorbances and TDM are more sensitive to biaxial strain.
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- 2024
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12. Effects of time delay and non-Gaussian noise on the dynamics of a perceptual bistability
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Yang, Tao, Liu, Ruifen, Zeng, Chunhua, and Duan, Weilong
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In this paper, we investigate the effects of time delay and non-Gaussian noise on the dynamics properties of the attractor network model of perceptual bistability. Using delay Fokker–Planck equation and projection operator method, the stationary probability distribution Pst(x), the associated relaxation time Tc, and the normalized correlation function C(s) for perceptual bistability are obtained, respectively. Research results show that: (i) the time delay τand the correlation time τ0 from non-Gaussian noise can induce the change of the peaks in the Pst(x), i.e., the phase transition of the system appears; (ii) there exhibits an optimal value of the τ0 or τby which the Tc or C(s) is maximum, this maximum shows the τ0 or τfirst reduces the stability of the attractor network model of perceptual bistability in the steady state, and then enhances it; and (iii) the noise intensity P or departure q from the Gaussian noise only enhances the stability of the attractor network model of perceptual bistability in the steady state.
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- 2017
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13. Noises-induced regime shifts and -enhanced stability under a model of lake approaching eutrophication.
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Zeng, Chunhua, Zhang, Chun, Zeng, Jiakui, Luo, Hongchun, Tian, Dong, Zhang, Huili, Long, Fei, and Xu, Yinghua
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EUTROPHICATION ,STATISTICAL correlation ,NOISE control ,PARAMETER estimation ,COMPARATIVE studies - Abstract
In this paper, we study the lake eutrophication by using a stochastic model that includes both input noise and recycling noise. The effects of the input noise ( α ), the recycling noise ( D ) and the cross-correlation between two noises ( λ ) in the model are discussed, respectively. Our results show: (i) the noise-induced ecological bistability (EB) expands in comparison with the deterministic case; (ii) noises still can induce EB when the recycling parameter r < 0.5; (iii) the noises can cause the regime shifts from the eutrophic state to the oligotrophic one (noise-induced oligotrophy); and (iv) the input noise can accelerate regime shifts from the oligotrophic state to the eutrophic one for the case of zero or small cross-correlation. Moreover, for the case of higher cross-correlation intensity, the mean first passage time (MFPT) as a function of α exhibits a maximum, which identifies the input noise-enhanced stability (NES) of the oligotrophic state. Finally, for whatever value of cross-correlation intensity, the theoretical results show that the recycling noise can accelerate regime shifts from the oligotrophic state to the eutrophic one. [ABSTRACT FROM AUTHOR]
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- 2015
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14. The Properties of Shuffle Screw Dislocations in Semiconductors Silicon and Germanium
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Zhang, Huili, Zhang, Chun, Zeng, Chunhua, and Tong, Lumei
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The dislocation widths, Peierls barriers and Peierls stresses for shuffle screw dislocations in diamond structure crystals, Si and Ge, have been calculated by the improved P-N theory. The widths are about 0.6b, where b is the Burgers vector. The Peierls barrier for shuffle screw dislocation in Si and Ge, is about 3.61~4.61meV/Å and 5.31~13.32meV/Å, respectively. The Peierls stress is about 0.28~0.33GPa and 0.31~0.53GPa, respectively. The calculated Peierls barriers and stresses are likely the results of shuffle screw dislocation with metastable core which is centered on the bond between two atoms.
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- 2015
15. Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate.
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Hou, Guoqing, Dick, Robert, Zeng, Chunhua, and Brewer, George J.
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Tetrathiomolybdate (TM) is an anticopper drug under development for treating Wilson’s disease. Its mechanism of action involves forming a tight tripartite complex in the blood with serum albumin and available copper. When available copper levels are lowered in animals with TM, strong antiangiogenic and antitumor effects are observed. Similarly, TM has excellent efficacy in animal models of fibrotic, inflammatory, and autoimmune diseases, and it protects against heart damage from doxorubicin (DXR) and liver damage from acetaminophen, carbon tetrachloride, and concanavalin A. Tetrathiotungstate (TT) also forms a similar tripartite complex in the blood and has similar effects to TM on copper. In this article, whether TT had similar antitumor effects, and similar effects in protecting the heart against DXR toxicity, as TM was evaluated. It was found that the 2 drugs were comparable in their effects when doses were used that lowered copper availability to the same extent. [Copyright &y& Elsevier]
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- 2007
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16. Comparison of lowering copper levels with tetrathiomolybdate and zinc on mouse tumor and doxorubicin models.
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Hou, Guoqing, Dick, Robert, Zeng, Chunhua, and Brewer, George J.
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Tetrathiomolybdate (TM), presumably by lowering copper levels and availability, has shown excellent efficacy in animal models of cancer and models of injury that produce fibrotic or inflammatory damage in lung, heart, and liver. Trials in human patients are underway. If the efficacy of TM is indeed through lowering copper levels, other anticopper drugs should be equally efficacious. Zinc is an anticopper drug, with proven efficacy in Wilson’s disease, a disease of copper toxicity. In this study, the efficacy of zinc is compared with TM on a mouse tumor model and on the doxorubicin model of heart damage, and it is hypothesized that when copper availability is lowered to an equivalent extent, the 2 drugs would show equivalent efficacy. No effect is found of zinc on inhibiting growth of a tumor that is markedly inhibited by TM, and zinc is found to be less effective than TM in inhibiting cardiac damage from doxorubicin. This study shows that TM’s mechanism of action in protecting against doxorubicin toxicity is because of its anticopper effects, as copper supplementation eliminated the protective effect of TM. It is also hypothesized that the differences between TM and zinc may be caused by TM’s mechanism of action in which it binds copper already in the body, whereas zinc does not. [Copyright &y& Elsevier]
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- 2006
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17. Escape of Brownian particles and stochastic resonance with low-temperature quantum fluctuations
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Zeng, ChunHua, Wang, Hua, and Hu, JianHang
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Abstract: In this paper, we investigate the escape of Brownian particles and stochastic resonance (SR) with low-temperatures quantum fluctuations by using the quantum Smoluchowski equations at low-temperature. Two specific examples have been considered: one is the example of bistable system, and the other is the example of metastable system. The explicit expressions of the mean-first passage time (MFPT) and signal-to-noise ratio (SNR) for both specific examples are obtained, respectively. Based on the numerical computations, we compare the quantum case with its classical counterpart. Our research results show that: (i) the quantum effect accelerates the escape of the Brownian particle in comparison with the classical result and (ii) the quantum effect enhances the SR in the SNR as a function of β for a bistable system (i.e., β = 1/k
B T, kB is the Boltzmann constant and T is the temperature), while for a metastable system, the β amplifies the quantum effects, and the quantum effect weakens the SNR as a function of β.- Published
- 2011
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18. Anisotropic Chalcogenide Perovskite CaZrS3: A Promising Thermoelectric Material
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Song, Xiefei, Shai, Xuxia, Deng, Shukang, Wang, Jinsong, Li, Jie, Ma, Xinru, Li, Xiaorui, Wei, Tingting, Ren, Weina, Gao, Lei, Fu, Yunchang, Wang, Hua, and Zeng, Chunhua
- Abstract
Chalcogenide perovskite materials have received extensive attention in the field of thermoelectrics (TEs) due to their inherent large Seebeck coefficient and ultra-low thermal conductivity. Herein, we demonstrate that the orthorhombic CaZrS3perovskite is a promising TE material by using first-principles calculations combined with the semiclassical Boltzmann transport theory. The anisotropic property has been observed clearly on the electronic properties and TE performances of CaZrS3along a, b, and cdirections. The orthorhombic CaZrS3shows excellent thermal stability, which leads to superior performance of electric and thermal conductivities simultaneously; thus it possesses outstanding power factor and ultra-low thermal conductivity and yields impressive ZT values of n-4.06 and p-2.62. This study provides a guideline for chemical doping and provides inspiration for the promotion of related experimental investigations.
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- 2022
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19. Tetrathiomolybdate Is Partially Protective Against Hyperglycemia in Rodent Models of Diabetes
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Zeng, Chunhua, Hou, Guoqing, Dick, Robert, and Brewer, George J.
- Published
- 2008
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