Search

Natural Plants are broadly used in treating inflammatory disorders. The current study focused on evaluating the hepato-protective and anti-inflammatory potential of A. modesta in MnCL2 induced hepatotoxicity and liver inflammation. The MnCl2 induce 6.0mg/kg was given for 30 days (p.o) to induced hepatotoxicity and liver inflammation. The ethanolic extract of A. modesta were given orally at the dose of 100mg/kg/day. The in vivo inflammatory manganese induced hepatotoxic model is used for evaluating the acacia heap to-protective effect. Gas chromatography-mass spectrometry analyses were performed to find out compounds responsible for anti-inflammatory properties. Results showed that administration of ethanolic extract (100 mg/kg), altogether diminished inflammation of the liver, expanded liver capacity, oxidative stress and his to-pathological outcomes in the current study compared with disease rats. The beneficial outcomes of A. modesta extract were observed on liver inflammation. [ABSTRACT FROM AUTHOR]

The study was designed to investigate the neuro-protection of lauric acid (LA) on haloperidol (HPD) induced Parkinson's disease (PkD) rat model. Rats were divided into group A (normal), group B (diseased, by HPD 1mg/kg i.p. for 14 days), group C (standard treatment, levodopa 30 mg/kg), group D (vehicle coconut oil 1ml/kg), group E (LA 0.66mg/kg) and group F (LA 1.32mg/kg) for 35 days after induction of PkD. The study displayed a state of oxidative stress in the striatum of rat model of PkD as shown from the increased MDA, NO levels and the decreased superoxide dismutase levels. HPD caused an increase in tumor necrosis factor-a level, NF-κB, IL-8 mRNA expression and suppress IL-4 expression. Neuro-protection with LA attenuated the oxidative stress and changes in pro-inflammatory cytokines induced due to PkD induction. The LA treatment also showed improvement in the histo-pathology of the rats' brain. LA also improved behavioral performances, food intake, weight gain as compared to animal of diseased group and prevented decline in motor activities (assessed Rotarod, and Beam walking test). LA showed significant neuro-protection against oxidative stress, inflammatory cytokines and behavioral changes in HPD induced rat model of PkD. [ABSTRACT FROM AUTHOR]

This study was schemed to comprehend the latest kaleidoscopic trends of bacterial resistance in neonatal pathogens against all those antibiotics commonly employed as empirical therapy in neonates. The methodological approach included; isolation and subsequent identification of those pathogens having caused bacterial infections in neonates, application of antibiotic sensitivity testing and finally construing the conclusion depicting patterns of antibiotic resistance by various pathogens, isolated from neonatal biological samples. Antibiotic resistance patterns was evident in gram-positive as well as in gram-negative bacteria in all the eight species identified in this study. Even antibiotic drugs which are being commonly relied upon for treating multi-resistant bacterial infections, found to be in effective against many newly emerged resistant bacteria, when used alone. Resistance Antibiotics drugs against which most prominent resistance pattern emerged include; Amikacin sulphate, Linezolid, Piperacillin / Tazobactam, Amoxicillin / Clavulanic acid, Vencomycin, Cefoperazone / Sulbactam, Ceftriaxone sodium, Ciprofloxacin, Cefixime trihydrate and Imipenem. The interred upshot suggests that antibiotic resistance is emerging fast and ever-changing phenomenon of antibiotic resistance has significantly reduced the therapeutic space to maneuver, particularly, in treating neonatal infections. [ABSTRACT FROM AUTHOR]

Clobazam belongs to benzodiazepine class and is preferably used against anti-epileptic disorders. However, when used in reduced doses, its ability for improving cognitive functions becomes explicitly evident. This study objectively undertook the task of using the reduced doses of clobazam for proving potentials effects on cognitive functions. The drug, clobazam was administered in "active group" which contained 15 young healthy volunteers. The "placebo group" also entailed 15 subjects and each was administered with placebo drug. The controlled group" also included 15 subjects. All these 45 young healthy subjects were subjected to tests for perceptual learning, creativity, selective memory, visual memory and intelligence. Results clearly demonstrated significant impact of clobazam at the dose of 5mg/day on perceptual learning (P=0.0380), creativity (P=0.0787), memory function (P=0.4920), visual memory (P=0.4816) and intelligence of the subject (P=0.4920). The outcomes highlighted in the studies reviled the positive effects of clobazam when used at reduced doses. [ABSTRACT FROM AUTHOR]

Neonatal sepsis maintains its rank as being one of the principal causes of neonatal morbidity as well as mortality in the developing countries. Treatment outcomes associated with neonatal sepsis continue to change with time and space. These varying trends fundamentally influenced by the resistance being emerged in neonatal pathogens which cause sepsis. This study focused on the comprehension kaleidoscopic trends of bacterial resistance in neonatal pathogens which in turn are manifesting in the form of failure of empirical antimicrobial treatment for sepsis in neonates. Our results showed that bacterial pathogens isolated found to be causing sepsis in neonates include; Klebsiella spp, Methicillin-resistant Staphylococcus aureus (M.R.S.A), Pseudomonas aeruginosa, Staphylococcus spp, Neisseria meningitides, Streptococcus spp and E.Coli. The most resistant of theses microbial isolates came out to be Klebsiella spp and Pseudomonas aeruginosa. In the current study the positive outcomes are signified by the improvements in pathological parameters as well as biochemical and physical signs and symptoms. The negative outcomes, on the other hand, are represented by deteriorating or absence of any improvement of the signs and symptoms neonates. Overall, the negative outcomes were found fifty two percent, whereas the positive outcomes were recorded as forty eight percent. This underscores the alarming trend of therapeutic failures due to emerging antimicrobial resistance in neonatal being emerged in population. • Neonatal sepsis remains one of the challenging problem in developing countries. • Treatment outcomes associated with neonatal sepsis change with time and space. • The positive outcomes are based on the improvements in signs and symptoms. • Eight different pathogens were isolated and subsequently identified. • Treatment failure was played by antimicrobial resistance in neonatal pathogens causing sepsis. [ABSTRACT FROM AUTHOR]