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The safety and potential benefits of home enteral route nutrition (HERN), referring specifically to home enteral nutrition (HEN) and oral nutritional supplements (ONS) in this article, after upper gastrointestinal (GI) resection are inconsistent. To evaluate the impact of HERN on nutritional status, complications, and quality of life (QOL) after upper GI resection. This systematic review was conducted in accordance with the PRISMA statement. Nine databases were searched from inception to October 2019. Randomized controlled trials (RCTs) comparing the impact of HERN after upper gastrointestinal resection were included. Relative risk/weighted mean difference/standardized mean difference (RR/WMD/SMD) and corresponding 95% confidence intervals (95% CI) were calculated using fixed- or random-effects models. Overall, 15 RCTs involving 1059 patients were included. Compared with normal oral diet, HERN significantly prevented weight loss (−3.95 vs −5.82 kg; SMD: 1.98 kg; 95% CI: 1.24–2.73); improved added-level of albumin (3.48 vs 2.41 g/L; SMD: 1.36 g/L; 95% CI: 0.81–1.91), hemoglobin (6.54 vs −1.29 g/L; WMD: 7.45 g/L; 95% CI: 5.05–9.86), pre-albumin (37.59 vs 7.35 mg/L; WMD: 21.6 mg/L; 95% CI: 5.96–37.24), and transferrin (63.08 vs 50.45 mg/L; WMD: 16.44 mg/L; 95% CI: 13.51–19.38); and reduced the incidence of malnutrition or latent malnutrition (RR = 0.54; P < 0.01). Subgroup analysis based on the approach of HERN showed that weight loss in the HEN subgroup was significantly lower than that of the control group (WMD = 2.69, P < 0.01), while there was no significant difference between the ONS subgroup and the control group (P = 0.1). The same results were found in albumin. Physical function (WMD: 5.29; 95% CI: 1.86–8.73) and fatigue (WMD: −8.59; 95% CI: −12.61, −4.58) dimensions in QOL were significantly better in the HERN group. No significant differences in gastrointestinal and tube-related complications. HERN improved nutritional status and some dimensions of QOL in upper GI malignancy patients after surgery, without increasing complications. Subgroup analysis showed that HEN experienced more benefits than ONS. [ABSTRACT FROM AUTHOR]

Abstract: According to the development indexes of China''s netizens and sites number, this paper simulates the life cycle of Chinese Internet development adopting the Logistic growth curve, and verifies the development priority of netizens and Internet sites in Chinese Internet development process. The result shows that the starting point of Chinese website growth period lags behind the starting point of Chinese netizen growth period, the starting point of Chinese website mature period is ahead of the starting point of Chinese netizen mature period, which presents a typical latemature and premature senility curve, and the average lagging time is two years. The result also indicates that the Chinese Internet development is of abundant breadth and insufficient depth, China should improve the priority of domestic website development, promote site construction, and encourage the Internet websites and netizens to develop with benign circulation. [Copyright &y& Elsevier]

The article presents a study aimed at investigating the effect of a common genetic variant on gene transcription. The study carried out bioinformatic analysis, oligonucleotide affinity chromatography, and eletrospray ionnization. Results indicate the influence of common genetic variation in the human chromogranin A (CHGA) promoter.

The article focuses on a study which assessed the role of derangements of catecholamines, reactive oxygen species (ROS) and the endothelium-derived relaxing factor nitric oxide (NO) in the development of a hyperadrenergic model of hereditary hypertension. The study included homozygous chromogranin A (Chga) gene knockout (KO) mice and wild-type control mice. Study authors concluded that ROS has a role in the development of hyperadrenergic hypertension in mice.

Abstract: This paper classifies common journal evaluation indicators into three categories, namely three first-level indicators. They are respectively the indicators on journal impact, on timeliness, and on journal characteristics. The data used here is drawn from the medical journals in CSTPCD, a citation database built by the Institute of Scientific and Technical Information of China. The three categories of indicators are correlated with one another, so a structural equation may be established. Then we calculate the value of three first-level indicators and give subjective weights to the indicators. The comprehensive evaluation upon the medical journals yields satisfactory results. By simulating the complex relationship among journal indicators, the structural equation can be used for the estimation of some implicit indicators and the screening of indicators. This approach provides a new perspective for scientific and technological evaluation in general sense. It should be noted that the availability of basic data and the rationality of modeling bear much upon the evaluation results. [Copyright &y& Elsevier]

The article focuses on the findings of a study that investigated heritability of albumin excretion in twin pairs and its genetic determination by adrenergic pathway polymorphism. It notes that albumin excretion is a risk factor for adverse cardiovascular events, even in subjects without primary glomerular disease. The authors hypothesized that albumin excretion is also subject to genetic determination and that common variations in albumin excretion might be adrenergically mediated.