1. Clinical Significance of the Oxidized Low Density Lipoprotein in Gout Inflammation.
- Author
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Joa Kim, Yun Sung Kim, Suyeon Park, Bo Young Kim, Jung Ran Choi, and Hyun-Sook Kim
- Abstract
Objective: Gout is a chronic inflammatory disease that is associated with a high prevalence of atherosclerotic cardiovascular mortality. Oxidized low-density lipoprotein (ox-LDL) is considered to play a critical role in the progression of atherosclerosis. Design: Gout patients were divided into five clinical subsets and ox-LDL were checked. Materials and Methods: They were divided into five clinical subsets. We compared clinical and laboratory parameters among the inflammatory status groups. Results: In a comparison of the four inflammatory status groups, with the exception of one asymptomatic hyperuricemia patient, ox-LDL was significantly higher in acute arthritis, and it was lowest in the well-controlled group. In post hoc analysis, ox-LDL was significantly different between acute arthritis and well-controlled status, between subacute arthritis and well-controlled status, and between chronic tophaceous gout and well-controlled status. Discussions: Ox-LDL is considered to be a key factor in the pathogenesis of atherosclerotic disease. Its levels were significantly different among the four inflammatory status groups; it was highest in acute arthritis, where the most active inflammation seems to occur, and lowest in the well-controlled status group. Conclusion: The present study emphasized that ox-LDL is associated with gout inflammatory status and may be a useful biomarker indicating a correlation of inflammation with atherosclerosis progression in gout patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021