10 results on '"Yue, Haodi"'
Search Results
2. Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis
- Author
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Wang, Jialin, Zhang, Mengjun, Huang, Xin, and Yue, Haodi
- Abstract
Osteosarcoma, a prevalent primary bone cancer in children, exhibits a poor prognosis due to the high prevalence of drug resistance. The objective of this study was to investigate the potential of fluorescent ultrafine polyethylenimine-coated caged platinum nanoclusters (PEI-Pt NCs) as an antitumor agent in osteosarcoma. The primary focus of this study involved the utilization of osteosarcoma cells (U2-OS and MG-63) and normal control cells (hBMSC) as the primary subjects of investigation. The capacity of PEI-Pt NCs to enter osteosarcoma cells was observed through the implementation of confocal microscopy. The impact of PEI-Pt NCs on migration and proliferation was assessed through the utilization of various methodologies, including the CCK8 assay, Ki-67 immunofluorescence, clone formation assay, transwell assay, and wound healing assay. Furthermore, the influence of PEI-Pt NCs on apoptosis and its underlying mechanism was explored through the implementation of flow cytometry and Western blotting techniques. The PEI-Pt NCs demonstrated the capability to enter osteosarcoma cells, including the nucleus, while also exhibiting fluorescent labeling properties. Furthermore, the PEI-Pt NCs effectively impeded the migration and proliferation of osteosarcoma cells. Additionally, the PEI-Pt NCs facilitated apoptosis by modulating the BAX-Bcl-2/Caspase 3/PARP axis. The novel nanomaterial PEI-Pt NCs possess diverse advantageous capabilities, including the ability to impede cell proliferation and migration, as well as the capacity to modulate the BAX-Bcl-2/Caspase 3/PARP axis, thereby promoting cell apoptosis. Consequently, this nanomaterial exhibits promising potential in addressing the issue of inadequate platinum-based treatment for osteosarcoma.
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- 2023
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- View/download PDF
3. Novel Platinum Nanoclusters Activate PI3K/AKT/mTOR Signaling Pathway-Mediated Autophagy for Cisplatin-Resistant Ovarian Cancer Therapy.
- Author
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Zhang, Mengjun, Yue, Haodi, Huang, Xin, Wang, Jialin, Li, Zengbei, and Deng, Xinjie
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- 2022
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- View/download PDF
4. Scientific knowledge graph and trend analysis of operation management: A bibliometric analysis.
- Author
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Song, Hongfang, Yue, Haodi, Li, Xifan, and Zhang, Ziao
- Subjects
OPERATIONS research ,KNOWLEDGE graphs ,TREND analysis ,CHINESE people ,SCIENTIFIC knowledge ,BIBLIOMETRICS - Abstract
Operation management, which has always been a hot topic in management research for seeking to increase the efficiency of the system using scientific methods. We use the Web of Science database to select the pertinent literature data from 2012 to 2022 with a focus on 10 significant international journals to perform the scoped literature on operation management in this paper. It then conducts a bibliometric analysis of operation management from two perspectives—main direction and development trend—using CiteSpace and VOSviewer. The analysis discovered that between 2012 and 2022, 22952 papers on operation management were published in significant international journals. Of these, 4398 were written by Chinese academics, making up 19.16% of the total. International Journal of Production Research, European Journal of Operational Research, and International Journal of Production Economics were the main venues for Chinese academics' publications. The National Natural Science Foundation of China supported 3446 papers in these journals, or 15.01% of all papers published. A variety of research hotspots are revealed by keyword analysis. The research's findings provide an excellent framework for describing the traits and developments in operation management. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Dynamic CSR investment decisions in the closed-loop supply chain of automotive lithium-ion batteries.
- Author
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Yue, Haodi, Song, Hongfang, Li, Xifan, and Wu, Guotao
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SOCIAL responsibility of business ,SUPPLY chains ,CORPORATE profits ,LITHIUM-ion batteries ,SOCIAL influence ,AUTOMOBILE sales & prices ,ECOLOGY - Abstract
Corporate Social Responsibility (CSR) has been receiving a lot of attention by companies and academics because of the complex situation of the social environment and the influence of public opinion. Accordingly, we believe that investing in CSR in the closed-loop supply chain (CLSC) of automotive lithium-ion battery (LIB) has theoretical and practical significance for automotive LIBs recycling. In the case of second-life automotive LIB, we propose three dynamic models of CLSCs, (1) automotive LIB manufacturer invests in CSR, (2) automotive LIB retailer invests in CSR, and (3) both automotive LIB manufacturer and retailer invest in CSR, to explore the optimal recycling decisions. The result shows that CSR can increase the sales of new automotive LIBs and the recycling of used automotive LIBs. The number of CLSC participants who invest in CSR is positively correlated with corporate profits, and the higher the number of CLSC participants who invest in CSR, the higher the profits of each CLSC participant and the overall profits of the CLSC. Investing in CSR by automotive LIB retailer is better than by automotive LIB manufacturer. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
6. Closed-loop supply chain models of lithium-ion battery considering corporate social responsibility.
- Author
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Yue, Haodi, Song, Hongfang, and Tian, Wen
- Subjects
SOCIAL responsibility of business ,SUPPLY chains ,PROFIT-sharing ,NUMERICAL analysis ,LITHIUM-ion batteries - Abstract
How to achieve harmonious development of economy, society, and environment, and scholars focus on closed-loop supply chain (CLSC) under corporate social responsibility (CSR). This paper focuses on the CLSC of lithium-ion battery (LIB) and explores the impact of CSR on the total profit of the CLSC. We propose a CLSC of LIB consisting of a manufacturer, a retailer, and a third-party recycler and develop a centralized decision-making model and two decentralized decision-making models for this problem. The results show that (1) total profit of the CLSC will be increased under CSR. (2) Consumers will pay attention to members that undertake CSR and thus influence the CLSC. (3) Profit sharing contracts increase the total profit of the CLSC in coordination. Verify the correctness of the model and the effectiveness of the coordination mechanism by numerical analysis. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Analysis on the difference of regional high-quality development in Beijing-Tianjin-Hebei city cluster.
- Author
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Tian, Wen, Li, Weihong, Song, Hongfang, and Yue, Haodi
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URBAN growth ,REGIONAL differences ,SELF-organizing maps ,CLUSTER analysis (Statistics) - Abstract
This paper about the high-quality development level of Beijing-Tianjin-Hebei region is of vital importance to promote high-quality development of China. An evaluation index system that can comprehensively describe the high-quality development of the Beijing-Tianjin-Hebei region is designed in this paper. There are 27 indexes selected to evaluate the high-quality development of the cities in Beijing, Tianjin and Hebei province from three dimensions: target level, standard level and index level. By applying the SOM (Self-Organizing Map) algorithm to cluster analysis of high-quality development levels. The results of the study showed that there are variations in high-quality development of Beijing-Tianjin-Hebei city cluster. Beijing has the highest quality development level, followed by Tianjin and Hebei, and a significant gap exists between Beijing and Hebei in terms of the level of quality development. In addition, the high-quality development level of cities in Hebei Province are not balanced. Therefore, Beijing-Tianjin-Hebei city cluster should break down administrative barriers, making overall plans and promoting coordinated development among regions. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Green supply chain coordination with substitutable products under cost sharing contract.
- Author
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Song, Hongfang, Chu, Hongrui, Yue, Haodi, and Chen, Yahong
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COST shifting ,SUPPLY chains ,PRODUCT costing ,GREEN products ,CONTRACTS ,WAREHOUSES - Abstract
For maintaining an excellent market performance of energy-saving products, it is critical for the players of the green supply chain to seek collaboration, one of the most popular trendies is cost sharing between players. In this paper, we explore a game-theoretical model of the green supply chain with a manufacturer and a retailer, the retailer sells two products with different environmental properties and same functionality. First, we explore the pricing issue of green supply chain which both sells the non-green traditional product and the new substitutable green product. Three factors, the retail price of a non-green traditional product, retail price and the green quality level of the green product, would influence demand and be served as decision variables. Then, we consider three scenarios: one integrated green supply chain model with the central manager makes all decisions; a decentralized model with the retailer decides the retail prices of non-green traditional products and green products, and the manufacturer decides the green quality level of the green product; a dual-channel green supply chain with contracts coordination to improve the profits of the whole channel. To this end, the numerical investigations reveal the ability of the cost sharing mechanism to coordinate the supply chain players and ensure higher profits for manufacturers and retailers compared with decentralized decision-making. [ABSTRACT FROM AUTHOR]
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- 2022
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9. β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation.
- Author
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Liu, Xiaozhuan, Zhang, Tingting, Zhou, Jianwei, Xiao, Ziting, Li, Yanjun, Zhang, Yuwei, Yue, Haodi, Li, Zhitao, and Tian, Jian
- Abstract
The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study was to track AEC II phenotypes at different phases of injury following thoracic irradiation and examine the expression of β-catenin, Lin28 and let-7 to identify their role in AEC II differentiation. Results showed that coexpression of prosurfactant protein C (proSP-C, an AEC II biomarker) and HOPX (homeobox only protein X, an AEC I biomarker) or vimentin (a differentiation marker) was detected in AEC II post-irradiation. The protein expression levels of HOPX and proSP-C were significantly downregulated, but vimentin was significantly upregulated following irradiation. The expression of E-cadherin, which prevents β-catenin from translocating to the nucleus, was downregulated, and the expression of β-catenin and Lin28 was upregulated after irradiation (P < 0.05 to P < 0.001). Four let-7 miRNA members (a, b, c and d) were upregulated in irradiated lungs (P < 0.05 to P < 0.001), but let-7d was significantly downregulated at 5 and 6 months (P < 0.001). The ratios of Lin28 to four let-7 members were low during the early phase of injury and were slightly higher after 2 months. Intriguingly, the Lin28/let-7d ratio was strikingly increased after 4 months. We concluded that β-catenin contributed to RILF by promoting Lin28 expression, which increased the number of AEC II and the transcription of profibrotic molecules. In this study, the downregulation of let-7d miRNA by Lin28 resulted in the inability of AEC II to differentiate into type I alveolar epithelial cells (AEC I).
- Published
- 2021
- Full Text
- View/download PDF
10. Novel Platinum Nanoclusters Activate PI3K/AKT/mTOR Signaling Pathway-Mediated Autophagy for Cisplatin-Resistant Ovarian Cancer Therapy
- Author
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Zhang, Mengjun, Yue, Haodi, Huang, Xin, Wang, Jialin, Li, Zengbei, and Deng, Xinjie
- Abstract
Platinum (Pt)-based chemotherapy drugs such as cisplatin are the first line and core options for the treatment of ovarian cancer (OC), while cisplatin resistance has a worse prognosis and low 5 year survival rate for patients. Chemotherapeutic drugs synthesized from nanomaterials have shown great potential in biomedicine; however, research into their application for OC resistance is rarely discussed. This study is proposed to elucidate the anti-tumor effects of polyethylenimine (PEI)-caged platinum nanoclusters (Pt NCs) on cisplatin-resistant OC. The results of confocal microscopy showed that Pt NCs entered cisplatin-resistant OC cells dose-dependently and aggregated both in the cytoplasm and inside the nucleus. Subsequently, according to the results of CCK8 assay, wound healing assay, clone formation assay, Transwell assay, Ki-67 immunofluorescence assay, and flow cytometry assay, the proliferation and migration of cisplatin-resistant OC cells were inhibited by Pt NCs, as well as their apoptosis was promoted. In addition, we validated the anti-tumor effect of Pt NCs on regulating autophagy via monodansylcadaverine (MDC) staining, transmission electron microscopy observation of the autophagic ultrastructure, LC3-II-GFP and P62-GFP adenovirus single-label immunofluorescence, and western blotting; meanwhile, the role of Pt NCs in adjusting autophagy through modulation of the PI3K-AKT-mTOR signaling was verified. Based on these results, it appears that cisplatin-resistant OC cells can undergo apoptosis when Pt NCs activate autophagy by inhibiting the PI3K/AKT/mTOR pathway, exhibiting a promising potential of Pt NCs in the development of a novel chemotherapeutic agent for patients suffering from cisplatin-resistant OC.
- Published
- 2022
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