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Thinner slices are more susceptible in detecting small lesions but suffer from higher statistical fluctuation. This work aimed to reduce image noise in multiphase contrast-enhanced CT reconstructed with slice thickness thinner than the clinical setting (i.e., 5 mm) using convolutional neural network (CNN) for enabling better detection of hypo-vascular liver metastasis. A DenseNet model was used to generate noise map for multiphase CT reconstructed with slice thickness of 2.5 mm and 1.25 mm. Image denoising was conducted by subtracting the CNN-generated noise map from CT images with reduced photon flux due to thinner slice thickness. The performance of DenseNet was evaluated on CT scans of electron density phantoms and patients with hypovascular liver metastases less than 1.5 cm in terms of Hounsfield Unit (HU) variation, statistical fluctuation, and contrast-to-noise ratio (CNR). The phantom study demonstrated that the CNN-based denoising method was able to reduce statistical fluctuation in CT images reconstructed with slice thickness of 2.5 mm and 1.25 mm without causing significant edge blurring or variation in HU values. With regards to patient study, it was found that the denoised 2.5-mm and 1.25-mm slices had higher CNR than the conventional 5-mm slices for hypo-vascular liver metastases in all 4 phases of multiphase CT. Our results demonstrated that the detection of hypo-vascular liver metastases in multiphase contrast-enhanced CT with slice thickness less than 5 mm could be improved by using the CNN-based denoising method. Reconstruction slice thickness has a strong influence on the image quality of CT imaging. A CNN-based denoising method was used in this work to reduce the image noise in multiphase contrast-enhanced CT reconstructed with slice thickness less than 5 mm. [ABSTRACT FROM AUTHOR]

The aim of this retrospective longitudinal study was to investigate the condylar growth after arthroscopic discopexy in adolescents with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDwoR), and to determine whether local or systemic factors influence this growth. A total of 145 patients aged 10–20 years who were diagnosed with ADDwoR by magnetic resonance imaging were included. Patients who underwent arthroscopic discopexy were assigned to the arthroscopy group (n = 108) and others to the control group (n = 37). Demographic information, clinical assessments, body indicators, and bone density information were collected. Condylar height, disc length, and disc position were measured. The mean condylar height change in the arthroscopy group was 2.12 mm more than that in the control group (P < 0.001). Condylar growth after surgery was negatively correlated with age (P = 0.017) and disc length (P = 0.015), and positively correlated with follow-up duration (P = 0.002) and disc position (P < 0.001). Moreover, arthroscopic discopexy patients had better outcomes regarding improvements in pain (P = 0.024), maximum inter-incisal opening (P < 0.001), and quality of life (P < 0.001) than control patients. In conclusion, arthroscopic discopexy can restore condylar growth and relieve symptoms in ADDwoR patients, and the condylar growth is closely related to the local factors. [ABSTRACT FROM AUTHOR]

The article focuses on the implementation of the Safe System Approach, emphasizing the need for community partnerships to ensure public understanding and acceptance. Topics discussed include the principles of the Safe System Approach, the importance of proactive communication about new roadway features, and strategies for effective community outreach to promote road safety.

The mixing of oil and gas forms the foundation of deep-sea oil and gas extraction and transportation. However, traditional conveying equipment has low efficiency and high failure rates. In this study, a spiral axial flow gas and liquid multiphase pump was used as the base model. The Eulerian multiphase flow model and RNG turbulence model were used for numerical simulations to analyze the internal flow field of the multiphase pump. A modification scheme was proposed to twist the airfoil shape and create a twisted vane. The twisted blade with the center of the hub-side flange chord length as the twisting center was twisted in the counterclockwise direction to help reduce the relative volume of gas in the flow channel. When the twisted vane with the hub-side airfoil type trailing edge point as the twisting center was twisted in the suction side direction, it helped to accelerate the movement of the gas-liquid mixture at the trailing edge of the back of the vane and further reduced the low velocity zone at the back of the vane. When the twist center is located at the hub side wing type trailing edge point of the twist vane, the twist degree is 0.214. This results in the maximum head and efficiency of the pump, improves gas phase aggregation phenomenon, and enhances the performance of the multiphase pump. [ABSTRACT FROM AUTHOR]

The aim of this study was to compare single- and double-layer digital template-assisted genioplasty for the correction of jaw deformity resulting from temporomandibular joint ankylosis (TMJA). Thirteen patients with jaw deformity resulting from TMJA who underwent lateral arthroplasty, costochondral graft, or total joint replacement combined with single- or double-layer digital template-assisted genioplasty were included. Computed tomography data were obtained for the preoperative design. Digital templates were designed and manufactured using three-dimensional printing to assist with the chin osteotomy and repositioning in single- or double-layer genioplasty. Of the 13 patients included, seven underwent single-layer genioplasty and six underwent double-layer genioplasty. The digital templates precisely reflected the osteotomy planes and repositioning of the chin segments intraoperatively. The radiographic evaluation showed that the patients who underwent double-layer genioplasty exhibited more chin advancement (11.95 ± 0.92 mm vs 7.50 ± 0.89 mm; P < 0.001) with a slightly larger mean surface error (1.19 ± 0.14 mm vs 0.75 ± 0.15 mm; P < 0.001) than those who underwent single-layer genioplasty. This indicates that double-layer genioplasty better promoted chin advancement and improved the facial shape, but was accompanied by more surgical error compared with the preoperative design. Furthermore, hardly any nerve damage was observed. Digital templates are useful for assisting in surgical procedures. [ABSTRACT FROM AUTHOR]

Change-point analysis of time-series data plays a vital role in various fields of earth sciences under changing environments. Most of the analysis approaches were usually designed to detect the change-point in the level of time-series mean. In this study, we aimed to propose a non-parametric approach to detect the change-point of different parameters of time-series data. In this approach, the Boot- strap method, coupling with Kernel density estimation, was first used to estimate the probability distribution function (pdf) of a parameter before and after any potential change-points. Second, the Ar-index based on the uncross area of the two pdfs was designed to quantify the difference of the parameter before and after each potential change-point. Finally, the potential change-point owning the largest Ar-index value was determined as the locations of the change-point of the parameter. The hydrological extreme series from four stations in the Hanjiang basin were used to demonstrate this approach. The Pettitt test method commonly used in hydrology was employed as a comparison to indirectly analyze the reliability of the proposed approach. The results show that change-point detected by the proposed approach in the four stations are identified with those detected by the Pettitt approach in the level of time-series mean. But in comparison with the Pettitt test, the proposed approach can provide more detection information for other parameters, such as coefficient of variation (Cv) and coefficient of skewness (Cs) of the series. The results also show that the degree of change in the series mean is greater than its Cv and Cs, while the degree of change in series Cv is greater than its Cs. [ABSTRACT FROM AUTHOR]

BACKGROUND: The double-J stent (DJS) is a commonly used ureteral stent in urological surgeries, which provides support and drainage. However, the DJS may result in various complications such as infection, hematuria, stone formation, stent occlusion, and migration. Normally, one end of the DJS is located in the renal pelvis, and the other end in the bladder. In this case report, we describe the rare occurrence of a misplaced DJS during laparoscopic pyeloplasty, which was unintentionally placed in the contralateral renal pelvis. CASE REPORT: A 4-month-old male infant was diagnosed with left hydronephrosis. After confirmation of the diagnosis, laparoscopic left pyeloplasty was performed with the placement of a DJS. The patient did not experience any discomfort, such as nausea, vomiting, refusal to feed, crying and restlessness, or fever, after the operation, and was discharged on postoperative day 4. The patient returned to the hospital for DJS removal 6 weeks after the operation. However, the kidneys, ureters, and bladder (KUB) X-ray examination showed that the DJS was unintentionally placed in the contralateral ureter and renal pelvis. The stent was confirmed and removed under cystoscopy. Postoperative examination of the DJS showed that there was a hole in the side of the middle of the stent for urine drainage, with no obstruction or contralateral hydronephrosis. CONCLUSIONS: Misplacement of a DJS in the contralateral renal pelvis during laparoscopic pyeloplasty is a rare but potentially serious complication. Surgeons should be cautious when placing the stent and confirm its placement with imaging studies. Patients should be closely monitored for postoperative complications and prompt intervention should be taken if necessary. [ABSTRACT FROM AUTHOR]

We primarily aimed to investigate whether there are phenotypic and genetic links underlying body mass index (BMI) and overall osteoarthritis (OA). We then intended to explore whether the relationships differ across sexes and sites. We first evaluated the phenotypic association between BMI and overall OA using data from the UK Biobank. We then investigated the genetic relationship leveraging summary statistics of the hitherto largest genome-wide association studies performed for BMI and overall OA. Finally, we repeated all analyses in a sex- (female, male) and site- (knee, hip, spine) specific manner. Observational analysis suggested an increased hazard of diagnosed OA per 5 kg/m2 increment in BMI (hazard ratio = 1.38, 95% confidence interval (CI) = 1.37–1.39). A positive overall genetic correlation was observed for BMI and OA (r g = 0.43, P = 4.72 × 10−133), corroborated by 11 significant local signals. Cross-trait meta-analysis identified 34 pleiotropic loci shared between BMI and OA, of which seven were novel. Transcriptome-wide association study revealed 29 shared gene–tissue pairs, targeting nervous, digestive, and exo/endocrine systems. Mendelian randomization demonstrated a robust BMI-OA causal relationship (odds ratio = 1.47, 95% CI = 1.42–1.52). A similar pattern of effects was observed in sex- and site-specific analyses, with BMI affecting OA comparably in both sexes and most strongly in the knee. Our work demonstrates an intrinsic relationship underlying BMI and overall OA, reflected by a pronounced phenotypic association, significant biological pleiotropy, and a putative causal link. Stratified analysis further reveals that the effects are distinct across sites and comparable across sexes. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The purpose of this study was to evaluate the clinical efficacy of laparoscopic pyeloureteroplasty in the treatment of children suffering from hydronephrosis. PATIENTS AND METHODS: Our pediatric department received 160 children with hydronephrosis from January 2019 through December 2021. These children were randomly assigned to either the control group or the study group with 80 cases in each group. The control group underwent traditional open pyeloureteroplasty, while the study group underwent laparoscopic pyeloureteroplasty. After assessing the results of both groups, the clinical outcomes were compared. RESULTS: The study group had a significantly shorter operating time, lower intraoperative bleeding rate, and shorter hospital stay than the control group. On the first day after the operation, there was no significant difference between the control and study groups, and on the seventh day after the operation, the study group's OPS was significantly lower than that of the control group. A significant difference was observed after treatment between the study group and the control group in terms of the anteroposterior diameter of the renal pelvis. Both groups' GFR increased significantly with time, and the GFR of the study group was significantly greater than that of the control group at 3 months after the operation, but there was no significant difference at 6 months after the operation. Postoperative adverse effects did not differ significantly between the two groups. CONCLUSIONS: Pediatric laparoscopic pyeloureteroplasty can reduce intraoperative bleeding, shorten operation time and hospital stay, alleviate postoperative pain, and promote the recovery of postoperative renal morphology and function in children with hydronephrosis, which merits further discussion. [ABSTRACT FROM AUTHOR]

OBJECTIVE: This study was performed to evaluate the clinical efficacy of the modified Brisson+Devine procedure in the management of concealed penis. PATIENTS AND METHODS: In this retrospective study, the medical data of 45 children diagnosed with concealed penis who underwent modified Brisson+Devine procedure in the Department of Urology of Anhui Provincial Children's Hospital between January 2019 and December 2021 were analyzed. Follow-up visits were performed at one, three, and six months postoperatively, and outcome measures included postoperative complications and parental satisfaction. RESULTS: All 45 children completed the surgery uneventfully. At 3-4 days after surgery, the penile dressing and the urinary catheter were removed. The patients were discharged 4-5 days postoperatively without ischemic necrosis of metastatic flaps. The follow-up visits spanned from 7 to 33 months, with a mean of 14.6 months. A statistically significant increase in the penile length after surgery was observed (p<0.05). The postoperative penile appearance was good, and the parents of the children had high treatment satisfaction (p<0.05). 38 children developed postoperative transferred flap edema, and the edema disappeared at 3 months postoperatively. CONCLUSIONS: The modified Brisson+ Devine procedure for concealed penis allows maximum use of the foreskin to improve the appearance of the penis and has a high safety profile by reducing postoperative complications, and provides high treatment satisfaction. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The aim of this study was to investigate the modular characteristics and mechanism of action of Chinese herbs for vascular calcification (VC) treatment. MATERIALS AND METHODS: Network pharmacology coupled with literature data mining was utilized to assess the Chinese herbal clinical performance as well as its similarity, characteristics, ingredient, target, and Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and network construction. RESULTS: The top 15 medications from the literature, according to the usage, and 190 active chemicals, 183 common targets between medication and VC-related targets were weeded out. Analysis of the relationships between the active ingredients, pharmacological targets, and signaling pathways helped to clearly define the therapeutic effect of Traditional Chinese Medicine (TCM). Importantly, we discovered seven most hub proteins (AKT1, CTNNB1, TNF, EGFR, TP53, JUN and IL-6) and two of the herbs' most fundamental ingredients (Formononetin and Luteolin) in TCM-mediated VC suppression. Mechanistically, the metabolic pathways [AGE-RAGE pathway, interleukin-17 (IL-17) pathway, and p53 pathway] as well as smooth muscle adaptation (functional remodeling) and oxidoreductase activity (redox homeostasis modulating) are also crucially implicated. CONCLUSIONS: Our work, accomplished by network pharmacology and data mining, increases our understanding of TCM in VC therapy and may offer insightful information for future drug discovery investigations. [ABSTRACT FROM AUTHOR]

The aim of this study was to assess the various outcomes of arthroscopic discopexy compared to the natural course of anterior disc displacement (ADD) longitudinally in the same patients. A retrospective review was performed of 108 patients (152 joints) who experienced the natural course of ADD for a period of time and then underwent arthroscopic discopexy. The outcome was evaluated clinically and by magnetic resonance imaging. The natural course of ADD showed significant deterioration in pain, diet, and quality of life, and also a significant reduction in inter-incisal opening (all P < 0.001), while significant improvements in all clinical parameters were observed at the final postoperative follow-up (all P < 0.001, compared to the last preoperative visit). During the natural course, there was a significant shortening of condylar height, mandibular height, and disc length, and an increase in disc displacement distance (all P < 0.001). Postoperative follow-up revealed the restoration of condylar height and mandibular height, and all discs were significantly repositioned with an increased disc length (unfolded) (all P < 0.001). Bearing in mind the assumption of a low evidence base due to bias resulting from the retrospective non-double-blinded study design and the variable duration of the natural disease course prior to surgery, this study found that the natural course of ADD led to degenerative changes in the joint structures and clinical symptoms, whereas arthroscopic discopexy led to a restoration of the bony structures and the alleviation of clinical symptoms. [ABSTRACT FROM AUTHOR]

In centrifugal compressors, the identification of flow instability signals from experiments is a difficult problem owing to the nonlinear and non-stationary characteristics. Otherwise, the complicated asymmetric structure of the volute brings a huge challenge to the evolution and circumferential nonuniformity characteristics of the flow instabilities. This paper presents experimental and numerical investigations on internal flow field to understand the flow instability characteristics in a centrifugal compressor. Considering nonlinear and non-stationary signals, a method based on Fourier-transform and variational mode decomposition was introduced to analyse the flow instability characteristics. The Fourier spectrum results show that at 0.21kg/s of 80krpm, the pressure signal has a noticeable high-frequency fluctuation, which indicates that the compressor enters the flow instability state. The variational mode decomposition results show that before a surge, the compressor experiences different flow instability stages: the RI stage, the coexistence stage of RI and stall, and the stall stage. Moreover, obvious circumferential nonuniformity characteristics of flow instabilities were observed during the throttling process. RI first occurred at the 180° circumferential position and then the stall first appeared in the circumferential range of 60° to 240°. The simulation results that it is because that the asymmetric volute causes the adverse pressure gradient inside the impeller passage and a high-pressure region (120°–240°) at the upstream of the impeller inlet. Under this combined action of the two, the effect region of tip leakage vortex expands the upstream of the impeller inlet. Meanwhile, the tip leakage vortex core migrates to a lower span of blades. This study demonstrates the ability to analyse nonlinear and non-stationary signals from a centrifugal compressor via variational mode decomposition, and provides a useful guidance for the identification of flow instability signals. [ABSTRACT FROM AUTHOR]

To investigate the downstream rim seal gas ingestion characteristics of a 1.5-stage turbine, the URANS equations were solved numerically using the SST turbulence model. The effects of different purge flow rates and the second vane on the ingestion characteristics of the aft cavity and the nonuniform fluctuations of the main gas path pressure are analysed. The results showed that the aft cavity is affected by the combined effects of the blade and the second vane, and the potential field at the leading edge of the second vane greatly influence the airflow variation in the aft cavity, which enhances the ingress of the mainstream into the wheel-space. The front purge flow weakens the egress between the suction side of the blade and the suction side of the second vane. The potential field at the leading edge of the second vane suppresses the nonuniform distribution of airflow in the aft cavity caused by the rotational effect of the blade. [ABSTRACT FROM AUTHOR]

This study evaluated the application of digital templates to guide custom-made total temporomandibular joint (TMJ) replacement. Patients treated with a custom-made total TMJ prosthesis for TMJ osteoarthrosis, ankylosis, or tumours were included prospectively. Before surgery, two types of digital template (articular eminence and condyle neck templates) were designed to guide the bone osteotomy and prosthesis positioning. The reconstructive outcomes were assessed through clinical examinations and accuracy analysis by superimposing the postoperative three-dimensional craniomaxillofacial model onto the preoperative virtual plan. Thirty-seven patients (45 joints) underwent successful TMJ reconstruction with the custom-made TMJ prosthesis guided by the digital templates, without intermaxillary fixation. For all patients, the occlusal relationship was stable in reference to the preoperative state. There were significant improvements in pain and maximum inter-incisal opening. Through merging of the pre- and postoperative craniomaxillofacial models, the maximum implanted error was 1.17 ± 0.23 mm in linear measurement and 1.19 ± 0.14 mm in surface deviation. There was more deviation in the anteromedial part of the fossa and inferior part of the mandibular handle. The digital templates were able to assist in the accurate placement of the TMJ prosthesis without the need for intermaxillary fixation. [ABSTRACT FROM AUTHOR]

Metals play an essential role in biochemistry, and the use of metals for antimicrobial applications has been well studied. Biomaterials incorporating copper and silver demonstrated high antimicrobial activity while maintaining good cytocompatibility. In this overview, nanostructure processing is underscored as a method to overcome the shortcomings of conventional bioceramics. Restructuring crystalline structures at the nanoscale make it less susceptible to brittle fracture. Furthermore, the bioactivity of the material is significantly improved through nanoscale surface modifications such as coatings. The effectiveness of nanostructured biomaterials featuring copper and silver in combatting bacterial attachment and proliferation is described. Nanoscale copper-containing stainless steel achieved antimicrobial activity by disrupting bacterial metabolism and damaging bacterial membranes while providing a conducive environment for cellular proliferation. Copper-containing stainless steels can be used to prevent marine corrosion, food preservation and combat implant-related infections. It is envisaged that future antimicrobial strategies will continue to feature copper and silver nanostructured biomaterials prominently. [ABSTRACT FROM AUTHOR]

This paper investigates a multistage production-inventory model for deteriorating items, including raw materials and finished goods, based on collaborative preservation technology investment. The major purpose is to determine the optimal materials supply, production delivery, replenishment, and investment policies for the retailer and manufacturer in which the joint total profit of the integrated system is maximized. Mathematical programming analysis is employed to ascertain the optimal solutions for the retailer and manufacturer. Furthermore, several numerical examples are presented to demonstrate solution process and verify the concavity of the proposed model. Sensitivity analyses with respect to major parameters are also performed. The numerical results show that market demand, fixed shipping cost, production rate, manufacturer's sales price, and holding cost of finished good may affect the optimal number of shipments. In addition, when collaborative preservation technology investment becomes an option, the effect of the deterioration rate on the shipping and ordering quantity will be reduced through investment in improving deterioration of raw material or finished good. Finally, the increase in the amount of raw materials used to produce a finished product implies that the amount of finished goods produced by the original material is reduced; therefore, the collaborative preservation technology investment is increased. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Osteoporosis is a severe degenerative chronic metabolic bone disease associated with high fracture risk. Polydatin (PD), a major bioactive component of Polygonum cuspidatum, has antioxidant and anti-inflammatory effects. This study investigated the anti-osteoporotic activity of PD in ovariectomized (OVX) mice and elucidated its underlying molecular mechanisms. SUBJECTS AND METHODS: An osteoporosis mouse model was established using OVX mice. OVX mice were then administered 10 or 40 mg/kg of PD for 60 days. Micro-CT and three-point bending tests were used to determine the therapeutic activities of PD in OVX mice. H&E staining was used to determine whether PD induced hepatorenal toxicity. In addition, the cellular and molecular mechanisms underlying the functionality of PD were elucidated. RESULTS: Micro-CT results showed that compared to control mice, the bone mass of OVX mice was significantly reduced due to estrogen deficiency; however, PD administration significantly elevated bone mass. Furthermore, PD substantially improved the trabecular microstructure parameters of the femur and enhanced bone strength compared with OVX mice. Hepatorenal toxicity was not observed in liver and kidney samples stained with H&E. PD significantly increased the proliferation of pre-osteoblast MC3T3-E1 cells and upregulated the expression of osteogenic differentiation markers compared to those in controls, as determined by qRT-PCR and western blotting. CONCLUSIONS: PD exerted a significant anti-osteoporotic effect in OVX mice by promoting osteogenesis. PD has great potential as a therapeutic option for osteoporosis. [ABSTRACT FROM AUTHOR]

The oil sands area of northern Alberta has river sediments that contain natural bitumen. Eggs and fish in these rivers may be exposed to bitumen-related chemicals early in life. This paper assesses a short embryo-larval fish exposure to oil sands sediment and follows the fish behaviour as they mature in clean water and examines their breeding success as adults (5 months afterwards). The three different oil sands river sediments tested were: a sediment collected outside of the bitumen deposit (tested at 3 g/L, Reference sediment from upstream Steepbank River site), and two sediments collected within the deposit (each tested at low (1 g/L) and high (3 g/L) concentrations). The sediments within the bitumen deposit were from the Ells and Steepbank (Stp) Rivers, and both contained significant total PAHs (>170 ng/g wet weight sediment) and alkylated PAHs (>4480 ng/g). Fish were exposed to these sediments for 21 days (as eggs and larval fish), and then transferred permanently to clean water to mature and breed. There was a significant decrease in the number of egg clutches produced by fish exposed early in life to Stp downstream high sediment (compared to Reference sediment). There was also a decrease in overall cumulative egg production, with fish from Stp downstream high sediment producing just over 1000 eggs in total while fish exposed to Ref sediment produced nearly 6900 eggs. The fish with reduced egg production were also less social than expected as they matured, and they had a lower % of early vitellogenic eggs in their ovaries. Overall, the exposure shows that a single, brief exposure during early life stages to natural bitumen can affect fish in adulthood. Naturally occurring bitumen-derived PAHs can reduce fish reproductive output by complex mechanisms, measurable as lower ovary maturity and changes in social behaviour. [Display omitted] • Fathead minnows were exposed early in life to oil sands sediments for 3 weeks. • Fish that were transferred to clean water for 5 months showed: • Decreased overall egg production and number of egg clutches. • Decreased percentage of early vitellogenic oocytes in ovaries. • Lower sociability than normal for adults. [ABSTRACT FROM AUTHOR]