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For the diagnosis of patients with gynecological acute abdomen, abdominal ultrasound, and vaginal color ultrasound are used for joint diagnosis to compare the effectiveness of diagnosis.

Polyphenols are important bioactive substances in apple. To explore the profiles of the nine representative polyphenols in this fruit, a high-performance liquid chromatography method has been established and validated. The validated method was successfully applied for the simultaneous characterization and quantification of these nine apple polyphenols in 11 apple extracts, which were obtained from six cultivars from Shaanxi Province, China. The results showed that only abscission of the Fuji apple sample was rich in the nine apple polyphenols, and the polyphenol contents of other samples varied. Although all the samples were collected in the same region, the contents of nine polyphenols were different. The proposed method could serve as a prerequisite for quality control of Malusproducts.

The slab track of high speed railway has higher environmental noise emissions caused by a train running than the ballasted track. In order to predict and control wheel/rail rolling noise radiation due to roughness of wheel and rail running surface on slab track, a model is developed to calculate wheel/rail rolling noise of the slab track and analyze the influences of railway slab structure parameters on wheel/rail rolling noise. The results show that the rail noise occurs mainly in the middle and high frequency ranges of 500–2000Hz. The wheel noise is chiefly in the high frequency ranges of 1600–4000Hz, and the track slab noise radiates in the frequency ranges of 125–500Hz. Instantaneous noise pressure of the rail is first, the slab is second, the wheel is in between. The weights of the slab have more influence on emissions of the slab, but have little impact on noise emission of the wheel and rail. Below 500Hz, the greater weight of the slab is, the greater noise emission of the slab is, but above 500Hz, the result is the opposite. The CA mortar elastic modulus under the slab has little impact on noise emission of the wheel and rail, whereas has more influence on noise emissions of the slab. The greater elastic modulus of CA mortar under the slab is, the less noise emission of the slab is. The rubber pads installed under the slab have more influence on noise emissions of the slab than that of wheel and rail. All in all, the rubber pad under the slab is beneficial to wheel-rail noise reduction.

The effect of high-speed train head shape on its aerodynamic performance is very important. In order to prove the effect of longitudinal profile shape of train head on aerodynamic performance, using CFD method, a two dimension model is developed to investigate outer flow field of high speed train head. Three types of train head profile schemes are calculated. The effects of longitudinal profile shape of high speed train head on aerodynamic performance are analyzed. The results show that different head profile curves cause different surface pressure distributions of body, different airflow velocities of outer flow field and different turbulent distributions. If the longitudinal profile shape of train head is spindle and streamline length of train head is 8m, aerodynamic drag of the train will well reduce.

Rheumatoid arthritis synovial fibroblasts (RASFs) contribute to arthritic cartilage degradation. Although RASFs are normally resistant to apoptosis, Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based gene therapy has been successfully used in a mouse model of arthritis. We investigated this further by treating human RASFs with nontoxic doses of the proteasome inhibitor lactacystin. Treatment induced cytosolic accumulation of p53 and enhanced the susceptibility of RASFs to apoptosis mediated by TRAIL-R2 (DR5) but not Fas. A specific role for p53 in TRAIL-R2-mediated apoptosis was indicated by the ability of p53 siRNA to significantly reduce RASF apoptosis and by the reduced apoptosis of RASFs bearing p53 mutations on treatment with anti-DR5 antibody or anti-DR5 antibody plus lactacystin. p53 immunoprecipitation followed by mass spectrometry identified a vimentin-p53 complex, an interaction that was confirmed by reciprocal vimentin-p53 immunoprecipitation and by co-immunofluorescence. Interestingly, human caspase-4 cleaved human vimentin, and blockade of caspase-4 with a chemical inhibitor or with specific siRNA significantly inhibited TRAIL-R2-mediated apoptosis of RASFs. Furthermore, blockade of caspase-4 was paralleled by persistence of a cytosolic pattern of p53 and absence of p53 translocation to the nucleus. Taken together, our findings suggest a unique role for caspase-4 in cleaving vimentin and releasing cytosolic p53 for nuclear translocation, events that may regulate the sensitivity of RASFs to receptor-mediated apoptosis.