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Objective: To examine the effect of multisensory exercise on balance disorders. Methods: PubMed, Scopus and Web of Science were searched to identify eligible studies published before January 1, 2020. Eligible studies included randomized control trials (RCTs), non-randomized studies, case-control studies, and cohort studies. The methodological quality of the included studies was evaluated using JBI Critical Appraisal Checklists for RCTs and for Quasi-Experimental Studies by two researchers independently. A narrative synthesis of intervention characteristics and health-related outcomes was performed. Results: A total of 11 non-randomized studies and 9 RCTs were eligible, including 667 participants. The results supported our assumption that multisensory exercise improved balance in people with balance disorders. All of the 20 studies were believed to be of high or moderate quality. Conclusion: Our study confirmed that multisensory exercise was effective in improving balance in people with balance disorders. Multisensory exercises could lower the risk of fall and enhance confidence level to improve the quality of life. Further research is needed to investigate the optimal strategy of multisensory exercises and explore the underlying neural and molecular mechanisms of balance improvement brought by multisensory exercises.

Background: Obesity is a significant risk factor for the development of types of cancer. Programmed death 1 and its ligand programmed death-ligand 1 (PD-L1) play a crucial role in tumor immune escape. Although, the role of PD-L1 in obesity-associated hepatocellular carcinoma (HCC) remains unknown. We previously showed that the natural flavonoid pentamethylquercetin (PMQ) possesses anti-obesity properties. Objective: This study was designed to investigate the effects of PMQ on the development of HCC in obese mice and whether PMQ regulates PD-L1 and expression in HCC. Methods: Monosodium glutamate-induced obese mice were inoculated with H22 tumor cells. Tumor volumes and weights were measured. In vitro, 3T3-L1 preadipocytes were differentiated and lipid accumulation was measured by oil-red staining, and IFN-γ level was detected by Elisa. Hepatoma HepG2 cells were treated with conditional media from 3T3-L1 adipocytes (adi-CM). Western blotting was applied to detect PD-L1 protein levels in tumor tissue and HepG2 cells. Results: Compared with control mice, H22 tumors grew faster and exhibited higher PD-L1 protein levels in obese mice. PMQ inhibited H22 tumor growth and reduced PD-L1 expression in tumor tissues. PD-L1 protein level was elevated in adi-CM-treated HepG2 cells. IFN-γ was detectable in adi-CM and exogenous IFN-γ induced PD-L1 expression in HepG2 cells. PMQ affected the differentiation of 3T3-L1 preadipocytes, decreased the level of IFN-γ secreted by adipocytes and downregulated adi-CM-induced PD-L1 expression in HepG2 cells. Conclusion: PMQ could inhibit HCC progression in obese mice at least in part through down-regulating adipocytes-induced PD-L1 expression via IFN-γ signaling.

N-Allyl-1-pyrenemethylammonium hydrochloride was found to form a binary complex with cucurbit[8]uril and further form a ternary complex with methyl viologen, which can be used to determine the content of cucurbit[8]uril and methyl viologen.

In analysis of association rules based on OLAP, the application of Apriori algorithm may need to scan the database frequently and generate massive number of candidate itemsets because of the complex system. According to the weakness, the paper proposes PApriori algorithm based on pretreatment, which reduces the time of scanning database to once, while not directly generate candidate itemsets, raise the efficiency Analysis of association rules based on OLAP efficiently.

The research of perception time is part of perception model, establish the perception based on depict, calculate the response time and duration of the process of perception, analysis the factor, point of direction of the future research.

For the actual results of visual perception for virtual soldier, the model of visual perception for virtual soldier based on limited rationality is established. The paper analyses the conditions which affect the visual perception for virtual soldier including geometrical gene, visual gene, moving gene and contrastive gene. The visibility of virtual soldier is computed and the persuasion for visual perception of virtual soldier is received.

This work investigated safety and stability of high speed milling cutter using FEM and Penghuanwu discriminance, propounded safety and stability criterion of cutter, and analyzed absolute degree of incidence on safety and stability of cutter using grey system theory, the influence laws of structure parameters and their interaction on safety and stability of cutter were acquired. Experiments of idling and high speed milling were carried out, analyzed the impact degree of structural parameters on safety and stability of cutter, and results validated the dependability and validity of safety and stability cutting criterion.

Using grey system theory in axiomatic design of high speed face milling cutter, the structural design method of cutter was investigated. The problem of parameter interaction and function coupling in axiomatic design of cutter was solved using the analysis method of grey cluster, and realized the reconstruction of design matrix and collaborative design planning. Results show that there is not design loop which exists in the development of high speed milling cutter, the effects of simplifying design process, shortening design cycle and improving collaborative design are validated in development of high speed face milling cutter. Results of experiments indicate that cutting vibration of high speed face milling cutter using structural design method is depressed, the cutters with higher safety and cutting stability, and their cutting performance have met the requirement of high speed milling.