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In this article, a high-performance and low-cost single-event multiple-node-upsets resilient (HLMR) latch is proposed in 55-nm CMOS technology. By using eight normal two-input Muller-C-elements (MCEs) and eight clock-gating (CG)-based two-input MCEs, a feedback loop storage module with 16 storage nodes is constructed, which makes the latch completely triple-node-upsets (TNUs) resilient. Meanwhile, through the special layout technique which guarantees the worst quadruple-node pairs as physically apart as possible, the proposed latch is completely quadruple-node-upsets (QNUs) tolerant and almost completely QNU resilient. Simulation results have validated the robustness and low cost of the proposed latch due to the use of high-speed transmission gates (TGs), CG technology, and fewer transistors. Overhead comparisons indicate that our design saves 383.53% area-power-delay product (APDP) on average and has a lower sensitivity on process, voltage and temperature (PVT) compared with other considered up-to-date multiple-node-upsets (MNUs) tolerant latches, thus providing high reliability for safety and low-cost critical applications, especially in harsh radiative environments.

Thalamocortical (TC) circuits are essential for sensory information processing. Clinical and preclinical studies of autism spectrum disorders (ASDs) have highlighted abnormal thalamic development and TC circuit dysfunction. However, mechanistic understanding of how TC dysfunction contributes to behavioral abnormalities in ASDs is limited. Here, our study on a Shank3mouse model of ASD reveals TC neuron hyperexcitability with excessive burst firing and a temporal mismatch relationship with slow cortical rhythms during sleep. These TC electrophysiological alterations and the consequent sensory hypersensitivity and sleep fragmentation in Shank3mutant mice are causally linked to HCN2 channelopathy. Restoring HCN2 function early in postnatal development via a viral approach or lamotrigine (LTG) ameliorates sensory and sleep problems. A retrospective case series also supports beneficial effects of LTG treatment on sensory behavior in ASD patients. Our study identifies a clinically relevant circuit mechanism and proposes a targeted molecular intervention for ASD-related behavioral impairments.

Nanocarbons in a unique spring-like helical structure were prepared by a simple and low-cost flame combustion method to act as active and conductive nano-springs in constructing a mattress-like graphene-based paper as a flexible freestanding electrode. As the electrode is applied in a supercapacitor, it simultaneously exhibits high activity, cycling and mechanical stability owing to its unique structure. At a working current density of 0.2 mA cm[?]2, the areal capacitance of this electrode is as high as 1.07 F cm[?]2, which is 228% higher than that of the electrode without the helical interlayer. In addition, the capacitive retention of the electrode reaches 93.02% after 1000 charge-discharge cycles at a current density of 2 mA cm[?]2, and it can remain at 81.22% even if the electrodes are bent 120deg in a symmetrical supercapacitor. Such a preparation route is simple and effective, which makes it a promising method for fabricating general spring-like nanomaterials for high-performance wearable electronic devices.

Nanocarbons in a unique spring-like helical structure were prepared by a simple and low-cost flame combustion method to act as active and conductive nano-springs in constructing a mattress-like graphene-based paper as a flexible freestanding electrode. As the electrode is applied in a supercapacitor, it simultaneously exhibits high activity, cycling and mechanical stability owing to its unique structure. At a working current density of 0.2 mA cm−2, the areal capacitance of this electrode is as high as 1.07 F cm−2, which is 228% higher than that of the electrode without the helical interlayer. In addition, the capacitive retention of the electrode reaches 93.02% after 1000 charge-discharge cycles at a current density of 2 mA cm−2, and it can remain at 81.22% even if the electrodes are bent 120° in a symmetrical supercapacitor. Such a preparation route is simple and effective, which makes it a promising method for fabricating general spring-like nanomaterials for high-performance wearable electronic devices.