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3. Ulinastatin improved cardiac dysfunction after cardiac arrest in New Zealand rabbits.

Author

Chun Lin Hu, Hui Li, Jin Ming Xia, Xin Li, Xiaoyun Zeng, Xiao Xing Liao, Hong Zhan, Xiao Li Jing, and Gang Dai

Abstract

Objective: The present study was designed to evaluate the effects of ulinastatin (UTI) on cardiac dysfunction after cardiopulmonary resuscitation (CPR). Methods: A total of 48 healthy adult male New Zealand rabbits were untreated for 8 minutes after the induction of ventricular fibrillation (VF) by an external transthoracic alternating current and then treated by CPR. These rabbits were then randomly divided into the control and UTI groups after the return of spontaneous circulation (ROSC) and were observed for 8 hours after the ROSC. Before CPR and after ROSC at 2, 4, and 8 hours, blood samples were collected to determine the levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), cardiac troponin I (cTnI), and N-terminal probrain natriuretic peptide (NT-proBNP), and the left ventricular ejection fraction (EF) was measured by echocardiography. Results: Nineteen of 24 rabbits in the control group and 18 of 24 in the UTI groupwere successfully resuscitated. The plasma levels of TNF-α, IL-6, MDA, cTnI, and NT-proBNP were significantly increased, accompanying a deceased EF in the control group, but the cotreatment with UTI decreased the plasma levels of TNF-α, IL-6, MDA, cTnI, and NT-proBNP (P b .05), attenuating themyocardial injury and improving the EF in theUTI group.Only 9 of 19 animals in the control group but 14 of 18 animals in the UTI group survived longer than 8 hours (P = .011). Conclusions: The progression of proinflammatory responses, oxidative stress, and myocardial injury have been linked to the reduced EF after VF/CPR, and the administration of UTI at a cardioprotective dosage preserved the cardiac function after VF/CPR. [ABSTRACT FROM AUTHOR]

Published
2013
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4. Gender differences in lipid goal attainment among Chinese patients with coronary heart disease: insights from the DYSlipidemia International Study of China

Author

Yu, Bilian, Zhao, Shuiping, Hu, Dayi, Ambegaonakr, Baishaili M., Investigators, on Behalf of the DYSIS-China Study, Investigators, on Behalf of the DYSIS-China Study, Jia Er, Bu Ai, Guiwen, Cao, Buxing, Chen, Hong, Chen, Jin, Chen, Jing, Chen, Liefeng, Chen, Min, Chen, Qiong, Chen, Shaoliang, Chen, Tielong, Chen, Xiaofei, Chen, Xiaohong, Chen, You, Chen, Guoli, Cheng, Mei, Cheng, Hongliang, Cong, Qin, Cui, Shiwei, Cui, Yong, Cui, Shudong, Dai, Henghua, Dai, Xiaomei, Deng, Yirong, Di, Xiaoyan, Ding, Birong, Dong, Yumei, Dong, Yugang, Dong, Ping, Du, Lei, Duan, Limei, Fan, Ningyuan, Fang, Lixia, Fei, Lie, Feng, Jun, Ge, GeWeihong, Hongmin, Guo, Minxia, Guo, Qinghua, Han, Fengchang, He, Dayi, Hu, Lingzhi, Hu, Xueqiang, Hu, Yaojun, Hu, Yiming, Hu, Zhiping, Hu, Fei, Hua, Qi, Hua, Dejia, Huang, Gewen, Huang, Hongman, Huang, Liming, Huang, Qiong, Huang, Ruowen, Huang, Taifu, Huang, Bin, Jiang, Kai, Jiao, Hui, Jin, Huigen, Jin, Jinsong, Kuang, Bao, Li, Chengjiang, Li, Hongjuan, Li, Jun(Xinjiang), Li, Jun(Jiangsu), Li, Nanfang, Li, Qifu, Li, Qiang, Li, Xin, Li, Xueyou, Li, Yanbing, Li, Yanping, Li, Yansheng, Li, Yong, Li, Yuling, Li, Zhanquan, Li, Zhengfang, Li, Li, Liang, Yongxue, Liang, Zerong, Liang, Yuhua, Liao, Fan, Liu, Hong, Liu, Hui, Liu, Minling, Liu, Qiang, Liu, Qingsong, Liu, Shaokui, Liu, Weidong, Liu, Xueping, Liu, Xinjian, Lu, Benyan, Luo, Shaonian, Luo, Suxin, Luo, Hong, Lv, LvYun, Aiqun, Ma, Jianhua, Ma, Qiang, Ma, Yan, Ma, Changsheng, Ma, Yide, Miao, Yiming, Mu, NieXiaoli, NiuXiaoyuan, Hongtao, Pan, Mingkang, Pan, Qiaoqing, Peng, Huifen, Qian, Qiumin, Qu, Lijie, Qu, Liqun, Ren, Jingshan, Shao, Qiang, Se, Jing, Huang, Xiuyun, Shen, Yongquan, Shi, Liangyi, Si, Zhi, Song, Zhiyuan, Song, Yufeng, Sun, Chunyan, Tan, TengXiaochun, Haoming, Tian, Wenhua, Tian, Qinwei, Tong, TuQiuyun, Keying, Wang, Aihong, Wang, Chaohui, Wang, Chunning, Wang, Dezhao, Wang, Guixia, Wang, Hanqiao, Wang, Jianan, Wang, Jianjun, Wang, Lan, Wang, Xiaoming, Wang, Yaping, Wang, Yangwei, Wang, Yongjun, Wang, Meifang, Wei, Yidong, Wei, Hongyun, Wu, Chun, Wu, Dongmei, Wu, Jiang, Wu, Jun, Wu, Xiaolin, Wu, Zonggui, Wu, XiGuangxia, Yi, Xiang, Qian, Xiao, Xiaoping, Xing, Yulong, Xing, Anding, Xu, XueYuanming, Chuanzhu, Yan, Tao, Yan, Xiaowei, Yan, Gangyi, Yang, Jian, Yang, Wangpingm, Yang, Xiaosu, Yang, Xinchun, Yang, Yifang, Yang, Yu, Yang, Mingyu, Yao, Min, Ye, Ping, Ye, Bo, Yu, Jiangyi, Yu, Jinming, Yu, Yan, Yu, Ling, Zeng, Longyi, Zeng, Xiaoyun, Zeng, Baorong, Zhang, Bei, Zhang, Chaoxin, Zhang, Xuelian, Zhang, Dadong, Zhang, Dongping, Zhang, Fuchun, Zhang, Hong, Zhang, Huifang, Zhang, Liping, Zhang, Liyang, Zhang, Rufu, Zhang, Saidan, Zhang, Weijuan, Zhang, Dong, Zhao, Gang, Zhao, Shuiping, Zhao, Xiuxin, Zhao, Qiangsun, Zheng, Yang, Zheng, Xiaohui, Zhou, Yali, Zhou, Yujie, Zhou, Yi, Zhu, Yulan, Zhu, and Xiangping, Zou

Abstract

Despite great advances in lipid-lowering therapy, the gender-based disparities in lipid goal success among Chinese coronary heart disease (CHD) patients receiving lipid-lowering treatment remained uncharacterized. Furthermore, little is known about potential causes for this gender imbalance. This cross-sectional trial included 25 697 patients treated with lipid-lowering agents from 122 centres between April 2012 and October 2012; data for 9420 participants with CHD were analysed in the present study; all underwent clinical examination and had their latest fasting lipid profiles while on lipid-lowering therapy recorded. Logistic regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes. Of 9420 CHD patients (42.5% women) evaluated, women had a significantly lower overall low-density lipoprotein cholesterol (LDL-C) success rate than men (46.2 vs. 62.7%, P < 0.0001). Among CHD patients with diabetes, only 31.5% of women and 46.4% of men (P < 0.0001) attained the optional LDL-C target of <80 mg/dL. More than half (54.0%) of female patients failed to attain their non-high-density lipoprotein cholesterol (HDL-C) goal. Approximately 7.5, 8.8, 7.5, and 6.8% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in use of an anti-diabetic, anti-hypertensive, anti-platelet treatment, and the dosage of statin treatment, respectively. Although great improvements have been made over the past decade, there is still a preventive gap in high-risk and very high-risk CHD patients regarding LDL-C and non-HDL-C levels and that this gap is apparently greater in women.

Published
2015
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