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In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp3)–H arylation of amides and intramolecular C–N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2H-quinolinone with good regioselectivity of C–H arylation and C–N coupling from C–I and C–X bonds from readily available starting materials.

This experiment was conducted to evaluate the effect of seed priming on the germination and physiology of Pinus bungeanaseeds. Seeds were treated by hydropriming with distilled water, halopriming with potassium nitrate (KNO3) at −0.3, −0.6, −1.2 MPa respectively (untreated dry seeds were taken as control). Properties of seed germination and physiology were determined and the effect of hydro- and halopriming on germination and physiology of P. bungeanaseeds were investigated. The results showed that, compared with control, each priming treatment had increased the ge rmination percentage (GP) and germination index (GI), shortened the mean germination time (MGT) and the time required for 50% of the seeds to germinate (G50). Primed P. bungeanaseeds significantly decreased the relative conductivity and the amount of malondialdehyde (MDA). Of all the treatments applied to seeds of P. bungeana, halopriming at −0.3 MPa KNO3produced the highest GP (65.0%) and the shortest MGT (18.8 d) and G50(18.2 d).This experiment was conducted to evaluate the effect of seed priming on the germination and physiology of Pinus bungeanaseeds. Seeds were treated by hydropriming with distilled water, halopriming with potassium nitrate (KNO3) at −0.3, −0.6, −1.2 MPa respectively (untreated dry seeds were taken as control). Properties of seed germination and physiology were determined and the effect of hydro- and halopriming on germination and physiology of P. bungeanaseeds were investigated. The results showed that, compared with control, each priming treatment had increased the ge rmination percentage (GP) and germination index (GI), shortened the mean germination time (MGT) and the time required for 50% of the seeds to germinate (G50). Primed P. bungeanaseeds significantly decreased the relative conductivity and the amount of malondialdehyde (MDA). Of all the treatments applied to seeds of P. bungeana, halopriming at −0.3 MPa KNO3produced the highest GP (65.0%) and the shortest MGT (18.8 d) and G50(18.2 d).

In this work, we successfully explored an unexpected dehydrogenation triggered by Pd/Cu-catalyzed C(sp3)–H arylation and intramolecular C–N coupling of amides to synthesize the bioactive 1,2-dihydroquinoline scaffold with good regioselectivity and good compatibility of functional groups. This strategy provides an alternative route to realize molecular complexity and diversity from simple and readily available molecules via multiple C–H bond activation. Preliminary mechanistic studies demonstrated that β,γ-dehydrogenation is triggered by the arylation of the C(sp3)–H bond and the intramolecular C–N coupling.

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