72 results on '"Wang, Tianjiao"'
Search Results
2. Environmental regulation of water use efficiency in Artemisia ordosica in Mu Us Sandy Land: From leaf to ecosystem.
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ZHAI Shuchen, WANG Tianjiao, LI Xinhao, HAO Shaorong, JIA Xin, ZHA Tian-shan, and LIU Peng
- Abstract
Water use efficiency (WUE) is a key indicator for predicting the impacts of climate change on ecosystem carbon and water cycles. Most studies have explored the changes in the response environment of WUE at a particular scale. Few studies have examined how WUE responds to environments at multiple scales, thus limiting our in-depth understanding of the cross-scale carbon and water cycles. In this study, we measured photosynthesis and transpiration in situ periodically and continuously from June to October 2022 in a community dominated by Artemisia ordosica in Mu Us Sandy Land, and analyzed the seasonal variations in WUE at leaf, canopy, and ecosystem scales. The results showed there were significant seasonal variations in leaf water use efficiency (WUEL), canopy water use efficiency (WUET), and ecosystem water use efficiency (WUEE). WUEL was large in June and small in both August and September, ranging from 0.73-2.98 µmol • mmol
-1 . Both WUET and WUEE were lowest in June and highest in July and August, ranging from 0.10-7.00 and 0.06-6.25 µmol • mmol-1 . WUEL was significantly negatively correlated with stomatal conductance. WUET was significantly positively correlated with canopy conductance and soil water content, and negatively correlated with vapor pressure deficit (VPD). There was a significant positive correlation between WUEE and soil water content (SWC10 ) in 10 cm soil depth. The structural equation model showed that SWC10 and air temperature affected net photosynthetic rate and transpiration rate by modifying stomatal conductance, and thus affecting WUEL . VPD and SWC10 affected WUET by altering transpiration. SWC10 , air temperature, and VPD affected WUEE by regulating ecosystem gross primary productivity. The modelling of carbon and water cycles should thoroughly consider the path and intensity of the effect of environmental factors on WUE at multiple scales. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial
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D'Angelo, Sandra P, Araujo, Dejka M, Abdul Razak, Albiruni R, Agulnik, Mark, Attia, Steven, Blay, Jean-Yves, Carrasco Garcia, Irene, Charlson, John A, Choy, Edwin, Demetri, George D, Druta, Mihaela, Forcade, Edouard, Ganjoo, Kristen N, Glod, John, Keedy, Vicki L, Le Cesne, Axel, Liebner, David A, Moreno, Victor, Pollack, Seth M, Schuetze, Scott M, Schwartz, Gary K, Strauss, Sandra J, Tap, William D, Thistlethwaite, Fiona, Valverde Morales, Claudia Maria, Wagner, Michael J, Wilky, Breelyn A, McAlpine, Cheryl, Hudson, Laura, Navenot, Jean-Marc, Wang, Tianjiao, Bai, Jane, Rafail, Stavros, Wang, Ruoxi, Sun, Amy, Fernandes, Lilliam, Van Winkle, Erin, Elefant, Erica, Lunt, Colin, Norry, Elliot, Williams, Dennis, Biswas, Swethajit, and Van Tine, Brian A
- Abstract
Afamitresgene autoleucel (afami-cel) showed acceptable safety and promising efficacy in a phase 1 trial (NCT03132922). The aim of this study was to further evaluate the efficacy of afami-cel for the treatment of patients with HLA-A*02and MAGE-A4-expressing advanced synovial sarcoma or myxoid round cell liposarcoma.
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- 2024
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4. Evaluation of accelerated magnetic resonance imaging with simultaneous multi-slice of the head and neck region
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Su, Tong, Xu, Zhentan, Wang, Tianjiao, Zhu, Jinxia, Wang, Xiaoye, Carinci, Flavio, Chen, Xingming, Zhang, Tao, Zhu, Xiaoli, Chen, Yu, Zhang, Zhuhua, and Jin, Zhengyu
- Abstract
Background: To investigate the feasibility of the simultaneous multi-slice (SMS) accelerated acquisition technique in 2 dimension-RARE/turbo spin echo (TSE) sequence with special purpose coils in head and neck imaging. Methods: Thirty-six healthy volunteers and eight patients with head and neck squamous cell carcinoma were recruited in this prospective study. The MR protocols included 2D-T1/T2-weighted TSE sequences, both with the SMS (T1/T2w-SMS-TSE) technique and without it (T1/T2w-TSE). A pair of special purpose coils was additionally used in sub-group of participants. Subjective image quality scores, quantitative values of images, including signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs), were evaluated. Results: The acquisition time was 1:15 min and 1:09 min for T1w and T2w-SMS-TSE, with a respective 39% and 47% reduction compared to conventional sequences. The image quality of all the images were scored equivalent. Although the SMS technique seemed to slightly reduce the SNRs of T1/T2w images and CNRs of T1w images, the additional use of special purpose coils further increased the SNRs and CNRs in most cases. Focal lesions of eight HNSCC patients were finely delineated in all the protocols with similar and good diagnostic value. Conclusions: Combining SMS–TSE imaging with special purpose coils is a feasible and effective approach to reduce the total acquisition time, and obtain equivalent image quality and better SNRs and CNRs in most cases, as compared to the conventional T1/T2w-TSE sequence in head and neck imaging.
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- 2024
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5. Capacity-Aware Undersea Cable System Design
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Wang, Tianjiao, Moran, Bill, and Zukerman, Moshe
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Undersea cables play a crucial role in enabling global communication and data transfer, significantly affecting Internet speeds. Without them, global communication would be severely limited. As technology advances and network demands increase, the number and variety of optical fibers within cables are constantly increasing. This growth results in more costly cable networks with the ability to transmit more data and enhances the speed and reliability of data transmission. The construction of an undersea cable system requires careful consideration of the appropriate bandwidth of the cable to meet network bandwidth requirements while minimizing costs. In this article, we formulate the undersea cable network optimization problem taking account of the bandwidth capacity of each cable edge on the cable network as a weighted edges Steiner minimum tree problem and describe a new algorithm called the weighted edges Steiner minimum tree (WE-SMT) algorithm. For the given locations of the terminal nodes and the bandwidth capacity requirement, the WE-SMT algorithm optimizes the position of Steiner nodes, the bandwidth capacity of each cable edge, and the cable path. We implement our algorithm in a real-world setting, evaluating the benefit gained against the outcomes obtained without accounting for bandwidth optimization, as well as studying the effect of data resolution on the quality of the path planning results. In addition, we assess the performance of our new algorithm in comparison with that of an operational real-world cable system.
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- 2024
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6. Lactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1to boost oncogenic DNA virus KSHV reactivation
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Yan, Qin, Zhou, Jing, Gu, Yang, Huang, Wenjing, Ruan, Mingpeng, Zhang, Haoran, Wang, Tianjiao, Wei, Pengjun, Chen, Guochun, Li, Wan, and Lu, Chun
- Abstract
N4-acetylcytidine (ac4C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification that controls protein functions. Our latest study demonstrates a NAT10-dependent ac4C modification, which occurs on the polyadenylated nuclear RNA (PAN) encoded by oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), can induce KSHV reactivation from latency and activate inflammasome. However, it remains unclear whether a novel lysine acylation occurs in NAT10 during KSHV reactivation and how this acylation of NAT10 regulates tRNAs ac4C modification. Here, we showed that NAT10 was lactylated by α-tubulin acetyltransferase 1 (ATAT1), as a writer at the critical domain, to exert RNA acetyltransferase function and thus increase the ac4C level of tRNASer-CGA-1-1. Mutagenesis at the ac4C site in tRNASer-CGA-1-1inhibited its ac4C modifications, translation efficiency of viral lytic genes, and virion production. Mechanistically, KSHV PAN orchestrated NAT10 and ATAT1 to enhance NAT10 lactylation, resulting in tRNASer-CGA-1-1ac4C modification, eventually boosting KSHV reactivation. Our findings reveal a novel post-translational modification in NAT10, as well as expand the understanding about tRNA-related ac4C modification during KSHV replication, which may be exploited to design therapeutic strategies for KSHV-related diseases.
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- 2024
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7. Validation of an automated iron stain process for use with bone marrow aspirate smear slides
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Shirai, Cara Lunn, Ruzinova, Marianna B., Barber, Philip, Bianchi, Elizabeth, Ackerman, Julie M., Wang, Tianjiao, Parrish, Shilah, and Frater, John L.
- Abstract
The assessment of bone marrow iron stores is typically performed on an aspirate smear slide that has been manually stained by a technologist using a commercially available kit. This approach can contribute to inconsistent results and limit the broad use of iron staining in bone marrow specimens, particularly when laboratories have low staffing and/or high specimen volumes. Here, we describe the adaptation and validation of the Ventana Benchmark automated stainer and iron stain kit for routine clinical use of staining iron in bone marrow aspirate smear slides. We assessed accuracy and precision of the Ventana automated iron staining protocol compared to the Perls Prussian blue manual iron staining index method. Hematopathologists assigned Gale scores and enumerated the percentages of erythroid sideroblasts on paired patient bone marrow aspirate smear slides stained by the automated method and the manual iron staining method. We found a similar level of performance of the Ventana automated iron stain relative to the index manual method (as assessed by Pearson correlation and Bland–Altman analyses). In addition, there was low imprecision between replicates performed via the automated iron stain protocol. We also report superior qualitative findings of the automated method in ease of localization of iron storage, visualization of sideroblasts, and counterstain consistency. Automated iron staining of bone marrow aspirate smear slides performed similarly to the manual method and may allow for accurate routine evaluation of bone marrow iron stores as part of bone marrow analysis.
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- 2024
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8. T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma.
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Qu, Jiangming, Pan, Boju, Su, Tong, Chen, Yu, Zhang, Tao, Chen, Xingming, Zhu, Xiaoli, Xu, Zhentan, Wang, Tianjiao, Zhu, Jinxia, Zhang, Zhuhua, Feng, Feng, and Jin, Zhengyu
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- 2023
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9. Droplet Boiling on Micro-Pillar Array Surface Transition Boiling Regime.
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Wang, Tianjiao, Hu, Zhixuan, Shen, Shengqiang, and Liang, Gangtao
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- 2023
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10. An Overview of Reproductive Carrier Screening Panels for Autosomal Recessive and/or X-Linked Conditions: How Much Do We Know?
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Wang, Tianjiao, Scuffham, Paul, Byrnes, Joshua, Delatycki, Martin B., and Downes, Martin
- Abstract
(Abstracted from Prenatal Diagnosis2023;43:1416–1424Reproductive carrier screening is designed to identify couples who are at a high risk of passing genetic disorders to their children. Advances in genetic screening technology have recently allowed for the commercial development and availability of genetic tests that can screen for autosomal recessive and X-linked genes for many disorders simultaneously.
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- 2024
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11. Durable control of metastases in an HLA-A2+ patient with refractory melanoma after low-dose radiotherapy in combination with MAGE-A4 T cell therapy: a case report
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He, Kewen, Hong, David S., Ke, Danxia, Kebriaei, Partow, Wang, Tianjiao, Danesi, Hassan, Bertolet, Genevieve, Leuschner, Carola, Puebla-Osorio, Nahum, Voss, Tiffany A., Lin, Quan, Norry, Elliot, Fracasso, Paula M., and Welsh, James W.
- Abstract
There is no currently approved adoptive cellular therapy for solid tumors. Pre-clinical and clinical studies have demonstrated that low-dose radiotherapy (LDRT) can enhance intratumoral T cell infiltration and efficacy. This case report describes a 71-year-old female patient with rectal mucosal melanoma that had developed metastases to liver, lung, mediastinum, axillary nodes, and brain. After systemic therapies had failed, she enrolled in the radiation sub-study of our phase-I clinical trial exploring the safety and efficacy of afamitresgene autoleucel (afami-cel), genetically engineered T cells with a T cell receptor (TCR) targeting the MAGE-A4 tumor antigen in patients with advanced malignancies (NCT03132922). Prior to the infusion of afami-cel, she received concurrent lymphodepleting chemotherapy and LDRT at 5.6 Gy/4 fractions to the liver. Time to partial response was 10 weeks, and duration of overall response was 18.4 weeks. Although the patient progressed at 28 weeks, the disease was well controlled after high-dose radiotherapy to liver metastases and checkpoint inhibitors. As of the last follow-up, she remains alive over two years after LDRT and afami-cel therapy. This report suggests that afami-cel in combination with LDRT safely enhanced clinical benefit. This provides evidence for further exploring the benefit of LDRT in TCR-T cell therapy.
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- 2023
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12. Radar: Reliable Resource Scheduling for Composable/Disaggregated Data Centers
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Guo, Chao, Zukerman, Moshe, and Wang, Tianjiao
- Abstract
Hardware disaggregation decouples resources (e.g., processors and memory) from monolithic servers, potentially improving service reliability. However, from another perspective, directly exposing resource modules to a shared network may adversely affect service reliability. In this article, we study a reliable resource allocation problem in disaggregated data centers, considering network impact and different disaggregation scales. We provide a mixed-integer linear programming formulation and a resource allocation framework named Radar for this problem. The numerical results demonstrate that the benefits of hardware disaggregation may be adversely affected by an imperfect network. It also shows that both the hardware backup and a proposed migration-based restoration can be applied to overcome this potential adverse effect.
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- 2023
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13. Biomimetic nanosystems harnessing NIR-II photothermal effect and hypoxia-responsive prodrug for self-amplifying and synergistic tumor treatment.
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Wang, Lu, Wang, Tianjiao, Zhang, Yushi, Kang, Xiaoying, Ouyang, Xiao–kun, Yu, Xuya, Chen, Ting, Li, Wen, and Mei, Lin
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MEMBRANE proteins ,THERAPEUTICS ,TUMOR treatment ,PHOTOTHERMAL effect ,TUMOR growth - Abstract
Tumor microenvironment-activated prodrugs have emerged as a promising strategy in precision medicine. However, the endogenous stimuli in the tumor microenvironment are often insufficient and unevenly distributed, impeding efficient and rapid prodrug conversion, necessitating the incorporation of complementary therapeutic strategies to amply treatment effectiveness. This study presents a self-synergistic therapeutic approach that combines hypoxia-activated paclitaxel prodrug (pro-PTX) with near-infrared-II (NIR-II) light-triggered photothermal therapy (PTT) for boosted tumor treatment. Initially, an organic polymer with strong NIR-II light harvesting capability, efficient photo-to-heat conversion, and excellent photostability was meticulously synthesized by introducing electron-withdrawing trifluoromethyl substituent. The high-performance NIR-II photothermal polymer then served as the matrix to encapsulate the hypoxia-responsive pro-PTX prodrug, forming the nanocore, on which the cell membrane derived from natural killer (NK) cells was further cloaked. The biomimetic nanopaltform exhibited a superior affinity towards tumor cells compared to normal cells, owing to the inherent tumor-recognition capability of NK cell membrane proteins. Upon exposure to NIR-II laser, the photothermal agent induced localized hyperthermia, facilitating not only direct tumor eradication but also exacerbating hypoxia within the tumor microenvironment. This, in turn, expedited the release of hypoxia-responsive prodrugs. Consequently, the synergistic effect of NIR-II PTT and chemotherapy efficiently induced cancer cell apoptosis and inhibited tumor growth. The developed nanoplatform, integrating hypoxia-responsive prodrug, high-performance NIR-II PTT agent-mediated complementary phototherapy, and NK cell-inspired active targeting, represents a promising strategy for precise and boosted tumor treatment. [Display omitted] • A nanoplatform integrates hypoxia-responsive prodrug, NIR-II PTT phototherapy, and NK cell-inspired active targeting. • Photothermal tumor ablation disrupted blood flow, creating severe hypoxia and expediting prodrug release. • NIR-II PTT and prodrug combo enhanced cancer cell apoptosis, suppressed tumor growth, and reduced pulmonary metastasis. [ABSTRACT FROM AUTHOR]
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- 2024
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14. The First High-Quality Reference Genome of Sika Deer Provides Insights into High-Tannin Adaptation
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Xing, Xiumei, Ai, Cheng, Wang, Tianjiao, Li, Yang, Liu, Huitao, Hu, Pengfei, Wang, Guiwu, Liu, Huamiao, Wang, Hongliang, Zhang, Ranran, Zheng, Junjun, Wang, Xiaobo, Wang, Lei, Chang, Yuxiao, Qian, Qian, Yu, Jinghua, Tang, Lixin, Wu, Shigang, Shao, Xiujuan, Li, Alun, Cui, Peng, Zhan, Wei, Zhao, Sheng, Wu, Zhichao, Shao, Xiqun, Dong, Yimeng, Rong, Min, Tan, Yihong, Cui, Xuezhe, Chang, Shuzhuo, Song, Xingchao, Yang, Tongao, Sun, Limin, Ju, Yan, Zhao, Pei, Fan, Huanhuan, Liu, Ying, Wang, Xinhui, Yang, Wanyun, Yang, Min, Wei, Tao, Song, Shanshan, Xu, Jiaping, Yue, Zhigang, Liang, Qiqi, Li, Chunyi, Ruan, Jue, and Yang, Fuhe
- Abstract
Sika deerare known to prefer oak leaves, which are rich in tannins and toxic to most mammals; however, the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear. In identifying the mechanism responsible for the tolerance of a highly toxic diet, we have made a major advancement by explaining the genome of sika deer. We generated the first high-quality, chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments. Comparative genome analyses showed that the UGTand CYPgene families are functionally involved in the adaptation of sika deer to high-tannin food, especially the expansion of the UGTfamily 2 subfamily B of UGTgenes. The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation. Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.
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- 2023
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15. Distinct clonal identities of B-ALLs arising after lenolidomide therapy for multiple myeloma
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Barnell, Erica K., Skidmore, Zachary L., Newcomer, Kenneth F., Chavez, Monique, Campbell, Katie M., Cotto, Kelsy C., Spies, Nicholas C., Ruzinova, Marianna B., Wang, Tianjiao, Abro, Brooj, Kreisel, Friederike, Parikh, Bijal A., Duncavage, Eric J., Frater, John L., Lee, Yi-Shan, Hassan, Anjum, King, Justin A., Kohnen, Daniel R., Fiala, Mark A., Welch, John S., Uy, Geoffrey L., Vij, Kiran, Vij, Ravi, Griffith, Malachi, Griffith, Obi L., and Wartman, Lukas D.
- Abstract
Patients with multiple myeloma (MM) who are treated with lenalidomide rarely develop a secondary B-cell acute lymphoblastic leukemia (B-ALL). The clonal and biological relationship between these sequential malignancies is not yet clear. We identified 17 patients with MM treated with lenalidomide, who subsequently developed B-ALL. Patient samples were evaluated through sequencing, cytogenetics/fluorescence in situ hybridization (FISH), immunohistochemical (IHC) staining, and immunoglobulin heavy chain (IgH) clonality assessment. Samples were assessed for shared mutations and recurrently mutated genes. Through whole exome sequencing and cytogenetics/FISH analysis of 7 paired samples (MM vs matched B-ALL), no mutational overlap between samples was observed. Unique dominant IgH clonotypes between the tumors were observed in 5 paired MM/B-ALL samples. Across all 17 B-ALL samples, 14 (83%) had a TP53 variant detected. Three MM samples with sufficient sequencing depth (>500×) revealed rare cells (average of 0.6% variant allele frequency, or 1.2% of cells) with the same TP53 variant identified in the subsequent B-ALL sample. A lack of mutational overlap between MM and B-ALL samples shows that B-ALL developed as a second malignancy arising from a founding population of cells that likely represented unrelated clonal hematopoiesis caused by a TP53 mutation. The recurrent variants in TP53 in the B-ALL samples suggest a common path for malignant transformation that may be similar to that of TP53-mutant, treatment-related acute myeloid leukemia. The presence of rare cells containing TP53 variants in bone marrow at the initiation of lenalidomide treatment suggests that cellular populations containing TP53 variants expand in the presence of lenalidomide to increase the likelihood of B-ALL development.
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- 2023
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16. Designing Cost-Effective and Reliable Submarine Communications Cable Path: Lessons From the Tonga Volcano Disaster
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Wang, Xinyu, Wang, Zengfu, Wang, Tianjiao, and Zukerman, Moshe
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Submarine communications cables are essential infrastructure in modern society, but they are also vulnerable to unpredictable disasters, and their breakage may have dire social and economic consequences. Motivated by the lessons from the Tonga volcano eruption in 2022, we incorporate the volcano risk factor with the other considerations (including earthquakes, fishing, anchoring, terrain slope, and marine protected areas) that have been considered in previous publications, and explain the Fast Marching Method-based path planning of submarine cables. To consider the effect of volcanos, we also introduce constraints based on keeping safety distances (zero, short or long) from each volcano, by setting infinite risk value in areas to be avoided. We then provide the approximate Pareto front of the cost and risk of submarine cable paths for different stakeholders' reference. We demonstrate that significant cost savings and reduced cable faults could have been achieved for the Tonga-Fiji cable system using our method, keeping in mind that our conclusions are based only on publicly available data.
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- 2023
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17. Submarine Cable Network Design for Regional Connectivity
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Wang, Tianjiao, Wang, Zengfu, Moran, Bill, and Zukerman, Moshe
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This paper optimizes path planning for a trunk-and-branch topology network in an irregular 2-dimensional manifold embedded in 3-dimensional Euclidean space with application to submarine cable network planning. We go beyond our earlier focus on the weighted costs of cables (cable laying cost, resilience, design level and repair rate) to include the cost of branching units (BUs), including material and labor, as well as submarine cable landing stations (CLSs). This optimization also includes choices of locations of BUs and CLSs. These are important issues for the economics of cable laying and significantly change the model and the optimization process. We pose the problem as a variant of the Steiner tree problem, but one in which the Steiner nodes can vary in number, while incurring a penalty. We refer to it as the weighted Steiner node problem. It differs from the Euclidean Steiner tree problem, where Steiner points are forced to have degree three; this is no longer the case, in general, when nodes incur a cost. We are able to prove that our algorithm is applicable to Steiner nodes with degree greater than three, enabling optimization of network costs in this context. The optimal solution is achieved in polynomial-time using dynamic programming.
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- 2022
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18. Utilization and quality assessment of digestive endoscopy in China: results from 5-year consecutive nationwide surveys
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Xin, Lei, Gao, Ye, Cheng, Zhiyuan, Wang, Tianjiao, Lin, Han, Pang, Yanan, Sun, Chang, Fu, Zengjun, Li, Zhaoshen, Ma, Xudong, Wang, Luowei, and Ji, Yuanyuan
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- 2022
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19. Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity
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Ou, Jiayao, Guan, Xiaoxing, Wang, Jiali, Wang, Tianjiao, Zhang, Bin, Li, Rong, Xu, Huji, Hu, Xiaoyu, and Guo, Xue-Kun
- Abstract
Well-orchestrated transcriptional programs in intestinal epithelial cells (IECs) are essential for maintenance of optimal mucosal barrier functions, whereas the contribution of elongation-related mechanisms to barrier function remains unknown. Here, a combination of genetic and genomic approaches defined a critical role of IEC-intrinsic negative elongation factor (NELF) complex in maintenance of epithelial homeostasis. By direct occupancy at endogenous gene loci, NELF sustained expression of a subset of genes related to junctional integrity. As a result, epithelial NELF deficiency results in subdued levels of these junction-related genes and excessive IEC necroptosis in vivo secondary to commensal microbial invasion. In a colitis model, NELF-deficient mice exhibited severely impaired barrier integrity characterized by increased intestinal permeability and significantly exacerbated intestinal inflammation with lethal consequences. Our findings reveal the protective function of the NELF complex against intestinal damage and inflammation and suggest that elongation represents a biologically important step in defining IEC transcriptome.
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- 2022
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20. Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity
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Ou, Jiayao, Guan, Xiaoxing, Wang, Jiali, Wang, Tianjiao, Zhang, Bin, Li, Rong, Xu, Huji, Hu, Xiaoyu, and Guo, Xue-Kun
- Abstract
Well-orchestrated transcriptional programs in intestinal epithelial cells (IECs) are essential for maintenance of optimal mucosal barrier functions, whereas the contribution of elongation-related mechanisms to barrier function remains unknown. Here, a combination of genetic and genomic approaches defined a critical role of IEC-intrinsic negative elongation factor (NELF) complex in maintenance of epithelial homeostasis. By direct occupancy at endogenous gene loci, NELF sustained expression of a subset of genes related to junctional integrity. As a result, epithelial NELF deficiency results in subdued levels of these junction-related genes and excessive IEC necroptosis in vivo secondary to commensal microbial invasion. In a colitis model, NELF-deficient mice exhibited severely impaired barrier integrity characterized by increased intestinal permeability and significantly exacerbated intestinal inflammation with lethal consequences. Our findings reveal the protective function of the NELF complex against intestinal damage and inflammation and suggest that elongation represents a biologically important step in defining IEC transcriptome.
- Published
- 2022
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21. Multi Objective Evaluation Between Learning Behavior and Learning Achievement
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Xia, Xiaona and Wang, Tianjiao
- Abstract
The artificial intelligence methods might be applied to see through the education problems, and make effective prediction and decision. The transformation from data to decision are inseparable from the learning analytics. In order to solve the dynamic multi-objective decision problems, a decision learning algorithm is designed to analyze the learning behavior and learning achievement based on the particle swarm optimization mechanism, which ensures the global optimization of data analysis. Compared with the performance indicators of several approximate algorithms, this algorithm has the advantage of association analysis, which improves the accuracy and robustness; Furthermore, three tested problems are constructed by GeoDa tool, and through data training and analysis, the dynamic multi-objective decision rules are obtained. The whole research can provide theoretical and technical support for other related or similar issues.
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- 2022
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22. Droplet Wetting Propagation on a Hybrid-Wettability Surface
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Wang, Tianjiao, Liang, Gangtao, Li, Lei, Zhou, Shihe, and Shen, Shengqiang
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Droplet impinging on the boundary between hydrophilic and hydrophobic regions of a hybrid-wettability surface is studied both experimentally and numerically in the present paper. The interfacial evolution and dynamic feature and the corresponding underlying mechanisms behind are mainly analyzed. Because of the unbalanced surface energy in the vicinity of a boundary, the droplet undergoes spreading–receding in the hydrophobic region before migration toward the hydrophilic region. This results in an increase first but then a decrease in the spreading factor in the hydrophobic region, while it increases continuously in the hydrophilic region. In addition, increasing Weber number leads to the increase in both the spreading factor and migration displacement of the droplet in the hydrophobic region, but the latter decreases in the hydrophilic region, resulting from different momentums of secondary spreading. The experimental determinations are verified in detail by a series of numerical simulations performed based on the single variable method by fixing contact angles in different regions separately and excluding the impact momentum. It is shown that the highly unsymmetrical pressure field is exactly one important reason for droplet migration on the hybrid-wettability surface. Despite the weak dependence of the spreading factor on the hydrophilic contact angle in the hydrophobic region, it has an appreciably positive effect on droplet migration, which is confirmed by the increased pressure gradient with its action area in the hydrophobic region when decreasing the hydrophilic contact angle. This paper advances the fundamental understanding for droplet migration on the hybrid-/gradient-wettability surface.
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- 2021
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23. Ultrafast Photocurrent Response and High Detectivity in Two-Dimensional MoSe2‑based Heterojunctions.
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Ornelas, Christian D., Bowman, Arthur, Walmsley, Thayer S., Wang, Tianjiao, Andrews, Kraig, Zhou, Zhixian, and Xu, Ya-Qiong
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- 2020
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24. Organic interfacial engineering of gold nanowires for selective glycerol electrooxidation
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Wang, Zhe, Hong, Qingling, Miao, Boqiang, Wang, Tianjiao, Ding, Yu, Jin, Pujun, Chen, Pei, and Chen, Yu
- Abstract
The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass utilization. In this work, Au nanowires (Au-NW) modified with polyethyleneimine (PEI) molecule (Au-NW@PEI) is obtained by an up-bottom post-modification approach. Physical characterization, molecular dynamics simulation and density functional theory demonstrate that the loose-packed PEI monolayer firmly and uniformly distribute on the Au-NW surface due to the strong Au-N interaction. Electrochemical experiments and product analysis display that PEI modification significantly enhance the electro-activity of Au-NW for the glycerol electro-oxidation reaction (GEOR) due to the electronic effect. Meanwhile, the steric hindrance and electrostatic effect of PEI layer make the optimizing adsorption of intermediates possible. Therefore, the selectivity of C3 product glyceric acid over Au-NW@PEI is increased by nearly 20%. The work thus indicates that the rational design of metal-organic interface can effectively elevate the electro-activity and selectivity of Au nanostructures, which may have wide application in biomass development.
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- 2024
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25. Development of RNA Aptamers Targeting Ebola Virus VP35
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Binning, Jennifer M., Wang, Tianjiao, Luthra, Priya, Shabman, Reed S., Borek, Dominika M., Liu, Gai, Xu, Wei, Leung, Daisy W., Basler, Christopher F., and Amarasinghe, Gaya K.
- Abstract
Viral protein 35 (VP35), encoded by filoviruses, is a multifunctional dsRNA binding protein that plays important roles in viral replication, innate immune evasion, and pathogenesis. The multifunctional nature of these proteins also presents opportunities to develop countermeasures that target distinct functional regions. However, functional validation and the establishment of therapeutic approaches toward such multifunctional proteins, particularly for nonenzymatic targets, are often challenging. Our previous work on filoviral VP35 proteins defined conserved basic residues located within its C-terminal dsRNA binding interferon (IFN) inhibitory domain (IID) as important for VP35 mediated IFN antagonism and viral polymerase cofactor functions. In the current study, we used a combination of structural and functional data to determine regions of Ebola virus (EBOV) VP35 (eVP35) to target for aptamer selection using SELEX. Select aptamers, representing, two distinct classes, were further characterized based on their interaction properties to eVP35 IID. These results revealed that these aptamers bind to distinct regions of eVP35 IID with high affinity (10–50 nM) and specificity. These aptamers can compete with dsRNA for binding to eVP35 and disrupt the eVP35–nucleoprotein (NP) interaction. Consistent with the ability to antagonize the eVP35–NP interaction, select aptamers can inhibit the function of the EBOV polymerase complex reconstituted by the expression of select viral proteins. Taken together, our results support the identification of two aptamers that bind filoviral VP35 proteins with high affinity and specificity and have the capacity to potentially function as filoviral VP35 protein inhibitors.
- Published
- 2024
- Full Text
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26. Research and practice progress of pulmonary rehabilitation in China and America.
- Author
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WANG Tianjiao
- Published
- 2020
- Full Text
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27. Ultrafast Photocurrent Response and High Detectivity in Two-Dimensional MoSe2-based Heterojunctions
- Author
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Ornelas, Christian D., Bowman, Arthur, Walmsley, Thayer S., Wang, Tianjiao, Andrews, Kraig, Zhou, Zhixian, and Xu, Ya-Qiong
- Abstract
Two-dimensional (2D) transition metal dichalcogenide (TMDC) materials have garnered great attention on account of their novel properties and potential to advance modern technology. Recent studies have demonstrated that TMDCs can be utilized to create high-performing heterostructures with combined functionality of the individual layers and new phenomena at these interfaces. Here, we report an ultrafast photoresponse within MoSe2-based heterostructures in which heavily p-doped WSe2and MoS2flakes share an undoped MoSe2channel, allowing us to directly compare the optoelectronic properties of MoSe2-based heterojunctions with different 2D materials. Strong photocurrent signals have been observed in both MoSe2–WSe2and MoSe2–MoS2heterojunctions with a photoresponse time constant of ∼16 μs, surmounting previous MoSe2-based devices by three orders of magnitude. Further studies have shown that the fast response is independent of the integrated 2D materials (WSe2or MoS2) but is likely attributed to the high carrier mobility of 260 cm2V–1s–1in the undoped MoSe2channel as well as the greatly reduced Schottky barriers and near absence of interface states at MoSe2–WSe2/MoS2heterojunctions, which lead to reduced carrier transit time and thus short photocurrent response time. Lastly, a high detectivity on the order of ∼1014Jones has been achieved in MoSe2-based heterojunctions, which supersedes current industry standards. These fundamental studies not only shed light on photocurrent generation mechanisms in MoSe2-based heterojunctions but also open up new avenues for engineering future high-performance 2D optoelectronic devices.
- Published
- 2020
- Full Text
- View/download PDF
28. Construction of Microporous Polyimides with Tunable Pore Size and High CO2Selectivity Based on Cross-Linkable Linear Polyimides
- Author
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Wang, Tianjiao, Yao, Hongyan, Song, Ningning, Yang, Yanchao, Shi, Kaixiang, and Guan, Shaowei
- Abstract
Polyimides with intrinsic microporosity have been well developed and explored in the field of gas adsorption and separation. However, most linear polyimides without rigid and distorted segments do not have porous structure owing to the densely packed polymer chains. Two cross-linked polyimides (PEDA-PI-CL and PEQDA-PI-CL) were synthesized from 3,3′-bis(2,3,5,6-tetrafluoro-4-vinylphenoxy)-4,4′-biphenyldiamine (TFVBPA) with 2,5-bis(3,4-dicarboxyphenoxy)-4′-phenyl dianhydride (PEDA) and 2,5-bis(3,4-dicarboxyphenoxy)-4′-phenylethynyl phenyl dianhydride (PEQDA) through polycondensation and thermal cross-linking reactions. Here, the cross-linked structure is utilized to construct microporous polyimides because it can restrict the movement of polymer segments and prevent the polymer chains from dense packing. The micropore size, microporous structure, and CO2adsorption performance can be finely tuned by increasing the cross-linking density from PEDA-PI-CL to PEQDA-PI-CL. The micropore size reduces from 1.06 to 0.54 nm and CO2adsorption increases from 6.32 to 9.88 wt %. Meanwhile, the CO2/N2and CO2/CH4selectivity values of PEQDA-PI-CL at 273 K/1 bar are 76.62 and 12.40, respectively, which is better than many other common microporous polyimides. These results reveal that increasing cross-linking density in cross-linked polyimides is favorable for preparing microporous polyimide networks with smaller pores and higher CO2adsorption selectivity.
- Published
- 2020
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29. Synergy Effect of Porphyrin Units and Alkynyl π Bridges Tunes the Memory Behavior and Threshold Voltage of Hyperbranched Polyimides
- Author
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Tian, Ye, Shi, Kaixiang, Yao, Hongyan, Wang, Tianjiao, Liu, Huiling, Song, Ying, Zhang, Yunhe, and Guan, Shaowei
- Abstract
Porphyrin units are a kind of ideal electron donor units, which have large π conjugation and well-defined planar and electron-rich structures. The inserted alkynyl π bridges between porphyrin units and anhydride moieties can effectively enlarge the π-electron delocalization and molecular dimension effect and thus enhance the electron-donating ability and reduce the dipole moment in the porphyrin-based hyperbranched polyimides (HBPIs). The synergy effect of porphyrin units and alkynyl π bridges can facilitate the charge-transfer formation and dissociation, realize the transformation of memory type, and shorten the retention time of HBPI-TAPEPP-6FDA-based memory devices. The HBPI-TAPEPP-6FDA-based memory devices manifest lower threshold voltages of −2.32 and 2.42 V, a higher ON/OFF current ratio up to 107, and a shorter retention time of ∼20 s.
- Published
- 2020
- Full Text
- View/download PDF
30. Parametric Effects on Interface Evolution and Heat Transfer in Droplet Impact on Flowing Liquid Film
- Author
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Liang, Gangtao, Chen, Liuzhu, Wang, Tianjiao, and Shen, Shengqiang
- Abstract
Interfacial phenomena and heat transfer associated with single droplet impact on a flowing liquid film are studied with three-dimensional simulations. Shear-induced sheet-film contact is detected successfully, governed by both flowing film and droplet velocities. Crown splashing at the downstream position is suppressed significantly, while cooling performance in the downstream crater is poorer than in the upstream crater because of slippage of the impact region along the streamwise direction. Increasing impact velocity and decreasing film thickness result in a very low wall temperature and high heat transfer coefficient because of enhanced convective heat transfer, but the increase in film velocity compromises cooling of the heating surface. Parametric effects of droplet impacting velocity, film thickness, and thermophysical properties on crown upstream and downstream heights in impact on the flowing film are virtually the same as those on the static film, but the unique parameter of film velocity in the former poses a negative effect on crown heights.
- Published
- 2020
- Full Text
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31. Direct Measurement of π Coupling at the Single-Molecule Level using a Carbon Nanotube Force Sensor.
- Author
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Hong, Tu, Wang, Tianjiao, and Xu, Ya-Qiong
- Published
- 2018
- Full Text
- View/download PDF
32. T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma
- Author
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Qu, Jiangming, Pan, Boju, Su, Tong, Chen, Yu, Zhang, Tao, Chen, Xingming, Zhu, Xiaoli, Xu, Zhentan, Wang, Tianjiao, Zhu, Jinxia, Zhang, Zhuhua, Feng, Feng, and Jin, Zhengyu
- Abstract
Background: This study seeks to assess the utility of T1 and T2 mapping in distinguishing metastatic lymph nodes from reactive lymphadenopathy in patients with head and neck squamous cell carcinoma (HNSCC), using diffusion-weighted imaging (DWI) as a comparison. Methods: Between July 2017 and November 2019, 46 HNSCC patients underwent neck MRI inclusive of T1 and T2 mapping and DWI. Quantitative measurements derived from preoperative T1 and T2 mapping and DWI of metastatic and non-metastatic lymph nodes were compared using independent samples t-test or Mann–Whitney U test. Receiver operating characteristic curves and the DeLong test were employed to determine the most effective diagnostic methodology. Results: We examined a total of 122 lymph nodes, 45 (36.9%) of which were metastatic proven by pathology. Mean T2 values for metastatic lymph nodes were significantly lower than those for benign lymph nodes (p< 0.001). Conversely, metastatic lymph nodes exhibited significantly higher apparent diffusion coefficient (ADC) and standard deviation of T1 values (T1
SD ) (p< 0.001). T2 generated a significantly higher area under the curve (AUC) of 0.890 (0.826–0.954) compared to T1SD (0.711 [0.613–0.809]) and ADC (0.660 [0.562–0.758]) (p= 0.007 and p< 0.001). Combining T2, T1SD , ADC, and lymph node size achieved an AUC of 0.929 (0.875–0.983), which did not significantly enhance diagnostic performance over using T2 alone (p= 0.089). Conclusions: The application of T1 and T2 mapping is feasible in differentiating metastatic from non-metastatic lymph nodes in HNSCC and can improve diagnostic efficacy compared to DWI.- Published
- 2023
- Full Text
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33. Errata to “Optimal Tree Topology for a Submarine Cable Network With Constrained Internodal Latency”
- Author
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Wang, Tianjiao, Wang, Xinyu, Wang, Zengfu, Guo, Chao, Moran, Bill, and Zukerman, Moshe
- Abstract
Presents corrections to the article “Optimal Tree Topology for a Submarine Cable Network With Constrained Internodal Latency”.
- Published
- 2023
- Full Text
- View/download PDF
34. Direct Measurement of π Coupling at the Single-Molecule Level using a Carbon Nanotube Force Sensor
- Author
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Hong, Tu, Wang, Tianjiao, and Xu, Ya-Qiong
- Abstract
We report a carbon nanotube (CNT) force sensor that combines a suspended CNT transistor with dual-trap optical tweezers to explore the interactions between two individual molecules in the near-equilibrium regime with sub-piconewton resolution. The directly measured equilibrium force (1.2 ± 0.5 pN) is likely related to the binding force between a CNT and a single DNA base, where two aromatic rings spontaneously attract to each other due to the noncovalent forces between them. On the basis of our force measurements, the binding free energy per base is calculated (∼0.34 eV), which is in good agreement with theoretical simulations. Moreover, three-dimensional scanning photocurrent microscopy enables us to simultaneously monitor the morphology changes of the CNT, leading to a comprehensive reconstruction of the CNT-DNA binding dynamics. These experimental results shed light on the fundamental understanding of the mechanical coupling between CNTs and DNA molecules and, more importantly, provide a new platform for direct observation of intermolecular interfaces at the single-molecule level.
- Published
- 2018
- Full Text
- View/download PDF
35. Enhancing the Selectivity of H2O2Electrogeneration by Steric Hindrance Effect
- Author
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Xiao, Xue, Wang, Tianjiao, Bai, Juan, Li, Fumin, Ma, Tianyi, and Chen, Yu
- Abstract
Selective hydrogen peroxide (H2O2) electrogeneration by oxygen reduction reaction (ORR) is an efficient and promising synthetic method for H2O2production. Herein, we build a particular inorganic–organic interface to enhance the electrocatalytic selectivity of reduced graphene oxide (rGO) aerogels for H2O2electrogeneration by modifying rGO aerogels with polyethyleneimine (PEI). The three-dimensional porous structure of aerogels and the steric hindrance effect of PEI on rGO endow PEI-functionalized rGO (rGO/PEI) aerogels with enhanced selectivity (90.7%), production rate (106.4 mmol gcat–1h–1), and durability for H2O2electrogeneration by the two-electron pathway of ORR.
- Published
- 2018
- Full Text
- View/download PDF
36. Association between Bone Marrow Immune Microenvironment Following Autologous Stem Cell Transplant and Duration of Response for Multiple Myeloma
- Author
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Wang, Tianjiao, Fiala, Mark A, Fortier, Julie M, Liu, Ruiyang, Jayasinghe, Reyka G., Vij, Ravi, and Ding, Li
- Published
- 2022
- Full Text
- View/download PDF
37. Association between Bone Marrow Immune Microenvironment Following Autologous Stem Cell Transplant and Duration of Response for Multiple Myeloma
- Author
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Wang, Tianjiao, Fiala, Mark A, Fortier, Julie M, Liu, Ruiyang, Jayasinghe, Reyka G., Vij, Ravi, and Ding, Li
- Published
- 2022
- Full Text
- View/download PDF
38. Clonal Myeloid Heterogeneity in Older Autopsy Patients Determined By Multiple Bone Marrow Site Sequencing
- Author
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Kodgule, Rohan, Robinson, Joshua, Nonavinkere Srivatsan, Sridhar, Shirai, Cara Lunn, Du, Feiyu, Wang, Tianjiao, Khanna, Ajay, Fronick, Catrina, Fulton, Robert, Spencer, David H, Walter, Matthew J, and Duncavage, Eric
- Published
- 2022
- Full Text
- View/download PDF
39. Needle in a Haystack: A Pilot Study Combining Single-Cell Multiomics with Clinical NGS-MRD Sequencing to Search for Circulating Clonotypic Dedifferentiated Myeloma Cells
- Author
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Goldsmith, Scott R., Jayasinghe, Reyka G., Scolnick, Jonathan Adam, Sia, Jaren, Fiala, Mark A, Slade, Michael J, Wang, Tianjiao, Ding, Li, and Vij, Ravi
- Published
- 2022
- Full Text
- View/download PDF
40. Clonal Myeloid Heterogeneity in Older Autopsy Patients Determined By Multiple Bone Marrow Site Sequencing
- Author
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Kodgule, Rohan, Robinson, Joshua, Nonavinkere Srivatsan, Sridhar, Shirai, Cara Lunn, Du, Feiyu, Wang, Tianjiao, Khanna, Ajay, Fronick, Catrina, Fulton, Robert, Spencer, David H, Walter, Matthew J, and Duncavage, Eric
- Published
- 2022
- Full Text
- View/download PDF
41. Needle in a Haystack: A Pilot Study Combining Single-Cell Multiomics with Clinical NGS-MRD Sequencing to Search for Circulating Clonotypic Dedifferentiated Myeloma Cells
- Author
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Goldsmith, Scott R., Jayasinghe, Reyka G., Scolnick, Jonathan Adam, Sia, Jaren, Fiala, Mark A, Slade, Michael J, Wang, Tianjiao, Ding, Li, and Vij, Ravi
- Published
- 2022
- Full Text
- View/download PDF
42. The First High-quality Reference Genome of Sika Deer Provides Insights for High-tannin Adaptation
- Author
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Xing, Xiumei, Ai, Cheng, Wang, Tianjiao, Li, Yang, Liu, Huitao, Hu, Pengfei, Wang, Guiwu, Liu, Huamiao, Wang, Hongliang, Zhang, Ranran, Zheng, Junjun, Wang, Xiaobo, Wang, Lei, Chang, Yuxiao, Qian, Qian, Yu, Jinghua, Tang, Lixin, Wu, Shigang, Shao, Xiujuan, Li, Alun, Cui, Peng, Zhan, Wei, Zhao, Sheng, Wu, Zhichao, Shao, Xiqun, Dong, Yimeng, Rong, Min, Tan, Yihong, Cui, Xuezhe, Chang, Shuzhuo, Song, Xingchao, Yang, Tongao, Sun, Limin, Ju, Yan, Zhao, Pei, Fan, Huanhuan, Liu, Ying, Wang, Xinhui, Yang, Wanyun, Yang, Min, Wei, Tao, Song, Shanshan, Xu, Jiaping, Yue, Zhigang, Liang, Qiqi, Li, Chunyi, Ruan, Jue, and Yang, Fuhe
- Abstract
Sika deerare known to prefer oak leaves, which are rich in tannins and toxic to most mammals; however, the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear. In identifying the mechanism responsible for the tolerance of a highly toxic diet, we have made a major advancement by explaining the genome of sika deer. We generated the first high-quality, chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments. Comparative genome analyses showed that the UGTand CYPgene families are functionally involved in the adaptation of sika deer to high-tannin food, especially the expansion of the UGTfamily 2 subfamily B of UGTgenes. The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation. Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.
- Published
- 2023
- Full Text
- View/download PDF
43. Droplet Boiling on Micro-Pillar Array Surface ─ Transition Boiling Regime
- Author
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Wang, Tianjiao, Hu, Zhixuan, Shen, Shengqiang, and Liang, Gangtao
- Abstract
Droplet boiling on the heating surface is a representative phenomenon in two-phase spray cooling under low volumetric fluxes. In particular, droplet boiling in the transition boiling regime holds the advantages of avoiding heat transfer deterioration in a film boiling regime and achieving comparable high heat transfer capacity in a nucleate boiling regime. While it is known to consist of intermittent liquid contact with the surface and surface dryout, quantifying the ensuing transient heat transfer performance and droplet behavior is very illusive. In this study, droplet boiling in the transition boiling regime on a micropillar array surface is investigated systematically, using the lattice Boltzmann model built up in the lab. The major contents discussed include the transient behaviors of the droplet, motion of the liquid bridge, and pinning/depinning of the three-phase contact line (TPCL), as well as the corresponding heat transfer performance. The evolution of a vapor film pierced by micropillars is analyzed from the views of morphological change and pressure distribution. The thickness of the vapor film is determined by the vapor generation rate dominated by the contact area and effective thermal conductivity, and the vapor escape rate by the permeability. The low permeability under a large pillar side length is responsible for the pressure buildup below the droplet, thus facilitating droplet rebound. The competition between capillary pressure and vapor film pressure dominates the trigger mode of the droplet rebound, i.e., fracture of the liquid bridge or filament and depinning of TPCL. The micropillar array surface is optimized to pursue the best cooling performance by assessing the impact from micropillar geometric dimensions on droplet contact time and area.
- Published
- 2023
- Full Text
- View/download PDF
44. Alternative sources use and misinformation exposure and susceptibility: The curvilinear moderation effects of socioeconomic status.
- Author
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Wang, Tianjiao and Yu, Wenting
- Subjects
SOCIOECONOMIC status ,MISINFORMATION ,POISSON regression ,MODERATION ,INFORMATION resources - Abstract
• This study responds to a call for rediscovering the role of socioeconomic status (SES) in studies of misinformation exposure and susceptibility. • Poisson regression models were fitted with the data coming from an online survey with 955 Chinese respondents. • Alternative sources use in mainland China is found to be positively related to misinformation exposure and susceptibility, respectively. • Socioeconomic status (SES), indicated by income levels, is found to quadratically moderate the relationship between alternative sources use and misinformation exposure/susceptibility. In contrast, educational attainment, another usual indicator of SES, does not show support for a quadratic moderation effect hypothesis. In an era of post-truth, the rise of alternative information sources is often blamed for the spread of misinformation. This study responds to a call for rediscovering the role of socioeconomic status (SES) by investigating the quadratic moderation effects of SES on associations between the use of alternative sources and misinformation exposure and susceptibility. Poisson regression models were fitted with the data coming from an online survey with 955 Chinese respondents. Findings show that the moderation effects are quadratic when income, rather than educational attainment, serves as the measurement of SES. The implications of the findings with respect to overeducation, income's cognitive effects, and the non-equivalence of SES's common measures in studies of media effects are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
45. Energy conversion analysis of hydrogen and electricity co-production coupled with in situ CO2 capture.
- Author
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Wang, Xun and Wang, Tianjiao
- Subjects
ELECTRIC power production ,ENERGY conversion ,CARBON sequestration ,HYDROGEN ,CARBON dioxide mitigation ,CHEMICAL kinetics ,FLUIDIZATION - Abstract
Abstract: CO
2 adsorption enhanced gasification process is a prospective technology to be used in hydrogen and power production with nearly zero CO2 emission. In this paper, a gasification kinetics steady state model is developed based on the chemical kinetics mechanism with the condition of fluidization. It is used to predict the parameters of gas phase and solid phase for a continuous flow reactor with steady state. The variation of distribution of components with gasification temperature and pressure are determined. Conceptual configurations of H2 and power co-production system are designed with the integration of CO2 adsorption enhanced gasification process, H2 separation unit, power generation unit and other auxiliary units. Mass and heat transfer between different parts are studied systematically by flow-sheet simulation and sensitivity analysis of parameters. According to the generalized exergy efficiency of the system, the influence of gasification temperature and pressure on the system performance is investigated and the optimum gasification temperature and pressure for system operation can be determined. [Copyright &y& Elsevier]- Published
- 2012
- Full Text
- View/download PDF
46. Review of Multiscale Simulation in Submicron Heat Transfer.
- Author
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Murthy, Jayathi Y., Narumanchi, Sreekant V. J., Pascual-Gutierrez, José A., Wang, Tianjiao, Chunjian Ni, and Mathur, Sanjay R.
- Subjects
SIMULATION methods & models ,HEAT transfer ,NANOSCIENCE ,NUMERICAL analysis ,TRANSPORT theory - Abstract
Over the last decade, interest in the simulation of micro- and nanoscale heat transfer has lead to the development of a variety of models and numerical methods for phonon transporanoscale heat transfer has lead to the development of a variety of models and numerical methods for phonon transport in semiconductors and dielectrics. These models span direct simulation using molecular dynamics, a range of models of varying fidelity based on the Boltzmann transport equation, as well as simpler hyperbolic extensions to the classical Fourier heat conduction equation. The paper reviews the basics of phonon transport in crystals, available models for phonon transport, as well as numerical methods for solving the equations resulting from these models. Recommendations are made for future work. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
47. GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features
- Author
-
Wang, Tianjiao, Feldman, Andrew L., Wada, David A., Lu, Ye, Polk, Avery, Briski, Robert, Ristow, Kay, Habermann, Thomas M., Thomas, Dafydd, Ziesmer, Steven C., Wellik, Linda E., Lanigan, Thomas M., Witzig, Thomas E., Pittelkow, Mark R., Bailey, Nathanael G., Hristov, Alexandra C., Lim, Megan S., Ansell, Stephen M., and Wilcox, Ryan A.
- Abstract
The cell of origin and the tumor microenvironment's role remain elusive for the most common peripheral T-cell lymphomas (PTCLs). As macrophages promote the growth and survival of malignant T cells and are abundant constituents of the tumor microenvironment, their functional polarization was examined in T-cell lymphoproliferative disorders. Cytokines that are abundant within the tumor microenvironment, particularly interleukin (IL)-10, were observed to promote alternative macrophage polarization. Macrophage polarization was signal transducer and activator of transcription 3 dependent and was impaired by the Janus kinase inhibitor ruxolitinib. In conventional T cells, the production of T helper (Th)2-associated cytokines and IL-10, both of which promote alternative macrophage polarization, is regulated by the T-cell transcription factor GATA-binding protein 3 (GATA-3). Therefore, its role in the T-cell lymphomas was examined. GATA-3 expression was observed in 45% of PTCLs, not otherwise specified (PTCL, NOS) and was associated with distinct molecular features, including the production of Th2-associated cytokines. In addition, GATA-3 expression identified a subset of PTCL, NOS with distinct clinical features, including inferior progression-free and overall survival. Collectively, these data suggest that further understanding the cell of origin and lymphocyte ontogeny among the T-cell lymphomas may improve our understanding of the tumor microenvironment's pathogenic role in these aggressive lymphomas.
- Published
- 2014
- Full Text
- View/download PDF
48. GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features
- Author
-
Wang, Tianjiao, Feldman, Andrew L., Wada, David A., Lu, Ye, Polk, Avery, Briski, Robert, Ristow, Kay, Habermann, Thomas M., Thomas, Dafydd, Ziesmer, Steven C., Wellik, Linda E., Lanigan, Thomas M., Witzig, Thomas E., Pittelkow, Mark R., Bailey, Nathanael G., Hristov, Alexandra C., Lim, Megan S., Ansell, Stephen M., and Wilcox, Ryan A.
- Abstract
The cell of origin and the tumor microenvironment’s role remain elusive for the most common peripheral T-cell lymphomas (PTCLs). As macrophages promote the growth and survival of malignant T cells and are abundant constituents of the tumor microenvironment, their functional polarization was examined in T-cell lymphoproliferative disorders. Cytokines that are abundant within the tumor microenvironment, particularly interleukin (IL)-10, were observed to promote alternative macrophage polarization. Macrophage polarization was signal transducer and activator of transcription 3 dependent and was impaired by the Janus kinase inhibitor ruxolitinib. In conventional T cells, the production of T helper (Th)2-associated cytokines and IL-10, both of which promote alternative macrophage polarization, is regulated by the T-cell transcription factor GATA-binding protein 3 (GATA-3). Therefore, its role in the T-cell lymphomas was examined. GATA-3 expression was observed in 45% of PTCLs, not otherwise specified (PTCL, NOS) and was associated with distinct molecular features, including the production of Th2-associated cytokines. In addition, GATA-3 expression identified a subset of PTCL, NOS with distinct clinical features, including inferior progression-free and overall survival. Collectively, these data suggest that further understanding the cell of origin and lymphocyte ontogeny among the T-cell lymphomas may improve our understanding of the tumor microenvironment’s pathogenic role in these aggressive lymphomas.
- Published
- 2014
- Full Text
- View/download PDF
49. Distinct clonal identities of B-ALLs arising after lenolidomide therapy for multiple myeloma
- Author
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Barnell, Erica K., Skidmore, Zachary L., Newcomer, Kenneth F., Chavez, Monique, Campbell, Katie M., Cotto, Kelsy C., Spies, Nicholas C., Ruzinova, Marianna B., Wang, Tianjiao, Abro, Brooj, Kreisel, Friederike, Parikh, Bijal A., Duncavage, Eric J., Frater, John L., Lee, Yi-Shan, Hassan, Anjum, King, Justin A., Kohnen, Daniel R., Fiala, Mark A., Welch, John S., Uy, Geoffrey L., Vij, Kiran, Vij, Ravi, Griffith, Malachi, Griffith, Obi L., and Wartman, Lukas D.
- Abstract
Patients with multiple myeloma (MM) who are treated with lenalidomide rarely develop a secondary B-cell acute lymphoblastic leukemia (B-ALL). The clonal and biological relationship between these sequential malignancies is not yet clear. We identified 17 patients with MM treated with lenalidomide, who subsequently developed B-ALL. Patient samples were evaluated through sequencing, cytogenetics/fluorescence in situ hybridization (FISH), immunohistochemical (IHC) staining, and immunoglobulin heavy chain (IgH) clonality assessment. Samples were assessed for shared mutations and recurrently mutated genes. Through whole exome sequencing and cytogenetics/FISH analysis of 7 paired samples (MM vs matched B-ALL), no mutational overlap between samples was observed. Unique dominant IgH clonotypes between the tumors were observed in 5 paired MM/B-ALL samples. Across all 17 B-ALL samples, 14 (83%) had a TP53variant detected. Three MM samples with sufficient sequencing depth (>500×) revealed rare cells (average of 0.6% variant allele frequency, or 1.2% of cells) with the same TP53variant identified in the subsequent B-ALL sample. A lack of mutational overlap between MM and B-ALL samples shows that B-ALL developed as a second malignancy arising from a founding population of cells that likely represented unrelated clonal hematopoiesis caused by a TP53mutation. The recurrent variants in TP53in the B-ALL samples suggest a common path for malignant transformation that may be similar to that of TP53-mutant, treatment-related acute myeloid leukemia. The presence of rare cells containing TP53variants in bone marrow at the initiation of lenalidomide treatment suggests that cellular populations containing TP53variants expand in the presence of lenalidomide to increase the likelihood of B-ALL development.
- Published
- 2022
- Full Text
- View/download PDF
50. Myeloma Cell Associated Therapeutic Protein Discovery Using Single Cell RNA-Seq Data
- Author
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Yao, Lijun, Jayasinghe, Reyka G, Wang, Tianjiao, O'Neal, Julie, Liu, Ruiyang, Rettig, Michael P., Tsai, Chia-Feng, Foltz, Steven M., Kohnen, Danny, Mani, Smrithi, Martins Rodrigues, Fernanda, Wendl, Michael C., Wyczalkowski, Matthew A., Goldsmith, Scott R., Zhu, Ying, Fiala, Mark A, Tao, Liu, Vij, Ravi, Ding, Li, and DiPersio, John F.
- Abstract
Goldsmith: Wugen Inc.: Consultancy. DiPersio:Magenta Therapeutics: Membership on an entity's Board of Directors or advisory committees.
- Published
- 2020
- Full Text
- View/download PDF
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